The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.
Clearance Properties of Nano-Sized Particles and Molecules as Imaging Agents: Considerations and Caveats
Open accessAbstract
Nanoparticles possess enormous potential as diagnostic imaging agents and hold promise for the development of multimodality agents with both imaging and therapeutic capabilities. Yet, some of the most promising nanoparticles demonstrate prolonged tissue retention and contain heavy metals. This presents serious concerns for toxicity. The creation of nanoparticles with optimal clearance characteristics will minimize toxicity risks by reducing the duration of exposure to these agents. Given that many nanoparticles possess easily modifiable surface and interior chemistry, if nanoparticle characteristics associated with optimal clearance from the body were well established, it would be feasible to design and create agents with more favorable clearance properties. This article presents a thorough discussion of the physiologic aspects of nanoparticle clearance, focusing on renal mechanisms, and provides an overview of current research investigating clearance of specific types of nanoparticles and nano-sized macromolecules, including dendrimers, quantum dots, liposomes and carbon, gold and silica-based nanoparticles.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Due to the threshold for rapid renal excretion being about 5.5 nm, the hydrodynamic diameters of the prepared nanoparticles need to be larger than this size [168–170].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [169]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors
Hardman, R. C. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8284 · Cited by 2,304
Nanoengineering of optical resonances
Oldenburg, S. J., Averitt, R. D., Westcott, S. L., & Halas, N. J. (1998) · Chemical Physics Letters · doi:10.1016/s0009-2614(98)00277-2 · Cited by 2,266
Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
de Jong, W. H., Hagens, W. I., Krystek, P., Burger, M. C., Sips, A. J. A. M., & Geertsma, R. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.037 · Cited by 1,620
Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)
Szoka, F. C., & Papahadjopoulos, D. (1980) · Annual Review of Biophysics and Bioengineering · doi:10.1146/annurev.bb.09.060180.002343 · Cited by 1,515
Recent advances in iron oxide nanocrystal technology for medical imaging☆
Corot, C., Robert, P., Idée, J., & Port, M. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.013 · Cited by 1,461
Gold nanoparticles: a new X-ray contrast agent
Hainfeld, J. F., Slatkin, D. N., Focella, T. M., & Smilowitz, H. M. (2006) · British Journal of Radiology · doi:10.1259/bjr/13169882 · Cited by 1,351
Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J.-W., Meijer, E. W., Paulus, W., & Duncan, R. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00246-1 · Cited by 1,228
Noninvasive Imaging of Quantum Dots in Mice
Ballou, B. T., Lagerholm, B. C., Ernst, L. A., Bruchez, M. P., & Waggoner, A. S. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034153y · Cited by 1,141
Liu, Z., Davis, C. R., Cai, W., He, L., Chen, X.-Y., & Dai, H. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0707654105 · Cited by 1,097
Research works printed but not linked: 2
- 10.1021/ja027555 · DOI
- Wisse E DoucetD Van Bossuyt H: A transmission electron microscopic study on the uptake of AMI-25 by sinusoidal liver cells. In: Cells of the Hepatic Sinusoid (Volume 3). Wisse E Knook DL McCuskey RS (Eds.). The Kupffer Cell Foundation Leiden The Netherlands 534–539 (1991).
