Cited by 49Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Non-Demented Individuals with Alzheimer's Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies

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Zolochevska, Olga, Taglialatela, Giulio·2016·Current Pharmaceutical Design

Abstract

Alzheimer's disease (AD) is a terminal neurodegenerative disorder that is characterized by accumulation of amyloid plaques and neurofibrillary tangles in the central nervous system. However, certain individuals remain cognitively intact despite manifestation of substantial plaques and tangles consistent with what would be normally associated with fully symptomatic AD. Mechanisms that allow these subjects to escape dementia remain unresolved and understanding such protective biological processes could reveal novel targets for the development of effective treatments for AD. In this review article we discuss potential compensatory mechanisms that allow these individuals to remain cognitively intact despite the typical AD neuropathology.

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  • Lewy-related pathology and Alzheimer's disease-type pathology have been documented in cognitively healthy individuals upon autopsy.

    “LRP [74] and AD-type pathology [75] have been documented in cognitively healthy individuals upon autopsy.”

    From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [75]

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Authors
Zolochevska, O., & Taglialatela, G.
Affiliations
The University of Texas Medical Branch at Galveston (US)
Venue
Current Pharmaceutical Design
Published
2016-08-01
Volume
22
Issue
26
Pages
4063-4068
ISSN
1381-6128 (ISSN-L)
OpenAlex
W2396757371
Cited by
49
References
91
Citations by year
2026: 2 · 2025: 5 · 2024: 8 · 2023: 2 · 2022: 5 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 1 · 2016: 1
FWCI
2.15
Type
journal article
Language
en
Open access
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG042890)
  • National Institute of Environmental Health Sciences (T32ES007254)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, cognitive resilience, amyloid plaques, neurofibrillary tangles, compensatory mechanisms, neurodegeneration, treatment goals
MeSH terms
Alzheimer Disease, Animals, Humans, Cognitive Dysfunction

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