Oleanolic Acid and Related Triterpenoids from Olives on Vascular Function: Molecular Mechanisms and Therapeutic Perspectives
Abstract
Oleanolic acid and related triterpenoids from olives modulate different signaling pathways, showing a wide range of pharmacological activities against inflammation, cancer or cardiovascular diseases. In particular, emerging evidences reveal the potential of oleanolic acid to restore vascular disorders associated to cardiovascular risk factors, i.e. hypertension, obesity and diabetes, and atherosclerosis. During the previous years, in vitro and in vivo studies with these triterpenoids have positioned them as being mainly responsible for cardiovascular risk protection traditionally associated to olive oil. This review updates recent investigations in olive oil triterpenoids function related to cardiovascular diseases, as well as the underlying mechanisms and structural implications. Important aspects of olive oil triterpenoids such as bioavailability and clinical perspectives on cardiovascular disorder are also extensively analyzed. All these investigations evidence the potential of triterpenoids from olive oil as a promising therapeutic strategy against vascular function, thus efficiently preventing the progression of cardiovascular diseases.
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Several minor OPO components such as pentacyclic triterpenes (mainly OA), squalene or aliphatic alcohols (mainly octacosanol) have been associated with beneficial effects on blood pressure dysregulation.
“Several minor OPO components such as pentacyclic triterpenes (mainly OA), squalene or aliphatic alcohols (mainly octacosanol) have been associated with beneficial effects on blood pressure dysregulation [7, 35–37].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [36]
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Sánchez-Rodríguez, E., Biel-Glesson, S., Fernandez-Navarro, J. R., Calleja, M. Á., Espejo-Calvo, J. A., Extremera, B. G., de la Torre, R., Fitó, M., Covas, M., Vílchez, P., et al. (2019) · Nutrients · doi:10.3390/nu11030561 · Cited by 68 · see citing works
Sanchez-Rodriguez, E., Lima-Cabello, E., Biel-Glesson, S., Fernandez-Navarro, J. R., Calleja, M. A., Roca, M., Espejo-Calvo, J. A., Gil-Extremera, B., Soria-Florido, M., De la Torre, R., et al. (2018) · Nutrients · doi:10.3390/nu10050626 · Cited by 59 · see citing works
de la Torre, R., Carbó, M., Pujadas, M., Biel, S., Mesa, M. D., Covas, M., Expósito, M., Espejo, J.-A., Sánchez-Rodríguez, E., Diaz‐Pellicer, P., et al. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126676 · Cited by 57 · see citing works
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Qin, D., Wang, W., Lei, H., Luo, H., Cai, H., Tang, C., Wu, Y., Wang, Y., Jin, J., Xiao, W., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12801 · Cited by 54 · see citing works
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Fernández-Pastor, I., Fernández‐Hernández, A., Perez-Criado, S., Rivas, F., Martı́nez, A., García‐Granados, A., & Parra, A. (2016) · Journal of Separation Science · doi:10.1002/jssc.201601130 · Cited by 48 · see citing works
Liehr, M., Mereu, A., Pastor, J. J., Quintela, J. C., Staats, S., Rimbach, G. H., & Ipharraguerre, I. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174239 · Cited by 48 · see citing works
Hosny, S., Sahyon, H. A. E., Youssef, M. M., et al. (2020) · Nutrition and Cancer · doi:10.1080/01635581.2020.1776887 · Cited by 45 · see citing works
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LUO, H.-Q., SHEN, J., CHEN, C.-P., MA, X., LIN, C., OUYANG, Q., XUAN, C.-X., LIU, J., SUN, H.-B., & LIU, J. (2018) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(18)30065-7 · Cited by 44 · see citing works
