Towards the Human Colorectal Cancer Microbiome
Open accessAbstract
Multiple factors drive the progression from healthy mucosa towards sporadic colorectal carcinomas and accumulating evidence associates intestinal bacteria with disease initiation and progression. Therefore, the aim of this study was to provide a first high-resolution map of colonic dysbiosis that is associated with human colorectal cancer (CRC). To this purpose, the microbiomes colonizing colon tumor tissue and adjacent non-malignant mucosa were compared by deep rRNA sequencing. The results revealed striking differences in microbial colonization patterns between these two sites. Although inter-individual colonization in CRC patients was variable, tumors consistently formed a niche for Coriobacteria and other proposed probiotic bacterial species, while potentially pathogenic Enterobacteria were underrepresented in tumor tissue. As the intestinal microbiota is generally stable during adult life, these findings suggest that CRC-associated physiological and metabolic changes recruit tumor-foraging commensal-like bacteria. These microbes thus have an apparent competitive advantage in the tumor microenvironment and thereby seem to replace pathogenic bacteria that may be implicated in CRC etiology. This first glimpse of the CRC microbiome provides an important step towards full understanding of the dynamic interplay between intestinal microbial ecology and sporadic CRC, which may provide important leads towards novel microbiome-related diagnostic tools and therapeutic interventions.
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Evidence is limited for a direct connection between particular gut bacteria or their virulence factors and sporadic colorectal cancer.
“Although dysbiosis is associated with chronic inflammation and production of carcinogenic metabolites, 175, 176 there is limited evidence to support a direct link between specific intestinal bacteria, their virulence factors, and sporadic CRC.”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [176]
Metagenomic and metatranscriptomic studies have identified an individualised oncogenic microbiome and specific bacterial species that selectively colonise the on-tumour and off-tumour sites.
“now metagenomic and metatranscriptomic studies have identified an individualised oncogenic microbiome and specific bacterial species that selectively colonise the on-tumour and off-tumour sites.87”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [87]
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Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 20,966 · see citing works
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682 · see citing works
The Ribosomal Database Project: improved alignments and new tools for rRNA analysis
Cole, J., Wang, Q., Cardenas, E., Fish, J., Chai, B., Farris, R. J., Kulam-Syed-Mohideen, A., Mcgarrell, D., Marsh, T., Garrity, G., et al. (2008) · Nucleic Acids Res. · doi:10.1093/nar/gkn879 · Cited by 4,940 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Bacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231 · see citing works
The global health burden of infection‐associated cancers in the year 2002
Parkin, D. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.21731 · Cited by 2,932 · see citing works
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362 · see citing works
The multistep nature of cancer
Vogelstein, B., & Kinzler, K. W. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90209-z · Cited by 1,858 · see citing works
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works
Nübel, U., Engelen, B., Felske, A., Snaidr, J., Wieshuber, A., Amann, R., Ludwig, W., & Backhaus, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.19.5636-5643.1996 · Cited by 1,356 · see citing works
Ironing out the wrinkles in the rare biosphere through improved OTU clustering
Huse, S. M., Welch, D. M., Morrison, H. G., & Sogin, M. L. (2010) · Environmental Microbiology · doi:10.1111/j.1462-2920.2010.02193.x · Cited by 1,346 · see citing works
Low counts of Faecalibacterium prausnitzii in colitis microbiota
Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G., Marteau, P., & Doré, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20903 · Cited by 1,275 · see citing works
