Cited by 82Bipolar Disorder and TreatmentSchizophrenia research and treatmentMaternal Mental Health During Pregnancy and Postpartum

Rationale and First Results of Developing At-Risk (Prodromal) Criteria for Bipolar Disorder

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Bechdolf, A., Ratheesh, A., J. Wood, S., Tecic, T., Conus, P., Nelson, B., M. Cotton, S., M. Chanen, A. +8 more·2012·Current Pharmaceutical Design

Abstract

Bipolar affective disorder (BD) is a severe, recurrent and disabling disorder with devastating consequences for individuals, families and society. Although these hazards and costs provide a compelling rationale for development of early detection and early intervention strategies in BD, the development of at-risk criteria for first episode mania is still in an early stage of development. In this paper we review the literature with respect to the clinical, neuroantomical and neuropsychological data, which support this goal. We also describe our recently developed bipolar at-risk criteria (BAR). This criteria comprises the peak age range of the first onset of bipolar disorder, genetic risk, presenting with sub-threshold mania, cyclothymic features or depressive symptoms. An initial pilot evaluation of the BAR criteria in 22 subjects indicated conversion rates to proxies of first-episode mania of 23% within 265 days on average, and high specificity and sensitivity of the criteria. If prospective studies confirm the validity of the BAR criteria, then the criteria would have the potential to open up new avenues of research for indicated prevention in BD and might therefore offer opportunities to ameliorate the severity of, or even prevent BD.

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Crossref · 10.2174/138161212799316226

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  • Indicated prevention in bipolar disorder was developed only fifteen years ago and is rapidly emerging, but its supporting evidence lags behind that for CHR-P.

    “Indicated prevention in bipolar disorder was developed, following the CHR-P template, only fifteen years ago 96,97 , and is rapidly emerging 98-101 . The supporting evidence lags behind that for CHR-P 99,102 .”

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Authors
Bechdolf, A., Ratheesh, A., J. Wood, S., Tecic, T., Conus, P., Nelson, B., M. Cotton, S., M. Chanen, A., P. Amminger, G., Ruhrmann, S., Schultze-Lutter, F., Klosterkotter, J., Fusar Poli, P., R. Yung, A., Berk, M., & D. McGorry, P.
Affiliations
  • University of Cologne (DE)
  • The University of Melbourne (AU)
Venue
Current Pharmaceutical Design
Published
2012-02-01
Volume
18
Issue
4
Pages
358-375
ISSN
1381-6128 (ISSN-L)
OpenAlex
W2167209772
Cited by
82
References
113
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2021: 7 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 11 · 2013: 11 · 2012: 8
FWCI
8.20
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • BORIS (University Library Bern) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
bipolar disorder, first-episode mania, early detection, early intervention, depressive symptoms, genetic risk, prevention
MeSH terms
Bipolar Disorder, Humans, Neuropsychological Tests, Psychiatric Status Rating Scales, Retrospective Studies, Risk Factors, Early Diagnosis

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