The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging
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// Carolina Simioni 1 , Giorgio Zauli 1 , Alberto M. Martelli 2 , Marco Vitale 3, 4 , Gianni Sacchetti 5 , Arianna Gonelli 1 and Luca M. Neri 1 1 Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy 2 Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy 3 Department of Medicine and Surgery, University of Parma, Parma, Italy 4 CoreLab, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy 5 Department of Life Sciences and Biotechnology, Pharmaceutical Biology Laboratory, University of Ferrara, Ferrara, Italy Correspondence to: Luca M. Neri, email: luca.neri@unife.it Keywords: exercise training; nutraceuticals; flavonoids intake; aging; antioxidant supplementation Received: January 26, 2018 Accepted: March 08, 2018 Published: March 30, 2018 ABSTRACT Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people. However, physical performance is also known to induce oxidative stress, inflammation, and muscle fatigue. Many efforts have been carried out to identify micronutrients and natural compounds, also known as nutraceuticals, able to prevent or attenuate the exercise-induced oxidative stress and inflammation. The aim of this review is to discuss the benefits deriving from a constant physical activity and by the intake of antioxidant compounds to protect the body from oxidative stress. The attention will be focused mainly on three natural antioxidants, which are quercetin, resveratrol and curcumin. Their properties and activity will be described, as well as their benefits on physical activity and on aging, which is expected to increase through the years and can get favorable benefits from a constant exercise activity.
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Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Curcumin: A Review of Its Effects on Human Health
Hewlings, S., & Kalman, D. (2017) · Foods · doi:10.3390/foods6100092 · Cited by 2,720
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107
Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668
Caramés, B., Taniguchi, N., Otsuki, S., Blanco, F. J., & Lotz, M. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27305 · Cited by 632
Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease
Reddy, P. H., Manczak, M., Yin, X., Grady, M. C., Mitchell, A., Tonk, S., Kuruva, C. S., Bhatti, J. S., Kandimalla, R., Vijayan, M., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170512 · Cited by 354
Antioxidant Supplementation during Exercise Training: Beneficial or Detrimental?
Peternelj, T.-T., & Coombes, J. S. (2011) · Sports Medicine · doi:10.2165/11594400-000000000-00000 · Cited by 314
Quercetin pharmacokinetics in humans
Moon, Y. J., Wang, L., DiCenzo, R., & Morris, M. E. (2008) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.605 · Cited by 287
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Valenzuela, P. L., Castillo-García, A., Morales, J. S., de la Villa, P., Hampel, H., Emanuele, E., Lista, S., & Lucia, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101108 · Cited by 337
Physical Exercise in the Oldest Old
Valenzuela, P. L., Castillo‐García, A., Morales, J. S., Izquierdo, M., Serra‐Rexach, J. A., Santos‐Lozano, A., & Lucia, A. (2019) · Comprehensive Physiology · doi:10.1002/cphy.c190002 · Cited by 152
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Li, S., Fasipe, B., & Laher, I. (2022) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2022.06.001 · Cited by 91
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Salucci, S., & Falcieri, E. (2020) · Nutrition Research · doi:10.1016/j.nutres.2019.11.004 · Cited by 83
Tkaczenko, H., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031098 · Cited by 80
Physical Activity and Oxidative Stress in Aging
Militello, R., Luti, S., Gamberi, T., Pellegrino, A., Modesti, A., & Modesti, P. A. (2024) · doi:10.20944/preprints202404.0293.v1 · Cited by 73
Rubin de Celis, M. F., Garcia-Martin, R., Syed, I., Lee, J., Aguayo-Mazzucato, C., Bonner-Weir, S., & Kahn, B. B. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2206923119 · Cited by 39
Ayaz, A., Zaman, W., Radák, Z., & Gu, Y. (2024) · Antioxidants · doi:10.3390/antiox13040437 · Cited by 26
Chatzakis, C., Sotiriadis, A., Fatouros, I. G., Jamurtas, A. Z., Deli, C. K., Papagianni, M., Dinas, K., & Mastorakos, G. (2022) · Diagnostics · doi:10.3390/diagnostics12071732 · Cited by 17
Metadata
- Authors
- Simioni, C., Zauli, G., Martelli, A. M., Vitale, M., Sacchetti, G., Gonelli, A., & Neri, L. M.
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2018-03-30
- Volume
- 9
- Issue
- 24
- Pages
- 17181-17198
- ISSN
- 1949-2553 (ISSN-L)
- OpenAlex
- W2795223464
- Cited by
- 518
- References
- 11
- FWCI
- 37.29
- Type
- journal article
- Language
- en
- Open access
- diamond
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