Cited by 40Eating Disorders and BehaviorsPharmacology and Obesity TreatmentNutrition, Health and Food Behavior

Novel pharmacologic treatment in acute binge eating disorder – role of lisdexamfetamine

Open access
Guerdjikova, Anna I., Mori, Nicole, Casuto, Leah S., McElroy, Susan L.·2016·Neuropsychiatric Disease and Treatment

Abstract

Binge eating disorder (BED) is the most common eating disorder and an important public health problem. It is characterized by recurrent episodes of excessive food consumption accompanied by a sense of loss of control over the binge eating behavior without the inappropriate compensatory weight loss behaviors of bulimia nervosa. BED affects both sexes and all age groups and is associated with medical and psychiatric comorbidities. Until recently, self-help and psychotherapy were the primary treatment options for patients with BED. In early 2015, lisdexamfetamine dimesylate, a prodrug stimulant marketed for attention deficit hyperactive disorder, was the first pharmacologic agent to be approved by the US Food and Drug Administration for the treatment of moderate or severe BED in adults. This article summarizes BED clinical presentation, and discusses the pharmacokinetic profile, efficacy, and safety of lisdexamfetamine dimesylate in the treatment of BED in adults.

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Crossref · 10.2147/ndt.s80881

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  • LDX inhibits the activity of SERT and MAO, not shared with MPH.

    “LDX inhibits the activity of two other important proteins, not shared with MPH, involved in the monoaminergic system described in ADHD: SERT [164] and MAO [165].”

    From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [164]

    The Pharmacology section says that d-amphetamine, the active metabolite of LDX, is a weak MAO inhibitor. The Pharmacodynamics section says LDX itself is inactive at enzymes in vitro, and the paper does not establish that MAO inhibition is absent with MPH. SERT is separately cited to [164] in the citing sentence, so it is not judged against this source. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Authors
Guerdjikova, A. I., Mori, N., Casuto, L. S., & McElroy, S. L.
Affiliations
Lindner Center of HOPE (US)
Corresponding author
Guerdjikova, Anna I.
Venue
Neuropsychiatric Disease and Treatment
Published
2016-04
Volume
12
Pages
833
ISSN
  • 1176-6328 (ISSN-L)
  • 1178-2021
OpenAlex
W2339283192
Cited by
40
References
48
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 3
FWCI
0.54
Type
journal article
Language
en
Open access
Locations
  • Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords
binge eating disorder, lisdexamfetamine dimesylate, pharmacotherapy, stimulant medication, pharmacokinetics, treatment efficacy, drug safety, FDA approval, eating disorders in adults

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