Mitochondria-Targeted Antioxidant SkQ1 Inhibits Age-Dependent Involution of the Thymus in Normal and Senescence-Prone Rats
Open accessAbstract
One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phosphonium (SkQ1). Here we report that, at low doses, SkQ1 (250 nmol/kg per day) inhibited age-dependent involution of the thymus in normal (Wistar) and senescence-prone (OXYS) rats. SkQ1 preserved total weight and volume of the organ, the volume of thymic cortex and medulla, the thymic cellularity, and the number of CD3+, CD4+, and CD8+ cells in the thymus. Moreover, SkQ1 was especially effective in senescence-prone rats. Thus SkQ1 slows down age-linked decline of the immune system, explaining prevention by this compound of infection-caused death in rodents, previously described in our group.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SkQ1 given to senescence prone rats at 250 μmol/kg/day may be sufficient to prevent physiological age-related deterioration of immunological defences.
“As for CoQ10, SkQ1 given to senescence prone rats at the concentration of 250 µmol/kg/day may be sufficient to prevent the physiological age-related deterioration of immunological defences [98].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works
Gruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834 · see citing works
An Attempt to Prevent Senescence: A Mitochondrial Approach
Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.008 · Cited by 430 · see citing works
Self-citationAntonenko, Y. N., Avetisyan, A. V., Bakeeva, L. E., Chernyak, B. V., Chertkov, V. A., Domnina, L. V., Ivanova, O. Y., Izyumov, D. S., Khailova, L. S., Klishin, S. S., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120018 · Cited by 326 · see citing works
Self-citationProgrammed and altruistic ageing
Longo, V. D., Mitteldorf, J., & Skulachev, V. P. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1706 · Cited by 306 · see citing works
Self-citationEffects of antioxidants on immune system ageing
la Fuente, M. D. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601476 · Cited by 229 · see citing works
Skulachev, V. P. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907120139 · Cited by 190 · see citing works
Self-citationNeroev, V. V., Archipova, M. M., Bakeeva, L. E., Фурсова, А. Ж., Григорян, Э. Н., Grishanova, A. Y., Иомдина, Е. Н., Ivashchenko, Z. N., Катаргина, Л. А., Хорошилова-Маслова, И. П., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120043 · Cited by 141 · see citing works
Self-citationKolosova, N. G., Shcheglova, T. V., Sergeeva, S. V., & Лоскутова, Л. В. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.022 · Cited by 115 · see citing works
Self-citationAnisimov, V. N., Bakeeva, L. E., Egormin, P. A., Филенко, О. Ф., Филипповна, И. Е., Манских, В. Н., Mikhelson, V. M., Panteleeva, A. A., PASYUKOVA, E. G., Pilipenko, D. I., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120055 · Cited by 113 · see citing works
Self-citationAging as a Mitochondria‐Mediated Atavistic Program: Can Aging Be Switched Off?
Skulachev, V. P., & Longo, V. D. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1356.009 · Cited by 93 · see citing works
Self-citationAntonenko, Y. N., Roginsky, V. A., Pashkovskaya, A. A., Rokitskaya, T. I., Kotova, Е. А., Zaspa, A. A., Chernyak, B. V., & Skulachev, V. P. (2008) · The Journal of Membrane Biology · doi:10.1007/s00232-008-9108-6 · Cited by 87 · see citing works
Self-citationRole of Neuroimmunomodulation in Aging
la Fuente, M. D. (2008) · Neuroimmunomodulation · doi:10.1159/000156465 · Cited by 61 · see citing works
Kinetic Analysis of Permeation of Mitochondria-Targeted Antioxidants Across Bilayer Lipid Membranes
Rokitskaya, T. I., Klishin, S. S., Severina, I. I., Skulachev, V. P., & Antonenko, Y. N. (2008) · The Journal of Membrane Biology · doi:10.1007/s00232-008-9124-6 · Cited by 50 · see citing works
Self-citationReversal of age-associated thymic atrophy: Treatments, delivery, and side effects
Aspinall, R., & Mitchell, W. A. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.014 · Cited by 44 · see citing works
Solov'eva, N. A., Ts, M., & Salganik, R. I. (1975) · PubMed · Cited by 41 · see citing works
Sergeeva, S. V., Bagryanskaya, E. G., Korbolina, E. E., & Kolosova, N. G. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.009 · Cited by 38 · see citing works
Self-citation19F NMR measurements of NO production in hypertensive ISIAH and OXYS rats
Bobko, A. A., Sergeeva, S. V., Bagryanskaya, E. G., Маркель, А. Л., Khramtsov, V. V., Резников, В. А., & Kolosova, N. G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.166 · Cited by 38 · see citing works
Self-citationSalganik, R. I., Shabalina, I. G., Solovyova, N. A., Kolosova, N. G., Solovyov, V. N., & Ростиславович, К. А. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2647 · Cited by 37 · see citing works
Self-citationIs thymocyte development functional in the aged?
