The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.
Clearance Properties of Nano-Sized Particles and Molecules as Imaging Agents: Considerations and Caveats
Open accessAbstract
Nanoparticles possess enormous potential as diagnostic imaging agents and hold promise for the development of multimodality agents with both imaging and therapeutic capabilities. Yet, some of the most promising nanoparticles demonstrate prolonged tissue retention and contain heavy metals. This presents serious concerns for toxicity. The creation of nanoparticles with optimal clearance characteristics will minimize toxicity risks by reducing the duration of exposure to these agents. Given that many nanoparticles possess easily modifiable surface and interior chemistry, if nanoparticle characteristics associated with optimal clearance from the body were well established, it would be feasible to design and create agents with more favorable clearance properties. This article presents a thorough discussion of the physiologic aspects of nanoparticle clearance, focusing on renal mechanisms, and provides an overview of current research investigating clearance of specific types of nanoparticles and nano-sized macromolecules, including dendrimers, quantum dots, liposomes and carbon, gold and silica-based nanoparticles.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Due to the threshold for rapid renal excretion being about 5.5 nm, the hydrodynamic diameters of the prepared nanoparticles need to be larger than this size [168–170].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [169]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors
Hardman, R. C. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8284 · Cited by 2,304
Nanoengineering of optical resonances
Oldenburg, S. J., Averitt, R. D., Westcott, S. L., & Halas, N. J. (1998) · Chemical Physics Letters · doi:10.1016/s0009-2614(98)00277-2 · Cited by 2,266
Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
de Jong, W. H., Hagens, W. I., Krystek, P., Burger, M. C., Sips, A. J. A. M., & Geertsma, R. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.037 · Cited by 1,620
Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)
Szoka, F. C., & Papahadjopoulos, D. (1980) · Annual Review of Biophysics and Bioengineering · doi:10.1146/annurev.bb.09.060180.002343 · Cited by 1,515
Recent advances in iron oxide nanocrystal technology for medical imaging☆
Corot, C., Robert, P., Idée, J., & Port, M. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.013 · Cited by 1,461
Gold nanoparticles: a new X-ray contrast agent
Hainfeld, J. F., Slatkin, D. N., Focella, T. M., & Smilowitz, H. M. (2006) · British Journal of Radiology · doi:10.1259/bjr/13169882 · Cited by 1,351
Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J.-W., Meijer, E. W., Paulus, W., & Duncan, R. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00246-1 · Cited by 1,228
Noninvasive Imaging of Quantum Dots in Mice
Ballou, B. T., Lagerholm, B. C., Ernst, L. A., Bruchez, M. P., & Waggoner, A. S. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034153y · Cited by 1,141
Liu, Z., Davis, C. R., Cai, W., He, L., Chen, X.-Y., & Dai, H. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0707654105 · Cited by 1,097
Research works printed but not linked: 2
- 10.1021/ja027555 · DOI
- Wisse E DoucetD Van Bossuyt H: A transmission electron microscopic study on the uptake of AMI-25 by sinusoidal liver cells. In: Cells of the Hepatic Sinusoid (Volume 3). Wisse E Knook DL McCuskey RS (Eds.). The Kupffer Cell Foundation Leiden The Netherlands 534–539 (1991).
Cited by
Sorted by citations
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002
The golden age: gold nanoparticles for biomedicine
Dreaden, E. C., Alkilany, A. M., Huang, X., Murphy, C. J., & El‐Sayed, M. A. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15237h · Cited by 3,659
Delivering nanomedicine to solid tumors
Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,265
Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
Tang, F., Li, L., & Chen, D. (2012) · Advanced Materials · doi:10.1002/adma.201104763 · Cited by 2,898
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. S. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,746
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
Kobayashi, H., Ogawa, M., Alford, R. E., Choyke, P. L., & Urano, Y. (2009) · Chemical Reviews · doi:10.1021/cr900263j · Cited by 2,205
Self-citationEngineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Nanoparticles for photothermal therapies
Jaque, D., Maestro, L. M., del Rosal, B., Haro‐González, P., Benayas, A., Plaza, J., Rodríguez, E. M., & Solé, J. G. (2014) · Nanoscale · doi:10.1039/c4nr00708e · Cited by 1,964
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
Omid Veiseh, A., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.002 · Cited by 1,854
Gai, S., Li, C., Yang, P., & Lin, J. (2013) · Chemical Reviews · doi:10.1021/cr4001594 · Cited by 1,464
Progress in applications of magnetic nanoparticles in biomedicine
Pankhurst, Q. A., Thanh, N. T. K., Jones, S. K., & Dobson, J. (2009) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/42/22/224001 · Cited by 1,452
Nanoparticle uptake: The phagocyte problem
Gustafson, H. H., Holt‐Casper, D., Grainger, D. W., & Ghandehari, H. (2015) · Nano Today · doi:10.1016/j.nantod.2015.06.006 · Cited by 1,458
Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination
Zhang, Y.-N., Poon, W., Tavares, A. J., McGilvray, I. D., & Chan, W. C. W. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.020 · Cited by 1,388
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Younan Xia, A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,183
A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications
James, M. L., & Gambhir, S. S. (2012) · Physiological Reviews · doi:10.1152/physrev.00049.2010 · Cited by 1,199
Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents
Sun, Z., Xie, H., Tang, S., Yu, X., Guo, Z., Shao, J., Zhang, H., Huang, H., Wang, H., & Chu, P. K.-H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506154 · Cited by 1,137
Targeting Strategies for Tissue-Specific Drug Delivery
Zhao, Z., Ukidve, A., Kim, J., & Mitragotri, S. (2020) · Cell · doi:10.1016/j.cell.2020.02.001 · Cited by 1,145
Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer?
