Information-driven modelling of antibody–antigen complexes
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HADDOCK is able to provide high quality models when only a loose definition of the epitope and the hypervariable loops of antibodies are used to drive the docking.
“In the case of antibodies, it has recently been demonstrated that HADDOCK is able to already provide high quality models when only a loose definition of the epitope and the hypervariable loops of antibodies are used to drive the docking [178].”
From Computational approaches to therapeutic antibody design: established methods and emerging trends (2020) · cites this paper as [178]
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Computational approaches to therapeutic antibody design: established methods and emerging trends
Norman, R. A., Ambrosetti, F., Bonvin, A. M. J. J., Colwell, L. J., Kelm, S., Kumar, S., & Krawczyk, K. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbz095 · Cited by 219 · see citing works
“In the case of antibodies, it has recently been demonstrated that HADDOCK is able to already provide high quality models when only a loose definition of the epitope and the hypervariable loops of antibodies are used to drive the docking [178].”
BackgroundSelf-citationNanobody engineering: computational modelling and design for biomedical and therapeutic applications
Salamouni, N. S. E., Cater, J. H., Spenkelink, L. M., & Yu, H. B. (2024) · FEBS Open Bio · doi:10.1002/2211-5463.13850 · Cited by 36 · see citing works
- Authors
- Ambrosetti, F., Jiménez-García, B., Roel-Touris, J., & Bonvin, A. M. J. J.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Bonvin, A.M.J.J.
- Venue
- SSRN Electronic Journal
- Publisher
- Elsevier BV
- Published
- 2019
- ISSN
- 1556-5068 (ISSN-L)
- OpenAlex
- W2995116666
- Cited by
- 2
- References
- 61
- Citations by year
- 2024: 1 · 2019: 1
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Locations
- SSRN Electronic Journal (publishedVersion)
- Topics
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- immune complexes, molecular docking, hypervariable region, binding epitope, haddock, ClusPro, ZDOCK, antigen-antibody reaction, therapeutic antibodies
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