Positive psychological determinants of treatment adherence among primary care patients
Open accessAbstract
Background: Patient adherence to medical treatment recommendations can affect disease prognosis, and may be beneficially or deleteriously influenced by psychological factors. Aim: We examined the relationships between both adaptive and maladaptive psychological factors and treatment adherence among a sample of primary care patients. Methods: One hundred and one rural, primary care patients completed the Life Orientation Test-Revised, Trait Hope Scale, Future Orientation Scale, NEO-FFI Personality Inventory (measuring positive and negative affect), and Medical Outcomes Study General Adherence Scale. Findings: In independent models, positive affect, optimism, hope, and future orientation were beneficially associated with treatment adherence, whereas pessimism and negative affect were negatively related to adherence. In multivariate models, only negative affect, optimism and hope remained significant and, in a comparative model, trait hope was most robustly associated with treatment adherence. Implications: Therapeutically, addressing negative emotions and expectancies, while simultaneously bolstering motivational and goal-directed attributes, may improve adherence to treatment regimens.
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The preponderance of current data supports a relationship between positive psychological factors and better medication and treatment adherence.
“Although fewer studies have considered whether positive psychological factors may lead to better medication and treatment adherence and findings are not fully consistent, the preponderance of current data support such a relationship. 156,157”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [156]
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Berrío, Á. I., Sampietro, H. M., Barrios, M., Montesinos, M. D. H., Martín-Ordiales, N., & Guilera, G. (2026) · BMC Psychology · doi:10.1186/s40359-025-03859-7
Future Orientation Scale: A Psychometric Evaluation Across Health-Vulnerable Samples
Altier, H. R., Sirois, F. M., Jeglic, E. L., & Hirsch, J. K. (2026) · Assessment · doi:10.1177/10731911261451782
Self-citation
- Authors
- Nsamenang, S. A., & Hirsch, J. K.
- Affiliations
- East Tennessee State University (US)
- Corresponding author
- Hirsch, Jameson K.
- Venue
- Primary Health Care Research & Development
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-08-27
- Volume
- 16
- Issue
- 4
- Pages
- 398-406
- ISSN
- 1463-4236 (ISSN-L)
- 1477-1128
- OpenAlex
- W2106764598
- Cited by
- 35
- References
- 73
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Primary Health Care Research & Development (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Applied Psychology › Optimism, Hope, and Well-being
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- medication adherence, positive psychology, hope, optimism, future orientation, negative affect, pessimism, positive affect, primary care patients, rural patients
- MeSH terms
- Adaptation, Psychological, Adolescent, Adult, Emotions, Female, Humans, Male, Middle Aged, Motivation, Patient Compliance, Primary Health Care, Rural Population, Young Adult, Hope
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