Rescuing apoptotic neurons in Alzheimer’s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin
Open accessAbstract
Liposomes with cardiolipin (CL) and wheat germ agglutinin (WGA) were developed to permeate the blood-brain barrier and treat Alzheimer's disease. WGA-conjugated and CL-incorporated liposomes (WGA-CL-liposomes) were used to transport nerve growth factor (NGF) and curcumin (CUR) across a monolayer of human brain-microvascular endothelial cells regulated by human astrocytes and to protect SK-N-MC cells against apoptosis induced by β-amyloid1-42 (Aβ(1-42)) fibrils. An increase in the CL mole percentage in lipids increased the liposomal diameter, absolute zeta potential value, entrapment efficiency of NGF and CUR, release of NGF, biocompatibility, and viability of SK-N-MC cells with Aβ(1-42), but decreased the atomic ratio of nitrogen to phosphorus and release of CUR. In addition, an increase in the WGA concentration for grafting enhanced the liposomal diameter, atomic ratio of nitrogen to phosphorus, and permeability of NGF and CUR across the blood-brain barrier, but reduced the absolute zeta potential value and biocompatibility. WGA-CL-liposomes carrying NGF and CUR could be promising colloidal delivery carriers for future clinical application in targeting the blood-brain barrier and inhibiting neurotoxicity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Encapsulation of curcumin and NGF in combination led to synergistic effect and showed clinical application in mitigating Aβ-induced neurotoxicity.
“Interestingly, the encapsulation of curcumin and NGF in combination led to a synergistic effect and showed a clinical application in mitigating Aβ-induced neurotoxicity.109,110”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [109]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diffusion of univalent ions across the lamellae of swollen phospholipids
Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664 · see citing works
2013 Alzheimer's disease facts and figures
Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,331 · see citing works
Aggarwal, B. B., & Harikumar, K. B. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.010 · Cited by 2,043 · see citing works
Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
Snider, W. D. (1994) · Cell · doi:10.1016/0092-8674(94)90048-5 · Cited by 1,421 · see citing works
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284 · see citing works
Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro
Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20025 · Cited by 1,254 · see citing works
Alzheimer's disease: strategies for disease modification
Citron, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2896 · Cited by 1,060 · see citing works
Classification and basic pathology of Alzheimer disease
Duyckaerts, C., Delatour, B., & Potier, M.-C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0532-1 · Cited by 1,031 · see citing works
Turner, P. R., O’Connor, K., Tate, W. P., & Abraham, W. C. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00089-3 · Cited by 751 · see citing works
Garcı́a-Alloza, M., Borrelli, L. A., Rozkalne, A., Hyman, B. T., & Bacskai, B. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04613.x · Cited by 663 · see citing works
Baum, L., Lam, C. W. K., Cheung, S. K. K., Kwok, T. C. Y., Lui, V. W.-C., Tsoh, J., LAM, L. C. W., Leung, V., Hui, E., Ng, C., et al. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318160862c · Cited by 594 · see citing works
Cardiolipin provides specificity for targeting of tBid to mitochondria
Lutter, M. L., Fang, M., Luo, X., Nishijima, M., Xie, X., & Wang, X. (2000) · Nature Cell Biology · doi:10.1038/35036395 · Cited by 472 · see citing works
Plasma Aβ1–40 and Aβ1–42 and the risk of dementia: a prospective case-cohort study
van Oijen, M., Hofman, A., Soares, H. D., Koudstaal, P. J., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70501-4 · Cited by 458 · see citing works
Nagele, R. G., D’Andrea, M. R., Anderson, W. J., & Wang, H.-Y. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00460-2 · Cited by 456 · see citing works
Stadelmann, C., Deckwerth, T., Srinivasan, A., Bancher, C., Brück, W., Jellinger, K. A., & Lassmann, H. (1999) · American Journal of Pathology · doi:10.1016/s0002-9440(10)65460-0 · Cited by 449 · see citing works
The role of cerebral amyloid accumulation in common forms of Alzheimer disease
Gandy, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25100 · Cited by 394 · see citing works
Takahashi, M., Uechi, S., Takara, K., Asikin, Y., & Wada, K. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9013923 · Cited by 390 · see citing works
Chen, Y., Jobanputra, P., Barton, P. M., Bryan, S., Fry-Smith, A., Harris, G., & Taylor, R. (2008) · Health Technology Assessment · doi:10.3310/hta12110 · Cited by 340 · see citing works
Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate
Friden, P. M., Walus, L. R., Watson, P. M., Doctrow, S. R., Kozarich, J. W., Bäckman, C. M., Bergman, H., Hoffer, B. J., Bloom, F. E., & Granholm, A. (1993) · Science · doi:10.1126/science.8420006 · Cited by 327 · see citing works
Chen, Y., Wu, Q., Zhang, Z., Yuan, L., Liu, X., & Zhou, L. (2012) · Molecules · doi:10.3390/molecules17055972 · Cited by 316 · see citing works
Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma
Dhule, S. S., Penfornis, P., Frazier, T. P., Walker, R., Feldman, J., Tan, G., He, J., Alb, A. M., John, V. T., & Pochampally, R. R. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.07.011 · Cited by 299 · see citing works
The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes
Lewis, R. N. A. H., & McElhaney, R. N. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.03.014 · Cited by 274 · see citing works
Oxidized LDL activates fas-mediated endothelial cell apoptosis.
