Effect of Curcumin-Associated and Lipid Ligand-Functionalized Nanoliposomes on Aggregation of the Alzheimer's Aβ Peptide
Abstract
The effect of various types of nanoliposomes (associated with curcumin, phosphatidic acid, cardiolipin, or GM1 ganglioside) on the aggregation of the amyloid-β(1-42) (Aβ(1-42)) peptide was investigated. Nanoliposomes incorporating curcumin (curcumin-liposomes) were prepared by adding curcumin in the lipid phase during liposome preparation, whereas curcumin surface-decorated liposomes were prepared by using a curcumin-lipid conjugate (lipid-S-curcumin liposomes) or by attaching a curcumin derivative on preformed liposomes by click chemistry (click-curcumin liposomes). The lipid ligands (phosphatidic acid, cardiolipin, or GM1) were also incorporated into nanoliposomes during their formation. All nanoliposomes with curcumin, or the curcumin derivative, were able to inhibit the formation of fibrillar and/or oligomeric Aβ in vitro. Of the three forms of curcumin liposomes tested, the click-curcumin type was by far the most effective. Liposomes with lipid ligands only inhibited Aβ fibril and oligomer formation at a very high ratio of liposome to peptide. Curcumin-based liposomes could be further developed as a novel treatment for Alzheimer's disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Curcumin-containing nanoliposomes and other delivery systems are very effective in reducing Aβ fibrils formation.
“curcumin-containing nanoliposomes as well as other delivery systems have been designed and show to be very effective in reducing the Aβ fibrils formation (Taylor et al., 2011; Lazar et al., 2013; Mourtas et al., 2014; Shahbaz et al., 2021)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Taylor et al., 2011
Cites
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
Amyloid deposition as the central event in the aetiology of Alzheimer’s disease
Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538 · see citing works
Self-citationYang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336 · see citing works
Colorimetric determination of phospholipids with ammonium ferrothiocyanate
Stewart, J. C. M. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90269-9 · Cited by 1,786 · see citing works
Brookmeyer, R., Gray, S. G., & Kawas, C. H. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.9.1337 · Cited by 1,774 · see citing works
Stability of curcumin in buffer solutions and characterization of its degradation products
Wang, Y., Pan, M., Cheng, A., Lin, L., Ho, Y., Hsieh, C., & Lin, J. (1997) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(96)02024-9 · Cited by 1,709 · see citing works
Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro
Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20025 · Cited by 1,254 · see citing works
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature
Anand, P., Thomas, S. G., Kunnumakkara, A. B., Sundaram, C., Harikumar, K. B., Sung, B., Tharakan, S. T., Misra, K., Priyadarsini, K. I., Rajasekharan, K. N., et al. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.08.008 · Cited by 1,205 · see citing works
Alzheimer's disease: strategies for disease modification
Citron, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2896 · Cited by 1,060 · see citing works
The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform
Hong, S., Leroueil, P. R., Majoros, I., Orr, B. G., Baker, J. R., & Holl, M. M. B. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.11.015 · Cited by 585 · see citing works
Studies on curcumin and curcuminoids
T√∏nnesen, H. H., & Karlsen, J. R. (1985) · European Food Research and Technology · doi:10.1007/bf01027775 · Cited by 514 · see citing works
Interaction of Cationic Antimicrobial Peptides with Model Membranes
Zhang, L., Rozek, A., & Hancock, R. E. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104925200 · Cited by 412 · see citing works
Survival Following a Diagnosis of Alzheimer Disease
Brookmeyer, R., Corrada, M. M., Curriero, F. C., & Kawas, C. H. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1764 · Cited by 408 · see citing works
