Cited by 55Diabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disordersDiabetes Treatment and Management

The Effects of Medications Used for the Management of Diabetes and Obesity on Postprandial Lipid Metabolism

Eleftheriadou, Ioanna, Grigoropoulou, Pinelopi, Katsilambros, Nicholas, Tentolouris, Nicholas·2008·Current Diabetes Reviews

Abstract

Postprandial lipemia has emerged as an independent risk factor for coronary artery disease. In this systematic review we examined the effect of the medications used for the management of diabetes, obesity and dyslipidemia on postprandial lipemia. It should be mentioned that no standardization exists for a test meal and for the duration of observation postprandially to allow for direct comparisons between the published studies. Type 2 diabetes mellitus and insulin resistance are associated with enhanced postprandial lipemia. Insulin is effective in reducing both fasting and post prandial total triglyceride levels as well as triglycerides contained in the triglyceride-rich lipoprotein sub-fractions. Additionally, the newer rapid-acting insulin analogues seem to be more effective in the reduction of postprandial lipemia than the short-acting human insulins. Acarbose ameliorates postprandial lipemia and reduces the atherogenic chylomicron and very low density lipoprotein remnants. Metformin reduces both fasting and postprandial triglyceridemia, fasting and post-prandial free fatty acids and may increase the concentrations of the high density lipoprotein cholesterol. Sulfonylureas reduce fasting and postprandial triglyceride levels while data on the effect on high density lipoprotein levels are inconsistent. The effect of meglitinides on postprandial lipid metabolism is neutral. Rosiglitazone decreases fasting and postprandial free fatty acids but has no significant effect on fasting and postprandial triglycerides. Pioglitazone has additional beneficial effects on lipid metabolism because it reduces postprandial free fatty acids, fasting and postprandial triglycerides and increases high density lipoprotein cholesterol levels. Limited available data suggest that glucagon-like peptide-1 analogues and vildagliptin reduce postprandial lipemia through reduction of intestinally-derived triglycerides. No data exist on the effect of sitagliptin on postprandial lipemia. Orlistat improves postprandial lipemia by reducing the absorption of the dietary fat; no data exist on the effect of sibutramine and rimonabant on the metabolism of lipids in the postprandial state.

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Crossref · 10.2174/157339908786241133

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  • Metformin is associated with improvements in lipoprotein metabolism, including decreases in LDL-C, fasting and postprandial triglycerides, and free fatty acids.

    “Metformin is associated with improvements in lipoprotein metabolism, including decreases in LDL-C [95], fasting and postprandial TGs, and free fatty acids [106].”

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Authors
Eleftheriadou, I., Grigoropoulou, P., Katsilambros, N., & Tentolouris, N.
Affiliations
National and Kapodistrian University of Athens (GR)
Corresponding author
Katsilambros, Nicholas
Venue
Current Diabetes Reviews
Published
2008-11-01
Volume
4
Issue
4
Pages
340-356
ISSN
1573-3998 (ISSN-L)
OpenAlex
W2116697145
Cited by
55
References
124
Citations by year
2025: 5 · 2024: 2 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 1 · 2013: 6 · 2012: 8
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Locations
  • Current Diabetes Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
postprandial lipemia, postprandial lipid metabolism, type 2 diabetes, obesity, insulin, insulin analogues, acarbose, metformin, sulfonylureas, meglitinides, rosiglitazone, pioglitazone, glucagon-like peptide-1 analogues, vildagliptin, sitagliptin, orlistat, triglyceridemia, free fatty acids, HDL cholesterol, dyslipidemia, coronary artery disease risk
MeSH terms
Chylomicrons, Clinical Trials as Topic, Diabetes Mellitus, Diabetes Mellitus, Type 2, Digestion, Humans, Hyperlipidemias, Hypoglycemic Agents, Lipase, Lipids, Obesity, Anti-Obesity Agents, Postprandial Period, Acarbose

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