<i>Escherichia coli</i> Induces DNA Double-Strand Breaks in Eukaryotic Cells
Nougayrède, J.-P., Homburg, S., Taieb, F., Boury, M., Brzuszkiewicz, E., Gottschalk, G., Buchrieser, C., Hacker, J., Dobrindt, U., & Oswald, E. (2006) · Science · doi:10.1126/science.1127059 · Cited by 1,188 · see citing works
Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshitá, T., Saito, N., Ochiai, A., Tomita, M., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4806 · Cited by 959 · see citing works
Zoetendal, E. G., von Wright, A., Vilpponen-Salmela, T., Ben-Amor, K., Akkermans, A. D. L., & de Vos, W. M. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.7.3401-3407.2002 · Cited by 868 · see citing works
Cuevas-Ramos, G., Petit, C. R., Marcq, I., Boury, M., Oswald, E., & Nougayrède, J.-P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001261107 · Cited by 855 · see citing works
Microbial Dysbiosis in Colorectal Cancer (CRC) Patients
Sobhani, I., Tap, J., Roudot‐Thoraval, F., Roperch, J. P., Letulle, S., Langella, P., Corthier, G., Nhieu, J. T. V., & Furet, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016393 · Cited by 832 · see citing works
Borneman, J., & Triplett, E. W. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.7.2647-2653.1997 · Cited by 701 · see citing works
War and peace at mucosal surfaces
Sansonetti, P. J. (2004) · Nature reviews. Immunology · doi:10.1038/nri1499 · Cited by 680 · see citing works
Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
Dhawan, P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24543 · Cited by 564 · see citing works
Boon, N., Windt, W. D., Verstraete, W., & Top, E. M. (2002) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2002.tb00911.x · Cited by 520 · see citing works
Assembly of the human intestinal microbiota
Dethlefsen, L., Eckburg, P. B., Bik, E. M., & Relman, D. A. (2006) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2006.06.013 · Cited by 509 · see citing works
A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer
Ulger Toprak, N., Yagci, A., Gulluoglu, B. M., Akin, M. L., Demirkalem, P., Celenk, T., & Soyletir, G. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01494.x · Cited by 454 · see citing works
Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas
Shen, X. J., Rawls, J. F., Randall, T. A., Burcall, L., Mpande, C., Jenkins, N., Jovov, B., Abdo, Z., Sandler, R. S., & Keku, T. O. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.12360 · Cited by 418 · see citing works
Corfield, A. P., MYERSCOUGH, N., LONGMAN, R., SYLVESTER, P., Arul, G. S., & Pignatelli, M. N. (2000) · Gut · doi:10.1136/gut.47.4.589 · Cited by 391 · see citing works
Bacteria and cancer: cause, coincidence or cure? A review
Mager, D. L. (2006) · Journal of Translational Medicine · doi:10.1186/1479-5876-4-14 · Cited by 278 · see citing works
Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis
Scanlan, P. D., Shanahan, F., Clune, Y., Collins, J. K., O'Sullivan, G. C., O'Riordan, M., Holmes, E., Wang, Y., & Marchesi, J. R. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01503.x · Cited by 245 · see citing works
Self-citationMäkivuokko, H., Tiihonen, K., Tynkkynen, S., Paulin, L. G., & Rautonen, N. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991553 · Cited by 243 · see citing works
Mucosa-Associated Bacterial Diversity in Relation to Human Terminal Ileum and Colonic Biopsy Samples
Ahmed, S., Macfarlane, G. T., Fite, A., McBain, A. J., Gilbert, P., & Macfarlane, S. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01143-07 · Cited by 227 · see citing works
Wang, X., Allen, T. D., May, R. J., Lightfoot, S. A., Houchen, C. W., & Huycke, M. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1551 · Cited by 205 · see citing works
ERK activation drives intestinal tumorigenesis in Apcmin/+ mice
Lee, S. H., Hu, L., González-Navajas, J. M., Seo, G. S., Shen, C., Brick, J., Herdman, S., Varki, N. M., Corr, M., Lee, J., et al. (2010) · Nature Medicine · doi:10.1038/nm.2143 · Cited by 188 · see citing works
Rapid quantitative profiling of complex microbial populations
Palmer, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gnj007 · Cited by 184 · see citing works
Bacterial Infection Promotes Colon Tumorigenesis in Apc Min/+ Mice