Kakio, A., Nishimoto, S., Yanagisawa, K., Kozutsumi, Y., & Matsuzaki, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100252200 · Cited by 406 · see citing works
Multivalent Effects of RGD Peptides Obtained by Nanoparticle Display
Montet, X., Funovics, M. A., Montet-Abou, K., Weissleder, R., & Josephson, L. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060515m · Cited by 388 · see citing works
McLaurin, J., & Chakrabartty, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.43.26482 · Cited by 333 · see citing works
Effects of Naturally Occurring Compounds on Fibril Formation and Oxidative Stress of β-Amyloid
Kim, H., Park, B., Lee, K., Choi, C. Y., Jang, S. S., Kim, Y., & Lee, S. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051985c · Cited by 297 · see citing works
Kim, D. S. H. L., Park, S., & Kim, J.-Y. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01677-9 · Cited by 262 · see citing works
Pharmaceutical manufacturing handbook : production and processes
Gad, S. C. (2008) · Wiley-Interscience eBooks · Cited by 234 · see citing works
Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide
Mourtas, S., Canovi, M., Zona, C., Aurilia, D., Niarakis, A., Ferla, B. L., Salmona, M., Nicotra, F., Gobbi, M., & Antimisiaris, S. G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.027 · Cited by 231 · see citing works
Bernabé‐Pineda, M., Ramı́rez-Silva, M. T., Romero-Romo, M., Vergara, E. G., & Rojas-Hernándéz, A. (2003) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/s1386-1425(03)00342-1 · Cited by 228 · see citing works
Physicochemical interactions of amyloid β-peptide with lipid bilayers
Matsuzaki, K. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.02.009 · Cited by 215 · see citing works
Lipid-based nanoparticles with high binding affinity for amyloid-β1–42 peptide
Gobbi, M., Re, F., Canovi, M., Beeg, M., Gregori, M., Sesana, S., Sonnino, S., Brogioli, D., Musicanti, C., Gasco, P., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.044 · Cited by 211 · see citing works
Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles
Tassa, C., Duffner, J. L., Lewis, T. A., Weissleder, R., Schreiber, S. L., Koehler, A. N., & Shaw, S. Y. (2009) · Bioconjugate Chemistry · doi:10.1021/bc900438a · Cited by 202 · see citing works
Mann, D. M. A., Iwatsubo, T., Ihara, Y., Cairns, N. J., Lantos, P. L., Bogdanović, N., Lannfelt, L., Winblad, B. G., Maat–Schieman, M. L. C., & Rossor, M. N. (1996) · Europe PMC (PubMed Central) · Cited by 184 · see citing works
Role of gangliosides in Alzheimer’s disease
Yanagisawa, K. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.01.018 · Cited by 178 · see citing works
Ray, B., Bisht, S., Maitra, A., Maitra, A., & Lahiri, D. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101374 · Cited by 177 · see citing works
Muhs, A., Hickman, D. T., Pihlgren, M., Chuard, N., Giriens, V., Meerschman, C., der Auwera, I. V., LEUVEN, F. V., Sugawara, M., Weingertner, M.-C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703137104 · Cited by 176 · see citing works
Taylor, M., Moore, S., Mayes, J., Parkin, E. T., Beeg, M., Canovi, M., Gobbi, M., Mann, D. M. A., & Allsop, D. (2010) · Biochemistry · doi:10.1021/bi100144m · Cited by 162 · see citing works
Targeted Liposomes: Convenient Coupling of Ligands to Preformed Vesicles Using “Click Chemistry”
Hassane, F. S., Frisch, B., & Schuber, F. J. (2006) · Bioconjugate Chemistry · doi:10.1021/bc050308l · Cited by 153 · see citing works
Liu, G., Men, P., Kudo, W., Perry, G., & Smith, M. A. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.064 · Cited by 148 · see citing works
Mulik, R. S., Mönkkönen, J., Juvonen, R. O., Mahadik, K. R., & Paradkar, A. R. (2010) · Molecular Pharmaceutics · doi:10.1021/mp900306x · Cited by 147 · see citing works
Re, F., Airoldi, C., Zona, C., Masserini, M., Ferla, B. L., Quattrocchi, N., & Nicotra, F. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791959729 · Cited by 139 · see citing works