Sata, M., & Walsh, K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3531 · Cited by 227 · see citing works
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
Huang, W., Choi, W.-Y., Hu, W., Mi, N., Guo, Q., Ma, M., Liu, M., Tian, Y., Lu, P., Wang, F., et al. (2012) · Cell Research · doi:10.1038/cr.2012.24 · Cited by 217 · see citing works
Lipid-based nanoparticles with high binding affinity for amyloid-β1–42 peptide
Gobbi, M., Re, F., Canovi, M., Beeg, M., Gregori, M., Sesana, S., Sonnino, S., Brogioli, D., Musicanti, C., Gasco, P., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.044 · Cited by 211 · see citing works
Gao, X., Wu, B., Zhang, Q., Chen, J., Zhu, J., Zhang, W., Rong, Z., Chen, H., & Jiang, X. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.026 · Cited by 207 · see citing works
Is Alzheimer disease caused by lack of nerve growth factor?
Hefti, F. F. (1983) · Annals of Neurology · doi:10.1002/ana.410130127 · Cited by 179 · see citing works
Ray, B., Bisht, S., Maitra, A., Maitra, A., & Lahiri, D. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101374 · Cited by 177 · see citing works
Xie, Y., Ye, L., Zhang, X., Cui, W., Lou, J., Nagai, T., & Hou, X. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.03.005 · Cited by 168 · see citing works
Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines
Sonnenfeld, K. H., & Ishii, D. N. (1982) · Journal of Neuroscience Research · doi:10.1002/jnr.490080226 · Cited by 167 · see citing works
Chien, P.-Y., Wang, J., Carbonaro, D., Lei, S., Miller, B., Sheikh, S., Ali, S. M., Ahmad, M. U., & Ahmad, I. (2004) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700793 · Cited by 152 · see citing works
Nerve growth factor promotes survival of new neurons in the adult hippocampus
Frielingsdorf, H., Simpson, D. R., Thal, L. J., & Pizzo, D. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.11.015 · Cited by 151 · see citing works
Taylor, M., Moore, S., Mourtas, S., Niarakis, A., Re, F., Zona, C., Ferla, B. L., Nicotra, F., Masserini, M., Antimisiaris, S. G., et al. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.06.015 · Cited by 149 · see citing works
KUO, Y., & SU, F. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.03.012 · Cited by 147 · see citing works
Self-citationThe cholinergic system, nerve growth factor and the cytoskeleton
Niewiadomska, G., Mietelska‐Porowska, A., & Mazurkiewicz, M. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.024 · Cited by 142 · see citing works
Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil
Soni, V., Kohli, D. V., & Jain, S. K. (2005) · Journal of drug targeting · doi:10.1080/10611860500107401 · Cited by 103 · see citing works
Re, F., Salvati, Sesana, Cambianica, Sancini, G., Masserini, & Gregori (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s42783 · Cited by 93 · see citing works
Cholesterol-Phospholipid Interactions: New Insights from Surface X-Ray Scattering Data
Ivankin, A., Kuzmenko, I., & Gidalevitz, D. (2010) · Physical Review Letters · doi:10.1103/physrevlett.104.108101 · Cited by 87 · see citing works
Expression of Fos, Jun, and Krox Family Proteins in Alzheimer's Disease
MacGibbon, G. A., Lawlor, P. A., Walton, M. R., Sirimanne, E. S., Faull, R. L. M., Synek, B. J. L., Mee, E. T., Connor, B. J., & Dragunow, M. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6600 · Cited by 86 · see citing works
The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes
Nicolay, K., Timmers, R. J. M., Spoelstra, E. C., van der Neut, R., Fok, J. J., Huigen, Y. M., Verkleij, A. J., & KRUIJFF, B. D. (1984) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(84)90380-8 · Cited by 86 · see citing works
Kuo, Y., & Lu, C.-H. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.04.005 · Cited by 80 · see citing works
Self-citationKuo, Y., Lin, P., & Wang, C. (2011) · Nanomedicine · doi:10.2217/nnm.11.25 · Cited by 68 · see citing works
