Cited by 168Sleep and Wakefulness ResearchAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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The sleep–wake Cycle and Alzheimer’s Disease: What do We know?

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Lim, Miranda M, Gerstner, Jason R, Holtzman, David M·2014·Neurodegenerative Disease Management

DOI 10.2217/nmt.14.33PMC PMC4257134

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Abstract

Sleep-wake disturbances are a highly prevalent and often disabling feature of Alzheimer's disease (AD). A cardinal feature of AD includes the formation of amyloid plaques, associated with the extracellular accumulation of the amyloid-β (Aβ) peptide. Evidence from animal and human studies suggests that Aβ pathology may disrupt the sleep-wake cycle, in that as Aβ accumulates, more sleep-wake fragmentation develops. Furthermore, recent research in animal and human studies suggests that the sleep-wake cycle itself may influence Alzheimer's disease onset and progression. Chronic sleep deprivation increases amyloid plaque deposition, and sleep extension results in fewer plaques in experimental models. In this review geared towards the practicing clinician, we discuss possible mechanisms underlying the reciprocal relationship between the sleep-wake cycle and AD pathology and behavior, and present current approaches to therapy for sleep disorders in AD.

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Authors: Lim, M. M., Gerstner, J. R., & Holtzman, D. M.
Affiliations: Oregon Health & Science University (US)
Washington State University Spokane (US)
Washington University in St. Louis (US)
ORCID: Lim, Miranda M
Gerstner, Jason R
Holtzman, David M
Venue: Neurodegenerative Disease Management
Publisher: Informa UK Limited
Published: 2014-10
Volume: 4
Issue: 5
Pages: 351-362
ISSN: 1758-2024 (ISSN-L)
1758-2032
DOI: 10.2217/nmt.14.33
PMC: PMC4257134
OpenAlex: W1984375619
Cited by: 168
References: 105
Citations by year: 2026: 17 · 2025: 15 · 2024: 15 · 2023: 8 · 2022: 20 · 2021: 14 · 2020: 16 · 2019: 16 · 2018: 17 · 2017: 14 · 2016: 11 · 2015: 4
FWCI: 0.94
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Neurodegenerative Disease Management (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P01 AG0 3991, P01AG003991)
National Heart, Lung, and Blood Institute (T32HL007713)
National Institute of Neurological Disorders and Stroke (P01NS080675, 1P01NS074969-A1, P01NS074969)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, sleep-wake cycle, sleep-wake disturbances, amyloid-beta, amyloid plaques, sleep fragmentation, chronic sleep deprivation, sleep extension, disease progression
MeSH terms: Alzheimer Disease, Animals, Brain, Disease Models, Animal, Humans, Sleep, Amyloid beta-Peptides, Disease Progression, Sleep Disorders, Circadian Rhythm, Plaque, Amyloid

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The sleep–wake Cycle and Alzheimer’s Disease: What do We know?

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