The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Practical Aspects of microRNA Target Prediction
Open accessAbstract
microRNAs (miRNAs) are endogenous non-coding RNAs that control gene expression at the posttranscriptional level. These small regulatory molecules play a key role in the majority of biological processes and their expression is also tightly regulated. Both the deregulation of genes controlled by miRNAs and the altered miRNA expression have been linked to many disorders, including cancer, cardiovascular, metabolic and neurodegenerative diseases. Therefore, it is of particular interest to reliably predict potential miRNA targets which might be involved in these diseases. However, interactions between miRNAs and their targets are complex and very often there are numerous putative miRNA recognition sites in mRNAs. Many miRNA targets have been computationally predicted but only a limited number of these were experimentally validated. Although a variety of miRNA target prediction algorithms are available, results of their application are often inconsistent. Hence, finding a functional miRNA target is still a challenging task. In this review, currently available and frequently used computational tools for miRNA target prediction, i.e., PicTar, TargetScan, DIANA-microT, miRanda, rna22 and PITA are outlined and various practical aspects of miRNA target analysis are extensively discussed. Moreover, the performance of three algorithms (PicTar, TargetScan and DIANAmicroT) is both demonstrated and evaluated by performing an in-depth analysis of miRNA interactions with mRNAs derived from genes triggering hereditary neurological disorders known as trinucleotide repeat expansion diseases (TREDs), such as Huntingtons disease (HD), a number of spinocerebellar ataxias (SCAs), and myotonic dystrophy type 1 (DM1). Keywords: Bioinformatics, gene regulation, miRNA, miRNA-mRNA interaction, neurodegeneration, target prediction algorithm, target validation, trinucleotide repeat expansion disorders, gene expression, RNA-induced silencing complex, computational miRNA target analysis, orthologous sequences alignment, high throughput methods, proteome level, miRNA inhibitors
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Lu, T. X., & Rothenberg, M. E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.08.034 · Cited by 2,425
MicroRNA-9 controls dendritic development by targeting REST
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miRTex: A Text Mining System for miRNA-Gene Relation Extraction
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Metadata
- Authors
- M. Witkos, T., Koscianska, E., & J. Krzyzosiak, W.
- Venue
- Current Molecular Medicine
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-03-01
- Volume
- 11
- Issue
- 2
- Pages
- 93-109
- ISSN
- 1566-5240 (ISSN-L)
- OpenAlex
- W2116661471
- Cited by
- 466
- References
- 137
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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