Self-citationZhang, E. Y., Knipp, G. T., Ekins, S., & Swaan, P. W. (2002) · Drug Metabolism Reviews · doi:10.1081/dmr-120015692 · Cited by 66 · see citing works
Kuo, Y., & Wang, C.-T. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.082 · Cited by 60 · see citing works
Self-citationCentis, V., & Vermette, P. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2008.04.009 · Cited by 60 · see citing works
Liu, Q., Shao, X., Chen, J., Shen, Y., Feng, C., Gao, X., Zhao, Y., Li, J., Zhang, Q., & Jiang, X. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.12.003 · Cited by 53 · see citing works
Chen, K.-S., Chen, P., Hsieh, Y., Lin, C.-Y., Lee, Y.-H., & Chu, S. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.01.007 · Cited by 52 · see citing works
Self-citationBroe, M., Shepherd, C. E., Milward, E. A., & Halliday, G. M. (2001) · Acta Neuropathologica · doi:10.1007/s004010000337 · Cited by 48 · see citing works
Li, W., Ghosh, M., Eftekhari, S., & Yuan, X. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.071 · Cited by 48 · see citing works
Kuo, Y.-C., & Chou, P.-R. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24081 · Cited by 43 · see citing works
Self-citationFischer, D., & Kissel, T. (2001) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(01)00159-x · Cited by 37 · see citing works
Muhonen, J., Holopainen, J. M., & Wiedmer, S. Κ. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.02.028 · Cited by 35 · see citing works
Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells
Bereczki, E., Re, F., Masserini, M., Winblad, B. G., & Pei, J. J. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.05.009 · Cited by 32 · see citing works
Kuo, Y., & Wang, L.-J. (2013) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2013.09.024 · Cited by 32 · see citing works
Self-citationTsuruda, A., Suzuki, S., Maekawa, T., & Oka, S. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00115-2 · Cited by 32 · see citing works
Begum, M. Y., Sudhakar, M., & Abbulu, K. (2012) · Journal of Young Pharmacists · doi:10.4103/0975-1483.104364 · Cited by 31 · see citing works
Chang, R. S., Kim, J., Lee, H. Y., Han, S.-E., Na, J., Kim, K., Kwon, I. C., Kim, Y. B., & Oh, Y. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.05.003 · Cited by 30 · see citing works
Böttger, D., Ullrich, C., & Humpel, C. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.062 · Cited by 29 · see citing works
Treatment of Focal Cerebral Ischemia with Liposomal Nerve Growth Factor
Luk, Y.-O., Chen, W. Y.-K., Wong, W.-J., Hu, H., Hsu, L., Chern, C.-M., Huang, K.-J., & Law, S.-L. (2004) · Drug Delivery · doi:10.1080/10717540490494104 · Cited by 23 · see citing works
Kuo, Y., & Liu, Y. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.07.003 · Cited by 21 · see citing works
Self-citationAnti-amyloidogenic effect of AA3E2 attenuates β-amyloid induced toxicity in SK-N-MC cells
Shaykhalishahi, H., Taghizadeh, M. T., Yazdanparast, R., & Chang, Y. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.03.042 · Cited by 19 · see citing works
Zazueta, C., Ramírez, J., Garcı́a, N., & Baeza, I. (2003) · The Journal of Membrane Biology · doi:10.1007/s00232-002-1047-z · Cited by 15 · see citing works
Kuo, Y., & Lin, C.-Y. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2014.965716 · Cited by 15 · see citing works
Self-citationPlattner, V. E., Germann, B., Neuhaus, W., Noe, C. R., Gabor, F., & Wirth, M. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.11.030 · Cited by 14 · see citing works
An overview of in vitro research models for Alzheimer`s disease (AD)
Ntimi, C. M., Rosli, R., Adam, A., & Nordin, N. (2013) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · Cited by 7 · see citing works
Cholesterol-phospholipid Interactions: New Insights From Surface X-ray Scattering Data