Cited by
Sorted by citations
Items 401–500 of 1,000
Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity
Shoudho, K. N., Uddin, S., Rumon, M. M. H., & Shakil, M. S. (2024) · ACS Omega · doi:10.1021/acsomega.4c02822 · Cited by 97
Toxicity evaluation of inorganic nanoparticles: considerations and challenges
Choi, S., Lee, J. K., Jeong, J., & Choy, J. (2013) · Molecular & Cellular Toxicology · doi:10.1007/s13273-013-0026-z · Cited by 90
Kutty, R. V., Chia, S. L., Setyawati, M. I., Muthu, M. S., Feng, S., & Leong, D. T. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.06.005 · Cited by 89
Xu, F., Zhu, J., Lin, L., Zhang, C., Sun, W., Fan, Y., Yin, F., van Hest, J. C. M., Wang, H., Du, L., et al. (2020) · Theranostics · doi:10.7150/thno.43402 · Cited by 89
Bai, S., Zhang, Y., Li, D., Shi, X., Lin, G., & Liu, G. (2020) · Nano Today · doi:10.1016/j.nantod.2020.101038 · Cited by 90
Engineered Bacteria Enhance Immunotherapy and Targeted Therapy through Stromal Remodeling of Tumors
Thomas, S. C., Madaan, T., Kamble, N. S., Siddiqui, N. A., Pauletti, G. M., & Kotagiri, N. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101487 · Cited by 93
Ren, H., Zeng, X., Zhao, X., Hou, D., Yao, H., Muhammad, Y., Zhao, L., Xu, W., Wang, H., & Li, L. (2022) · Nature Communications · doi:10.1038/s41467-021-27932-y · Cited by 88
Aptamer-conjugated dendrimer-modified quantum dots for cancer cell targeting and imaging
Li, Z., Huang, P., He, R., Lin, J., Yang, S., Zhang, X., Ren, Q., & Cui, D. (2009) · Materials Letters · doi:10.1016/j.matlet.2009.11.022 · Cited by 89
Zhang, B., Jin, H., Li, Y., Chen, B., Liu, S., & Shi, D. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm30629h · Cited by 88
Chen, D., Yu, Y., Huang, F. H., Lin, H., Huang, P., Yang, A., Wang, Z., & Wang, Y. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm14589d · Cited by 88
Nanocarriers Used in Drug Delivery to Enhance Immune System in Cancer Therapy
Lôbo, G. C. N. B., Paiva, K. L. R., Silva, A. L. G., Simões, M. M., Radicchi, M. A., & Báo, S. N. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081167 · Cited by 93
Renal Clearance and Degradation of Glutathione-Coated Copper Nanoparticles
Yang, S., Sun, S., Zhou, C., Hao, G., Liu, J., Ramezani, S., Yu, M., Sun, X., & Zheng, J. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00003 · Cited by 88
Brazzale, C., Canaparo, R., Racca, L., Foglietta, F., Durando, G., Fantozzi, R., Caliceti, P., Salmaso, S., & Serpe, L. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0293 · Cited by 90
The Effects of Extensive Glomerular Filtration of Thin Graphene Oxide Sheets on Kidney Physiology
Jasim, D. A., Murphy, S., Newman, L., Mironov, A., Prestat, É., McCaffrey, J., Ménard‐Moyon, C., Rodrigues, A. F., Bianco, A., Haigh, S. J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b03358 · Cited by 90
Surface Engineering of Nanoparticles for Targeted Delivery to Hepatocellular Carcinoma
Lu, J., Wang, J., & Ling, D. (2017) · Small · doi:10.1002/smll.201702037 · Cited by 88
Kefayat, A., Ghahremani, F. H., Motaghi, H., & Amouheidari, A. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.12.007 · Cited by 88
Nanoparticle‐Mediated Target Delivery of TRAIL as Gene Therapy for Glioblastoma
Wang, K., Kievit, F. M., Jeon, M., Silber, J. R., Ellenbogen, R. G., & Zhang, M. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500563 · Cited by 87
In vitromicrofluidic models of tumor microenvironment to screen transport of drugs and nanoparticles
Özçelikkale, A., Moon, H., Linnes, M. P., & Han, B. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1460 · Cited by 89
Biodegradable Polydisulfide Dendrimer Nanoclusters as MRI Contrast Agents
Huang, C., Nwe, K., Zaki, A. A., Brechbiel, M. W., & Tsourkas, A. (2012) · ACS Nano · doi:10.1021/nn304160p · Cited by 86
Dinish, U. S., Song, Z., Ho, C. J. H., Balasundaram, G., Attia, A. B. E., Lu, X., Tang, B. Z., Liu, B., & Olivo, M. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201404341 · Cited by 83