Aw, D., Silva, A. B., & Palmer, D. B. (2009) · Aging · doi:10.18632/aging.100027 · Cited by 37 · see citing works
Aging: past, present and future
Blagosklonny, M. V., Campisi, J., & Sinclair, D. A. (2009) · Aging · doi:10.18632/aging.100009 · Cited by 35 · see citing works
Kolosova, N. G., Aidagulova, S. V., Nepomnyashchikh, G. I., Shabalina, I. G., & Shalbuyeva, N. (2001) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1013014919721 · Cited by 23 · see citing works
Self-citationImmunopharmacology of Thymosin α1 and Cytokine Synergy
Naylor, P. H., Quadrini, K. J., Garaci, E., Rasi, G., & Hadden, J. W. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1415.036 · Cited by 22 · see citing works
Opposite effects of antioxidants on anxiety in Wistar and OXYS rats
Kolosova, N. G., Trofimova, N. A., & Фурсова, А. Ж. (2006) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-006-0266-1 · Cited by 16 · see citing works
Self-citationActivity of Cell Immune Response and Open Field Behavior in Wistar and Oxys Rats
Markova, E. V., Obukhova, L. A., & Kolosova, N. G. (2003) · Bulletin of Experimental Biology and Medicine · doi:10.1023/b:bebm.0000010957.87077.ae · Cited by 15 · see citing works
Self-citationShabalina, I. G., Shalbuyeva, N., Dikalova, A., Sinitsyna, O. I., Krysanova, Z. S., & Kolosova, N. G. (2001) · PubMed · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [22]Skulachev VP Nystrom T Osiewacz HD Aging and the programmed death phenomena Topics in Current Genetics. Model systems in ageing 2003 Berlin-Heidelberg Springer-Verlag 191 238
Cited by
Sorted by citations
Liu, M., & Lu, S. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01898 · Cited by 194 · see citing works
Neuroprotective effects of berry fruits on neurodegenerative diseases
Essa, M. M., Subash, S., Al‐Adawi, S., Memon, M. A., Manivasagam, T., & Akbar, M. D. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.139483 · Cited by 172 · see citing works
Immunosenescence: signaling pathways, diseases and therapeutic targets
Fu, Y., Wang, B., Alu, A., Hong, W., Hong, L., He, X., Shi, H., Cheng, P., & Yang, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02371-z · Cited by 157 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Phenoptosis: Programmed Death of an Organism
Skulachev, M. V., & Skulachev, V. P. (2018) · Wiley eBooks · doi:10.1002/9781119432463.ch13 · Cited by 145 · see citing works
Self-citationBrand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123 · see citing works
Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents
Anisimov, V. N., Egorov, M. V., Krasilshchikova, M. S., Lyamzaev, K. G., Манских, В. Н., Moshkin, M. P., Новиков, Е. А., Popovich, I. G., Rogovin, K. A., Shabalina, I. G., et al. (2011) · Aging · doi:10.18632/aging.100404 · Cited by 119 · see citing works
Self-citationNeoteny, Prolongation of Youth: From Naked Mole Rats to “Naked Apes” (Humans)
Skulachev, V. P., Holtze, S., Vyssokikh, M. Y., Bakeeva, L. E., Skulachev, M. V., Markov, A. V., Hildebrandt, T. B., & Садовничий, В. А. (2017) · Physiological Reviews · doi:10.1152/physrev.00040.2015 · Cited by 114 · see citing works
Self-citationStefanova, N. A., Kozhevnikova, O. S., Vitovtov, A. O., Maksimova, K. Y., Logvinov, S. V., Rudnitskaya, E. A., Korbolina, E. E., Muraleva, N. A., & Kolosova, N. G. (2014) · Cell Cycle · doi:10.4161/cc.28255 · Cited by 97 · see citing works
Self-citationTargeting immunosenescence and inflammaging: advancing longevity research
Nguyen, T. Q. T., & Cho, K. A. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01527-9 · Cited by 94 · see citing works
Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium
Zinovkin, R. A., Romaschenko, V. P., Galkin, I. I., Zakharova, V., Pletjushkina, O. Y., Chernyak, B. V., & Popova, E. N. (2014) · Aging · doi:10.18632/aging.100685 · Cited by 89 · see citing works
What is “phenoptosis” and how to fight it?