Ivankin, A., Antipova, A., & Gidalevitz, D. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.12.3196 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease
Zhang, K., Chen, M., Du, Z.-Y., Zheng, X., Li, D., & Zhou, R. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.230303 · Cited by 236 · see citing works
Xi, K., Gu, Y., Tang, J., Chen, H., Xu, Y., Wu, L., Cai, F., Deng, L., Yang, H., Shi, Q., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18265-3 · Cited by 231 · see citing works
Teixeira, M. I., Lopes, C. M., Amaral, M. H., & Costa, P. C. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112999 · Cited by 155 · see citing works
Doppalapudi, S., Jain, A., Chopra, D. K., & Khan, W. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.10.025 · Cited by 145 · see citing works
Laurindo, L. F., de Carvalho, G. M., Zanuso, B. D. O., Figueira, M. E., Direito, R., Goulart, R. D. Á., Buglio, D. S., & Barbalho, S. M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010229 · Cited by 128 · see citing works
Neuroprotection by curcumin: A review on brain delivery strategies
Askarizadeh, A., Barreto, G. E., Henney, N. C., Majeed, M. A., & Sahebkar, A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119476 · Cited by 120 · see citing works
Curcumin in Alzheimer’s disease: Can we think to new strategies and perspectives for this molecule?
Serafini, M. M., Catanzaro, M., Rosini, M., Racchi, M., & Lanni, C. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.08.004 · Cited by 119 · see citing works
Kuo, Y., & Cheng, S.-J. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.054 · Cited by 87 · see citing works
Self-citationGuo, J., Guan, P.-P., Ding, W.-Y., Wang, S., Huang, X., Wang, Z., & Wang, P. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.023 · Cited by 87 · see citing works
Amphiphilic Nanocarrier Systems for Curcumin Delivery in Neurodegenerative Disorders
Rakotoarisoa, M., & Angelova, A. (2018) · Medicines · doi:10.3390/medicines5040126 · Cited by 84 · see citing works
Faustino, C. M. C., Rijo, P. M., & Reis, C. P. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.03.020 · Cited by 82 · see citing works
Liposome based drug delivery as a potential treatment option for Alzheimer’s disease
Shukla, S., & Hernandez, C. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.327328 · Cited by 76 · see citing works
Nanotechnology to improve the Alzheimer’s disease therapy with natural compounds
Ramalho, M. J., Andrade, S., Loureiro, J. A., & do Carmo Pereira, M. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-019-00694-3 · Cited by 75 · see citing works
Effects of Micro-environmental pH of Liposome on Chemical Stability of Loaded Drug
Shao, X., Wei, X.-Q., Zhang, S., Fu, N., Lin, Y., Cai, X., & Peng, Q. (2017) · Nanoscale Research Letters · doi:10.1186/s11671-017-2256-9 · Cited by 68 · see citing works
Kuo, Y., Lin, C.-Y., Li, J., & Lou, Y.-I. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s128396 · Cited by 64 · see citing works
Self-citationEffects of curcumin on neurological diseases: focus on astrocytes
Eghbaliferiz, S., Farhadi, F., Barreto, G. E., Majeed, M. A., & Sahebkar, A. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00112-3 · Cited by 63 · see citing works
Elezaby, R. S., Gad, H. A., Metwally, A. A., Geneidi, A. S., & Awad, G. A. S. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.06.019 · Cited by 56 · see citing works
Sancho, M. I., Andújar, S. A., Porasso, R. D., & Enriz, R. D. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b11317 · Cited by 53 · see citing works
Nanotechnology for the diagnosis and treatment of Alzheimer's disease: A bibliometric analysis
Li, L., He, R., Yan, H., Leng, Z., Zhu, S., & Gu, Z. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101654 · Cited by 48 · see citing works
Advances in Nanomedicine for the Treatment of Alzheimer’s and Parkinson’s Diseases
