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MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer

Cekaite, Lina, Eide, Peter W., Lind, Guro E., Skotheim, Rolf I., Lothe, Ragnhild A.·2016·Oncotarget
DOI 10.18632/oncotarget.6390PMC PMC4872728
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Figure 1 An overview of miRNA studies in colorectal cancer (CRC) A. A rapid growth of the published research reports illustrated by the number of studies (with and without clinical samples) per year; the box plots represent numbers of the analyzed patient samples per year; B. The proportion of studies reporting aberrant miRNA (expression) and miRNA regulation by copy number variation (CNV), miRNAs regulated by epigenetic modifications, miRNA regulation by transcription factors (TF); single nucleotide polymorphism (SNP) in miRNA coding genes or binding sites of their target genes. C. The quantity of patient cohorts segregated by the type of analysis performed.
Figure 1 An overview of miRNA studies in colorectal cancer (CRC) A. A rapid growth of the published research reports illustrated by the number of studies (with and without clinical samples) per year; the box plots represent numbers of the analyzed patient samples per year; B. The proportion of studies reporting aberrant miRNA (expression) and miRNA regulation by copy number variation (CNV), miRNAs regulated by epigenetic modifications, miRNA regulation by transcription factors (TF); single nucleotide polymorphism (SNP) in miRNA coding genes or binding sites of their target genes. C. The quantity of patient cohorts segregated by the type of analysis performed.CC BY · PubMed Central
Figure 2 Main miRNA research themes in colorectal cancer (CRC) studies A. The trends of miRNA research themes exemplified by article keywords. B. An illustration and a heatmap of miRNAs validated to regulate CDH1, its regulators and other mesenchymal markers in CRC. The miRNA/mRNA was obtained from CRC patients registered in TCGA. values represent RPM normalized, median-centered values (for further information see Supplementary Material).
Figure 2 Main miRNA research themes in colorectal cancer (CRC) studies A. The trends of miRNA research themes exemplified by article keywords. B. An illustration and a heatmap of miRNAs validated to regulate CDH1, its regulators and other mesenchymal markers in CRC. The miRNA/mRNA was obtained from CRC patients registered in TCGA. values represent RPM normalized, median-centered values (for further information see Supplementary Material).CC BY · PubMed Central
Figure 3 MiRNA regulation of target genes A. and B. The most frequently validated miRNA and target genes. C. The enlarged leading miRNA-targets nodes generated using the validated miRNA-target pairs. The network edges are coded by degree of expressional miRNA-mRNA associations obtained in TCGA CRC patients. MiRNA nodes are indicated by rectangles, target nodes as ovals. Size of nodes reflects the number of connections, with bigger nodes representing more densely connected regions. The node of miR-143/miR-145-KRAS should be taken with precaution in light of the recent results by Chivukala et. al.[105].
Figure 3 MiRNA regulation of target genes A. and B. The most frequently validated miRNA and target genes. C. The enlarged leading miRNA-targets nodes generated using the validated miRNA-target pairs. The network edges are coded by degree of expressional miRNA-mRNA associations obtained in TCGA CRC patients. MiRNA nodes are indicated by rectangles, target nodes as ovals. Size of nodes reflects the number of connections, with bigger nodes representing more densely connected regions. The node of miR-143/miR-145-KRAS should be taken with precaution in light of the recent results by Chivukala et. al.[105].CC BY · PubMed Central
Figure 4 An overview of key signaling pathways in CRC and the regulation of their components by miRNAs MiRNAs that are involved in multiple pathways and contribute to the cross-talk among the pathways are marked in bold.
Figure 4 An overview of key signaling pathways in CRC and the regulation of their components by miRNAs MiRNAs that are involved in multiple pathways and contribute to the cross-talk among the pathways are marked in bold.CC BY · PubMed Central

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Metadata

Authors
Cekaite, L., Eide, P. W., Lind, G. E., Skotheim, R. I., & Lothe, R. A.
Affiliations
Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2015-11-25
Volume
7
Issue
6
Pages
6476-6505
ISSN
1949-2553
DOI
10.18632/oncotarget.6390
PMC
PMC4872728
Cited by
84
References
6
Language
en

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