Nakamura, Y., Mochida, A., Choyke, P. L., & Kobayashi, H. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00437 · Cited by 1,144
Self-citationThe unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy
Doane, T. L., & Burda, C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15260f · Cited by 1,113
Wu, J. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11080771 · Cited by 1,030
Kobayashi, H., Watanabe, R., & Choyke, P. L. (2014) · Theranostics · doi:10.7150/thno.7193 · Cited by 996
Self-citationCompound Copper Chalcogenide Nanocrystals
Coughlan, C., Ibáñez, M., Dobrozhan, O., Singh, A., Cabot, A., & Ryan, K. M. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00376 · Cited by 944
Zhao, L., Seth, A., Wibowo, N., Zhao, C., Mitter, N., Yu, C., & Middelberg, A. P. J. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.11.069 · Cited by 952
Gold Nanoparticles for Photothermal Cancer Therapy
Vines, J. B., Yoon, J.-H., Ryu, N.-E., Lim, D.-J., & Park, H. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00167 · Cited by 910
Elsaesser, A., & Howard, C. V. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.09.001 · Cited by 934
Liu, Y., Tu, D., Zhu, H., & Chen, X. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60060b · Cited by 900
Clearance Pathways and Tumor Targeting of Imaging Nanoparticles
Yu, M., & Zheng, J. (2015) · ACS Nano · doi:10.1021/acsnano.5b01320 · Cited by 900
Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents
Sun, Z., Xie, H., Tang, S., Yu, X., Guo, Z., Shao, J., Zhang, H., Huang, H., Wang, H., & Chu, P. K.-H. (2015) · Angewandte Chemie · doi:10.1002/ange.201506154 · Cited by 883
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00541h · Cited by 830
Abdukayum, A., Chen, J., Zhao, Q., & Yan, X. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404243v · Cited by 713
Application of zirconium MOFs in drug delivery and biomedicine
Lázaro, I. A., & Forgan, R. S. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.09.009 · Cited by 693
Nanomaterial cytotoxicity is composition, size, and cell type dependent
Sohaebuddin, S. K., Thevenot, P., Baker, D. W., Eaton, J. W., & Tang, L. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-22 · Cited by 691
Size Matters: Gold Nanoparticles in Targeted Cancer Drug Delivery
Dreaden, E. C., Austin, L. A., Mackey, M. A., & El‐Sayed, M. A. (2012) · Therapeutic Delivery · doi:10.4155/tde.12.21 · Cited by 656
Applications of nanoparticles in biomedical imaging
Han, X., Xu, K., Taratula, O. R., & Farsad, K. (2018) · Nanoscale · doi:10.1039/c8nr07769j · Cited by 638
Chen, G., Ohulchanskyy, T. Y., Kumar, R., Ågren, H., & Prasad, P. N. (2010) · ACS Nano · doi:10.1021/nn100457j · Cited by 632
Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents
Busquets, M. A., Estelrich, J., & Sánchez‐Martín, M. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s76501 · Cited by 643
Li, X., Zhang, F., & Zhao, D. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00163j · Cited by 616
Beating cancer in multiple ways using nanogold
Dreaden, E. C., Mackey, M. A., Huang, X., Kang, B., & El‐Sayed, M. A. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00180e · Cited by 607
Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
Tang, W., Fan, W., Lau, J., Deng, L., Shen, Z., & Chen, X. S. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00805a · Cited by 610
Surface Engineering of Iron Oxide Nanoparticles for Targeted Cancer Therapy
Kievit, F. M., & Zhang, M. (2011) · Accounts of Chemical Research · doi:10.1021/ar2000277 · Cited by 606
Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies
Chauhan, V. P., Stylianopoulos, T., Boucher, Y., & Jain, R. K. (2011) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061010-114300 · Cited by 597
Glomerular barrier behaves as an atomically precise bandpass filter in a sub-nanometre regime
Du, B., Jiang, X., Das, A., Zhou, Q., Yu, M., Jin, R. M., & Zheng, J. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.170 · Cited by 595
Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice
Lasagna‐Reeves, C. A., Gonzalez-Romero, D., Barria, M. A., Olmedo, I., Clos, A. L., Ramanujam, V. M. S., Urayama, A., Vergara, L. A., Kogan, M. J., & Soto, C. A. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.046 · Cited by 584
In VivoBiodistribution of Nanoparticles
Almeida, J. P. M., Chen, A. L., Foster, A. E., & Drezek, R. A. (2011) · Nanomedicine · doi:10.2217/nnm.11.79 · Cited by 589
Surface Modifications of Nanoparticles for Stability in Biological Fluids
Guerrini, L., Álvarez‐Puebla, R. A., & Pérez, N. P. (2018) · Materials · doi:10.3390/ma11071154 · Cited by 599
Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy
Parhi, P., Mohanty, C., & Sahoo, S. K. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.05.010 · Cited by 573
Two-photon excitation nanoparticles for photodynamic therapy
Shen, Y., Shuhendler, A. J., Ye, D., Xu, J., & Chen, H. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00442c · Cited by 577
Emerging concepts in dendrimer‐based nanomedicine: from design principles to clinical applications
Kannan, R., Nance, E. A., Kannan, S., & Tomalia, D. A. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12280 · Cited by 561
In Vivo Biodistribution and Toxicology of Carboxylated Graphene Quantum Dots
Nurunnabi, M., Khatun, Z., Huh, K. M., Park, S. Y., Lee, D. Y., Cho, K.-J., & Lee, Y.-K. (2013) · ACS Nano · doi:10.1021/nn402043c · Cited by 546
Ligand-targeted liposome design: challenges and fundamental considerations
Noble, G. T., Stefanick, J. F., Ashley, J. D., Kiziltepe, T., & Bilgiçer, B. (2013) · Trends in biotechnology · doi:10.1016/j.tibtech.2013.09.007 · Cited by 546
Metabolism of Nanomaterials in Vivo: Blood Circulation and Organ Clearance
Wang, B., He, X. B., Zhang, Z., Zhao, Y., & Feng, W. (2012) · Accounts of Chemical Research · doi:10.1021/ar2003336 · Cited by 539
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
Mechanisms of drug release in nanotherapeutic delivery systems
Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506
PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application
Grossen, P., Witzigmann, D., Sieber, S., & Huwyler, J. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.05.028 · Cited by 512
Biodistribution of extracellular vesicles following administration into animals: A systematic review
Kang, M., Jordan, V., Blenkiron, C., & Chamley, L. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12085 · Cited by 519
Applications of nanoparticles for diagnosis and therapy of cancer
Baetke, S. C., Lammers, T., & Kiessling, F. M. (2015) · British Journal of Radiology · doi:10.1259/bjr.20150207 · Cited by 515
Anti-Stokes shift luminescent materials for bio-applications
Zhu, X., Su, Q., Feng, W., & Li, F. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00415f · Cited by 497
Luminescent Gold Nanoparticles with Efficient Renal Clearance
Zhou, C., Long, M., Qin, Y., Sun, X., & Zheng, J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007321 · Cited by 496
Hersh, A. M., Alomari, S., & Tyler, B. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084153 · Cited by 478
Nanobodies as therapeutics: big opportunities for small antibodies
Steeland, S., Vandenbroucke, R. E., & Libert, C. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.04.003 · Cited by 476
Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials
Bourquin, J., Milosevic, A. M., Hauser, D., Lehner, R., Blank, F., Petri‐Fink, A., & Rothen‐Rutishauser, B. (2018) · Advanced Materials · doi:10.1002/adma.201704307 · Cited by 482
Behavior and Toxicity of Graphene and Its Functionalized Derivatives in Biological Systems
Yang, K., Li, Y., Tan, X., Peng, R., & Liu, Z. (2012) · Small · doi:10.1002/smll.201201417 · Cited by 464
Magnetic Nanoparticles in Cancer Theranostics
Gobbo, O. L., Sjaastad, K., Radomski, M. W., Volkov, Y., & Prina‐Mello, A. (2015) · Theranostics · doi:10.7150/thno.11544 · Cited by 462
DNA Vaccines—How Far From Clinical Use?