Newman, J. V., Kosaka, T., Sheppard, B. J., Fox, J. G., & Schauer, D. B. (2001) · The Journal of Infectious Diseases · doi:10.1086/321998 · Cited by 155 · see citing works
DuPont, H. L. (2009) · New England Journal of Medicine · doi:10.1056/nejmcp0904162 · Cited by 155 · see citing works
Methods for comparative metagenomics
Huson, D. H., Richter, D. C., Mitra, S., Auch, A. F., & Schuster, S. C. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-s1-s12 · Cited by 135 · see citing works
Bordonaro, M., Lazarova, D. L., & Sartorelli, A. C. (2008) · Cell Cycle · doi:10.4161/cc.7.9.5818 · Cited by 130 · see citing works
The Role of the Gastrointestinal Microbiota in Colorectal Cancer
Rowland, I. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168191 · Cited by 129 · see citing works
Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol
Jin, J., Kitahara, M., Sakamoto, M., Hattori, M., & Benno, Y. (2009) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.016774-0 · Cited by 104 · see citing works
Tjalsma, H., Schöller‐Guinard, M., Lasonder, E., Ruers, T. J. M., Willems, H. L., & Swinkels, D. W. (2006) · International Journal of Cancer · doi:10.1002/ijc.22116 · Cited by 97 · see citing works
Self-citationWaisberg, J., Matheus, C. D. O., & Pimenta, J. (2002) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032002000300008 · Cited by 94 · see citing works
Clostridium septicum aortitis: Report of two cases and review of the literature
Seder, C. W., Kramer, M., Long, G. W., et al. (2009) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2008.11.058 · Cited by 91 · see citing works
Kang, H. Y., Kim, N., Park, Y. S., Hwang, J., Kim, J., Jeong, S., Lee, D. H., Jung, H. C., & Song, I. S. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9276-0 · Cited by 89 · see citing works
Molecular characterization of the bacteria adherent to human colorectal mucosa
Green, G. L., Brostoff, J., Hudspith, B. N., Michael, M., Mylonaki, M., Rayment, N. B., Staines, N. A., Sanderson, J. D., Rampton, D. S., & Bruce, K. D. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02783.x · Cited by 75 · see citing works
Association between Streptococcus bovis and Colon Cancer
Boleij, A., Schaeps, R. M. J., & Tjalsma, H. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.01755-08 · Cited by 71 · see citing works
Self-citationIncreased exposure to bacterial antigen RpL7/L12 in early stage colorectal cancer patients
Boleij, A., Roelofs, R., Schaeps, R. M. J., Schülin, T., Glaser, P., Swinkels, D. W., Kato, I., & Tjalsma, H. (2010) · Cancer · doi:10.1002/cncr.25212 · Cited by 54 · see citing works
Self-citationUse of multivariate statistics for 16S rRNA gene analysis of microbial communities
Rudi, K., Zimonja, M., Trosvik, P., & Næs, T. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.06.004 · Cited by 49 · see citing works
Streptococcus bovis: Causal or incidental involvement in cancer of the colon?
Hausen, H. Z. (2006) · International Journal of Cancer · doi:10.1002/ijc.22314 · Cited by 45 · see citing works
Righi, V., Durante, C., Cocchi, M., Calabrese, C., Febo, G. D., Lecce, F., Pisi, A., Tugnoli, V., Mucci, A., & Schenetti, L. (2009) · Journal of Proteome Research · doi:10.1021/pr801094b · Cited by 43 · see citing works
Choi, E. J., Ahn, W. S., & Bae, S. M. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.09.031 · Cited by 42 · see citing works
Maggio‐Price, L., Treuting, P. M., Bielefeldt‐Ohmann, H., Seamons, A., Drivdahl, R. H., Zeng, W., Lai, L., Huycke, M. M., Phelps, S. R., Brabb, T., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080485 · Cited by 39 · see citing works
Rudi, K., Zimonja, M., & Næs, T. (2006) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.63936-0 · Cited by 33 · see citing works
Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis
Scanlan, P. D., Shanahan, F., Clune, Y., Collins, J. K., O’Sullivan, G. C., O'Riordan, M., Holmes, E. C., Wang, Y., & Marchesi, J. R. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01622.x · Cited by 29 · see citing works
Self-citationRudi, K., Zimonja, M., Kvenshagen, B. K., Rugtveit, J., Midtvedt, T., & Eggesbø, M. Å. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01205-06 · Cited by 28 · see citing works
Cancer staging using the American Joint Committee on Cancer TNM System.