Pan, Y., Zhou, F., Song, Z., Huang, H., Chen, Y., Shen, Y., Jia, Y., & Chen, J. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.11.151 · Cited by 45 · see citing works
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Kahnt, M., Wiemann, J., Fischer, L., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.066 · Cited by 39 · see citing works
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Mabhida, S. E., Dludla, P. V., Johnson, R., Ndlovu, M., Louw, J., Opoku, A. R., & Mosa, R. A. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.10.004 · Cited by 35 · see citing works
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Shen, S.-F., Zhu, L.-F., Wu, Z., Wang, G., Ahmad, Z., & Chang, M. (2019) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2019.1692218 · Cited by 35 · see citing works
Claro-Cala, C. M., Quintela, J. C., Pérez-Montero, M., Miñano, J., Alvarez de Sotomayor, M., Herrera, M. D., & Rodríguez-Rodríguez, R. (2020) · Nutrients · doi:10.3390/nu12020323 · Cited by 33 · see citing works
Self-citationHuang, K., Wang, Y., Bai, Y., Luo, Q., Lin, X., Yang, Q., Wang, S., & Xin, H. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01077-21 · Cited by 33 · see citing works
Mokhtari, K., Pérez‐Jiménez, A., Garcı́a-Salguero, L., Lupiáñez, J. A., & Rufino‐Palomares, E. E. (2020) · Molecules · doi:10.3390/molecules25174020 · Cited by 32 · see citing works
Reyes‐Zurita, F. J., Medina‐O’Donnell, M., Ferrer‐Martín, R. M., et al. (2016) · RSC Advances · doi:10.1039/c6ra18879f · Cited by 31 · see citing works
Alcaide‐Hidalgo, J. M., Margalef, M., Bravo, F. I., Muguerza, B., & López‐Huertas, E. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.05.016 · Cited by 31 · see citing works
Claro, C., Jiménez‐Altayó, F., Zagmutt, S., & Rodríguez‐Rodríguez, R. (2022) · Nutrients · doi:10.3390/nu14081606 · Cited by 34 · see citing works
Self-citationOlmo‐García, L., Bajoub, A., Fernández‐Gutiérrez, A., & Carrasco‐Pancorbo, A. (2015) · Talanta · doi:10.1016/j.talanta.2015.12.042 · Cited by 29 · see citing works
González-Rámila, S., Mateos, R., García-Cordero, J., Seguido, M. Á., Bravo, L., & Sarriá, B. (2022) · Foods · doi:10.3390/foods11152186 · Cited by 28 · see citing works
Fernández-Aparicio, Á., Schmidt-RioValle, J., Perona, J. S., Correa-Rodríguez, M., Castellano, J. M., & González-Jiménez, E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091294 · Cited by 25 · see citing works
Liu, Y., Hu, Z., Xing, H., Kang, L., Chen, X., Liu, B., & Niu, K. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.10.074 · Cited by 28 · see citing works
de Souza, P., Boeing, T., Somensi, L. B., et al. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1333-4 · Cited by 25 · see citing works
González-Rámila, S., Sarriá, B., Seguido, M. A., García-Cordero, J., Mateos, R., & Bravo, L. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-03001-y · Cited by 24 · see citing works
Tret’yakova, E. V., Ma, X., Kazakova, O. B., Андреевна, Ш. А., Petukhova, G. D., Маркович, К. А., Dyatlov, D. S., Smirnova, A. A., Xu, H., & Xiao, S. (2022) · Phytochemistry Letters · doi:10.1016/j.phytol.2022.07.010 · Cited by 24 · see citing works
Liu, Y., Xia, H., Guo, S., et al. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136220 · Cited by 24 · see citing works
Alagna, F., Reed, J., Calderini, O., Thimmappa, R. B., Cultrera, N. G. M., Cattivelli, A., Tagliazucchi, D., Mousavi, S., Mariotti, R., Osbourn, A., et al. (2023) · New Phytologist · doi:10.1111/nph.18863 · Cited by 21 · see citing works
