The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD) – Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease
Open accessPreprint — published as 10.1038/s41591-023-02543-w · Paper page
Abstract
Cellular senescence has been identified as a pathological mechanism linked to tau and amyloid beta (Aβ) accumulation in mouse models of Alzheimer's disease (AD). Clearance of senescent cells using the senolytic compounds dasatinib (D) and quercetin (Q) reduced neuropathological burden and improved clinically relevant outcomes in the mice. Herein, we conducted a vanguard open-label clinical trial of senolytic therapy for AD with the primary aim of evaluating central nervous system (CNS) penetrance, as well as exploratory data collection relevant to safety, feasibility, and efficacy. Participants with early-stage symptomatic AD were enrolled in an open-label, 12-week pilot study of intermittent orally-delivered D+Q. CNS penetrance was assessed by evaluating drug levels in cerebrospinal fluid (CSF) using high performance liquid chromatography with tandem mass spectrometry. Safety was continuously monitored with adverse event reporting, vitals, and laboratory work. Cognition, neuroimaging, and plasma and CSF biomarkers were assessed at baseline and post-treatment. Five participants (mean age: 76±5 years; 40% female) completed the trial. The treatment increased D and Q levels in the blood of all participants ranging from 12.7 to 73.5 ng/ml for D and 3.29-26.30 ng/ml for Q. D levels were detected in the CSF of four participants ranging from 0.281 to 0.536 ng/ml (t(4)=3.123, p=0.035); Q was not detected. Treatment was well-tolerated with no early discontinuation and six mild to moderate adverse events occurring across the study. Cognitive and neuroimaging endpoints did not significantly differ from baseline to post-treatment. CNS levels of IL-6 and GFAP increased from baseline to post-treatment (t(4)=3.913, p=008 and t(4)=3.354, p=0.028, respectively) concomitant with decreased levels of several cytokines and chemokines associated with senescence, and a trend toward higher levels of Aβ42 (t(4)=-2.338, p=0.079). Collectively the data indicate the CNS penetrance of D and provide preliminary support for the safety, tolerability, and feasibility of the intervention and suggest that astrocytes and Aβ may be particularly responsive to the treatment. While early results are promising, fully powered, placebo-controlled studies are needed to evaluate the potential of AD modification with the novel approach of targeting cellular senescence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53221.x · Cited by 25,553
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,584
Self-citationA complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278
(2015) · HAL · Cited by 2,238
Health effects of quercetin: From antioxidant to nutraceutical
Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.008 · Cited by 2,121
Jack, C. R., Albert, M. S., Knopman, D. S., McKhann, G. M., Sperling, R. A., Carrillo, M. C., Thies, B., & Phelps, C. H. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.004 · Cited by 2,042
Morris, J. C. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004870 · Cited by 1,641
Benedict, R. H. B., Schretlen, D., Groninger, L., & Brandt, J. (1998) · The Clinical Neuropsychologist · doi:10.1076/clin.12.1.43.1726 · Cited by 1,597
Tombaugh, T. N., Kozak, J., & Rees, L. M. (1999) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/14.2.167 · Cited by 1,520
Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383
Self-citationClearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018) · Nature · doi:10.1038/s41586-018-0543-y · Cited by 1,289
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.052 · Cited by 1,261
Self-citationSenolytic drugs: from discovery to translation
Kirkland, J. L., & Tchkonia, T. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13141 · Cited by 1,227
Self-citationArchives of Clinical Neuropsychology
Reynolds, C. R. (2014) · Wiley eBooks · doi:10.1002/9781118660584.ese0182 · Cited by 1,057
Cellular senescence drives age-dependent hepatic steatosis
Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15691 · Cited by 1,044
Self-citationO'Hare, T., Walters, D. K., Stoffregen, E. P., Jia, T., Manley, P. W., Mestan, J., Cowan-Jacob, S. W., Lee, F. Y., Heinrich, M. C., Deininger, M. W. N., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0259 · Cited by 1,036
Cellular senescence: a translational perspective
Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013
Self-citationZhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977
An aged immune system drives senescence and ageing of solid organs
Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.-A., McGowan, S. J., et al. (2021) · Nature · doi:10.1038/s41586-021-03547-7 · Cited by 972
The Alzheimer's Disease Centers' Uniform Data Set (UDS)
Weıntraub, S., Salmon, D. P., Mercaldo, N. D., Ferris, S. H., Graff‐Radford, N. R., Chui, H. C., Cummings, J. L., DeCarli, C. S., Foster, N. L., Galasko, D. R., et al. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318191c7dd · Cited by 911
Andreasen, N., Hesse, C., Davidsson, P., Minthon, L., Wallin, A., Winblad, B., Vanderstichele, H., Vanmechelen, E., & Blennow, K. (1999) · Archives of Neurology · doi:10.1001/archneur.56.6.673 · Cited by 660
Benedet, A. L., Milà-Alomà, M., Vrillon, A., Ashton, N. J., Pascoal, T. A., Lussier, F., Karikari, T. K., Hourregue, C., Cognat, E., Dumurgier, J., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.3671 · Cited by 638
Jurk, D., Wang, C., Miwa, S., Maddick, M., Korolchuk, V., Tsolou, A., Gonos, E. S., Thrasivoulou, C., Jill Saffrey, M., Cameron, K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00870.x · Cited by 598
Tau protein aggregation is associated with cellular senescence in the brain
Musi, N., Valentine, J. M., Sickora, K. R., Baeuerle, E., Thompson, C. S., Shen, Q., & Orr, M. E. (2018) · Aging Cell · doi:10.1111/acel.12840 · Cited by 595
Self-citationAstrocyte Senescence as a Component of Alzheimer’s Disease
Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045069 · Cited by 586
Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease
Erickson, M. A., & Banks, W. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.135 · Cited by 572
Chinta, S. J., Woods, G., Demaria, M., Rane, A., Zou, Y., McQuade, A., Rajagopalan, S., Limbad, C., Madden, D. T., Campisi, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.092 · Cited by 530
Ageing, Cellular Senescence and Neurodegenerative Disease
Kritsilis, M., V. Rizou, S., Koutsoudaki, P. N., Evangelou, K., Gorgoulis, V. G., & Papadopoulos, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102937 · Cited by 448
Porkka, K., Koskenvesa, P., Lundán, T., Rimpiläinen, J., Mustjoki, S., Smykla, R., Wild, R., Luo, R., Arnan, M., Brethon, B., et al. (2008) · Blood · doi:10.1182/blood-2008-02-140665 · Cited by 445
Doshi, J., Erus, G., Ou, Y., Resnick, S. M., Gur, R. C., Gur, R. E., Satterthwaite, T. D., Furth, S., & Davatzikos, C. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.073 · Cited by 309
Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies
Tchkonia, T., & Kirkland, J. L. (2018) · JAMA · doi:10.1001/jama.2018.12440 · Cited by 302
Self-citationQuercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
Vafadar, A., Shabaninejad, Z., Movahedpour, A., Fallahi, F., Taghavipour, M., Ghasemi, Y., Akbari, M., Shafiee, A., Hajighadimi, S., Moradizarmehri, S., et al. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00397-0 · Cited by 296
Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats
Ishisaka, A., Ichikawa, S., Sakakibara, H., Piskula, M. K., Nakamura, T., Kato, Y., Ito, M., Miyamoto, K.-I., Tsuji, A., Kawai, Y., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.017 · Cited by 293
Wiley, C. D., Flynn, J. M., Morrissey, C., Lebofsky, R., Shuga, J., Dong, X., Unger, M. A., Vijg, J., Melov, S., & Campisi, J. (2017) · Aging Cell · doi:10.1111/acel.12632 · Cited by 234
Mixed Dementia—the Most Common Cause of Dementia
KORCZYN, A. D. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04807.x · Cited by 219
The Lawton Instrumental Activities of Daily Living (IADL) Scale.