Skulachev, V. P. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912070012 · Cited by 87 · see citing works
Self-citationImplications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution
Barbouti, A., Vasileiou, P. V. S., Evangelou, K., Vlasis, K. G., Papoudou‐Bai, A., Gorgoulis, V. G., & Kanavaros, P. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7986071 · Cited by 83 · see citing works
Thymic Atrophy: Experimental Studies and Therapeutic Interventions
Majumdar, S., & Nandi, D. (2017) · Scandinavian Journal of Immunology · doi:10.1111/sji.12618 · Cited by 81 · see citing works
Stefanova, N. A., Muraleva, N. A., Skulachev, V. P., & Kolosova, N. G. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-131034 · Cited by 80 · see citing works
Self-citationStefanova, N. A., Фурсова, А. Ж., & Kolosova, N. G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091675 · Cited by 78 · see citing works
Self-citationStefanova, N. A., Muraleva, N. A., Maksimova, K. Y., Rudnitskaya, E. A., Владимировна, К. Е., Telegina, D. V., & Kolosova, N. G. (2016) · Aging · doi:10.18632/aging.101054 · Cited by 77 · see citing works
Self-citationDibrova, D. V., Cherepanov, D. A., Galperin, M. Y., Skulachev, V. P., & Mulkidjanian, A. Y. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.07.006 · Cited by 76 · see citing works
Self-citationWhen the Damage Is Done: Injury and Repair in Thymus Function
Kinsella, S. M., & Dudakov, J. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01745 · Cited by 74 · see citing works
Rat retinal transcriptome: Effects of aging and AMD-like retinopathy
Kozhevnikova, O. S., Korbolina, E. E., Ershov, N., & Kolosova, N. G. (2013) · Cell Cycle · doi:10.4161/cc.24825 · Cited by 71 · see citing works
Self-citationMarkovets, A. M., Фурсова, А. Ж., & Kolosova, N. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021682 · Cited by 66 · see citing works
Self-citationMarkovets, A. M., Saprunova, V. B., Александровна, Ж. А., Фурсова, А. Ж., Bakeeva, L. E., & Kolosova, N. G. (2010) · Aging · doi:10.18632/aging.100243 · Cited by 66 · see citing works
Self-citationKolosova, N. G., Stefanova, N. A., Muraleva, N. A., & Skulachev, V. P. (2012) · Aging · doi:10.18632/aging.100493 · Cited by 53 · see citing works
Self-citationAntioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure
Vays, V. B., Eldarov, C. M., Vangeli, I. M., Kolosova, N. G., Bakeeva, L. E., & Skulachev, V. P. (2014) · Aging · doi:10.18632/aging.100636 · Cited by 51 · see citing works
Self-citationMitochondrial membrane lipidome defines yeast longevity
Beach, A., Richard, V. R., Leonov, A., Burstein, M. T., Bourque, S. D., Koupaki, O., Juneau, M., Feldman, R., Iouk, T. L., & Titorenko, V. I. (2013) · Aging · doi:10.18632/aging.100578 · Cited by 43 · see citing works
Skulachev, M. V., & Skulachev, V. P. (2017) · Biochemistry (Moscow) · doi:10.1134/s000629791712001x · Cited by 43 · see citing works
Self-citationSenescence-accelerated OXYS rats: A genetic model of premature aging and age-related diseases
Kolosova, N. G., Stefanova, N. A., Korbolina, E. E., Фурсова, А. Ж., & Kozhevnikova, O. S. (2014) · Advances in Gerontology · doi:10.1134/s2079057014040146 · Cited by 42 · see citing works
Self-citationJankauskas, S. S., Pevzner, I. B., Andrianova, N. V., Zorova, L. D., Popkov, V. A., Silachev, D. N., Kolosova, N. G., Plotnikov, E. Y., & Zorov, D. B. (2017) · Scientific Reports · doi:10.1038/srep44430 · Cited by 41 · see citing works