Hobernik, D., & Bros, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113605 · Cited by 466
Nanoparticles for biomedical imaging
Nune, S. K., Gunda, P., Thallapally, P. K., Lin, Y., Forrest, M. L., & Berkland, C. J. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903229031 · Cited by 456
Laurent, S., Saei, A. A., Behzadi, S., Panahifar, A., & Mahmoudi, M. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.924501 · Cited by 454
Gold nanoparticles for cancer radiotherapy: a review
Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., Solov’yov, A. V., Prise, K. M., Golding, J. P., & Mason, N. J. (2016) · Cancer Nanotechnology · doi:10.1186/s12645-016-0021-x · Cited by 462
Dong, Z., Feng, L., Chao, Y., Hao, Y., Chen, M., Gong, F., Han, X., Zhang, R., Cheng, L., & Liu, Z. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b03905 · Cited by 437
Gorris, H. H., & Wolfbeis, O. S. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201208196 · Cited by 436
Magnetite nanoparticles for medical MR imaging
Stephen, Z. R., Kievit, F. M., & Zhang, M. (2011) · Materials Today · doi:10.1016/s1369-7021(11)70163-8 · Cited by 445
Paradoxical glomerular filtration of carbon nanotubes
Ruggiero, A., Villa, C. H., Bander, E. D., Rey, D. A., Bergkvist, M., Batt, C. A., Manova-Todorova, K. O., Deen, W. M., Scheinberg, D. A., & McDevitt, M. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913667107 · Cited by 426
Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents
Luke, G. P., Yeager, D., & Emelianov, S. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0449-4 · Cited by 417
Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities
Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415
Advances in carbon dots: from the perspective of traditional quantum dots
Liu, Y., Huang, H., Cao, W., Mao, B., Liu, Y., & Kang, Z. (2020) · Materials Chemistry Frontiers · doi:10.1039/d0qm00090f · Cited by 419
Size-Tunable, Ultrasmall NaGdF4 Nanoparticles: Insights into Their T1 MRI Contrast Enhancement
Johnson, N. J. J., Oakden, W., Stanisz, G. J., Prosser, R. S., & van Veggel, F. C. J. M. (2011) · Chemistry of Materials · doi:10.1021/cm201297x · Cited by 419
Erdbrügger, U., Blijdorp, C. J., Bijnsdorp, I. V., Borràs, F. E., Burger, D. E., Bussolati, B., Byrd, J. B., Clayton, A., Dear, J. W., Falcón‐Pérez, J. M., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12093 · Cited by 422
Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Navya, P. N., & Daima, H. K. (2016) · Nano Convergence · doi:10.1186/s40580-016-0064-z · Cited by 408
Noble Metal Nanomaterials for NIR‐Triggered Photothermal Therapy in Cancer
Lv, Z., He, S., Wang, Y., & Zhu, X. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001806 · Cited by 399
A repertoire of biomedical applications of noble metal nanoparticles
Azharuddin, M., Zhu, G. H., Das, D., Özgür, E., Uzun, L., Turner, A. P. F., & Patra, H. K. (2019) · Chemical Communications · doi:10.1039/c9cc01741k · Cited by 405
Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice
BarathManiKanth, S., Kalishwaralal, K., Sriram, M. I., Pandian, S. R. K., Youn, H., Eom, S.-H., & Gurunathan, S. (2010) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-8-16 · Cited by 392
Nanoemulsions for drug delivery
Wilson, R. J., Li, Y., Yang, G., & Zhao, C. (2021) · Particuology · doi:10.1016/j.partic.2021.05.009 · Cited by 410
Holá, K., Marková, Z., Zoppellaro, G., Tuček, J., & Zbořil, R. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.02.003 · Cited by 377
Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection
Yu, E. Y., Bishop, M. D., Zheng, B., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Krishnan, K. M., Goodwill, P. W., & Conolly, S. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b04865 · Cited by 379
Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation
Choi, H. S., & Frangioni, J. V. (2010) · Molecular Imaging · doi:10.2310/7290.2010.00031 · Cited by 361
