Peripheral nerve conduits: technology update
Open accessAbstract
Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS) and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, peripheral nerve grafts or nerve conduits are used. The limited availability of autografts, and drawbacks of the allografts and xenografts like immunological reactions, forced the researchers to investigate and develop alternative approaches, mainly nerve conduits. In this review, recent information on the various types of conduit materials (made of biological and synthetic polymers) and designs (tubular, fibrous, and matrix type) are being presented.
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Some implantable devices, such as regeneration conduits, are designed to exploit the inflammatory process to degrade after carrying out their therapeutic role.
“Some implantable devices are designed to exploit this inflammatory process to degrade after they have carried out their therapeutic role. A common example of this are regeneration conduits: implants inserted into lesioned tissue designed to guide tissue regrowth and be degraded as the tissue heals (Arslantunali et al., 2014).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Arslantunali et al., 2014
The Nerve conduits section describes implanted conduits that guide nerve regeneration and identifies biodegradable materials whose degradation rates can be controlled. It does not say that the conduits are designed to exploit inflammation to degrade, or that degradation occurs only after healing; it notes that some biodegradable polymers do not initiate immunological responses. The indexed passages provide no page numbers. (LLM, conf=0.85)
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- Authors
- Hasirci, V., Arslantunali, D., Dursun, T., Yucel, D., & Hasirci, N.
- Affiliations
- Middle East Technical University (TR)
- ORCID
- Arslantunali, Damla
- Venue
- Medical Devices Evidence and Research
- Publisher
- Informa UK Limited
- Published
- 2014-12
- Volume
- 7
- Pages
- 405
- ISSN
- 1179-1470 (ISSN-L)
- PMC
- PMC4257109
- OpenAlex
- W2117518170
- Cited by
- 224
- References
- 159
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 20 · 2023: 20 · 2022: 19 · 2021: 26 · 2020: 30 · 2019: 29 · 2018: 31 · 2017: 18 · 2016: 14 · 2015: 4
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Medical Devices Evidence and Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Gümüşhane University Institutional Repository (submittedVersion, other-oa)
- OpenMETU (Middle East Technical University) (submittedVersion, cc-by-nc-nd)
- Acibadem University Open Access Repository (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- peripheral nerve injury, nerve regeneration, peripheral nerve grafts, nerve conduits, synthetic polymers, biopolymers, autograft, allograft, xenografts
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