Type-2 diabetes mellitus and cardiovascular disease
Abstract
The global prevalence of diabetes has risen in adults from 4.7% in 1980 to 8.5% in 2014. 90-95% of adults with diabetes have Type 2 diabetes (T2D). This paper focuses on the diagnosis and treatment of T2D patients who have or are at risk for cardiovascular disease. Hyperglycemia, insulin resistance and excess fatty acids increase oxidative stress, disrupt protein kinase C signaling and increase advanced glycation end-products that result in vascular inflammation, vasoconstriction, thrombosis and atherogenesis. Intensive T2D treatment produces a ≥10% risk reduction in major macrovascular and microvascular events. Glucose-lowering therapies must be individualized. Metformin is an optimal drug for monotherapy. If hemoglobin A1c is not at goal, a sodium-glucose cotransporter-2 inhibitor or a dipeptidyl peptidase-4 inhibitor should be considered for therapy with metformin. Coronary angioplasty/stenting is recommended for diabetic patients with acute myocardial infarctions. Coronary artery bypass grafting is recommended for symptomatic diabetic patients with multivessel disease.
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Cardiovascular diseases, involving coronary heart disease, peripheral vascular disease and cerebrovascular disease, are the primary contributors of death and disability in diabetic people.
“Cardiovascular diseases, involving coronary heart disease, peripheral vascular disease and cerebrovascular disease, are the primary contributors of death and disability in diabetic people (112).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [112]
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- Authors
- Henning, R. J.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Henning, Robert J
- ORCID
- Henning, Robert J
- Venue
- Future Cardiology
- Publisher
- Informa UK Limited
- Published
- 2018-11
- Volume
- 14
- Issue
- 6
- Pages
- 491-509
- ISSN
- 1479-6678 (ISSN-L)
- 1744-8298
- OpenAlex
- W2900050340
- Cited by
- 398
- References
- 111
- Citations by year
- 2026: 32 · 2025: 64 · 2024: 62 · 2023: 70 · 2022: 69 · 2021: 69 · 2020: 27 · 2019: 4 · 2018: 1
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Future Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, cardiovascular disease, hyperglycemia, insulin resistance, oxidative stress, advanced glycation end products, atherogenesis, vascular inflammation, tight glycemic control, metformin, SGLT2 inhibitors, DPP-4 inhibitors, coronary angioplasty, coronary stenting, coronary artery bypass grafting, acute myocardial infarction
- MeSH terms
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans
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