CoChat
Sign Up
Cited by 1Inflammatory Bowel DiseasePsychosomatic Disorders and Their TreatmentsTryptophan and brain disorders

PSYCHO-EMOTIONAL STATUS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Open access
Romanukha, Viktoriya, Hryniv, Olena, Hvozdetska, Halyna, Baryla, Nadiia, Hrushetska, Anna·2024·Eastern Ukrainian Medical Journal
DOI 10.21272/eumj.2024;12(2):202-211
Open this paper in CoChat — free accountOpen PDF

Abstract

Introduction. Inflammatory bowel disease is a chronic disease of unclear etiology, with periods of exacerbation and remission, has negative social, physical and emotional consequences and reduces quality of life. It is an obvious fact that psychological status and quality of life are influenced by a significant number of factors, including the disease itself (Crohn's disease is most often more severe, especially in young patients), the severity of the disease, the prevalence of digestive tract involvement, extraintestinal manifestations, complications, surgical interventions and the effectiveness of the chosen therapy. Materials and methods. The literature review was based on scientific studies published by Science Direct using the information retrieval systems PubMed, Web of Science, Scopus, Google Scholar, The Cochrane Librar, Medknow. We mainly reviewed the studies that were published in the last 5 years. 68 scientific papers were selected for the article. Results After analysing the sources of national and international literature, the risk factors (poor sleep quality, reduced physical activity, fatigue, female gender, obesity, intestinal dysbiosis, surgery with stoma formation) that contributed to a negative impact on the patient's quality of life were identified. Possible methods to alleviate psychopathological symptoms, namely psychotherapy, medication and regular physical activity, were described. Conclusions. Inflammatory bowel disease contributes to the development of depressive and anxiety disorders, asthenia, sexual dysfunction, poor sleep quality, reduced physical activity, work quality, and productivity. The use of psychotherapy, namely cognitive behavioural therapy, psychodynamic therapy, acceptance and commitment therapy, stress management programs, mindfulness, hypnosis, antidepressant medication and regular physical activity, leads to an improvement in the patient's quality of life. © 2024 by the author(s).

AI snapshot

Written from the paper’s full text.

## TL;DR

This is a narrative literature review on how inflammatory bowel disease (IBD) affects psycho-emotional status and quality of life, and on factors and interventions linked to these outcomes. The paper argues that IBD is associated with depression, anxiety, fatigue, sleep problems, sexual dysfunction, and reduced physical activity and work productivity, while psychotherapy, antidepressants, and regular physical activity may improve quality of life.

## Key findings

  • The review found risk factors that worsen quality of life in IBD, including poor sleep quality, reduced physical activity, fatigue, female sex, obesity, intestinal dysbiosis, and surgery with stoma formation.
  • The paper states that IBD contributes to depressive and anxiety disorders, asthenia, sexual dysfunction, poor sleep quality, reduced physical activity, and reduced work quality/productivity.
  • A literature review based on published studies selected 68 scientific papers in one description and 69 works in another search strategy description, with searches conducted from October 2023 to February 2024 and mainly focused on the last 5 years.
  • The article reports that psychotherapy options such as cognitive behavioral therapy, psychodynamic therapy, acceptance and commitment therapy, stress management programs, mindfulness, hypnosis, antidepressants, and regular physical activity can improve quality of life; it also notes that an ACT trial reduced perceived stress and depression, but not anxiety.

## Methods

  • Narrative literature review of published research on IBD psycho-emotional status and quality of life.
  • Sources were searched in PubMed, Web of Science, Scopus, Google Scholar, The Cochrane Library, and Medknow using combinations of terms related to IBD, men, women, and quality of life.
  • The review prioritized studies from the last 5 years and synthesized national and international literature on physical activity, obesity, fatigue, surgery with stoma, sex differences, and pharmacologic/nonpharmacologic correction of psycho-emotional status.

