The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Engineered nanomaterial uptake and tissue distribution: from cell to organism
Open accessAbstract
Improved understanding of interactions between nanoparticles and biological systems is needed to develop safety standards and to design new generations of nanomaterials. This article reviews the molecular mechanisms of cellular uptake of engineered nanoparticles, their intracellular fate, and their distribution within an organism. We have reviewed the available literature on the uptake and disposition of engineered nanoparticles. Special emphasis was placed on the analysis of experimental systems and their limitations with respect to their usefulness to predict the in vivo situation. The available literature confirms the need to study particle characteristics in an environment that simulates the situation encountered in biological systems. Phenomena such as protein binding and opsonization are of prime importance since they may have a strong impact on cellular internalization, biodistribution, and immunogenicity of nanoparticles in vitro and in vivo. Extrapolation from in vitro results to the in vivo situation in the whole organism remains a challenge. However, improved understanding of physicochemical properties of engineered nanoparticles and their influence on biological systems facilitates the design of nanomaterials that are safe, well tolerated, and suitable for diagnostic or therapeutic use in humans.
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Cites
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
Wicki, A., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.030 · Cited by 1,901
Self-citationRelevance of nano- and microplastics for freshwater ecosystems: A critical review
Triebskorn, R., Braunbeck, T., Grummt, T., Hanslik, L., Huppertsberg, S., Jekel, M., Knepper, T. P., Krais, S., Müller, Y. K., Pittroff, M., et al. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.11.023 · Cited by 507
Nanomaterials in food and agriculture: An overview on their safety concerns and regulatory issues
Jain, A., Ranjan, S., Dasgupta, N., & Ramalingam, C. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1160363 · Cited by 367
Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery
Buck, J., Grossen, P., Cullis, P. R., Huwyler, J., & Witzigmann, D. (2019) · ACS Nano · doi:10.1021/acsnano.8b07858 · Cited by 312
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Metadata
- Authors
- Huwyler, J., Kettiger, H., Schipanski, A., & Wick, P.
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2013-08
- Volume
- 8
- Pages
- 3255
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- OpenAlex
- W2055574464
- Cited by
- 210
- References
- 16
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- gold
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- Huwyler, J., Kettiger, H., Schipanski, A., & Wick, P. (2013). Engineered nanomaterial uptake and tissue distribution: from cell to organism. International Journal of Nanomedicine. https://doi.org/10.2147/ijn.s49770
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