Scott‐Conner, C. E. H., & Christie, D. W. (1995) · PubMed · Cited by 14 · see citing works
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- [21]Lane DJ Stackebrandt E Goodfellow M 1991 16S/23S rRNA Sequencing. Nucleic Acids Techniques in Bacterial Systematics Chichester John Wiley & Sons 115 175
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Environment dominates over host genetics in shaping human gut microbiota
Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859 · see citing works
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
The gut microbiota and host health: a new clinical frontier
Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., Quraishi, M. N., Kinross, J., Smidt, H., Tuohy, K. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309990 · Cited by 2,302 · see citing works
Self-citation<i>Fusobacterium nucleatum</i> infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · see citing works
Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000 · see citing works
Potential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375 · see citing works
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
Tjalsma, H., Boleij, A., Marchesi, J. R., & Dutilh, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2819 · Cited by 903 · see citing works
Self-citationInfluence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works
The oral microbiota in colorectal cancer is distinctive and predictive
Flemer, B., Warren, R. D., Barrett, M. P., Cisek, K., Das, A., Jeffery, I. B., Hurley, E., O‘Riordain, M., Shanahan, F., & O‘Toole, P. W. (2018) · Gut · doi:10.1136/gutjnl-2017-314814 · Cited by 646 · see citing works
Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults
Weir, T. L., Manter, D. K., Sheflin, A. M., Barnett, B. A., Heuberger, A. L., & Ryan, E. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070803 · Cited by 642 · see citing works
Effects of antibiotics on gut microbiota
Lange, K., Buerger, M., Stallmach, A., & Bruns, T. (2016) · Digestive Diseases · doi:10.1159/000443360 · Cited by 607 · see citing works
Microbiota disbiosis is associated with colorectal cancer
Gao, Z., Guo, B., Gao, R., Zhu, Q., & Qin, H. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00020 · Cited by 537 · see citing works
An update on the use and investigation of probiotics in health and disease
Sanders, M. E., Guarner, F., Guerrant, R., Holt, P. R., Quigley, E. M., Sartor, R. B., Sherman, P. M., & Mayer, E. A. (2013) · Gut · doi:10.1136/gutjnl-2012-302504 · Cited by 503 · see citing works
Flanagan, L., Schmid, J., Ebert, M., Soucek, P., Kunicka, T., Liska, V., Bruha, J., Neary, P., Dezeeuw, N., Tommasino, M., et al. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2081-3 · Cited by 498 · see citing works
Mitra, A., MacIntyre, D. A., Lee, Y. S., Smith, A., Marchesi, J. R., Lehne, B., Bhatia, R., Lyons, D., Paraskevaidis, E., Li, J. V., et al. (2015) · Scientific Reports · doi:10.1038/srep16865 · Cited by 498 · see citing works
Mitra, A., MacIntyre, D. A., Marchesi, J. R., Lee, Y. S., Bennett, P. R., & Kyrgiou, M. (2016) · Microbiome · doi:10.1186/s40168-016-0203-0 · Cited by 484 · see citing works
Microbial shifts in the aging mouse gut
Langille, M. G., Meehan, C. J., Koenig, J. E., Dhanani, A. S., Rose, R. A., Howlett, S. E., & Beiko, R. G. (2014) · Microbiome · doi:10.1186/s40168-014-0050-9 · Cited by 437 · see citing works
Role of the intestinal microbiome in health and disease: from correlation to causation
de Vos, W. M., & de Vos, E. A. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00505.x · Cited by 440 · see citing works
Weingarden, A. R., Chen, C., Bobr, A., Yao, D., Lu, Y., Nelson, V. M., Sadowsky, M. J., & Khoruts, A. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00282.2013 · Cited by 423 · see citing works