## Limitations

  • The paper itself notes that there are no clinical recommendations or guidelines for prescribing antidepressants to IBD patients and that evidence remains uncertain due to lack of randomized studies, small samples, and heterogeneous drugs.
  • It also states that studies on the relationship between physical activity and quality of life in IBD are few, especially for moderate-to-high intensity activity.
  • Evident from the text: this is a literature review rather than an original empirical study, so its conclusions depend on the quality and scope of the cited studies rather than on new patient data.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.21272/eumj.2024;12(2):202-211

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

32 of 61 cited sources checked · 2 supported · 2 flagged · accuracy not yet measured

  • Premisecitation
    § INTRODUCTION / ВСТУП

    In a 2020 study, one third of examined IBD patients had sleep disturbance.

    “Дослідження 2020 р. показало, що у третини обстежуваних пацієнтів із ЗЗК відмічається порушення сну, що, в свою чергу, пов'язано з низькою якістю життя, інвалідністю та позакишковими проявами.”
    Quote in the paperNot a substantial claim3 of 3 sources checked
    • cites [25] source

      The Discussion (Main results) says two thirds of the 166 IBD patients had sleep disturbance, not one third; the Abstract gives the figure as 67.5%. The sentence’s associations with low quality of life, disability, and extraintestinal manifestations are supported, but its prevalence claim is contrary to the paper. (LLM, conf=0.95)

      Checked by a reasoning model — may be wrong.

      Experimental — accuracy not yet measured
    • cites [26] source

      The Results report sleep problems among examined IBD patients, but 43.6% met the study’s threshold for reduced sleep quality and 49.6% met its threshold for mild insomnia—not one third. The paper does not establish the citing sentence’s further links between sleep disturbance, disability, and extraintestinal manifestations. (LLM, conf=0.86)

      Experimental — accuracy not yet measured
    • cites [27] source

      The Introduction reports that 31.6% of ulcerative colitis patients had poor sleep in an earlier study, but that figure does not describe all IBD patients examined in this study. The Results report sleep-quality scores for this study’s IBD group, not a finding that one third had sleep disturbance. (LLM, conf=0.84)

      Experimental — accuracy not yet measured
  • Interpretationnone given
    § https://orcid.org/0009-0000-2023-5593

    The use of psychotherapy, namely cognitive behavioural therapy, psychodynamic therapy, acceptance and commitment therapy, stress management programs, mindfulness, hypnosis, antidepressant medication and regular physical activity, leads to an improvement in the patient's quality of life.

    “The use of psychotherapy, namely cognitive behavioural therapy, psychodynamic therapy, acceptance and commitment therapy, stress management programs, mindfulness, hypnosis, antidepressant medication and regular physical activity, leads to an improvement in the patient's quality of life.”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites [61] source
    • cites [62] source

      The Discussion reports that antidepressants may improve quality of life in people with inflammatory bowel disease, but says the evidence is insufficient for firm conclusions about their effectiveness. The Current Guidelines section mentions psychotherapy as an option for psychological distress; it does not establish quality-of-life benefits for the named therapies or regular physical activity. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
  • Premisecitation
    § INTRODUCTION / ВСТУП

    Women with IBD in the postpartum period are at increased risk of a new psychiatric diagnosis.

    “Жінки, які страждають на ЗЗК у післяпологовому періоді, піддаються підвищеному ризику виникнення нового психіатричного діагнозу [18].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [18] source

      The Epidemiology > Psychiatric diseases section reports higher rates of anxiety and depression in patients with IBD. It does not address women in the postpartum period or the risk of receiving a new psychiatric diagnosis; searches for postpartum and pregnancy-related psychiatric diagnoses found no such passage in our copy. Page numbers were not available. (LLM, conf=0.85)

      Experimental — accuracy not yet measured
  • Premisecitation
    § INTRODUCTION / ВСТУП

    The above risk factors contribute to increased levels of anxiety, depression and stress.

    “Згадані вище фактори ризику сприяють збільшенню рівня тривожності, депресії та стресу [52].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [52] source

      The Conclusions (page unavailable) report correlations between disease activity, gender, age and disease duration and the level of fear and anxiety in patients with ulcerative colitis. The paper does not establish that these factors cause an increase, and it does not report corresponding findings for depression or stress. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
  • Premisecitation
    § INTRODUCTION / ВСТУП

    In a review article by T. Grimstad et al. analyzing 156 articles, asthenia in IBD persons occurred significantly more often than in the general population.