Graf, C. L. (2008) · PubMed · Cited by 218
Tuttle, C. S. L., Waaijer, M. E. C., Slee‐Valentijn, M. S., Stijnen, T., Westendorp, R., & Maier, A. B. (2020) · Aging Cell · doi:10.1111/acel.13083 · Cited by 211
Gonzales, M. M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., & Orr, M. E. (2022) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.62 · Cited by 203
Self-citationAgreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse
Alcolea, D., Pegueroles, J., Muñoz, L., Camacho, V., López‐Mora, D., Fernández‐León, A., Le Bastard, N., Huyck, E., Nadal, A., Olmedo, V., et al. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.50873 · Cited by 183
Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
Riessland, M., Kolisnyk, B., Kim, T. W., Cheng, J., Ni, J., Pearson, J. A., Park, E. J., Dam, K., Acehan, D., Ramos-Espiritu, L. S., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.08.013 · Cited by 180
Cummings, J., Ritter, A., & Zhong, K. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179901 · Cited by 176
Habes, M., Pomponio, R., Shou, H., Doshi, J., Mamourian, E., Erus, G., Nasrallah, I., Launer, L. J., Rashid, T., Bilgel, M., et al. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12178 · Cited by 173
Self-citationProfiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology
Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., Woost, B., Bennett, R. E., Orr, T. C., Zhou, Y., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00142-3 · Cited by 169
Self-citationHaass, C., & Selkoe, D. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001694 · Cited by 145
Lamers, K. J. B., Vos, P., Verbeek, M. M., Rosmalen, F., van Geel, W. J. A., & van Engelen, B. G. M. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00089-3 · Cited by 138
Zhang, X., Pearsall, V. M., Carver, C. M., Atkinson, E. J., Clarkson, B. D. S., Grund, E. M., Baez-Faria, M., Pavelko, K. D., Kachergus, J. M., White, T. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33226-8 · Cited by 102
Self-citationMarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols
Wilcock, D. M., Jicha, G. A., Blacker, D., Albert, M., D’Orazio, L. M., Elahi, F. M., Fornage, M., Hinman, J. D., Knoefel, J. E., Kramer, J. H., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12215 · Cited by 100
Self-citationWróbel-Biedrawa, D., Grabowska, K., Galanty, A., Sobolewska, D., & Podolak, I. (2022) · Life · doi:10.3390/life12040591 · Cited by 95
Cytokines in innate and adaptive immunity.
Banyer, J., Hamilton, N. H. R., Ramshaw, I. A., & Ramsay, A. J. (2000) · PubMed · Cited by 88
Human CNS immune senescence and neurodegeneration
Streit, W. J., & Xue, Q.-S. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.05.005 · Cited by 86
Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
Bryant, A. G., Hu, M., Carlyle, B. C., Arnold, S. E., Frosch, M. P., Das, S., Hyman, B. T., & Bennett, R. E. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.575953 · Cited by 79
Sun, S. W., Yu, H. Q., Zhang, H., Zheng, Y. L., Wang, J. J., & Luo, L. (2007) · Nutrition Research · doi:10.1016/j.nutres.2007.01.010 · Cited by 62
Ito, K., Corrigan, B., Romero, K., Anziano, R., Neville, J., Stephenson, D., & Lalonde, R. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130575 · Cited by 62
The Future of Anti-Amyloid Trials
Aisen, P. S. S., Cummings, J. L., Doody, R. S., Kramer, L. D., Salloway, S., Selkoe, D. J., Sims, J. R., Sperling, R. A., & Vellas, B. J. (2020) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.24 · Cited by 61
Lindauer, M., & Hochhaus, A. (2010) · Recent Results in Cancer Research · doi:10.1007/978-3-642-01222-8_7 · Cited by 57
Srinivasan, D., Erus, G., Doshi, J., Wolk, D. A., Shou, H., Habes, M., & Davatzikos, C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117248 · Cited by 45
Self-citationSharma, V., Gilhotra, R., Dhingra, D., & Gilhotra, N. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11026fp · Cited by 31
Gong, X., Li, L., Wei, H., Liu, B., Zhou, C., Zhang, G., Liu, K., Lin, D., Gong, B., Wei, S., et al. (2021) · Clinical Therapeutics · doi:10.1016/j.clinthera.2021.05.009 · Cited by 28
Yu, L., Liu, J., Huang, X., & Jiang, Q. (2019) · Scientific Reports · doi:10.1038/s41598-019-54033-0 · Cited by 24
[Quercetin permeability across blood-brain barrier and its effect on the viability of U251 cells].
Ren, S., Suo, Q., Du, W.-T., Pan, H., Yang, M., Wang, R.-H., & Liu, J. (2010) · PubMed · Cited by 23
Wiczkowski, W., Skipor, J., Misztal, T., Szawara‐Nowak, D., Topolska, J., & Piskula, M. K. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400567 · Cited by 18
Dasatinib‐induced hypoglycemia in a patient with acute lymphoblastic leukemia
Lundholm, M. D., & Charnogursky, G. A. (2020) · Clinical Case Reports · doi:10.1002/ccr3.2901 · Cited by 9
Cited by
Sorted by citations
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy
Vogler, M., Braun, Y., Smith, V. M., Westhoff, M.-A., Pereira, R. S., Pieper, N. M., Anders, M., Callens, M., Vervliet, T., Abbas, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02176-0 · Cited by 462
From geroscience to precision geromedicine: Understanding and managing aging
Kroemer, G., Maier, A. B., Cuervo, A. M., Gladyshev, V. N., Ferrucci, L., Gorbunova, V., Kennedy, B. K., Rando, T. A., Seluanov, A., Sierra, F., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.011 · Cited by 395
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165
Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders
Huang, Y., Liu, B., Sinha, S. C., Amin, S., & Gan, L. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00672-x · Cited by 164
Emerging role of senescent microglia in brain aging-related neurodegenerative diseases
Rim, C., You, M., Nahm, M., & Kwon, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00402-3 · Cited by 158
Metadata
- Authors
- Orr, M., Gonzales, M., Garbarino, V., Kautz, T., Palavicini, J., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J., Zare, H., Xu, P., Zhang, B., Franklin, C., Habes, M., Craft, S., Petersen, R., Tchkonia, T., Kirkland, J., Salardini, A., Seshadri, S., & Musi, N.