Kokkona, M., Kallinteri, P., Fatouros, D. G., & Antimisiaris, S. G. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(99)00064-0 · Cited by 133 · see citing works
Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-β aggregation
Thomas, T., Nadackal, T. G., & Thomas, K. (2001) · Neuroreport · doi:10.1097/00001756-200110290-00024 · Cited by 127 · see citing works
Chauhan, A., Ray, I., & Chauhan, V. P. S. (2000) · Neurochemical Research · doi:10.1023/a:1007509608440 · Cited by 117 · see citing works
γ-Secretase Substrate Concentration Modulates the Aβ42/Aβ40 Ratio
Yin, Y. I., Bassit, B., Zhu, L., Yang, X., Wang, C., & Li, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704601200 · Cited by 116 · see citing works
Usta, M., Wortelboer, H. M., Vervoort, J. J. M., Boersma, M. G., Rietjens, I. M. C. M., van BLADEREN, P. J., & Cnubben, N. H. P. (2007) · Chemical Research in Toxicology · doi:10.1021/tx7002245 · Cited by 57 · see citing works
Macromolecular Crowding at Membrane Interfaces: Adsorption and Alignment of Membrane Peptides
Aisenbrey, C., Bechinger, B., & Gröbner, G. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.10.053 · Cited by 54 · see citing works
Controlling Amyloid‐β Peptide(1–42) Oligomerization and Toxicity by Fluorinated Nanoparticles
Saraiva, A. M., Cardoso, I., Pereira, M. D. C., Coelho, M. A. N., Saraiva, M. J., Möhwald, H., & Brezesinski, G. (2010) · ChemBioChem · doi:10.1002/cbic.201000237 · Cited by 41 · see citing works
Antimisiaris, S. G., Kallinteri, P., & Fatouros, D. G. (2007) · doi:10.1002/9780470259818.ch13 · Cited by 38 · see citing works
Overcoming synthetic Aβ peptide aging: a new approach to an age-old problem
Manzoni, C., Colombo, L., Messa, M., Cagnotto, A., Cantú, L., Favero, E. D., & Salmona, M. (2009) · Amyloid · doi:10.1080/13506120902879848 · Cited by 37 · see citing works
Saraiva, A. M., Cardoso, I., Saraiva, M. J., Tauer, K., Pereira, M. D. C., Coelho, M. A. N., Möhwald, H., & Brezesinski, G. (2010) · Macromolecular Bioscience · doi:10.1002/mabi.200900448 · Cited by 35 · see citing works
Shen, Y., & Yu, L. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9720-y · Cited by 30 · see citing works
Role of Biochemical Alzheimer's Disease Biomarkers as End Points in Clinical Trials
Siemers, E., Demattos, R. B., May, P. C., & Dean, R. A. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.85 · Cited by 23 · see citing works
Antimisiaris, S. G., Kallinteri, P., & Fatouros, D. G. (2010) · Pharmaceutical Sciences Encyclopedia · doi:10.1002/9780470571224.pse352 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Curcumin—From Molecule to Biological Function
Esatbeyoglu, T., Huebbe, P., Ernst, I. M. A., Chin, D., Wagner, A. E., & Rimbach, G. H. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107724 · Cited by 908 · see citing works
Lee, W., Loo, C., Bebawy, M., Luk, F., Mason, R. S., & Rohanizadeh, R. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040002 · Cited by 539 · see citing works
Mathew, A., Fukuda, T., Nagaoka, Y., Hasumura, T., Morimoto, H., Yoshida, Y., Maekawa, T., Venugopal, K., & Kumar, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032616 · Cited by 399 · see citing works
Therapeutic Applications of Curcumin Nanoformulations
Yallapu, M. M., Nagesh, P. K. B., Jaggi, M., & Chauhan, S. C. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9811-z · Cited by 397 · see citing works
Protective effect of curcumin against heavy metals-induced liver damage
García‐Niño, W. R., & Pedraza‐Chaverrí, J. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.04.016 · Cited by 383 · see citing works
Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs
Naqvi, S., Panghal, A., & Flora, S. J. S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00494 · Cited by 305 · see citing works
Mourtas, S., Lazar, A. N., Markoutsa, E., Duyckaerts, C., & Antimisiaris, S. G. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.04.050 · Cited by 263 · see citing works
Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?