    “В оглядовій статті Т. Grimstad et al. проаналізовано 156 статей, у яких астенія в осіб із ЗЗК траплялася значно частіше, ніж серед населення загалом.”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [46] source

      The Introduction states that fatigue is twice as common in patients with IBD as in healthy controls. But this review is by Nocerino et al., not Grimstad et al.; its References list a Grimstad study on newly diagnosed IBD, and our copy does not say that Grimstad reviewed 156 articles. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
  • May combine two claims. 27
  • Classified as probably not a substantial claim. 16

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    A 2016 study did not confirm a negative impact of stoma on quality of life, nor its connection with anxiety, depression, sleep disturbances, reduced sexual interest and satisfaction.

    “2016 р. не було підтверджено негативного впливу стоми на якість життя, а також її зв'язку з тривогою, депресією, порушеннями сну, зниженням сексуального інтересу та задоволеності.”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [40] source

      The Results (Effects of Stoma Formation) find significantly higher odds of anxiety and depression among patients with stomas than among surgical patients without stomas, contrary to the claim that no connection was confirmed. The paper does not report findings on stoma-related quality of life, sleep disturbances, or sexual interest and satisfaction; it was published in 2020, not 2016. (LLM, conf=0.90)

      Checked by a reasoning model — may be wrong.

      Experimental — accuracy not yet measured

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Increased disease activity leads to a significant reduction in quality of life and emotional stress.

    “Підвищена активність захворювання призводить до значущого зниження якості життя та емоційного стресу [3].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [3] source

      The Results (section 3; page not provided) report that active inflammatory bowel disease was significantly associated with lower health-related quality of life, including a lower mental-component score. The paper does not establish that increased activity causes the decline or report a separate finding about emotional stress. (LLM, conf=0.86)

      Experimental — accuracy not yet measured

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    Predictors of nutritional insufficiency are associated with abdominal pain syndrome, disease activity, and repeated hospitalizations.

    “Предиктори недостатності харчування, на думку авторів, пов'язані з больовим абдомінальним синдромом, активністю захворювання, повторними госпіталізаціями [11, 12].”
    Quote in the paperNot a substantial claim2 of 2 sources checked
    • cites [11] source

      The Study variables section lists clinical measures but does not identify nutritional insufficiency as an outcome. The Discussion links disease activity to hospitalizations, not to predictors of nutritional insufficiency. Searches for nutritional insufficiency, malnutrition, abdominal pain, and repeated hospitalizations found no passage establishing the claimed association. (LLM, conf=0.76)

      Experimental — accuracy not yet measured
    • cites [12] source

      The Introduction (page unavailable) says malnutrition is a common consequence of IBD, while the questionnaire-validation methods record disease activity and nutritional risk separately. Our copy does not link nutritional insufficiency to abdominal pain, disease activity, or repeated hospitalizations as predictors; searches for those terms found no such analysis. (LLM, conf=0.74)

      Experimental — accuracy not yet measured

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    No significant correlation was found between the clinical form of IBD and laboratory parameters, namely hemoglobin, CRP, and ferritin level.

    “При цьому не було виявлено значущої кореляції між клінічною формою ЗЗК і лабораторними показниками, а саме гемоглобіном, СРБ, рівнем феритину [47].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [47] source

      The Cytokines and inflammation section mentions increased CRP in patients with chronic fatigue syndrome, not a correlation between laboratory values and clinical forms of IBD. Searches for IBD clinical form, hemoglobin, ferritin, and laboratory-parameter correlations found no passage addressing the claimed analysis in our copy. (LLM, conf=0.76)

      Experimental — accuracy not yet measured

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    The development of anxiety and depression is associated with surgical history, disease complications (including extraintestinal manifestations), smoking and female sex.

    “Розвиток тривоги і депресії, на думку багатьох авторів, пов'язаний із наявністю хірургічного анамнезу, ускладненнями захворювання (включаючи позакишкові прояви), курінням і жіночою статтю [53].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [53] source

      The Psychological Factors section (page not provided) reports that depression is more prevalent in women than in men with IBD, supporting the female-sex association for depression. The passages on smoking and complications discuss IBD outcomes, not anxiety or depression; the copy does not link surgical history, complications, extraintestinal manifestations, or smoking to the development of either condition, or address the claimed association with anxiety. (LLM, conf=0.87)

      Experimental — accuracy not yet measured

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    In a 2011 study, authors did not find a significant difference in anxiety and depression levels, and in the frequency of probable mental disorder among patients with Crohn's disease and ulcerative colitis.