Metagenome-wide association studies: fine-mining the microbiome
Wang, J., & Jia, H. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.83 · Cited by 429 · see citing works
Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer
Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383 · see citing works
Breast Cancer and Its Relationship with the Microbiota
Fernández, M. F., Reina-Pérez, I., Astorga, J. M., Rodríguez-Carrillo, A., Plaza-Díaz, J., & Fontana, L. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081747 · Cited by 350 · see citing works
Drewes, J. L., White, J. R., Dejea, C. M., Fathi, P., Iyadorai, T., Vadivelu, J., Roslani, A. C., Wick, E. C., Mongodin, E. F., Loke, M. F., et al. (2017) · npj Biofilms and Microbiomes · doi:10.1038/s41522-017-0040-3 · Cited by 335 · see citing works
Taurocholic acid metabolism by gut microbes and colon cancer
Ridlon, J. M., Wolf, P. G., & Gaskins, H. R. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1150414 · Cited by 327 · see citing works
Cancer-promoting effects of microbial dysbiosis
Sheflin, A. M., Whitney, A. K., & Weir, T. L. (2014) · Current Oncology Reports · doi:10.1007/s11912-014-0406-0 · Cited by 301 · see citing works
Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis
Konishi, H., Fujiya, M., Tanaka, H., Ueno, N., Moriichi, K., Sasajima, J., Ikuta, K., Akutsu, H., Tanabe, H., & Kohgo, Y. (2016) · Nature Communications · doi:10.1038/ncomms12365 · Cited by 287 · see citing works
Scott, A. J., Alexander, J. L., Merrifield, C. A., Cunningham, D., Jobin, C., Brown, R., Alverdy, J., O’Keefe, S. J., Gaskins, H. R., Teare, J., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318556 · Cited by 288 · see citing works
Self-citationAn integrative view of microbiome-host interactions in inflammatory bowel diseases
Wlodarska, M., Kostic, A. D., & Xavier, R. J. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.008 · Cited by 287 · see citing works
Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet
Candela, M., Biagi, E., Soverini, M., Consolandi, C., Quercia, S., Severgnini, M., Peano, C., Turroni, S., Rampelli, S., Pozzilli, P., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001045 · Cited by 260 · see citing works
Probiotic Strain Lactobacillus casei BL23 Prevents Colitis‐Associated Colorectal Cancer
Jacouton, E., Chain, F., Sokol, H., Langella, P., & Bermúdez-Humarán, L. G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01553 · Cited by 249 · see citing works
Gut microbiota, inflammation and colorectal cancer
Sun, J., & Kato, I. (2016) · Genes & Diseases · doi:10.1016/j.gendis.2016.03.004 · Cited by 257 · see citing works
“, imbalance in of normal intestinal microbiota, can promote chronic inflammatory conditions and the production of carcinogenic metabolites, leading to neoplasia.(4,5) Gut microbiota represents a complex ecosystem that develops in close parallel with hosts and depends on the physiological environment of hosts.”
BackgroundDistinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer
Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-11237-6 · Cited by 227 · see citing works
Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic
Tomkovich, S., Dejea, C. M., Winglee, K., Drewes, J. L., Chung, L., Housseau, F., Pope, J. L., Gauthier, J., Sun, X., Mühlbauer, M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124196 · Cited by 209 · see citing works
Analysis of the Intestinal Lumen Microbiota in an Animal Model of Colorectal Cancer
Zhu, Q., Jin, Z., Wu, W., Gao, R., Guo, B., Gao, Z., Yang, Y., & Qin, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090849 · Cited by 206 · see citing works
Bacteria and tumours: causative agents or opportunistic inhabitants?