Pinheiro, R. G. R., Coutinho, A. J., Pinheiro, M., & Neves, A. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111654 · Cited by 251 · see citing works
Song, Q., Huang, M., Yao, L., Wang, X., Gu, X., Chen, J., Chen, J., Huang, J., Hu, Q., Kang, T., et al. (2014) · ACS Nano · doi:10.1021/nn4058215 · Cited by 219 · see citing works
Nanotechnology—novel therapeutics for CNS disorders
Srikanth, M., & Kessler, J. A. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.76 · Cited by 198 · see citing works
Liposome delivery systems for the treatment of Alzheimer’s disease
Ross, C., Taylor, M., Fullwood, N., & Allsop, D. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s183117 · Cited by 198 · see citing works
Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases
Salehi, B., Călina, D. C., Docea, A. O., Koirala, N., Aryal, S., Lombardo, D., Pasqua, L., Taheri, Y., Castillo, C. M. S., Martorell, M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020430 · Cited by 197 · see citing works
Curcumin and neurodegenerative diseases: a perspective
Darvesh, A. S., Carroll, R. T., Bishayee, A., Novotny, N. A., Geldenhuys, W. J., & der Schyf, C. J. V. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.693479 · Cited by 189 · see citing works
Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders
Moradi, S. Z., Momtaz, S., Bayrami, Z., Farzaei, M. H., & Abdollahi, M. R. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00238 · Cited by 181 · see citing works
Nanotechnology for neurodegenerative disorders
Re, F., Gregori, M., & Masserini, M. (2012) · Maturitas · doi:10.1016/j.maturitas.2011.12.015 · Cited by 174 · see citing works
Targeted Delivery of Nano-Therapeutics for Major Disorders of the Central Nervous System
Gao, H., Pang, Z., & Jiang, X. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1122-4 · Cited by 164 · see citing works
Palmal, S., Maity, A. R., Singh, B. K., Basu, S., Jana, N. R., & Jana, N. R. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201400079 · Cited by 155 · see citing works
Teixeira, M. I., Lopes, C. M., Amaral, M. H., & Costa, P. C. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112999 · Cited by 155 · see citing works
Bana, L., Minniti, S., Salvati, E., Sesana, S., Zambelli, V., Cagnotto, A., Orlando, A., Cazzaniga, E., Zwart, R., Scheper, W., et al. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.12.001 · Cited by 151 · see citing works
Lazar, A. N., Mourtas, S., Youssef, I., Parizot, C., Dauphin, A., Delatour, B., Antimisiaris, S. G., & Duyckaerts, C. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.11.004 · Cited by 149 · see citing works
Ansari, N., & Khodagholi, F. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040005 · Cited by 131 · see citing works
Nanomaterials for the treatment and diagnosis of Alzheimer's disease: An overview
Bilal, M., Barani, M., Sabir, F., Rahdar, A., & Kyzas, G. Z. (2020) · NanoImpact · doi:10.1016/j.impact.2020.100251 · Cited by 126 · see citing works
Laurindo, L. F., de Carvalho, G. M., Zanuso, B. D. O., Figueira, M. E., Direito, R., Goulart, R. D. Á., Buglio, D. S., & Barbalho, S. M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010229 · Cited by 128 · see citing works
Curcumin in Alzheimer’s disease: Can we think to new strategies and perspectives for this molecule?
Serafini, M. M., Catanzaro, M., Rosini, M., Racchi, M., & Lanni, C. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.08.004 · Cited by 119 · see citing works
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108 · see citing works
“Nanoliposomes of curcumin have high affinity for Aβ1-42 fibrils and were found to inhibit the formation of fibrillar and oligomeric Aβ in-vitro [101,102].”