    “У дослідженні 2011 р. автори не виявили суттєвої різниці за рівнем тривоги та депресії, а також за частотою ймовірного психічного розладу серед пацієнтів із ХК та ВК [55].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [55] source

      The Discussion (§4.1; page unavailable) says the authors found no difference in anxiety and depression prevalence between ulcerative colitis and Crohn’s disease patients, consistent with the 2011 study they cite. It does not report that the 2011 study found no difference in the frequency of probable mental disorder, and the finding presented as the authors’ own is from this 2017 paper, not a 2011 study. (LLM, conf=0.85)

      Experimental — accuracy not yet measured

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Fatigue is one of the factors that noticeably reduces quality of life and is observed in almost half of IBD patients.

    “Втома є одним із чинників, який помітно знижує якість життя і спостерігається практично в половини пацієнтів із ЗЗК [44].”
    Quote in the paperNot a substantial claim1 of 1 sources checked

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Sleep disturbance in IBD is associated with low quality of life, disability, and extraintestinal manifestations.

    “Дослідження 2020 р. показало, що у третини обстежуваних пацієнтів із ЗЗК відмічається порушення сну, що, в свою чергу, пов'язано з низькою якістю життя, інвалідністю та позакишковими проявами.”
    Quote in the paperNot a substantial claim3 of 3 sources checked
    • cites [25] source

      The Discussion (Main results) supports the association with low quality of life, greater disability, and extraintestinal manifestations. But the citing sentence says sleep disturbance affected one third of patients; the paper reports two thirds of its 166 patients. (LLM, conf=0.93)

      Experimental — accuracy not yet measured
    • cites [26] source

      The Results section reports sleep impairment in IBD patients, and the Conclusions section says sleep counseling can improve their quality of life. The paper does not establish an association between sleep disturbance and disability or extraintestinal manifestations; it also reports 43.6% meeting its PSQI threshold, rather than one-third. (LLM, conf=0.86)

      Experimental — accuracy not yet measured
    • cites [27] source

      The Introduction links good sleep with improved quality of life, and the Discussion reports worse sleep in patients with IBD-associated peripheral arthritis, an extraintestinal manifestation. The paper does not report that one-third of its examined patients had sleep disturbance or establish an association with disability. Its Introduction cites a previous study in which 31.6% of patients with ulcerative colitis had poor sleep scores. (LLM, conf=0.86)

      Experimental — accuracy not yet measured

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    The higher the number of aerobic enterococci, the more severe the neurological and cognitive impairments, including nervousness, memory loss, forgetfulness and confusion.

    “Крім того, доведено твердження про те, що чим вища кількість аеробних ентерококів, тим важчі неврологічні та когнітивні порушення, включно з нервозністю, втратою пам'яті, забудькуватістю і сплутаністю свідомості.”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [49] source

      The Discussion (page unavailable) reports anxiety, stress, and depressive symptoms in patients with inflammatory bowel disease, but does not link them to aerobic enterococci. Searches for enterococci, memory loss, forgetfulness, and confusion found no passage addressing the claimed relationship. (LLM, conf=0.77)

      Experimental — accuracy not yet measured

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Fatigue was the main complaint of patients during exacerbations and correlated with depression level.

    “Крім того, втома була основною скаргою пацієнтів у період загострень і корелювала з рівнем депресії [46].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [46] source

      The Introduction (page unavailable) reports that lack of energy was the most burdensome symptom in one IBD study, but does not limit that finding to exacerbations. The Pro-Inflammatory State section (page unavailable) reports an association between fatigue and depression, but does not specify a correlation with depression level. (LLM, conf=0.86)

      Experimental — accuracy not yet measured

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    In a randomized controlled trial, acceptance and commitment therapy led to a reduction in perceived stress and depression, but not anxiety, compared to controls.