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Zhang, Z., Jiang, M., Xie, X., Yang, H., Wang, X., Xiao, L., & Wang, N. (2017) · Scientific Reports · doi:10.1038/srep40237 · Cited by 23 · see citing works
Yin, Y., Sheng, L., Zhang, J., Zhang, L., Liu, J., Wen, X., Liu, Y., Si, Y., & Cheng, K. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105865 · Cited by 21 · see citing works
Fukumitsu, S., Villareal, M. O., Aida, K., et al. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.16-40 · Cited by 20 · see citing works
Martín, M. E., Millán-Linares, M. C., Naranjo, M. C., et al. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.12941 · Cited by 18 · see citing works
Kell, D. B., Pretorius, E., & Zhao, H. (2025) · Pharmaceuticals · doi:10.3390/ph18050712 · Cited by 17 · see citing works
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González-Rámila, S., Sarriá, B., Seguido, M. Á., García-Cordero, J., Bravo, L., & Mateos, R. (2022) · Nutrients · doi:10.3390/nu14193927 · Cited by 17 · see citing works
Amaral, L., Spengler, G., & Molnar, J. A. (2016) · Anticancer Research · doi:10.21873/anticanres.11149 · Cited by 18 · see citing works
Fontana, G., Badalamenti, N., Bruno, M., Castiglione, D., Notarbartolo, M., Poma, P., Spinella, A., Tutone, M., & Labbozzetta, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126594 · Cited by 15 · see citing works
Nyakudya, T. T., Mukwevho, E., & Erlwanger, K. H. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0314-7 · Cited by 16 · see citing works
Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus
Munteanu, C., Kotova, P. D., & Schwartz, B. (2025) · Nutrients · doi:10.3390/nu17030570 · Cited by 16 · see citing works
Kanshana, J. S., Rebello, S. C., Pathak, P., Kanuri, B., Aggarwal, H., Srivastava, V., Khanna, V., Singh, V., Jagavelu, K., Barthwal, M. K., et al. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.11.004 · Cited by 12 · see citing works
Krajewska, M., Dopierała, K., & Prochaska, K. (2022) · Membranes · doi:10.3390/membranes12121215 · Cited by 10 · see citing works
Sha, Y., Liu, X., He, Y., Zhao, S., Hu, J., Wang, J., Li, W., Shao, P., Wang, F., Chen, X., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1339889 · Cited by 9 · see citing works
Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review
Sangweni, N. F., Dludla, P. V., Mosa, R. A., Kappo, A. P., Opoku, A. R., Muller, C. J. F., & Johnson, R. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9733-9 · Cited by 9 · see citing works
Jiao, P., Wang, S., Liang, S., Li, M., Gao, Q., Ji, D., Chen, Y., Li, H., Ran, F.-X., Zhang, Y., et al. (2018) · Chinese Chemical Letters · doi:10.1016/j.cclet.2018.10.009 · Cited by 10 · see citing works
Application and Development of Natural Plant Metabolite Oleanolic Acid in the Nano Era
Wang, K., Lu, Q., Cao, X., Wang, Y., Wu, Y., Chen, Z., & Yang, Z. (2022) · Agriculture · doi:10.3390/agriculture12122142 · Cited by 7 · see citing works
Chronic Kidney Disease and Dietary Supplementation: Effects on Inflammation and Oxidative Stress
Martello, E., Perondi, F., Bruni, N., et al. (2021) · Veterinary Sciences · doi:10.3390/vetsci8110277 · Cited by 7 · see citing works
Yang, K., Wang, S., Pei, D., et al. (2024) · Journal of Chromatography B · doi:10.1016/j.jchromb.2024.124069 · Cited by 6 · see citing works
Ciocan, A.-G., Maximilian, C., Mitoi, M. E., et al. (2023) · Metabolites · doi:10.3390/metabo13080894 · Cited by 6 · see citing works
İskender, H., Dokumacıoğlu, E., Hayırlı, A., Kapakin, K. A. T., Bolat, İ., & Kirman, E. M. (2023) · PubMed Central · doi:10.22038/ijbms.2023.71321.15504 · Cited by 5 · see citing works
Nutrition and Chronic Conditions
