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Cited by 1,558

The DOI matches its Crossref record.

Regulation of bone formation by applied dynamic loads.

Rubin, C T, Lanyon, L E·1984·The Journal of Bone & Joint Surgery
DOI 10.2106/00004623-198466030-00012
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Abstract

UNLABELLED: In studies on a functionally isolated avian-bone preparation to which external loads could be applied in vivo, we determined the following information. Removal of load-bearing resulted in substantial remodeling endosteally, intracortically, and, to a lesser extent, periosteally. Since the balance of this remodeling was negative, bone mass declined. It therefore appears that functional load-bearing prevents a remodeling process that would otherwise lead to disuse osteoporosis. Four consecutive cycles a day of an externally applied loading regimen that engendered physiological strain magnitudes but an altered strain distribution prevented remodeling and was thus associated with no change in bone mass. A small exposure to, or the first effect of, a suitable dynamic strain regimen appears to be sufficient to prevent the negatively balanced remodeling that is responsible for disuse osteoporosis. Thirty-six 0.5-hertz cycles per day of the same load regimen also prevented intracortical resorption but was associated with substantial periosteal and endosteal new-bone formation. Over a six-week period, bone-mineral content increased to between 133 and 143 per cent of the original value. Physiological levels of strain imposed with an abnormal strain distribution can produce an osteogenic stimulus that is capable of increasing bone mass. Neither the size nor the character of the bone changes that we observed were affected by any additional increase in the number of load cycles from thirty-six to 1800. CLINICAL RELEVANCE: The results of this experiment must be considered in relation to the type and duration of the non-physiological loads that were imposed.(ABSTRACT TRUNCATED AT 250 WORDS)

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Metadata

Authors
Rubin, C. T., & Lanyon, L. E.
Venue
The Journal of Bone & Joint Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1984-03
Volume
66
Issue
3
Pages
397-402
ISSN
0021-9355 (ISSN-L)
DOI
10.2106/00004623-198466030-00012
OpenAlex
W2114495080
Cited by
1,558
References
0
FWCI
17.64
Type
journal article
Language
en
Open access
closed

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