Cited by 22Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementIntestinal and Peritoneal Adhesions

Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies

Mihalyi, Attila, Mutinda, Kyama C, Simsa, Peter, Debrock, Sophie, Mwenda, Jason M, D’Hooghe, Thomas M·2005·Therapy

Abstract

This article presents an overview of immunologic/inflammatory factors related to endometriosis with special attention to their potential relevance to future treatment strategies. The development of endometriosis appears to involve several immunologic and inflammatory factors. Increased inflammatory, proteolytic and angiogenic activity of the peritoneum and the peritoneal fluid, and poor immune surveillance and clearance of endometrial cells from the pelvic cavity all appear to contribute to the development of endometriosis. The presently available pharmacotherapeutic treatments are characterized by high recurrence rates, severe side effects and limited duration of application. These and the consequences of endometriosis on the quality of life of affected women, their environment and the society, clearly indicate the need for the development of new drugs, abolishing endometriosis and its symptoms, without interfering with the hormonal homeostasis. Substances potentially capable of modulating immunologic/in...

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Crossref · 10.2217/14750708.2.4.623

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199 of 199 references verified0 citation errors · 0 not checkable

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Authors
Mihalyi, A., Mutinda, K. C., Simsa, P., Debrock, S., Mwenda, J. M., & D’Hooghe, T. M.
Affiliations
KU Leuven (BE)
Venue
Therapy
Published
2005-07
Volume
2
Issue
4
Pages
623-639
ISSN
  • 1475-0708 (ISSN-L)
  • 1744-831X
OpenAlex
W2140404610
Cited by
22
References
199
Citations by year
2024: 1 · 2023: 1 · 2022: 2 · 2019: 1 · 2017: 2 · 2014: 3 · 2013: 1
FWCI
2.09
Type
journal article
Language
en
Open access
closed
Locations
Therapy (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
Keywords
endometriosis, immunological factors, inflammatory mediators, peritonitis, peritoneal fluid, angiogenesis, proteolysis, immune surveillance, pharmacotherapy, treatment options, quality of life

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