Self-citationImpact papers on aging in 2009
Blagosklonny, M. V., Campisi, J., Sinclair, D. A., Bartke, A., Blasco, M. A., Bonner, W. M., Bohr, V. A., Brosh, R. M., Brunet, A., DePinho, R. A., et al. (2010) · Aging · doi:10.18632/aging.100132 · Cited by 38 · see citing works
Self-citationSkulachev, V. P. (2009) · Biochemistry (Moscow) · doi:10.1134/s0006297909120165 · Cited by 35 · see citing works
Self-citationSkulachev, V. P., Vyssokikh, M. Y., Chernyak, B. V., Mulkidjanian, A. Y., Skulachev, M. V., Shilovsky, G. A., Lyamzaev, K. G., Borisov, V. B., Severin, F. F., & Садовничий, В. А. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612540 · Cited by 33 · see citing works
Self-citationStefanova, N. A., Ershov, N., Maksimova, K. Y., Muraleva, N. A., Tyumentsev, M. A., & Kolosova, N. G. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly198 · Cited by 32 · see citing works
Self-citationPerspectives of Homo sapiens lifespan extension: focus on external or internal resources?
Skulachev, V. P., Shilovsky, G. A., Putyatina, T. S., Popov, N. A., Markov, A. V., Skulachev, M. V., & Садовничий, В. А. (2020) · Aging · doi:10.18632/aging.102981 · Cited by 32 · see citing works
Self-citationMuraleva, N. A., Kozhevnikova, O. S., Фурсова, А. Ж., & Kolosova, N. G. (2019) · Antioxidants · doi:10.3390/antiox8060177 · Cited by 31 · see citing works
Self-citationMuraleva, N. A., Kozhevnikova, O. S., Александровна, Ж. А., Stefanova, N. A., Karamysheva, T. V., Фурсова, А. Ж., & Kolosova, N. G. (2014) · Cell Cycle · doi:10.4161/15384101.2014.958393 · Cited by 31 · see citing works
Self-citationSalen Mn Complexes are Superoxide Dismutase/Catalase Mimetics that Protect the Mitochondria
Doctrow, S. R., Liesa, M., Melov, S., Shirihai, O. S., & Tofilon, P. J. (2012) · Current Inorganic Chemistry · doi:10.2174/1877944111202030325 · Cited by 31 · see citing works
SkQ1 as a Tool for Controlling Accelerated Senescence Program: Experiments with OXYS Rats
Kolosova, N. G., Kozhevnikova, O. S., Muraleva, N. A., Rudnitskaya, E. A., Rumyantseva, Y. V., Stefanova, N. A., Telegina, D. V., Tyumentsev, M. A., & Фурсова, А. Ж. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922120124 · Cited by 28 · see citing works
Self-citationShipounova, I. N., Svinareva, D. A., Petrova, T. V., Lyamzaev, K. G., Chernyak, B. V., Дризе, Н. И., & Skulachev, V. P. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.06.003 · Cited by 27 · see citing works
Self-citationTikhonova, M. A., Yu, C., Kolosova, N. G., Gerlinskaya, L. A., Maslennikova, S. O., Yudina, A. V., Amstislavskaya, T. G., & Ho, Y. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.01.012 · Cited by 27 · see citing works
Self-citationYang, J., Liu, J., Liang, J., Fan, L., Wang, W., Chen, H., & Xie, X. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102115 · Cited by 26 · see citing works
SkQ1 treatment and food restriction — two ways to retard an aging program of organisms
Skulachev, V. P. (2011) · Aging · doi:10.18632/aging.100410 · Cited by 26 · see citing works
Self-citationSiddiqui, S., Lustig, A., Carter, A., Sankar, M., Daimon, C. M., Premont, R. T., Etienne, H., van Gastel, J., Azmi, A., Janssens, J., et al. (2017) · Aging · doi:10.18632/aging.101185 · Cited by 21 · see citing works
Santamaria, J. C., & Irla, M. (2026) · Science Advances · doi:10.1126/sciadv.aeb2970 · Cited by 19 · see citing works
The potential role of the thymus in immunotherapies for acute myeloid leukemia
