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New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
Open accessAbstract
Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the 'old' and 'new' hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.
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![Figure 2 The force of natural selection in ageing. The force that selects different traits declines as a function of age after reproductive age. Natural selection benefits survival to maturity and reproduction. Therefore, traits that present harmful effects late in life (selection shadow) will likely have already been passed to the next generation. The figure was generated based on the reference [34].](/paper-figures/b467c0630faa42d0a54925adc9c62d3b/new-hallmarks-of-ageing-a-2022-copenhagen-ageing-meeting-summary-figure-2.jpg)
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“Maintenance of organizational spatial compartmentalization is a hallmark of organismal health, while aging is associated with a decline in this capacity.56”
From Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging (2024) · cites this paper as [56]
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“The accumulation of senescent cells contributes to tissue and organismal aging and is a well-known aging hallmark.56”
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Metadata
- Authors
- Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., Li, Z., Shiloh, Y., Opresko, P. L., Egly, J.-M., Kirkwood, T., Verdin, E., Bohr, V. A., Cox, L. S., Stevnsner, T., Rasmussen, L. J., & Fang, E. F.
- Affiliations
- Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog 1478, Norway
- University of Oslo (NO)
- Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow 30-348, Poland
- University of Copenhagen (DK)
- Bispebjerg Hospital (DK)
- Lund University (SE)
- Copenhagen University Hospital (DK)
- Tel Aviv University (IL)
- University of Pittsburgh (US)
- Centre National de la Recherche Scientifique (FR)
- Buck Institute for Research on Aging (US)
- University of Oxford (GB)
- Aarhus University (DK)
- Corresponding author
- Stevnsner, Tinna
- Rasmussen, Lene Juel
- Fang, Evandro F.
- ORCID
- Molière, Adrian
- Lautrup, Sofie
- Zhang, Jianying
- Madsen, Helena Borland
- Cao, Shuqin
- Soendenbroe, Casper
- Mansell, Els
- Vestergaard, Mark Bitsch
- Li, Zhiquan
- Shiloh, Yosef
- Opresko, Patricia L.
- Egly, Jean-Marc
- Kirkwood, Thomas
- Verdin, Eric
- Bohr, Vilhelm A.
- Cox, Lynne S.
- Stevnsner, Tinna
- Rasmussen, Lene Juel
- Fang, Evandro F.
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2022-08-29
- Volume
- 14
- Issue
- 16
- Pages
- 6829-6839
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC9467401
- OpenAlex
- W4293462467
- Cited by
- 319
- References
- 58
- Citations by year
- 2026: 42 · 2025: 67 · 2024: 100 · 2023: 102 · 2022: 8
- FWCI
- 23.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- HAL (submittedVersion, other-oa)
- Lund University Publications (Lund University) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- Lundbeckfonden (R347-2020-2176)
- Novo Nordisk
- Biotechnology and Biological Sciences Research Council (BB/W01825X/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- hallmarks of aging, aging, autophagy, microbiome, mechanical properties, splicing dysregulation, inflammation, age-related diseases, cellular senescence, stem cell exhaustion, intercellular communication, proteostasis, nutrient sensing, telomere shortening, epigenetic modifications, mitochondrial dysfunction, genomic instability
- MeSH terms
- Aged, Aging, Humans, Telomere, Cellular Senescence, Genomic Instability, Epigenesis, Genetic
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