Renal clearable inorganic nanoparticles: a new frontier of bionanotechnology
Liu, J., Yu, M., Zhou, C., & Zheng, J. (2013) · Materials Today · doi:10.1016/j.mattod.2013.11.003 · Cited by 360
Physiologically Based Pharmacokinetic Modeling of Nanoparticles
Li, M., Al‐Jamal, K. T., Kostarelos, K., & Reineke, J. (2010) · ACS Nano · doi:10.1021/nn1018818 · Cited by 358
Zhigaltsev, I. V., Belliveau, N. M., Hafez, I. M., Leung, A. K. K., Huft, J., Hansen, C., & Cullis, P. (2012) · Langmuir · doi:10.1021/la204833h · Cited by 330
Liu, Y., Ai, K., & Lu, L. (2012) · Accounts of Chemical Research · doi:10.1021/ar300150c · Cited by 347
Upconverting and NIR emitting rare earth based nanostructures for NIR-bioimaging
Hemmer, E., Venkatachalam, N., Hyodo, H., Hattori, A., Ebina, Y., Kishimoto, H., & Soga, K. (2013) · Nanoscale · doi:10.1039/c3nr02286b · Cited by 354
Metabolizable Semiconducting Polymer Nanoparticles for Second Near‐Infrared Photoacoustic Imaging
Jiang, Y., Upputuri, P. K., Xie, C., Zeng, Z., Sharma, A., Xu, Z. J., Li, J., Huang, J., Pramanik, M., & Pu, K. (2019) · Advanced Materials · doi:10.1002/adma.201808166 · Cited by 339
Advanced optoacoustic methods for multiscale imaging of in vivo dynamics
Deán‐Ben, X. L., Gottschalk, S., Larney, B. M., Shoham, S., & Razansky, D. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00765a · Cited by 335
Gold Nanozymes: From Concept to Biomedical Applications
Lou-Franco, J., Das, B., Elliott, C. T., & Cao, C. (2020) · Nano-Micro Letters · doi:10.1007/s40820-020-00532-z · Cited by 344
Sub‐10‐nm Pd Nanosheets with Renal Clearance for Efficient Near‐Infrared Photothermal Cancer Therapy
Tang, S., Chen, M., & Zheng, N. (2014) · Small · doi:10.1002/smll.201303631 · Cited by 327
Colloidal capsules: nano- and microcapsules with colloidal particle shells
Bollhorst, T., Rezwan, K., & Maas, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00632a · Cited by 327
Zhou, M., Li, J., Su, L., Sood, A. K., Liang, D., & Li, C. (2015) · ACS Nano · doi:10.1021/acsnano.5b02635 · Cited by 326
Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica nanoparticles
Souris, J. S., Lee, C., Cheng, S., Chen, C.-T., Yang, C., Ho, J. A., Mou, C., & Lo, L. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.048 · Cited by 328
Sustained Small Interfering RNA Delivery by Mesoporous Silicon Particles
Tanaka, T., Mangala, L. S., Vivas‐Mejía, P. E., Nieves-Alicea, R., Mann, A. P., Mora, E., Han, H., Shahzad, M. M. K., Liu, X., Bhavane, R. C., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3931 · Cited by 317
Metadata
- Authors
- Longmire, M., Choyke, P. L., & Kobayashi, H.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Kobayashi, Hisataka
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2008-09-25
- Volume
- 3
- Issue
- 5
- Pages
- 703-717
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- PMC
- PMC3407669
- OpenAlex
- W2150146274
- Cited by
- 2,149
- References
- 77
- Citations by year
- 2026: 84 · 2025: 139 · 2024: 128 · 2023: 157 · 2022: 146 · 2021: 175 · 2020: 181 · 2019: 178 · 2018: 160 · 2017: 170 · 2016: 156 · 2015: 121 · 2014: 99 · 2013: 88 · 2012: 63
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 CA999999)
- National Cancer Institute (ZIABC010657)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › General Materials Science › Nanotechnology research and applications
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- nanoparticle clearance, diagnostic imaging agents, renal clearance, nanoparticle toxicity, heavy metals, dendrimers, quantum dots, liposomes, carbon nanoparticles, gold nanoparticles, silica nanoparticles, tissue retention
- MeSH terms
- Biocompatible Materials, Diagnostic Imaging, Gold, Humans, Kidney, Liposomes, Liver, Magnetic Resonance Imaging, Particle Size, Polymers, Silicon Dioxide, Nanotubes, Carbon, Quantum Dots, Dendrimers, Metal Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