Freund, B., Tromsdorf, U. I., Bruns†, O. T., Heine, M., Giemsa, A., Bartelt, A., Salmen, S. C., Raabe, N., Heeren, J., Ittrich, H., et al. (2012) · ACS Nano · doi:10.1021/nn3024267 · Cited by 86
Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications
Fatima, A., Ahmad, M. W., Saidi, A. K. A. A., Choudhury, A., Chang, Y., & Lee, G. H. (2021) · Nanomaterials · doi:10.3390/nano11092449 · Cited by 86
Fatima, M., Sheikh, A., Hasan, N., Sahebkar, A., Riadi, Y., & Kesharwani, P. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2022.111156 · Cited by 87
Chen, Q., Riviere, J. E., & Lin, Z. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1808 · Cited by 92
Shedding light on nanomedicine
Tong, R., & Kohane, D. S. (2012) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1188 · Cited by 88
Wang, S., Shao, J., Li, Z., Ren, Q., Yu, X., & Liu, S. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b02127 · Cited by 86
ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
Hueso, M., Mallén, A., Suñé-Pou, M., Aran, J. M., Suñé-Negre, J. M., & Navarro, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111596 · Cited by 86
Targeted nanosystems: Advances in targeted dendrimers for cancer therapy
Yang, H. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.11.012 · Cited by 88
Plant Protein-Directed Synthesis of Luminescent Gold Nanocluster Hybrids for Tumor Imaging
Li, Z., Peng, H., Liu, J., Tian, Y., Yang, W., Yao, J., Shao, Z., & Chen, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b13088 · Cited by 85
Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles
Bruschi, M. L., & de Toledo, L. D. A. S. (2019) · Magnetochemistry · doi:10.3390/magnetochemistry5030050 · Cited by 83
Higbee-Dempsey, E. M., Amirshaghaghi, A., Case, M. J., Bouché, M., Kim, J., Cormode, D. P., & Tsourkas, A. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b13813 · Cited by 84
Zhao, Y., Sultan, D. H., Detering, L., Luehmann, H. P., & Liu, Y. (2014) · Nanoscale · doi:10.1039/c4nr04569f · Cited by 84
PFPE-Based Polymeric 19F MRI Agents: A New Class of Contrast Agents with Outstanding Sensitivity
Zhang, C., Moonshi, S. S., Han, Y., Puttick, S. G., Peng, H., Magoling, B. J. A., Reid, J. C., Bernardi, S., Searles, D. J., Král, P., et al. (2017) · Macromolecules · doi:10.1021/acs.macromol.7b01285 · Cited by 83
Jin, Z., Yue, Q., Duan, W., Sui, A., Zhao, B., Deng, Y., Zhai, Y., Zhang, Y., Sun, T., Zhang, G., et al. (2022) · Advanced Science · doi:10.1002/advs.202104935 · Cited by 83
Ho, S. L., Yue, H., Tegafaw, T., Ahmad, M. Y., Liu, S., Nam, S., Chang, Y., & Lee, G. H. (2022) · ACS Omega · doi:10.1021/acsomega.1c06603 · Cited by 83
Biomedical applications of gold nanomaterials: opportunities and challenges
Sasidharan, A., & Monteiro-Riviere, N. A. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1341 · Cited by 83
Tan, M., Wu, X., Jeong, E., Chen, Q., & Lu, Z. (2010) · Biomacromolecules · doi:10.1021/bm901352v · Cited by 83
Toxicity Assessment in the Nanoparticle Era
Matteis, V. D., & Rinaldi, R. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-72041-8_1 · Cited by 85
Maßgeschneiderte Nanopartikel für den Wirkstofftransport in der Krebstherapie
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Younan Xia, A. (2014) · Angewandte Chemie · doi:10.1002/ange.201403036 · Cited by 82
Cancer Drug Delivery: Considerations in the Rational Design of Nanosized Bioconjugates
Kobayashi, H., Türkbey, B., Watanabe, R., & Choyke, P. L. (2014) · Bioconjugate Chemistry · doi:10.1021/bc500481x · Cited by 82
Self-citationFacile synthesis of gold nanomaterials with unusual crystal structures
Fan, Z., Huang, X. B., Chen, Y., Huang, W., & Zhang, H. (2017) · Nature Protocols · doi:10.1038/nprot.2017.097 · Cited by 82
Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles
Chen, F., Goel, S., Hernandez, R. T., Graves, S. A., Shi, S., Nickles, R. J., & Cai, W. (2016) · Small · doi:10.1002/smll.201600194 · Cited by 82
Lee, K.-T., Lin, Y.-J., Mi, F., Burnouf, T., Wei, Y.-T., Chiu, S.-C., Chuang, E., & Lu, S. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b13529 · Cited by 83