Hernando, S., Gartziandia, O., Herrán, E., Pedraz, J. L., Igartúa, M., & Hernández, R. M. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0019 · Cited by 48 · see citing works
Biomaterials-based anti-inflammatory treatment strategies for Alzheimer’s disease
Chu, J., Zhang, W., Liu, Y., Gong, B., Ji, W., Yin, T., Gao, C., Liangwen, D., Hao, M., Chen, C., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.374137 · Cited by 48 · see citing works
Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials
Alshamrani, M. (2022) · Polymers · doi:10.3390/polym14061221 · Cited by 44 · see citing works
Exosome-based approaches in the management of Alzheimer’s disease
Kandimalla, R., Saeed, M., Tyagi, N., Gupta, R. C., & Aqil, F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104974 · Cited by 43 · see citing works
Kuo, Y., & Chao, I. (2015) · Biotechnology Progress · doi:10.1002/btpr.2214 · Cited by 43 · see citing works
Self-citationChen, M., & Chiang, B. (2020) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2020.124862 · Cited by 40 · see citing works
Luo, Y., Liu, G., Xu, K., & Li, J. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.189196 · Cited by 37 · see citing works
Liu, Y., Xie, X., Chen, H., Hou, X., He, Y., Shen, J., Shi, J.-P., & Feng, N. (2020) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2020.102237 · Cited by 36 · see citing works
Rassu, G., Sorrenti, M., Catenacci, L., Pavan, B., Ferraro, L., Gavini, E., Bonferoni, M. C., Giunchedi, P., & Dalpiaz, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061578 · Cited by 36 · see citing works
Far, B., Safaei, M., Pourmolaei, A., Adibamini, S., Shirdel, S., Shirdel, S., Emadi, R., & Kaushik, A. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00112 · Cited by 30 · see citing works
Song, Q., Li, J., Li, T., & Li, H. (2024) · Advanced Science · doi:10.1002/advs.202403473 · Cited by 34 · see citing works
Wang, Z., Sreenivasmurthy, S. G., Song, J., Liu, J.-Y., & Li, M. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.11.001 · Cited by 31 · see citing works
Ligand Conjugated Targeted Nanotherapeutics for Treatment of Neurological Disorders.
Mittal, S., Ashhar, M. U., Qizilbash, F. F., Qamar, Z., Narang, J., Kumar, S., Ali, J., & Baboota, S. (2020) · Current pharmaceutical design · doi:10.2174/1381612826666200417141600 · Cited by 24 · see citing works
Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons
Stankowska, D. L., Krishnamoorthy, V. R., Ellis, D. Z., & Krishnamoorthy, R. R. (2015) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1119377 · Cited by 25 · see citing works
Kim, Y. S., Gulfam, M., & Lowe, T. L. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b01044 · Cited by 24 · see citing works
Xiao, Y., Cheng, L., Xie, H., Ju, R.-J., Wang, X., Fu, M., Liu, J., & Li, X. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1501377 · Cited by 24 · see citing works
Bode, G. H., Coué, G. M. J. P. C., Freese, C., Pickl, K. E., Sánchez-Purrà, M., Albaiges, B., Borrós, S., van Winden, E. C. A., Tziveleka, L., Sideratou, Z., et al. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.11.009 · Cited by 24 · see citing works
Zhang, Y., Lv, C., & Zhao, G. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1888973 · Cited by 23 · see citing works
Kuo, Y., Lou, Y.-I., Rajesh, R., & Chen, C.-L. (2020) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2020.02.017 · Cited by 19 · see citing works
Self-citationMishra, K., Rana, R., Tripathi, S., Siddiqui, S., Yadav, P. K., Yadav, P. N., & Chourasia, M. K. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03955-3 · Cited by 18 · see citing works
Hossain, M. M., & Richardson, J. R. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz239 · Cited by 15 · see citing works
A critical overview of therapeutic strategy and advancement for Alzheimer's disease treatment
