Presence of Salmonella AvrA in colorectal tumor and its precursor lesions in mouse intestine and human specimens
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// Rong Lu 1 , Maarten Bosland 2 , Yinglin Xia 1, 3 , Yong-guo Zhang 1 , Ikuko Kato 4 and Jun Sun 1 1 Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA 2 Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA 3 Division of Academic Internal Medicine and Geriatrics, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA 4 Department of Oncology and Pathology, Wayne State University School of Medicine, Detroit, MI, USA Correspondence to: Jun Sun, email: junsun7@uic.edu Ikuko Kato, email: katoi@karmanos.org Keywords: colorectal cancer, inflammation, infection, IBD, Salmonella Received: April 19, 2017 Accepted: June 26, 2017 Published: July 06, 2017 ABSTRACT Evidence directly supporting an association between Salmonella infection and colorectal cancer in human subjects is sparse. It has been well recognized that Salmonella infection increases the risk of gallbladder cancer. AvrA, a bacterial protein from Salmonella enterica, plays a crucial role in establishing chronic infection. To our knowledge, the presence of the bacterial AvrA has never been studied in human samples. Here, we demonstrated the presence and cellular localization of AvrA in inflamed, colorectal tumor and its precursor lesions, using both animal experimental infection models and human clinical specimens. We performed a newly developed AvrA serological assay and to determine the presence of anti- Salmonella AvrA antibody in chronic infected mouse serum samples. Further, we tested the presence of AvrA gene in healthy human fecal samples, in order to advance etiological studies of Salmonella AvrA in human population. Our study suggests a potential role of this bacterial protein in human colorectal cancer. Moreover, our new serological assay may serve a useful tool to identify individuals at increased risk for colorectal cancer.
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Immunohistochemistry showed more AvrA protein in pre-cancerous colon tissue than in normal colon or tumor tissue.
“Expression of AvrA protein, detected by immunohistochemistry, was significantly higher in pre-cancer colon tissues than in normal human colon or tumor tissues, based on pathology differences.181”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [181]
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Microbiome in Colonic Carcinogenesis
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Microbiome in Colonic Carcinogenesis
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- Authors
- Lu, R., Bosland, M., Xia, Y., Zhang, Y.-G., Kato, I., & Sun, J.
- Affiliations
- University of Illinois Chicago (US)
- Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
- Wayne State University (US)
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2017-07-06
- Volume
- 8
- Issue
- 33
- Pages
- 55104-55115
- ISSN
- 1949-2553 (ISSN-L)
- PMC
- PMC5589645
- OpenAlex
- W2731914191
- Cited by
- 75
- References
- 49
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 9 · 2023: 13 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 6 · 2018: 8
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Oncotarget (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK105118)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- Salmonella enterica, colorectal cancer, inflammation-associated cancer, inflammatory bowel disease, fecal samples, mouse infection model, cancer risk identification
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