Hino, C., Xu, Y., Xiao, J., Baylink, D. J., Reeves, M. E., & Cao, H. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1102517 · Cited by 17 · see citing works
Cellular Models of Aging and Senescence
Kim, B., Lee, D. I., Basisty, N., & Dai, D.-F. (2025) · Cells · doi:10.3390/cells14161278 · Cited by 16 · see citing works
Majumdar, S., Adiga, V., Raghavan, A., Rananaware, S. R., & Nandi, D. (2019) · Immunology · doi:10.1111/imm.13043 · Cited by 16 · see citing works
Korbolina, E. E., Kozhevnikova, O. S., Stefanova, N. A., & Kolosova, N. G. (2012) · Aging · doi:10.18632/aging.100427 · Cited by 15 · see citing works
Self-citationXia, T., Zhou, Y., An, J., Cui, Z. G., Zhong, X., Cui, T., Lv, B., Zhao, X., & Gao, X. (2024) · Aging Cell · doi:10.1111/acel.14317 · Cited by 15 · see citing works
Korbolina, E. E., Ershov, N., Bryzgalov, L. O., & Kolosova, N. G. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-s12-s3 · Cited by 14 · see citing works
Self-citationAmeliorative effects of SkQ1 eye drops on cataractogenesis in senescence-accelerated OXYS rats
Rumyantseva, Y. V., Ryabchikova, E. I., Фурсова, А. Ж., & Kolosova, N. G. (2014) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-014-2806-0 · Cited by 13 · see citing works
Self-citationMitochondria in cell senescence: A Friend or Foe?
Chen, Q., Young, L. H., & Barsotti, R. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.02.019 · Cited by 13 · see citing works
Korbolina, E. E., Александровна, Ж. А., Фурсова, А. Ж., Kozhevnikova, O. S., & Kolosova, N. G. (2016) · BMC Genetics · doi:10.1186/s12863-016-0461-7 · Cited by 12 · see citing works
Self-citationSugimoto, Y., Endo, D., & Aratani, Y. (2020) · Inflammation · doi:10.1007/s10753-020-01342-6 · Cited by 11 · see citing works
Calorie Restriction Provides Kidney Ischemic Tolerance in Senescence-Accelerated OXYS Rats
Andrianova, N. V., Zorova, L. D., Pevzner, I. B., Kolosova, N. G., Plotnikov, E. Y., & Zorov, D. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315224 · Cited by 11 · see citing works
Self-citationBiogerontology in Russia: from past to future
Anisimov, V. N., Khavinson, V. K., & Mikhailova, O. N. (2010) · Biogerontology · doi:10.1007/s10522-010-9307-2 · Cited by 10 · see citing works
Kourti, M., & Kontoghiorghes, G. J. (2025) · Antioxidants · doi:10.3390/antiox15010015 · Cited by 8 · see citing works
Rogov, A. G., Goleva, T. N., Aliverdieva, D. A., & Zvyagilskaya, R. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021107 · Cited by 8 · see citing works
Igonina, T. N., Ragaeva, D. S., Tikhonova, M. A., Petrova, O. M., Herbeck, Y. E., Рожкова, И. Н., Amstislavskaya, T. G., & Amstislavsky, S. Y. (2017) · Brain Research · doi:10.1016/j.brainres.2017.12.021 · Cited by 8 · see citing works
Thymic involution in ontogenesis: Role in aging program
Shilovsky, G. A., Feniouk, B. A., & Skulachev, V. P. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915120135 · Cited by 7 · see citing works
Self-citationSKQ1: a mitochondria-targeted antioxidant with therapeutic potential
Wu, R., & Wu, Y. (2026) · Journal of drug targeting · doi:10.1080/1061186x.2026.2613054 · Cited by 6 · see citing works
Yurova, M. N., Zabezhinski, M. A., Piskunova, T. S., Тындык, М. Л., Popovich, I. G., & Anisimov, V. N. (2011) · Advances in Gerontology · doi:10.1134/s2079057011030155 · Cited by 6 · see citing works
Receptor regulation of senile phenoptosis
Skulachev, M. V., Severin, F. F., & Skulachev, V. P. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914100022 · Cited by 6 · see citing works