Design of superparamagnetic nanoparticles for magnetic particle imaging (MPI)
Du, Y., Lai, P., Leung, C., & Pong, P. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140918682 · Cited by 81
In Silico Design and Enzymatic Synthesis of Functional RNA Nanoparticles
Afonin, K. A., Kasprzak, W. K., Bindewald, E., Kireeva, M. L., Viard, M., Kashlev, M., & Shapiro, B. A. (2014) · Accounts of Chemical Research · doi:10.1021/ar400329z · Cited by 81
Synthesis of polymeric nano/microgels: a review
Hamzah, M. Y., Hashim, S., & Rahman, W. A. W. A. (2017) · Journal of Polymer Research · doi:10.1007/s10965-017-1281-9 · Cited by 81
Jing, X., Xu, Y., Liu, D., Wu, Y., Zhou, N., Wang, D., Yan, K. Q., & Meng, L. (2019) · Nanoscale · doi:10.1039/c9nr04768a · Cited by 81
Biomedical applications of metal organic polygons and polyhedra (MOPs)
Samanta, S. K., & Isaacs, L. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213181 · Cited by 81
In vivo self-assembled nanomedicine
Mamuti, M., Zheng, R., An, H., & Wang, H. (2020) · Nano Today · doi:10.1016/j.nantod.2020.101036 · Cited by 82
Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy
Kato, T., Wakiyama, H., Furusawa, A., Choyke, P. L., & Kobayashi, H. (2021) · Cancers · doi:10.3390/cancers13112535 · Cited by 84
Self-citationYang, M., Fan, Q., Zhang, R., Cheng, K., Yan, J., Pan, D., Ma, X., Lu, A., & Cheng, Z. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.001 · Cited by 82
Covalent nano delivery systems for selective imaging and treatment of brain tumors
Ljubimova, J. Y., Sun, T., Mashouf, L. A., Ljubimov, A. V., Israel, L. L., Ljubimov, V. A., Falahatian, V., & Holler, E. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.002 · Cited by 82
Nanomedicines Targeting the Tumor Microenvironment
Tong, R., & Langer, R. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000123 · Cited by 79
Zhang, J., Hao, G., Yao, C., Yu, J., Wang, J., Yang, W., Hu, C., & Zhang, B. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b04738 · Cited by 80
Theranostic applications of selenium nanomedicines against lung cancer
Liu, S., Wei, W., Wang, J., & Chen, T. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01825-2 · Cited by 82
Green-synthesized metal nanoparticles: a promising approach for accelerated wound healing
Singaravelu, S., Motsoene, F., Abrahamse, H., & Kumar, S. S. D. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1637589 · Cited by 89
Brown, A. L., & Goforth, A. M. (2012) · Chemistry of Materials · doi:10.1021/cm300083j · Cited by 80
Imaging applications of nanotechnology in cancer
Gunasekera, U. A., Pankhurst, Q. A., & Douek, M. (2009) · Targeted Oncology · doi:10.1007/s11523-009-0118-9 · Cited by 77
Teston, E., Richard, S., Maldiney, T., Lievre, N., Wang, G. Y., Motte, L., Richard, C., & Lalatonne, Y. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201406599 · Cited by 80
On-Demand Degradation of Metal–Organic Framework Based on Photocleavable Dianthracene-Based Ligand
Collet, G., Lathion, T., Besnard, C., Piguet, C., & Pètoud, S. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b05047 · Cited by 79
Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
Verma, J., Warsame, C., Seenivasagam, R. K., Katiyar, N. K., Aleem, E. A., & Goel, S. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10086-2 · Cited by 84
Selective excitation of Eu 3+ in the core of small β-NaGdF 4 nanocrystals
Bański, M., Podhorodecki, A., Misiewicz, J., Afzaal, M., Abdelhady, A. L., & O’Brien, P. (2012) · Journal of Materials Chemistry C · doi:10.1039/c2tc00132b · Cited by 79
Small molecule nanodrugs for cancer therapy
Ma, Y., Mou, Q., Zhu, X., & Yan, D. (2017) · Materials Today Chemistry · doi:10.1016/j.mtchem.2017.01.004 · Cited by 79
Cell-borne 2D nanomaterials for efficient cancer targeting and photothermal therapy
Li, Z., Shao, J., Luo, Q., Yu, X., Xie, H., Fu, H., Tang, S., Wang, H., Han, G., & Chu, P. K.-H. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.012 · Cited by 79