Cummins, J., & Tangney, M. (2013) · Infectious Agents and Cancer · doi:10.1186/1750-9378-8-11 · Cited by 178 · see citing works
Shah, M. S., DeSantis, T. Z., Weinmaier, T., McMurdie, P. J., Cope, J. L., Altrichter, A., Yamal, J.-M., & Hollister, E. B. (2018) · Gut · doi:10.1136/gutjnl-2016-313189 · Cited by 180 · see citing works
The microbiome and the hallmarks of cancer
Fulbright, L. E., Ellermann, M., & Arthur, J. C. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006480 · Cited by 164 · see citing works
Carcinogenesis and therapeutics: the microbiota perspective
Tsilimigras, M. C. B., Fodor, A., & Jobin, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.8 · Cited by 144 · see citing works
Hintze, K. J., Cox, J. E., Rompato, G., Benninghoff, A. D., Ward, R. E., Broadbent, J., & Lefevre, M. (2014) · Gut Microbes · doi:10.4161/gmic.28403 · Cited by 135 · see citing works
Gut microbiome and anticancer immune response: really hot Sh*t!
Viaud, S., Daillère, R., Boneca, I. G., Lepage, P., Langella, P., Chamaillard, M., Pittet, M. J., Ghiringhelli, F., Trinchieri, G., Goldszmid, R., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.56 · Cited by 123 · see citing works
Association of dietary fibre intake and gut microbiota in adults
Lin, D., Peters, B. A., Friedlander, C., Freiman, H. J., Goedert, J. J., Sinha, R., Miller, G., Bernstein, M. A., Hayes, R. B., & Ahn, J. (2018) · British Journal of Nutrition · doi:10.1017/s0007114518002465 · Cited by 109 · see citing works
Lu, R., Bosland, M., Xia, Y., Zhang, Y.-G., Kato, I., & Sun, J. (2017) · Oncotarget · doi:10.18632/oncotarget.19052 · Cited by 75 · see citing works
Partial associations of dietary iron, smoking and intestinal bacteria with colorectal cancer risk
Kato, I., Boleij, A., Kortman, G. A. M., Roelofs, R., Djuric, Z., Severson, R. K., & Tjalsma, H. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.748922 · Cited by 46 · see citing works
Gut microbiome response to short‐term dietary interventions in reactive hypoglycemia subjects
Quercia, S., Turroni, S., Fiori, J., Soverini, M., Rampelli, S., Biagi, E., Castagnetti, A., Consolandi, C., Severgnini, M., Pianesi, M., et al. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2927 · Cited by 27 · see citing works
- Authors
- Marchesi, J. R., Dutilh, B. E., Hall, N., Peters, W. H. M., Roelofs, R., Boleij, A., & Tjalsma, H.
- Affiliations
- Cardiff University (GB)
- San Diego State University (US)
- Radboud University Medical Center (NL)
- Corresponding author
- Tjalsma, Harold
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-05-24
- Volume
- 6
- Issue
- 5
- Pages
- e20447
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3101260
- OpenAlex
- W2144464830
- Cited by
- 552
- References
- 57
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 26 · 2023: 22 · 2022: 41 · 2021: 47 · 2020: 49 · 2019: 55 · 2018: 52 · 2017: 39 · 2016: 40 · 2015: 38 · 2014: 36 · 2013: 45 · 2012: 24
- FWCI
- 14.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- KWF Kankerbestrijding (KUN 2006-3591)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- colorectal cancer, gut microbiota, colonic dysbiosis, tumor microenvironment, Enterobacteriaceae, commensal bacteria, tumor microbiome, cancer etiology, microbiome-based diagnostics
- MeSH terms
- Aged, Bacterial Adhesion, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Ribosomes, RNA, Bacterial, RNA, Ribosomal, 16S, Colorectal Neoplasms, DNA Fingerprinting, Sequence Analysis, RNA, DNA, Intergenic, Metagenome, Denaturing Gradient Gel Electrophoresis
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