Self-citationKhan, W. A. (2023) · Pure and Applied Biology · doi:10.19045/bspab.2023.120065 · Cited by 6 · see citing works
Maslov, M. Y., Чернышева, Г. А., Smol’yakova, V. I., Алиев, О. И., Kolosova, N. G., & Плотников, М. Б. (2015) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-141860 · Cited by 5 · see citing works
Self-citationStefanova, N. A., Korbolina, E. E., Ershov, N., Rogaev, E. I., & Kolosova, N. G. (2016) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059716040195 · Cited by 4 · see citing works
Self-citationDevelopmental aspects of senescence
Brusentsev, E. Y., Tikhonova, M. A., Herbeck, Y. E., Ragaeva, D. S., Рожкова, И. Н., & Amstislavsky, S. Y. (2017) · Russian Journal of Developmental Biology · doi:10.1134/s1062360417020035 · Cited by 4 · see citing works
How to cancel the program of body aging?
Skulachev, V. P. (2010) · Russian Journal of General Chemistry · doi:10.1134/s1070363210070492 · Cited by 4 · see citing works
Self-citationPremature aging and structural organization of the mesenteric lymph node
Gorchakova, O., Kolosova, N. G., Николаевич, Г. В., Starkova, E., & Демченко, Г. А. (2019) · Archiv Euromedica · doi:10.35630/2199-885x/2019/9/3.7 · Cited by 3 · see citing works
Self-citationRogovin, K. A., Khrushcheva, A. M., Shekarova, O. N., Ushakova, M. V., Манских, В. Н., Sokolova, O. V., & Vasilieva, N. Y. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914100137 · Cited by 3 · see citing works
Valdés‐Fuentes, M., Rodrı́guez-Martı́nez, E., & Rivas-Arancibia, S. (2025) · Medical Sciences · doi:10.3390/medsci13040293 · Cited by 2 · see citing works
RatDNA: A database on microarray studies of rats bearing genes associated with age-related diseases
Kozhevnikova, O. S., Мартыщенко, М. К., Александрович, Г. М., Korbolina, E. E., Muraleva, N. A., Kolosova, N. G., & Orlov, Y. L. (2013) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059713030076 · Cited by 2 · see citing works
Self-citationMitochondrial Reactive Oxygen Species Aging Theory
Skulachev, V. P., & Lyamzaev, K. G. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_47-1 · Cited by 2 · see citing works
Self-citationCellular Respiration in Thymic Fragments from Mice
Alshamsi, M., Hassane, M., Almarzooqi, F., & Souid, A. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2708230 · Cited by 1 · see citing works
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0010 · Cited by 1 · see citing works
Wu, Z.-G., Zhao, Q.-Q., Lin, S., Lei, J.-Y., Yang, C.-J., Sun, S., Yang, Z.-Q., Ni, S.-H., Chen, X.-L., & Lu, L. (2026) · npj Aging · doi:10.1038/s41514-026-00433-2 · Cited by 1 · see citing works
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0004 · Cited by 1 · see citing works
Howard, G. C. (2021) · doi:10.1093/oso/9780190687724.001.0001 · Cited by 1 · see citing works
Mitochondrial Reactive Oxygen Species Aging Theory
Skulachev, V. P., & Lyamzaev, K. G. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_47 · Cited by 1 · see citing works
Self-citationStructural and functional basis of accelerated involution of the thymus in OXYS rats
Obukhova, L. A., Vays, V. B., Bakeeva, L. E., Sergeeva, S. V., & Kolosova, N. G. (2014) · Advances in Gerontology · doi:10.1134/s2079057014010081
Self-citationLymph nodes morphology as predictor natural and premature aging
Gorchakova, O., Николаевич, Г. В., & Демченко, Г. А. (2020) · IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB) · doi:10.1109/csgb51356.2020.9214771