The Roles of Morphology on the Relaxation Rates of Magnetic Nanoparticles
Yang, L., Wang, Z., Ma, L., Li, A., Xin, J., Wei, R., Lin, H., Wang, R., Chen, Z., & Gao, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b01048 · Cited by 80
Elbehiry, A., Aldubaib, M., Marzouk, E., & Moussa, I. M. (2018) · MicrobiologyOpen · doi:10.1002/mbo3.698 · Cited by 81
Gold nanoparticles to enhance ophthalmic imaging
Chen, F., Si, P., de la Zerda, A., Jokerst, J. V., & Myung, D. J. (2020) · Biomaterials Science · doi:10.1039/d0bm01063d · Cited by 78
Taratula, O. R., Doddapaneni, B. S., Schumann, C., Li, X., Bracha, S., Milovancev, M., Alani, A. W. G., & Taratula, O. (2015) · Chemistry of Materials · doi:10.1021/acs.chemmater.5b03128 · Cited by 77
Chaturvedi, K., Ganguly, K., Kulkarni, A. R., Rudzinski, W. E., Krauss, L., Nadagouda, M. N., & Aminabhavi, T. M. (2015) · Nanomedicine · doi:10.2217/nnm.15.36 · Cited by 77
Pearce, A. K., Simpson, J. D., Fletcher, N. L., Houston, Z. H., Fuchs, A. V., Russell, P. J., Whittaker, A. K., & Thurecht, K. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.004 · Cited by 76
Magnetic‐directed patterning of cell spheroids
Whatley, B. R., Li, X., Zhang, N., & Wen, X. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34797 · Cited by 77
Huang, J., Wang, L., Zhong, X., Li, Y., Yang, L. P. H., & Mao, H. Z. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb00811a · Cited by 76
Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery
Wang, J., Poon, C. J., Chin, D. D., Milkowski, S., Lu, V., Hallows, K. R., & Chung, E. J. (2018) · Nano Research · doi:10.1007/s12274-018-2100-2 · Cited by 80
Liu, J., Yu, M., Ning, X., Zhou, C., Yang, S., & Zheng, J. (2013) · Angewandte Chemie · doi:10.1002/ange.201304465 · Cited by 77
Recent Advances in Small Copper Sulfide Nanoparticles for Molecular Imaging and Tumor Therapy
Liu, Y., Ji, M., & Wang, P. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00273 · Cited by 76
Introduction to Nanotechnology (NT) and Nanomaterials (NMs)
Madkour, L. H. (2019) · Advanced structured materials · doi:10.1007/978-3-030-21621-4_1 · Cited by 77
Clinical Relevance of Pre-Existing and Treatment-Induced Anti-Poly(Ethylene Glycol) Antibodies
Haddad, H. F., Burke, J. A., Scott, E. A., & Ameer, G. A. (2021) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-021-00198-y · Cited by 76
Strategies for Liposome Drug Delivery Systems to Improve Tumor Treatment Efficacy
Wang, J., Gong, J., & Wei, Z. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-02179-4 · Cited by 79
Transport of Nanoparticles through the Placental Barrier
Kulvietis, V., Žalgevičienė, V., Didžiapetrienė, J., & Rotomskis, R. (2011) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.225.225 · Cited by 76
Freedman, J. D., Lusic, H., Snyder, B. D., & Grinstaff, M. W. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201404519 · Cited by 77
Silvero, M. J., Rocca, D. M., de la Villarmois, E. A., Fournier, K., Lanterna, A. E., Pérez, M. F., Becerra, M. C., & Scaiano, J. C. (2018) · ACS Omega · doi:10.1021/acsomega.7b01779 · Cited by 75
Intraoperative Imaging Techniques to Support Complete Tumor Resection in Partial Nephrectomy
Hekman, M. C. H., Rijpkema, M., Langenhuijsen, J. F., Boerman, O. C., Oosterwijk, E., & Mulders, P. (2017) · European Urology Focus · doi:10.1016/j.euf.2017.04.008 · Cited by 75
Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications
Stafford, S., Serrano‐García, R., & Gun’ko, Y. K. (2018) · Applied Sciences · doi:10.3390/app8010097 · Cited by 75
The Impact of Engineered Silver Nanomaterials on the Immune System
Ninan, N., Goswami, N., & Vasilev, K. A. (2020) · Nanomaterials · doi:10.3390/nano10050967 · Cited by 78
Ma, Z., Zhang, Y., Zhang, J. C., Zhang, W., Foda, M. F., Dai, X., & Han, H. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c11469 · Cited by 75
Nanozyme as a rising star for metabolic disease management
Wang, Y., He, X., Huang, K., & Cheng, N. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02478-5 · Cited by 78