BackgroundAdvances in developing therapeutic strategies for Alzheimer's disease
Nguyen, T. T., Nguyen, T. T. D., Nguyen, T. K. O., Vo, T. K., & Giau, V. V. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111623 · Cited by 107 · see citing works
Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress
Park, J. H., Lee, B. M., & Kim, H. S. (2020) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2020.1860842 · Cited by 106 · see citing works
Squillaro, T., Cimini, A., Peluso, G., Giordano, A., & Melone, M. A. B. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.05.016 · Cited by 102 · see citing works
Nanomaterials and neurodegeneration
Migliore, L., Uboldi, C., Bucchianico, S. D., & Coppedè, F. (2015) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21931 · Cited by 101 · see citing works
Nanomedicine for the Treatment of Alzheimer’s Disease
Gregori, M., Masserini, M., & Mancini, S. (2015) · Nanomedicine · doi:10.2217/nnm.14.206 · Cited by 99 · see citing works
Novel concept of exosome-like liposomes for the treatment of Alzheimer's disease
Fernandes, M. S., Lopes, I., Magalhães, L., Sárria, M. P., Machado, R., Sousa, J. C., Botelho, C., Teixeira, J. A., & Gomes, A. C. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.06.018 · Cited by 95 · see citing works
Kim, M., Shin, M., Zhao, Y., Ghosh, M., & Son, Y. (2024) · Small Science · doi:10.1002/smsc.202400280 · Cited by 101 · see citing works
Parthsarathy, V., McClean, P. L., Hölscher, C., Taylor, M., Tinker, C. L., Jones, G., Kolosov, O., Salvati, E., Gregori, M., Masserini, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054769 · Cited by 93 · see citing works
Abdel-Hafez, S. M., Hathout, R. M., & Sammour, O. A. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.03.051 · Cited by 90 · see citing works
Babazadeh, A., Vahed, F. M., & Jafari, S. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.02.015 · Cited by 89 · see citing works
Mitochondrial therapeutic interventions in Alzheimer’s disease
Giau, V. V., An, S. S. A., & Hulme, J. (2018) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2018.09.033 · Cited by 87 · see citing works
Role of curcumin and its nanoformulations in neurotherapeutics: A comprehensive review
Mandal, M., Jaiswal, P., & Mishra, A. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22478 · Cited by 86 · see citing works
Nanotechnology for neurodegenerative disorders
Re, F., Gregori, M., & Masserini, M. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.05.007 · Cited by 84 · see citing works
A Review on Natural Antioxidants for Their Role in the Treatment of Parkinson’s Disease
Mittal, P., Dhankhar, S., Chauhan, S., Garg, N., Bhattacharya, T., Ali, M., Chaudhary, A. A., Rudayni, H. A., Al-Zharani, M. M., Ahmad, W., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16070908 · Cited by 82 · see citing works
Cadmium‐induced toxicity is rescued by curcumin: A review
Mohajeri, M., Rezaee, M., & Sahebkar, A. (2017) · BioFactors · doi:10.1002/biof.1376 · Cited by 80 · see citing works
Inhibition of Amyloid Fibril Growth by Nanoparticle Coated with Histidine-Based Polymer
Palmal, S., Jana, N., & Jana, N. (2014) · The Journal of Physical Chemistry C · doi:10.1021/jp505613g · Cited by 71 · see citing works
Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works
Bose, T., Latawiec, D., Mondal, P. P., & Mandal, S. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-014-2527-7 · Cited by 71 · see citing works
Zheng, X., Zhang, C., Guo, Q., Xu, W., Shao, X., Liu, Q., & Zhang, Q. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.04.033 · Cited by 71 · see citing works
Nanotechnology to improve the Alzheimer’s disease therapy with natural compounds
Ramalho, M. J., Andrade, S., Loureiro, J. A., & do Carmo Pereira, M. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-019-00694-3 · Cited by 75 · see citing works
Riccardi, C., Napolitano, F., Montesarchio, D., Sampaolo, S., & Melone, M. A. B. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111897 · Cited by 66 · see citing works
Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation
Shao, X., Yan, C., Wang, C., Wang, C., Cao, Y. Q., Zhou, Y., Guan, P., Hu, X., Zhu, W., & Ding, S. (2022) · Nanoscale Advances · doi:10.1039/d2na00625a · Cited by 63 · see citing works
Gregori, M., Taylor, M., Salvati, E., Re, F., Mancini, S., Balducci, C., Forloni, G., Zambelli, V., Sesana, S., Michael, M., et al. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.10.006 · Cited by 62 · see citing works
Omidian, H., Cubeddu, L. X., & Wilson, R. L. (2025) · Molecules · doi:10.3390/molecules30071572 · Cited by 60 · see citing works
Rabanel, J., Faivre, J., Paka, G. D., Ramassamy, C., Hildgen, P., & Banquy, X. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.09.004 · Cited by 58 · see citing works
Kuo, Y.-C., & Lin, C.-C. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s79528 · Cited by 56 · see citing works
Nanotechnology-based herbal medicine: Preparation, synthesis, and applications in food and medicine
Awlqadr, F. H., Majeed, K. R., Altemimi, A. B., Hassan, A. M. A., Qadir, S. A., Saeed, M. N., Faraj, A. M., Salih, T. H., Al‐Manhel, A. J. A., Najm, M. A. A., et al. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.101661 · Cited by 56 · see citing works
Markoutsa, E., Παπαδιά, Κ., Clemente, C., Flores, O., & Antimisiaris, S. G. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.02.006 · Cited by 56 · see citing works
Παπαδιά, Κ., Giannou, A. D., Markoutsa, E., Bigot, C., Vanhoute, G., Mourtas, S., der Linded, A. V., Stathopoulos, G. T., & Antimisiaris, S. G. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.03.010 · Cited by 56 · see citing works
Extracellular vesicles and their synthetic analogues in aging and age-associated brain diseases
Smith, J. A., Leonardi, T., Huang, B., Iraci, N., Vega, B., & Pluchino, S. (2014) · Biogerontology · doi:10.1007/s10522-014-9510-7 · Cited by 53 · see citing works
Advances in nanotechnology for diagnosis and treatment of tuberculosis
Banyal, S., Malik, P., Tuli, H. S., & Mukherjee, T. K. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e32835eff08 · Cited by 53 · see citing works
Nanomedicine in Alzheimer's disease: Amyloid beta targeting strategy
Tosi, G., Pederzoli, F., Belletti, D., Vandelli, M. A., Forni, F., Duskey, J. T., & Ruozi, B. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.001 · Cited by 53 · see citing works
Application of Nanodiagnostics and Nanotherapy to CNS Diseases
Zhang, W., Wang, W., Yu, D. X., Xiao, Z., & He, Z. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0163 · Cited by 50 · see citing works
Role of Nanomedicine-Based Therapeutics in the Treatment of CNS Disorders
Guo, Z.-H., Khattak, S., Rauf, M. A., Ansari, M. A., Alomary, M. N., Razak, S., Yang, C., Wu, D., & Ji, X. (2023) · Molecules · doi:10.3390/molecules28031283 · Cited by 49 · see citing works
Chakraborty, A., Mohapatra, S. S., Barik, S., Roy, I., Gupta, B., & Biswas, A. (2023) · Bioscience Reports · doi:10.1042/bsr20220324 · Cited by 45 · see citing works
Aloisio, C., Antimisiaris, S. G., & Longhi, M. R. (2016) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2016.12.035 · Cited by 45 · see citing works
Nanomedicines in the Management of Alzheimer’s Disease: Current View and Future Prospects
Chopra, H., Bibi, S., Singh, I., Kamal, M. A., Islam, F., Alhumaydhi, F. A., Emran, T. B., & Cavalu, S. D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.879114 · Cited by 47 · see citing works
Nanoneuromedicine for management of neurodegenerative disorder
Dwivedi, N., Shah, J., Mishra, V. K., Tambuwala, M. M., & Kesharwani, P. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.12.021 · Cited by 44 · see citing works
Albadrani, H. M., Chauhan, P., Ashique, S., Babu, M. A., Iqbal, D., Almutary, A. G., Abomughaid, M. M., Kamal, M., Paiva‐Santos, A. C., Alsaweed, M., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116376 · Cited by 44 · see citing works
Liao, L., Shi, J., Jiang, C., Zhang, L., Feng, L., Liu, J., & Zhang, J. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.026 · Cited by 44 · see citing works
Mirzaie, Z., Ansari, M., Kordestani, S. S., Habibi-Rezaei, M., & Mozafari, M. (2019) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1751 · Cited by 43 · see citing works
Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides
Huang, Y., Chang, Y. K., Liu, L., & Wang, J. (2021) · Molecules · doi:10.3390/molecules26144301 · Cited by 42 · see citing works
Bandiwadekar, A., Jose, J., Khayatkashani, M., Habtemariam, S., Kashani, H. R. K., & Nabavi, S. M. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01922-7 · Cited by 42 · see citing works
Multifunctional LUV Liposomes Decorated for BBB and Amyloid Targeting. A. In Vitro Proof-of-Concept
Papadia, K., Markoutsa, E., Mourtas, S., Giannou, A. D., La Ferla, B., Nicotra, F., Salmona, M., Klepetsanis, P., Stathopoulos, G. T., & Antimisiaris, S. G. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.02.019 · Cited by 40 · see citing works
Diagnostic and Therapeutic Uses of Nanomaterials in the Brain
Garbayo, E., de Mendoza, A. E., & Blanco‐Prieto, M. J. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140815124246 · Cited by 37 · see citing works
Delivery systems for theranostics in neurodegenerative diseases
Li, Y., Liu, R., Ji, W., Li, Y., Liu, L., & Zhang, X. (2018) · Nano Research · doi:10.1007/s12274-018-2067-z · Cited by 35 · see citing works
Nanotherapeutic strategies for the treatment of neurodegenerative diseases
Huang, M., Gu, X. Q., & Gao, X. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814001-7.00013-5 · Cited by 34 · see citing works
Far, B., Safaei, M., Pourmolaei, A., Adibamini, S., Shirdel, S., Shirdel, S., Emadi, R., & Kaushik, A. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00112 · Cited by 30 · see citing works
Alzheimer’s disease: review of current nanotechnological therapeutic strategies
Baranowska‐Wójcik, E., & Szwajgier, D. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1719069 · Cited by 33 · see citing works
Nanotechnology in the diagnostic and therapy for Alzheimer's disease
Panghal, A., & Flora, S. J. S. (2024) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2024.130559 · Cited by 31 · see citing works
Wang, Z., Sreenivasmurthy, S. G., Song, J., Liu, J.-Y., & Li, M. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.11.001 · Cited by 31 · see citing works
Curcumin – vom Molekül zur biologischen Wirkung
Esatbeyoglu, T., Huebbe, P., Ernst, I. M. A., Chin, D., Wagner, A. E., & Rimbach, G. H. (2012) · Angewandte Chemie · doi:10.1002/ange.201107724 · Cited by 30 · see citing works
Nanomedicine applications in women's health: state of the art
Lloyd-Parry, O., Downing, C., Aleisaei, E., Jones, C., & Coward, K. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s97572 · Cited by 31 · see citing works
Re, F., Antonina, O., Sesana, Rivolta, I., Panariti, Brambilla, Nicolas, J., Couvreur, Andrieux, K., Masserini, et al. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s40297 · Cited by 29 · see citing works
Pillai, S. C., Borah, A., Jacob, E. M., & Kumar, D. S. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1892241 · Cited by 29 · see citing works
Airoldi, C., Mourtas, S., Cardona, F., Zona, C., Sironi, E., D’Orazio, G., Markoutsa, E., Nicotra, F., Antimisiaris, S. G., & Ferla, B. L. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.07.085 · Cited by 28 · see citing works
Cheikh‐Ali, Z., Caron, J., Cojean, S., Bories, C., Couvreur, P., Loiseau, P. M., Desmaële, D., Poupon, E., & Champy, P. (2014) · ChemMedChem · doi:10.1002/cmdc.201402449 · Cited by 27 · see citing works
Parthsarathy, V., McClean, P. L., Hölscher, C., Taylor, M., Tinker, C. L., Jones, G., Kolosov, O., Salvati, E., Gregori, M., Masserini, M., et al. (2013) · PLoS ONE · doi:10.1371/annotation/57e0a947-8600-4658-b04c-cf7a45c8bd8d · Cited by 27 · see citing works
Khot, K. B., Gopan, G., Bandiwadekar, A., & Jose, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101806 · Cited by 25 · see citing works
Modern aspects of the use of natural polyphenols in tumor prevention and therapy
Суфианова, Г. З., Фанилевич, Г. И., Beylerli, O., Wu, J., Shumadalova, A. V., Sufianov, A. A., Chen, X., & Zhao, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1011435 · Cited by 24 · see citing works
Inhibition of Early Upstream Events in Prodromal Alzheimer’s Disease by Use of Targeted Antioxidants
Prasad, K. N., & Bondy, S. C. (2014) · Current Aging Science · doi:10.2174/1874609807666140804115633 · Cited by 24 · see citing works
