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A uniform system for microRNA annotation
Abstract
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that miRNAs can be reliably distinguished from other RNAs such as small interfering RNAs. We describe specific criteria for the experimental verification of miRNAs, and conventions for naming miRNAs and miRNA genes. Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families.
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“The hsa-mir-548 mature miRNAs meet both the expression and biogenesis criteria that were articulated to ensure the accurate identification of miRNAs and the distinction between miRNAs and siRNAs [13].”
From A Family of Human MicroRNA Genes from Miniature Inverted-Repeat Transposable Elements (2007) · cites this paper as [13]
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Self-citationA microRNA array reveals extensive regulation of microRNAs during brain development
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The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Self-citationA Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626
Self-citationFunctional siRNAs and miRNAs exhibit strand bias
Khvorova, A., Reynolds, A., & Jayasena, S. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00801-8 · Cited by 2,645
A pancreatic islet-specific microRNA regulates insulin secretion
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Metadata
- Authors
- AMBROS, V., BARTEL, B., BARTEL, D. P., BURGE, C. B., CARRINGTON, J. C., CHEN, X., DREYFUSS, G., EDDY, S. R., GRIFFITHS-JONES, S., MARSHALL, M., MATZKE, M., RUVKUN, G., & TUSCHL, T.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-03
- Volume
- 9
- Issue
- 3
- Pages
- 277-279
- ISSN
- 1355-8382
- 1469-9001
- Cited by
- 1,553
- References
- 2
- Language
- en
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