Novel nanotechnology approaches to diagnosis and therapy of ovarian cancer
Kim, P. S., Djazayeri, S., & Zeineldin, R. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.11.029 · Cited by 76
Roggers, R. A., Kanvinde, S., Boonsith, S., & Oupický, D. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0142-7 · Cited by 76
Nanomedicines for developing cancer nanotherapeutics: from benchtop to bedside and beyond
Iqbal, J., Abbasi, B. A., Ahmad, R., Mahmood, T., Ali, B., Khalil, A. T., Kanwal, S., Shah, S. A., Alam, M. M., Badshah, H., et al. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9352-3 · Cited by 77
Gómez‐Vallejo, V., Puigivila, M., Plaza‐García, S., Szczupak, B., Piñol, R., Murillo, J. L., Sorribas, V., Lou, G., Veintemillas-Verdaguer, S., Ramos‐Cabrer, P., et al. (2018) · Nanoscale · doi:10.1039/c8nr03084g · Cited by 75
Hefnawy, A., Khalil, I. A. H., Arafa, K. K., Emara, M., & El-sherbiny, I. M. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s240359 · Cited by 74
Multifunctional peptides for tumor therapy
Li, K., Liu, C., & Zhang, X. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.10.009 · Cited by 74
Usama, S. M., Marker, S. C., Li, D., Caldwell, D. R., Stroet, M. C. M., Patel, N. L., Tebo, A. G., Hernot, S., Kalen, J. D., & Schnermann, M. J. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c01765 · Cited by 74
The Role of Magnetic Nanoparticles in the Localization and Treatment of Breast Cancer
Ahmed, M., & Douek, M. (2013) · BioMed Research International · doi:10.1155/2013/281230 · Cited by 74
Taratula, O. R., Dani, R. K., Schumann, C., Xu, H. T., Wang, A., Song, H. S., Dhagat, P., & Taratula, O. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.09.032 · Cited by 74
Yu, M., Lei, B., Gao, C., Yan, J., & Ma, P. X. (2016) · Nano Research · doi:10.1007/s12274-016-1265-9 · Cited by 74
Ozkan, A., Ghousifam, N., Hoopes, P. J., Yankeelov, T. E., & Rylander, M. N. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26919 · Cited by 73
Karlsson, J. E., Tzeng, S. Y., Hemmati, S., Luly, K. M., Choi, O., Rui, Y., Wilson, D. R., Kozielski, K., Quiñones‐Hinojosa, A., & Green, J. J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009768 · Cited by 73
Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: A step forward
de Oliveira, A. M., Jäger, E., Jäger, A., Štěpánek, P., & Giacomelli, F. C. (2013) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2013.08.056 · Cited by 73
Dimitriou, N. M., Tsekenis, G., Balanikas, E., Pavlopoulou, A., Mitsiogianni, M., Mantso, T., Pashos, G., Boudouvis, A. G., Lykakis, I. N., Tsigaridas, G., et al. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.03.006 · Cited by 78
Metadata
- Authors
- Longmire, M., Choyke, P. L., & Kobayashi, H.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Kobayashi, Hisataka
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2008-09-25
- Volume
- 3
- Issue
- 5
- Pages
- 703-717
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- PMC
- PMC3407669
- OpenAlex
- W2150146274
- Cited by
- 2,149
- References
- 77
- Citations by year
- 2026: 84 · 2025: 139 · 2024: 128 · 2023: 157 · 2022: 146 · 2021: 175 · 2020: 181 · 2019: 178 · 2018: 160 · 2017: 170 · 2016: 156 · 2015: 121 · 2014: 99 · 2013: 88 · 2012: 63
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 CA999999)
- National Cancer Institute (ZIABC010657)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › General Materials Science › Nanotechnology research and applications
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- nanoparticle clearance, diagnostic imaging agents, renal clearance, nanoparticle toxicity, heavy metals, dendrimers, quantum dots, liposomes, carbon nanoparticles, gold nanoparticles, silica nanoparticles, tissue retention
- MeSH terms
- Biocompatible Materials, Diagnostic Imaging, Gold, Humans, Kidney, Liposomes, Liver, Magnetic Resonance Imaging, Particle Size, Polymers, Silicon Dioxide, Nanotubes, Carbon, Quantum Dots, Dendrimers, Metal Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review