Kuo, Y., & Rajesh, R. (2017) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2017.05.011 · Cited by 15 · see citing works
Self-citationLiu, S., Song, X., Wang, Y., Wang, X., Xiao, Y., Wang, X., Cheng, L., & Li, X. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1298602 · Cited by 14 · see citing works
Zholos, A. V., Moroz, O. F., & Storozhuk, M. (2018) · Current Molecular Pharmacology · doi:10.2174/1874467211666181012150847 · Cited by 12 · see citing works
Kuo, Y., & Wang, I.-H. (2017) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2017.05.003 · Cited by 11 · see citing works
Self-citationSaroj, M. K., Payal, R., Jain, S. K., Sharma, N., & Rastogi, R. C. (2018) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-018-0782-4 · Cited by 11 · see citing works
Recent Trends in Nano-Particulate Carriers for the Diagnosis and Treatment of Alzheimer’s Disease
Yadav, A. K., & Mazahir, F. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220420133059 · Cited by 6 · see citing works
Nanoparticles for the potential treatment of Alzheimer’s disease: A physiopathological approach
Martínez, N. M. N., Toledo, J. A., & Morales, J. O. (2023) · Nanotechnology Reviews · doi:10.1515/ntrev-2022-0548 · Cited by 6 · see citing works
Liposomes as carrier for drug delivery in Alzheimer's disease
Patel, R. J., Patel, A. A., Trivedi, N., Pandya, V., Alexander, A., Patel, V. F., Prajapati, B. G., & Parejiya, P. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13205-6.00008-x · Cited by 7 · see citing works
Alzheimer’s Disease: Evolving Therapeutics, Scientific Progress, and Key Challenges
Sai Yasasvi, K., Goswami, A. K., Prasad, M. R., Chauhan, V. S., & Yadav, N. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02468 · Cited by 4 · see citing works
Sitompul, J., Rahma, M. N., Afandi, F., Elamin, K. M., Mohammed, A., & Wathoni, N. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s598705 · Cited by 5 · see citing works
Nanotechnology Based Approaches for Neurodegenerative Disorders: Diagnosis and Treatment
Hernando, S., Herrán, E., Pedraz, J. L., Igartúa, M., & Hernández, R. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-57696-1_3 · Cited by 4 · see citing works
Curcumin-Loaded Nanoparticles in Neurodegenerative Diseases
Youshia, J., Gabal, Y. M., Mansour, M., & Gad, H. A. (2023) · Springer eBooks · doi:10.1007/978-981-99-7731-4_17 · Cited by 2 · see citing works
Shi, Y.-T., Li, F., Shu, T., Min, W., & Xu, Y. (2026) · Food Chemistry · doi:10.1016/j.foodchem.2026.150021 · Cited by 1 · see citing works
Basics of Targeted Drug Delivery
Doshi, K. A. (2022) · Methods and principles in medicinal chemistry · doi:10.1002/9783527827855.ch1 · Cited by 1 · see citing works
Nanocarriers mediated DNA repair mechanism against neurological disorders
Bora, S., Jadav, M., Kulhari, H., & Pooja, D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33623-2.00009-x
- Authors
- Kuo, Y.-C., & Lin, C.-C.
- Affiliations
- National Chung Cheng University (TW)
- Corresponding author
- Kuo, Yung-Chih
- ORCID
- Kuo, Yung-Chih
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2015-04
- Volume
- 10
- Pages
- 2653
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC4388084
- OpenAlex
- W2015976719
- Cited by
- 56
- References
- 66
- Citations by year
- 2026: 4 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 10 · 2016: 5 · 2015: 3
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- Alzheimer's disease, liposomes, wheat germ agglutinin, cardiolipin, nerve growth factor, curcumin, blood-brain barrier permeability, neuronal apoptosis, brain microvascular endothelial cells, SK-N-MC cells, drug carriers, liposome encapsulation
- MeSH terms
- Alzheimer Disease, Cardiolipins, Curcumin, Humans, Liposomes, Neurons, Wheat Germ Agglutinins, Apoptosis, Nerve Growth Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review