    “ACT була викликана зниженням сприйманого стресу і депресії, але не тривогою, у порівнянні з контрольними особами.”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [62] source

      The RCT section (page unavailable) describes a duloxetine-versus-placebo trial, not acceptance and commitment therapy; it reports improvement in both depression and anxiety. Searches for acceptance and commitment therapy, perceived stress, and an ACT randomized trial found no passage addressing the claimed intervention or outcome, so this copy cannot verify the claim. (LLM, conf=0.75)

      Experimental — accuracy not yet measured

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Hair cortisol concentration correlated with anxiety at baseline, but did not significantly change in the ACT group over the study period compared to the control group.

    “Крім того, під час вивчення оцінювали рівень кортизолу у волоссі: з'ясувалося, що концентрація кортизолу корелювала з тривогою на вихідному рівні, але істотно не змінилася в групі ACT за період дослідження у порівнянні з контрольною групою [62].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [62] source

      The RCT section describes duloxetine versus placebo and measures anxiety with HADS; it does not report hair cortisol or an ACT group. Searches for hair cortisol and acceptance and commitment therapy found no passage addressing the claimed baseline correlation or change relative to controls. Page numbers were not available in our copy. (LLM, conf=0.72)

      Experimental — accuracy not yet measured

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    In IBD patients, a high level of fear and worry is observed, especially in patients with ulcerative colitis and more often in the group with complications and exacerbations.

    “Крім того, у пацієнтів із ЗЗК спостерігається високий рівень страху і занепокоєння, особливо це стосується пацієнтів з ВК і частіше спостерігається в групі з ускладненнями і загостреннями [54].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [54] source

      The paper’s main text says that IBD can cause psychiatric problems, describes fear associated with ulcerative colitis (UC), and reports that disease flares and psychiatric symptoms increase together. It does not establish that fear and worry are more frequent in UC than in other IBD patients, or specifically more frequent among patients with complications. (LLM, conf=0.84)

      Experimental — accuracy not yet measured

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    In the first work by S. Saraiva et al., exacerbation of ulcerative colitis and female sex are significantly associated with a high level of fatigue.

    “У першій роботі S. Saraiva et al. показано, що загострення ГК і жіноча стать достовірно пов'язані з високим рівнем втоми.”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [47] source

      The Cytokines and inflammation section (page unavailable) says fatigue is prevalent in inflammatory bowel disease, supporting only the broad connection between bowel inflammation and fatigue. It does not report that ulcerative colitis exacerbation or female sex is significantly associated with high fatigue, nor does it present a finding by Saraiva et al. (LLM, conf=0.76)

      Experimental — accuracy not yet measured

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    In another retrospective cohort study, IBD patients who underwent surgery had higher levels of anxiety and depression, and stoma formation was an additional risk factor for reduced quality of life.

    “В іншому ретроспективному когортному дослідженні, навпаки, пацієнти із ЗЗК, які перенесли хірургічне втручання, мали вищий рівень тривожності та депресії, а формування стоми являло собою додатковий фактор ризику зниження якості життя [41, 42].”
    Quote in the paperNot a substantial claim1 of 2 sources checked
    • cites [41] source
    • cites [42] source

      The Methods describe a study of fatigue scales in people with IBD and the use of an anxiety and depression scale; the Introduction links fatigue with lower quality of life. Searches for surgery, stoma formation, and their association with anxiety, depression, or quality of life found no passage addressing the claimed retrospective cohort finding. (LLM, conf=0.76)

      Experimental — accuracy not yet measured

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    Disturbance of intestinal barrier function in chronic fatigue syndrome promotes bacterial translocation.

    “Порушення бар'єрної функції кишечнику при синдромі хронічної астенії сприяє бактеріальній транслокації [49].”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [49] source

      The Introduction discusses fatigue in inflammatory bowel disease and the metabolism of tryptophan by intestinal bacteria, but does not link impaired intestinal barrier function to bacterial translocation in chronic fatigue syndrome. Searches for intestinal barrier dysfunction and bacterial or microbial translocation found no passage addressing that claim; page numbers were unavailable in our copy. (LLM, conf=0.76)

      Experimental — accuracy not yet measured

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Many IBD patients note limitation and reduction of physical activity during exacerbation and relapses, and most patients prefer low-load exercises such as walking.

