Cited by 75Natural product bioactivities and synthesisEdible Oils Quality and AnalysisNatural Products and Biological Research

Oleanolic Acid and Related Triterpenoids from Olives on Vascular Function: Molecular Mechanisms and Therapeutic Perspectives

Rodriguez-Rodriguez, Rosalia·2015·Current Medicinal Chemistry

Abstract

Oleanolic acid and related triterpenoids from olives modulate different signaling pathways, showing a wide range of pharmacological activities against inflammation, cancer or cardiovascular diseases. In particular, emerging evidences reveal the potential of oleanolic acid to restore vascular disorders associated to cardiovascular risk factors, i.e. hypertension, obesity and diabetes, and atherosclerosis. During the previous years, in vitro and in vivo studies with these triterpenoids have positioned them as being mainly responsible for cardiovascular risk protection traditionally associated to olive oil. This review updates recent investigations in olive oil triterpenoids function related to cardiovascular diseases, as well as the underlying mechanisms and structural implications. Important aspects of olive oil triterpenoids such as bioavailability and clinical perspectives on cardiovascular disorder are also extensively analyzed. All these investigations evidence the potential of triterpenoids from olive oil as a promising therapeutic strategy against vascular function, thus efficiently preventing the progression of cardiovascular diseases.

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Crossref · 10.2174/0929867322666141212122921

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Authors
Rodriguez-Rodriguez, R.
Venue
Current Medicinal Chemistry
Published
2015-03-17
Volume
22
Issue
11
Pages
1414-1425
ISSN
0929-8673 (ISSN-L)
OpenAlex
W2324100466
Cited by
75
References
0
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 14 · 2021: 2 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 1
FWCI
3.47
Type
journal article
Language
en
Open access
closed
Locations
  • Current Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
Keywords
oleanolic acid, triterpenoids, olive oil, vascular function, cardiovascular disease, hypertension, obesity, diabetes mellitus, atherosclerosis, bioavailability, olive oil phenolic compounds, inflammation, cancer
MeSH terms
Animals, Cardiovascular Diseases, Humans, Molecular Conformation, Oleanolic Acid, Triterpenes, Olea

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