Ojo, O. (2019) · MDPI eBooks · doi:10.3390/books978-3-03897-603-5 · Cited by 3 · see citing works
Efficacy of a Once-Daily Supplement in Managing Canine Chronic Kidney Disease
Perondi, F., Ruggiero, A., Cutrignelli, M. I., et al. (2025) · Animals · doi:10.3390/ani15192884 · Cited by 2 · see citing works
Oleanolic Acid and Alzheimer’s Disease: Mechanistic Hypothesis of Therapeutic Potential
Espinosa-Cabello, J. M., Fernández‐Aparicio, Á., González‐Jiménez, E., Perez-Muñoz, G., Castellano, J. M., & Perona, J. S. (2026) · Applied Sciences · doi:10.3390/app16010494 · Cited by 2 · see citing works
de Sousa, N. F., Duarte, G. D., Moraes, C. B., Barbosa, C. G., Martin, H., Muratov, N. N., do Nascimento, Y. M., Scotti, L., Freitas-Junior, L. H., Barbosa‐Filho, J. M., et al. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16070912 · Cited by 2 · see citing works
UPLC–HDMS Revealed Numerous Novel Compounds in Extra Virgin Olive Oil
Dong, F., Li, Z., Tong, J., et al. (2026) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.70109 · Cited by 1 · see citing works
Lopez-Cortes, J. V., Acı́n, S., Montoya, G., et al. (2025) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/adpp/4687213 · Cited by 1 · see citing works
Balzano, M., Pacetti, D., Loizzo, M. R., et al. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-812780-3.00040-4 · Cited by 1 · see citing works
Bioactive compounds in the management of nutritional disorders
Odoh, U. E., Egbuna, C., Onyegbulam, C. M., Palai, S., Eyüpoğlu, O. E., Adetunji, C. O., Olaniyan, O. T., Onyekere, P. F., Yasmin, I., Ejaz, R., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824412-8.00010-2 · Cited by 1 · see citing works
Dong, F., Li, Z., Zhang, R., Sun, Z., Jiang, H., Sun, Y., Song, X., Dong, Y., Zhong, J., Huang, X., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4592053 · Cited by 1 · see citing works
Yin, Y., Sheng, L., Zhang, J., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4054179
Uso de preparações culinárias como coadjuvante no tratamento e prevenção da depressão e ansiedade
Lampert, E. A., Leite, M. E. F., & Lima, C. M. A. D. M. E. (2024) · Research Society and Development · doi:10.33448/rsd-v13i6.46084
Lachica, M., Borrás‐Linares, I., Borges, T. H., Nieto, R., Seiquer, I., García-Contreras, C., Lara, L., Arraéz-Román, D., Segura‐Carretero, A., Pinilla, J. M., et al. (2024) · Animals · doi:10.3390/ani14192826
Wang, S., Yang, K., Pei, D., Pu, L.-M., & Huang, X. (2026) · Analytical Methods · doi:10.1039/d5ay01925g
Elaissaoui, F., Hajli, F. E., Bakloul, N., et al. (2025) · Egyptian Journal of Basic and Applied Sciences · doi:10.1080/2314808x.2026.2695502
García‐González, A., Matamoros-Domínguez, A., Espinosa-Cabello, J. M., Perez-Muñoz, G., Aranda, M. J. L., Roque-Cuéllar, M. D. C., García-Rey, S., Jiménez‐Sánchez, A., Martínez-Ortega, A. J., Mangas-Cruz, M. Á., et al. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.71206
- Authors
- Rodriguez-Rodriguez, R.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-03-17
- Volume
- 22
- Issue
- 11
- Pages
- 1414-1425
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2324100466
- Cited by
- 75
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 14 · 2021: 2 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- oleanolic acid, triterpenoids, olive oil, vascular function, cardiovascular disease, hypertension, obesity, diabetes mellitus, atherosclerosis, bioavailability, olive oil phenolic compounds, inflammation, cancer
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Molecular Conformation, Oleanolic Acid, Triterpenes, Olea
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