    “Багато хворих відзначають обмеження і зниження регулярності фізичної активності в період загострення, при рецидивах, у результаті чого більшість пацієнтів віддають перевагу вправам із низьким навантаженням, таким як ходьба [21, 22].”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [21] source
    • cites [22] source

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Women with higher levels of depression and anxiety experienced more emotional disorders associated with the disease and had more frequent gastrointestinal symptoms compared to men, leading to low health-related quality of life.

    “Є дані, згідно з якими жінки з вищим рівнем депресії та тривоги зазнавали більше емоційних розладів, пов'язаних із захворюванням, а також мали частіші симптоми з боку ШКТ у порівнянні з чоловіками, що призводило до низького рівня якості життя, пов'язаного зі здоров'ям [15].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [15] source

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    The prevalence of mental disorders such as depression, bipolar disorder, schizophrenia, autism spectrum disorders, and dementia is higher in IBD patients compared to the general population.

    “Поширеність психічних розладів, таких як депресія, біполярний розлад, шизофренія, розлади аутистичного спектра, деменція, очевидно, вища у пацієнтів із ЗЗК у порівнянні з населенням загалом [19].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [19] source

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    In a cross-sectional study of 107 IBD patients by J. Pulley et al. (2019), the prevalence of malnutrition was 16%.

    “Поширеність недоїдання серед 107 пацієнтів із ЗЗК, за даними поперечного дослідження, виконаного J. Pulley et al. (2019), становила 16%.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites J. Pulley et al. (2019)

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Interpretationnone given
    § https://orcid.org/0009-0000-2023-5593

    Inflammatory bowel disease contributes to the development of depressive and anxiety disorders, asthenia, sexual dysfunction, poor sleep quality, reduced physical activity, work quality, and productivity.

    “Inflammatory bowel disease contributes to the development of depressive and anxiety disorders, asthenia, sexual dysfunction, poor sleep quality, reduced physical activity, work quality, and productivity.”
    Quote in the paperNot a substantial claim

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    The presence of complaints of abdominal pain, joint pain, depressive disorders, and elevated C-reactive protein serve as factors influencing sleep quality.

    “Наявність скарг на біль у животі, в суглобах, депресивні порушення, виявлення підвищення С-реактивного білка (СРБ), на думку авторів, слугують фактором, що впливає на якість сну[28].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [28] source

  • May combine two claims.

    Interpretationreasoning
    § INTRODUCTION / ВСТУП

    Evidence for prescribing antidepressants in IBD is uncertain because of the absence of randomized studies, small sample sizes, and the use of different types of drugs.

    “Звісно, залишається багато невирішених питань, що потребує подальшого вивчення (відсутність рандомізованих досліджень, невелика вибірка учасників, використання різних видів препаратів), тому докази для призначення антидепресантів невизначені.”
    Quote in the paperSubstantial claim

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Existing studies confirm a connection between asthenia and disease severity, unlike patients in remission.

    “Існуючі дослідження підтверджують зв'язок між астенією і ступенем тяжкості захворювання на відміну від пацієнтів у ремісії [45].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [45] source

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    There are data about reduced quality of life in obese patients with IBD and intensification of systemic low-grade inflammation in concomitant diseases related to metabolic syndrome.

    “Є дані про зниження якості життя пацієнтів з ожирінням при ЗЗК, посилення системного низькоінтенсивного запалення за супутніх захворювань, пов'язаних із метаболічним синдромом.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [43] source

  • Classified as probably not a substantial claim. May combine two claims.

    Interpretationreasoning
    § INTRODUCTION / ВСТУП

    Current data and the insufficient number of experimental studies do not allow formulating recommendations for prescribing therapy for this group of patients.

    “невизначеність щодо медикаментозної терапії, співвідношення ризику та користі призначення лікарських препаратів, недостатня кількість проведених експериментальних досліджень і наявні дані на сьогоднішній день не дають змоги сформулювати рекомендації щодо призначення терапії для цієї групи хворих.”
    Quote in the paperSubstantial claim

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    In another study, authors indicate a clear reduction in sleep quality in extraintestinal manifestations of IBD, particularly peripheral arthritis.

    “В іншому дослідженні автори вказують на явне зниження якості сну при позакишкових проявах ЗЗК, зокрема при периферичному артриті.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [28] source

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    There is very limited research, but some authors note a positive effect of antidepressants on the course of IBD.