- Affiliations
- W. G. (Bill) Hefner VA Medical Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Texas Health Science Center
- Icahn School of Medicine at Mount Sinai (US)
- Wake Forest University Health Sciences (US)
- Mayo Clinic (US)
- Mayo Clinic
- Boston University (US)
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Orr, Miranda
- Gonzales, Mitzi
- ORCID
- Venue
- Nature Medicine
- Published
- 2023-04-24
- Volume
- 29
- Issue
- 10
- Pages
- 2481-2488
- ISSN
- 1078-8956 (ISSN-L)
- PMC
- PMC10875739
- OpenAlex
- W4386499275
- Cited by
- 319
- References
- 64
- Citations by year
- 2026: 100 · 2025: 116 · 2024: 82 · 2023: 21
- FWCI
- 56.36
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Nature Medicine (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- PubMed Central (submittedVersion, cc-by)
- ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley) (submittedVersion)
- Funders
- Hevolution Foundation
- U.S. Department of Health and Human Services (TR002647, RF1AG059421, T32-AG021890, P30 AG062677, R01AG068293, R37AG13925, U01AG22307, R01AG080821, UF1 NS125417, R21NS125171, U19AG024904, R01AG069690, P30 AG066546, U54AG07594, R33AG061456, U01 AG046170, 1R01AG065301, R01AG054076, R01NS017950, P01AG062413, P30-AG013319, R01AG077472, R01AG068030, R01AG075684, R01AG033193, U01 AG006786, U24AG059624, PG30AG044271, U19NS115388, P30AG044271, R01AG066524, 1R01AG0665241A, P30AG072947, R01AG057896, U24 AG057437, 1RF1AG063507, RF1NS112391)
- U.S. Department of Veterans Affairs (I01 BX005717, P30AG013319)
- Alzheimer's Association (PTC REG-20-651687)
- American Federation for Aging Research
- Alzheimer's Drug Discovery Foundation (AG059421, GC-201908-2019443)
- Cure Alzheimer's Fund
- McGill University
- GHR Foundation
- Noaber Foundation
- National Heart and Lung Institute (R01HL105756)
- National Institutes of Health (4r01ag065301-03, TL1TR002647)
- University of Texas Health Science Center at San Antonio (TR002647)
- National Institute on Aging (R24AG073199, 1R01AG0665241A, RF1AG065301, U01AG22307, AG054076, U01AG046170, R01AG066524, R01AG069690, U01AG006786, R37 AG13925, R01AG068030, U54AG07594, R01AG057896, R01AG054076, R01AG065839, R01AG013925, 1R01AG065301, R01 AG065301, AG059421, PG30AG044271, RF1AG063507, R01AG033193, T32AG021890, RF1AG059421, R33AG061456, P30AG013319, U01AG022307, R37AG013925, R01AG080821, R01AG077472, U24AG057437, U19AG024904, U24AG059624, U54AG079754, P01AG062413, P30AG062677, R01AG068293, P30AG044271, P30AG072947, R01AG075684, P30AG066546)
- National Heart, Lung, and Blood Institute (R01HL105756)
- National Institute of Neurological Disorders and Stroke (R21NS125171, U19NS115388, RF1NS112391, UF1NS125417, R01NS017950)
- National Center for Advancing Translational Sciences (TR002647)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- senolytic therapy, Alzheimer's disease, cellular senescence, dasatinib, quercetin, oral drug delivery, CNS penetration, cerebrospinal fluid drug concentration, drug safety and tolerability, interleukin-6, glial fibrillary acidic protein, amyloid-beta 42, aging biomarkers, early Alzheimer's disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
