Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies
Abstract
This article presents an overview of immunologic/inflammatory factors related to endometriosis with special attention to their potential relevance to future treatment strategies. The development of endometriosis appears to involve several immunologic and inflammatory factors. Increased inflammatory, proteolytic and angiogenic activity of the peritoneum and the peritoneal fluid, and poor immune surveillance and clearance of endometrial cells from the pelvic cavity all appear to contribute to the development of endometriosis. The presently available pharmacotherapeutic treatments are characterized by high recurrence rates, severe side effects and limited duration of application. These and the consequences of endometriosis on the quality of life of affected women, their environment and the society, clearly indicate the need for the development of new drugs, abolishing endometriosis and its symptoms, without interfering with the hormonal homeostasis. Substances potentially capable of modulating immunologic/in...
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CRP production is stimulated by pro-inflammatory cytokines IL-6, IL-1 and TNF-alpha, which are up-regulated in women with endometriosis compared to controls.
“Its production is stimulated by pro-inflammatory cytokines such as IL-6, IL-1 and TNF-alpha [6] which are up-regulated in women with endometriosis when compared to controls [1,7].”
From A high sensitivity assay is more accurate than a classical assay for the measurement of plasma CRP levels in endometriosis (2011) · cites this paper as [1]
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Endometriosis: cost estimates and methodological perspective
Simoens, S., Hummelshoj, L., & D'Hooghe, T. (2007) · Human Reproduction Update · doi:10.1093/humupd/dmm010 · Cited by 357 · see citing works
Self-citationNon-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers
Mihalyi, A., Gevaert, O., Kyama, C. M., Simsa, P., Pochet, N., De Smet, F., De Moor, B., Meuleman, C., Billen, J., Blanckaert, N., et al. (2010) · Human Reproduction · doi:10.1093/humrep/dep425 · Cited by 161 · see citing works
Self-citationVodolazkaia, A., Bossuyt, X., Fassbender, A., Kyama, C. M., Meuleman, C., Peeraer, K., Tomassetti, C., & D'Hooghe, T. M. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-113 · Cited by 28 · see citing works
Self-citation
- Authors
- Mihalyi, A., Mutinda, K. C., Simsa, P., Debrock, S., Mwenda, J. M., & D’Hooghe, T. M.
- Affiliations
- KU Leuven (BE)
- Venue
- Therapy
- Publisher
- OMICS Publishing Group
- Published
- 2005-07
- Volume
- 2
- Issue
- 4
- Pages
- 623-639
- ISSN
- 1475-0708 (ISSN-L)
- 1744-831X
- OpenAlex
- W2140404610
- Cited by
- 22
- References
- 199
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2019: 1 · 2017: 2 · 2014: 3 · 2013: 1
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Therapy (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Keywords
- endometriosis, immunological factors, inflammatory mediators, peritonitis, peritoneal fluid, angiogenesis, proteolysis, immune surveillance, pharmacotherapy, treatment options, quality of life
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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