    “Є дуже обмежена кількість досліджень, але відзначається позитивний вплив антидепресантів на перебіг ЗЗК деякими авторами [64].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [64] source

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Obesity increases the risk of disease relapse and is associated with higher anxiety, depression, asthenia and pain, more frequent seeking of medical help, and increased risks of therapy ineffectiveness due to competitive influence of drugs aimed at IBD therapy.

    “Крім того, ожиріння збільшує ризик рецидиву захворювання і пов'язане з вищими тривожністю, депресією, астенією та болем, частішим зверненням за медичною допомогою, а також зі збільшенням ризиків неефективності терапії в результаті конкурентного впливу препаратів, спрямованих на терапію ЗЗК [43].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [43] source

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    The antidepressants reported in these publications included paroxetine, bupropion, amitriptyline, phenelzine, and mirtazapine.

    “Антидепресанти, про які повідомлялося в цих публікаціях, включали пароксетин, бупропіон, амітриптилін, фенелзин і міртазапін.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [65] source

  • May combine two claims.

    Premisecitation
    § INTRODUCTION / ВСТУП

    Positive action, efficacy and safety of cannabis in achieving remission in Crohn's disease and ulcerative colitis patients was not achieved, and side effects were significantly more common in the group receiving this drug.

    “Позитивної дії, ефективності та безпеки канабісу в досягненні ремісії хворими на ХК і ВК досягнуто не було, причому були значно поширені побічні ефекти в групі тих, хто отримував цей препарат [63].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [63] source

  • May combine two claims.

    Interpretationnone given
    § CONCLUSIONS / ВИСНОВКИ

    A number of scientific studies clearly indicate that IBD contribute to the development of depressive and anxiety disorders, asthenia, sexual dysfunction, worsened sleep quality, reduced regularity of physical activity, and reduced quality and productivity of work.

    “Ряд наукових досліджень однозначно свідчать про те, що ЗЗК сприяють розвитку депресивних та тривожних розладів, астенії, сексуальної дисфункції, погіршенню якості сну, зниженню регулярності фізичної активності, якості та продуктивності праці.”
    Quote in the paperNot a substantial claim

  • May combine two claims.

    Premisecitation
    § REFERENCES/СПИСОК ЛІТЕРАТУРИ

    Efficacy of antidepressants was also confirmed in a 2019 review, which showed improvement of anxiety and depression symptoms compared to placebo, and improvement not only in quality of life but also reduction of IBD activity.

    “Ефективність антидепресантів також підтверджено в огляді від 2019 р., у якому показано поліпшення симптомів тривоги та депресії у порівнянні з групою плацебо, крім того, відбулося поліпшення не тільки якості життя, а й зниження активності ЗЗК.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [66] source

  • May combine two claims.

    Premisecitation
    § REFERENCES/СПИСОК ЛІТЕРАТУРИ

    Specific side effects noted include nausea, headache, dizziness, drowsiness, sexual disorders, insomnia, asthenia, decreased mood and/or anxiety, dry mouth, muscle cramps, and hot flashes.

    “Зокрема, відзначено такі побічні ефекти, як нудота, головний біль, запаморочення, сонливість, сексуальні порушення, безсоння, астенія, зниження настрою та/або занепокоєння, сухість у роті, м'язові спазми та припливи.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [66] source

  • May combine two claims.

    Premisecitation
    § REFERENCES/СПИСОК ЛІТЕРАТУРИ

    In a study of bupropion in Crohn's disease, its positive effect on the course of exacerbations, reduction of abdominalgia, stool frequency regardless of smoking status, reduction of fatigue among patients, and positive effect on sleep quality were determined.

    “При вивченні впливу бупропіону при ХК визначено його позитивний вплив на перебіг загострень ХК, зменшення абдоміналгії, частоти випорожнень незалежно від статусу паління, зменшення стомлюваності серед пацієнтів і позитивний вплив на якість сну [67].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [67]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    Overall, a positive effect of antidepressant treatment was noted.

    “Загалом відзначено позитивний ефект лікування антидепресантами, але відсутність достовірних даних щодо їхньої ефективності при ЗЗК не дає змоги рекомендувати ці препарати всім пацієнтам цієї категорії [65].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [65] source

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § INTRODUCTION / ВСТУП

    Mirtazapine was not recommended for patients with IBD.

