Cited by 444Treatment of Major DepressionTryptophan and brain disordersStress Responses and Cortisol

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Biomarkers for depression: recent insights, current challenges and future prospects

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Strawbridge, Rebecca, Young, Allan H, Cleare, Anthony J·2017·Neuropsychiatric Disease and Treatment

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Abstract

Abstract: A plethora of research has implicated hundreds of putative biomarkers for depression, but has not yet fully elucidated their roles in depressive illness or established what is abnormal in which patients and how biologic information can be used to enhance diagnosis, treatment and prognosis. This lack of progress is partially due to the nature and heterogeneity of depression, in conjunction with methodological heterogeneity within the research literature and the large array of biomarkers with potential, the expression of which often varies according to many factors. We review the available literature, which indicates that markers involved in inflammatory, neurotrophic and metabolic processes, as well as neurotransmitter and neuroendocrine system components, represent highly promising candidates. These may be measured through genetic and epigenetic, transcriptomic and proteomic, metabolomic and neuroimaging assessments. The use of novel approaches and systematic research programs is now required to determine whether, and which, biomarkers can be used to predict response to treatment, stratify patients to specific treatments and develop targets for new interventions. We conclude that there is much promise for reducing the burden of depression through further developing and expanding these research avenues. Keywords: mood disorder, major depressive disorder, inflammation, treatment response, stratification, personalized medicine

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Authors: Strawbridge, R., Young, A. H., & Cleare, A. J.
Affiliations: King's College London (GB)
Corresponding author: Strawbridge, Rebecca
ORCID: Strawbridge, Rebecca
Young, Allan H
Cleare, Anthony J
Venue: Neuropsychiatric Disease and Treatment
Publisher: Informa UK Limited
Published: 2017-05
Volume: Volume 13
Pages: 1245-1262
ISSN: 1176-6328 (ISSN-L)
1178-2021
DOI: 10.2147/ndt.s114542
OpenAlex: W3141564337
Cited by: 415
References: 212
Citations by year: 2026: 35 · 2025: 55 · 2024: 57 · 2023: 36 · 2022: 38 · 2021: 55 · 2020: 50 · 2019: 40 · 2018: 43 · 2017: 5
FWCI: 4.79
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/3.0/ (unspecified)
Locations: Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
Research Portal (King's College London) (submittedVersion, cc-by-nc)
Funders: South London and Maudsley NHS Foundation Trust
Wellcome Trust
National Institute for Health and Care Research (NF-SI-0616-10091)
King's College London
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: depression biomarkers, major depressive disorder, inflammation, neurotrophic factors, metabolic biomarkers, neurotransmitters, neuroendocrine system, epigenetics, transcriptomics, proteomics, metabolomics, neuroimaging, treatment response prediction, patient stratification, personalized medicine, depression heterogeneity

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