Cited by 149Alzheimer's disease research and treatmentsCurcumin's Biomedical ApplicationsNanoparticle-Based Drug Delivery

Effect of Curcumin-Associated and Lipid Ligand-Functionalized Nanoliposomes on Aggregation of the Alzheimer's Aβ Peptide

Taylor, Mark, Moore, Susan, Mourtas, Spyridon, Niarakis, Anna, Re, Francesca, Zona, Cristiano, Ferla, Barbara La, Nicotra, Francesco +4 more·2011·Nanomedicine Nanotechnology Biology and Medicine

Abstract

The effect of various types of nanoliposomes (associated with curcumin, phosphatidic acid, cardiolipin, or GM1 ganglioside) on the aggregation of the amyloid-β(1-42) (Aβ(1-42)) peptide was investigated. Nanoliposomes incorporating curcumin (curcumin-liposomes) were prepared by adding curcumin in the lipid phase during liposome preparation, whereas curcumin surface-decorated liposomes were prepared by using a curcumin-lipid conjugate (lipid-S-curcumin liposomes) or by attaching a curcumin derivative on preformed liposomes by click chemistry (click-curcumin liposomes). The lipid ligands (phosphatidic acid, cardiolipin, or GM1) were also incorporated into nanoliposomes during their formation. All nanoliposomes with curcumin, or the curcumin derivative, were able to inhibit the formation of fibrillar and/or oligomeric Aβ in vitro. Of the three forms of curcumin liposomes tested, the click-curcumin type was by far the most effective. Liposomes with lipid ligands only inhibited Aβ fibril and oligomer formation at a very high ratio of liposome to peptide. Curcumin-based liposomes could be further developed as a novel treatment for Alzheimer's disease.

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Crossref · 10.1016/j.nano.2011.06.015

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Authors
Taylor, M., Moore, S., Mourtas, S., Niarakis, A., Re, F., Zona, C., Ferla, B. L., Nicotra, F., Masserini, M., Antimisiaris, S. G., Gregori, M., & Allsop, D.
Affiliations
  • Lancaster University (GB)
  • University of Patras (GR)
  • University of Milano-Bicocca (IT)
Corresponding author
Allsop, David
Venue
Nanomedicine Nanotechnology Biology and Medicine
Publisher
Elsevier BV
Published
2011-10
Volume
7
Issue
5
Pages
541-550
ISSN
1549-9634 (ISSN-L)
OpenAlex
W2082371846
Cited by
149
References
46
Citations by year
2026: 4 · 2025: 11 · 2024: 10 · 2023: 9 · 2022: 13 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 4 · 2015: 10 · 2014: 17 · 2013: 9 · 2012: 10
FWCI
7.86
Type
journal article
Language
en
Open access
closed
Locations
  • Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
  • Lancaster EPrints (Lancaster University) (submittedVersion)
Funders
Seventh Framework Programme (212043)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
curcumin, nanoliposomes, amyloid-beta 42, peptide aggregation inhibition, Alzheimer's disease, phosphatidic acid, cardiolipin, GM1 ganglioside, click chemistry, fibril formation, oligomerization, lipid ligands, nanomedicine
MeSH terms
Alzheimer Disease, Cardiolipins, Curcumin, G(M1) Ganglioside, Humans, Ligands, Liposomes, Peptide Fragments, Phosphatidic Acids, Amyloid beta-Peptides, Nanoparticles

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