    “Міртазапін не був рекомендований пацієнтам із ЗЗК.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [65] source
37 of 37

  • The paper relies on this without support.

    Inflammatory bowel disease is a chronic disease of unclear etiology, with periods of exacerbation and remission, has negative social, physical and emotional consequences and reduces quality of life.

    “Inflammatory bowel disease is a chronic disease of unclear etiology, with periods of exacerbation and remission, has negative social, physical and emotional consequences and reduces quality of life.”

  • The paper relies on this without support.

    Psychological status and quality of life in IBD are influenced by many factors including the disease itself, disease severity, extent of digestive tract involvement, extraintestinal manifestations, complications, surgical interventions, and effectiveness of therapy.

    “It is an obvious fact that psychological status and quality of life are influenced by a significant number of factors, including the disease itself (Crohn's disease is most often more severe, especially in young patients), the severity of the disease, the prevalence of digestive tract involvement, extraintestinal manifestations, complications, surgical interventions and the eff”

  • The paper relies on this without support.

    Current data on gender differences in IBD are contradictory and depend on social status, lifestyle, and country of residence.

    “На даний час дані про відмінності в гендерному відношенні суперечливі й залежать від соціального становища, способу життя, країни проживання .”

  • The paper relies on this without support.

    Anxiety and depression are the most common psychological disorders among both non-IBD and IBD patients.

    “Тривогу та депресію вважають найпоширенішими психологічними розладами серед як осіб, які не страждають на ЗЗК, так і пацієнтів із ЗЗК.”

  • The paper relies on this without support.

    Most risk factors are potentially modifiable and may thereby improve quality of life.

    “Хоча більшість факторів ризику потенційно піддається зміні і тим самим, можливо, підвищенню якості життя, але на даний момент немає підтверджуючих експериментальних робіт щодо їх доведеної ефективності.”

  • The paper relies on this without support.

    Currently there are no confirming experimental works on the proven effectiveness of modifying these risk factors.

    “Хоча більшість факторів ризику потенційно піддається зміні і тим самим, можливо, підвищенню якості життя, але на даний момент немає підтверджуючих експериментальних робіт щодо їх доведеної ефективності.”

  • The paper relies on this without support.

    There are no clinical recommendations or guidelines for prescribing antidepressants to patients with IBD.

    “Клінічних рекомендацій та настанов щодо призначення антидепресантів пацієнтам із ЗЗК немає.”
7 of 7

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Selected study count contradicts later count

    Minor

    The English methods section says 68 papers were selected, but the Ukrainian strategy section says 69 works were selected. This is a direct inconsistency in the reported number of included sources.

1 of 1

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Greuter T, Manser C, Pittet V, Vavricka,SR, Biedermann L.; on behalf of Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology. Gender Differences in Inflammatory Bowel Disease. Digestion. 2020;101(1):98-104. https://doi.org/10.1159/000504701. · DOI · Paper page

Cited by

Sorted by citations

Related

Authors
Romanukha, V., Hryniv, O., Hvozdetska, H., Baryla, N., & Hrushetska, A.
Affiliations
  • Ivano-Frankivsk National Medical University (UA)
  • Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
ORCID
Venue
Eastern Ukrainian Medical Journal
Publisher
Sumy State University
Published
2024
Volume
12
Issue
2
Pages
202-211
ISSN
  • 2663-5909 (ISSN-L)
  • 2664-4231
DOI
10.21272/eumj.2024;12(2):202-211
OpenAlex
W4400256877
Cited by
1
References
67
Citations by year
2025: 1
FWCI
0.27
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Eastern Ukrainian Medical Journal (publishedVersion, cc-by)
  • Electronic Sumy State University Institutional Repository (Sumy State University) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
inflammatory bowel disease, Crohn's disease, psychosocial status, quality of life, depression, anxiety, sleep quality, fatigue, physical activity, psychotherapy, cognitive behavioral therapy, acceptance and commitment therapy, psychodynamic psychotherapy, stress management, mindfulness, hypnosis, antidepressants, stoma creation, gut dysbiosis, obesity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-11.

Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-11.

Cited sources are checked by gpt-6-sol.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review