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Synaptic integration and plasticity of new neurons in the adult hippocampus

Ge, Shaoyu, Sailor, Kurt A., Ming, Guo‐li, Song, Hongjun·2008·The Journal of Physiology
DOI 10.1113/jphysiol.2008.155655
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Abstract

Adult neurogenesis, a developmental process encompassing the birth of new neurons from adult neural stem cells and their integration into the existing neuronal circuitry, highlights the plasticity and regenerative capacity of the adult mammalian brain. Substantial evidence suggests essential roles of newborn neurons in specific brain functions; yet it remains unclear how these new neurons make their unique contribution. Recently, a series of studies have delineated the basic steps of the adult neurogenesis process and shown that many of the distinct steps are dynamically regulated by the activity of the existing circuitry. Here we review recent findings on the synaptic integration and plasticity of newborn neurons in the adult hippocampus, including the basic biological process, unique characteristics, critical periods, and activity‐dependent regulation by the neurotransmitters GABA and glutamate. We propose that adult neurogenesis represents not merely a replacement mechanism for lost neurons, but also an ongoing developmental process in the adult brain that offers an expanded capacity for plasticity for shaping the existing circuitry in response to experience throughout life.

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  • Successful integration of neurons into existing neurocircuits depends on the level of stimulation they receive.

    “Once these neurons begin forming synapses, successful integration into existing neurocircuits also depends on the level of stimulation they receive [18, 19].”

    From MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation. (2017) · cites this paper as [19]

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Cited by

Sorted by citations

Authors
Ge, S., Sailor, K. A., Ming, G., & Song, H.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2008-08-15
Volume
586
Issue
16
Pages
3759-3765
ISSN
  • 0022-3751
  • 1469-7793
DOI
10.1113/jphysiol.2008.155655
Cited by
206
References
3
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3 d)

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