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0001
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0007
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0016
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0014
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0005
Shamsi, M. A., Hassane, M., Almarzooqi, F., & Souid, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1484167/v1
Alshamsi, M., Hassane, M., Almarzooqi, F., & Souid, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1484167/v2
Rensing, L., & Rippe, V. (2013) · Springer eBooks · doi:10.1007/978-3-642-37733-4_7
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0008
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0002
Ashes to Ashes and Dust to Dust
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0006
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0003
Death in Bacteria, Fungi, and Protista
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0011
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0015
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0012
Programmed Cell Death in Humans
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0009
Howard, G. C. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780190687724.003.0013
Phytocorrection of the Rate of Aging of the intestinal Region Lymph Node
Николаевич, Г. В., Абдрешов, С. Н., Gorchakova, O., Михайлович, Н. К., Демченко, Г. А., & Bekeneva, M. (2022) · IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB) · doi:10.1109/csgb56354.2022.9865556
ФУНДАМЕНТАЛЬНАЯ И ПРИКЛАДНАЯ НАУКА: СОСТОЯНИЕ И ТЕНДЕНЦИИ РАЗВИТИЯ
университет», Ф. В. «. Г. Т., Киселев, А. А., Кабанов, А. М., Уральский федеральный университет, У. Г. Г. У., Невраева, Н. Ю., университет, У. Ф., Parshin, A. V., Гагарина», В. В. «.-В. А. И. П. Н. Е. Ж. И. Ю. А., Фролов, И. В., Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского, А. Ф. Н., et al. (2023) · ICSP «NEW SCIENCE» eBooks · doi:10.46916/18122023-1-978-5-00215-184-4
Новосибирский государственный университет НИИ клинической и экспериментальной лимфологии, Ф. И. С. Р., Горчаков, В. Н., Амансахатова, Е. Н., университет, Н. Г., Абдрешов, С. Н., Казахстан, И. Г. И. Ф. Р., Демченко, Г. А., Казахстан, И. Г. И. Ф. Р., Yeshmukhanbet, A. N., Казахстан, И. Г. И. Ф. Р., et al. (2023) · ICSP «NEW SCIENCE» eBooks · doi:10.46916/18122023-2-978-5-00215-184-4
- Authors
- Obukhova, L. A., Skulachev, V. P., & Kolosova, N. G.
- Affiliations
- Russian Academy of Sciences (RU)
- Lomonosov Moscow State University (RU)
- Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk 630090, Russia
- Corresponding author
- Skulachev, Vladimir P.
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2009-04-22
- Volume
- 1
- Issue
- 4
- Pages
- 389-401
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC2830050
- OpenAlex
- W1536029675
- Cited by
- 106
- References
- 27
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 23 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 2 · 2014: 12 · 2013: 6 · 2012: 5
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Russian Foundation for Basic Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- SkQ1, mitochondria-targeted antioxidants, thymic involution, OXYS rats, thymic cellularity, thymic cortex and medulla, CD3+ T cells, CD4+ T cells, CD8+ T cells, immunosenescence, infection susceptibility
- MeSH terms
- Aging, Animals, Antioxidants, Mitochondria, Plastoquinone, Thymus Gland, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