Development and application of nano-flavor-drug carriers in neurodegenerative diseases
Ji, W., Xiao, Z.-B., Liu, G., & Zhang, X. (2017) · Chinese Chemical Letters · doi:10.1016/j.cclet.2017.06.024 · Cited by 22 · see citing works
Kuo, Y., & Liu, Y. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.07.003 · Cited by 21 · see citing works
Nanopharmaceuticals: Innovative theranostics for the neurological disorders
Hassanzadeh, P. (2014) · Biomedical Reviews · doi:10.14748/bmr.v25.1043 · Cited by 21 · see citing works
Drugs and drug delivery systems targeting amyloid-β in Alzheimer's disease
Robinson, M. J., Lee, B. Y., & Leonenko, Z. (2015) · AIMS molecular science · doi:10.3934/molsci.2015.3.332 · Cited by 24 · see citing works
Akkol, E. K., Bardakçı, H., Yücel, Ç., Karatoprak, G. Ş., Karpuz, B., & Khan, H. Z. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6168199 · Cited by 20 · see citing works
Polyphenols in the Central Nervous System: Cellular Effects and Liposomal Delivery Approaches
Kaluza, M., Ksiazek-Winiarek, D. J., Szpakowski, P., Czpakowska, J., Fijalkowska, J., & Glabinski, A. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136477 · Cited by 24 · see citing works
Kanojia, N., Thapa, K., Kaur, G., Sharma, A., Puri, V., & Verma, N. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.104074 · Cited by 19 · see citing works
Elawad, M. A., Ayaz, M., Mosa, O. F., Usman, A., Hamdoon, A. A. E., Almawash, S., Salim, L. H. M., Ahmed, A., & Elkhalifa, M. E. M. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400525 · Cited by 20 · see citing works
Molecular dynamic studies of amyloid-beta interactions with curcumin and Cu2+ ions
Kozmon, S., & Tvaroška, I. (2015) · Chemical Papers · doi:10.1515/chempap-2015-0134 · Cited by 18 · see citing works
Reich, N., Allsop, D., Parkin, E. T., & Dawson, N. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18477 · Cited by 14 · see citing works
Mourtas, S., Mavroidi, B., Marazioti, A., Kannavou, M., Sagnou, M., Pelecanou, M., & Antimisiaris, S. G. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00811 · Cited by 14 · see citing works
Gao, C., Liu, Y., Zhang, T., Luo, Y., Gao, J., Chu, J., Gong, B., Chen, X., Yin, T., Zhang, J., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s436774 · Cited by 14 · see citing works
Ortiz-Islas, E., Montes, P., Rodríguez-Pérez, C. E., Ruiz-Sánchez, E., Sánchez-Barbosa, T., Pichardo-Rojas, D., Zavala‐Tecuapetla, C., Carvajal, K., & Campos‐Peña, V. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17010128 · Cited by 12 · see citing works
Curcumin Reduces Amyloid Beta Oligomer Interactions with Anionic Membranes
Sallaberry, C. A., Voss, B. J., Stone, W. B., Estrada, F., Bhatia, A., Soto, J. D., Griffin, C. W., & Zanden, C. M. V. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00512 · Cited by 11 · see citing works
- Authors
- Taylor, M., Moore, S., Mourtas, S., Niarakis, A., Re, F., Zona, C., Ferla, B. L., Nicotra, F., Masserini, M., Antimisiaris, S. G., Gregori, M., & Allsop, D.
- Affiliations
- Lancaster University (GB)
- University of Patras (GR)
- University of Milano-Bicocca (IT)
- Corresponding author
- Allsop, David
- ORCID
- Venue
- Nanomedicine Nanotechnology Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 7
- Issue
- 5
- Pages
- 541-550
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2082371846
- Cited by
- 149
- References
- 46
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 10 · 2023: 9 · 2022: 13 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 4 · 2015: 10 · 2014: 17 · 2013: 9 · 2012: 10
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- Funders
- Seventh Framework Programme (212043)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- curcumin, nanoliposomes, amyloid-beta 42, peptide aggregation inhibition, Alzheimer's disease, phosphatidic acid, cardiolipin, GM1 ganglioside, click chemistry, fibril formation, oligomerization, lipid ligands, nanomedicine
- MeSH terms
- Alzheimer Disease, Cardiolipins, Curcumin, G(M1) Ganglioside, Humans, Ligands, Liposomes, Peptide Fragments, Phosphatidic Acids, Amyloid beta-Peptides, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review