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Cited by 171Characterization and Applications of Magnetic NanoparticlesNeuroscience and Neural EngineeringMultiferroics and related materials

Magnetoelectric ‘spin’ on stimulating the brain.

Open access
Guduru, Rakesh, Liang, Ping, Hong, J, Rodzinski, Alexandra, Hadjikhani, Ali, Horstmyer, Jeffrey, Levister, Ernest, Khizroev, Sakhrat·2015·Nanomedicine
DOI 10.2217/nnm.15.52PMC PMC4910966
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Abstract

AIM: The in vivo study on imprinting control region mice aims to show that magnetoelectric nanoparticles may directly couple the intrinsic neural activity-induced electric fields with external magnetic fields. METHODS: Approximately 10 µg of CoFe2O4-BaTiO3 30-nm nanoparticles have been intravenously administrated through a tail vein and forced to cross the blood-brain barrier via a d.c. field gradient of 3000 Oe/cm. A surgically attached two-channel electroencephalography headmount has directly measured the modulation of intrinsic electric waveforms by an external a.c. 100-Oe magnetic field in a frequency range of 0-20 Hz. RESULTS: The modulated signal has reached the strength comparable to that due the regular neural activity. CONCLUSION: The study opens a pathway to use multifunctional nanoparticles to control intrinsic fields deep in the brain.

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  • Magnetoelectric nanoparticles might also induce nanoparticles to traverse the blood-brain barrier by applying a direct-current magnetic field gradient to the cranial vault.

    “Magnetoelectric nanoparticles might also induce nanoparticles to traverse the blood–brain barrier (BBB) by applying a direct-current magnetic field gradient to the cranial vault.”

    From Human Brain/Cloud Interface (2019) · cites this paper as Guduru et al., 2015

  • Magnetoelectric nanoparticles have already been utilized to control intrinsic fields deep within the mouse brain and have permitted the coupling of external magnetic fields to neuronal electric fields.

    “Magnetoelectric nanoparticles have already been utilized to control intrinsic fields deep within the mouse brain and have permitted the coupling of external magnetic fields to neuronal electric fields.”

    From Human Brain/Cloud Interface (2019) · cites this paper as Guduru et al., 2015

  • Magnetoelectric nanoparticles may be employed to enhance coupling between external magnetic fields and localized electric fields that emanate from neural networks.

    “One promising near-term technology that may enable an interface with brain-based neural networks is magnetoelectric nanoparticles, which may be employed to enhance coupling between external magnetic fields and localized electric fields that emanate from neural networks”

    From Human Brain/Cloud Interface (2019) · cites this paper as Guduru et al., 2015

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Research works printed but not linked: 30

  1. [1]Marblestone AH, et al. Physical principles for scalable neural recording. Front. Comput. Neurosci. 2013;7:137. doi: 10.3389/fncom.2013.00137. [DOI] [PMC free article] [PubMed] [Google Scholar]; • Gives a unique technology angle on the current state of neuroengineering. · DOI
  2. [3]De Kramer J. The electrical circuitry of an olfactory sensillum in Antheraea polyphemus . J. Neurosci. 1985;5:2484–2493. doi: 10.1523/JNEUROSCI.05-09-02484.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]; • Presents the concept of the brain's electric circuitry. · DOI
  3. [5]Yue K, et al. Magneto-electric nano-particles for non-invasive brain stimulation. PLoS ONE. 2012;7:e44040. doi: 10.1371/journal.pone.0044040. [DOI] [PMC free article] [PubMed] [Google Scholar]; • Gives a theoretical insight into using magnetoelectric nanoparticles for noninvasive brain stimulation. · DOI · Paper page
  4. [6]Brambilla D, Le Droumaguet B, Nicolas J, et al. Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues. Nanomedicine. 2011;7:521–540. doi: 10.1016/j.nano.2011.03.008. [DOI] [PubMed] [Google Scholar] · DOI
  5. [7]Kringelbach ML, Jenkinson N, Owen SL, Aziz TZ. Translational principles of deep brain stimulation. Nat. Rev. Neurol. 2007;8:623–635. doi: 10.1038/nrn2196. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  6. [8]Stefani A, et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain. 2007;130:1596–1607. doi: 10.1093/brain/awl346. [DOI] [PubMed] [Google Scholar] · DOI
  7. [9]Schlaepfer TE, et al. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology. 2008;33:368–377. doi: 10.1038/sj.npp.1301408. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  8. [10]Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985;325:1106–1107. doi: 10.1016/s0140-6736(85)92413-4. [DOI] [PubMed] [Google Scholar] · DOI
  9. [11]Pascual-Leone A. Transcranial magnetic stimulation: studying the brain–behaviour relationship by induction of ‘virtual lesions’. Philos. Trans. R. Soc. Lond. B Biol. Sci. 1999;354:1229–1238. doi: 10.1098/rstb.1999.0476. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  10. [12]Nitsche MA, Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology. 2001;57:1899–1901. doi: 10.1212/wnl.57.10.1899. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  11. [13]Boggio PS, Ferrucci R, Rigonatti SP, et al. Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease. J. Neurol. Sci. 2006;249:31–38. doi: 10.1016/j.jns.2006.05.062. [DOI] [PubMed] [Google Scholar] · DOI
  12. [14]Fregni F, Pascual-Leone A. Technology insight: noninvasive brain stimulation in neurology – perspectives on the therapeutic potential of rTMS and tDCS. Nat. Clin. Pract. Neuro. 2007;3:383–393. doi: 10.1038/ncpneuro0530. [DOI] [PubMed] [Google Scholar] · DOI
  13. [15]Yoo SS, Bystritsky A, Lee JH, et al. Focused ultrasound modulates region-specific brain activity. Neuroimage. 2011;56:1267–1275. doi: 10.1016/j.neuroimage.2011.02.058. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  14. [16]Huang YZ, Sommer M, Thickbroom G, et al. Consensus: new methodologies for brain stimulation. Brain Stimul. 2009;2:2–13. doi: 10.1016/j.brs.2008.09.007. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  15. [17]Coenen AM. Neuronal activities underlying the electroencephalogram and evoked potentials of sleeping and waking: implications for information processing. Neurosci. Biobehav. Rev. 1995;19:447–463. doi: 10.1016/0149-7634(95)00010-c. [DOI] [PubMed] [Google Scholar] · DOI
  16. [18]Zhao Z, Zhou Z, Bao J. Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging. Nat. Commun. 2013;4:2266. doi: 10.1038/ncomms3266. [DOI] [PubMed] [Google Scholar] · DOI
  17. [19]Corral-Flores V, Bueno-Baques D, Ziolo R. Synthesis and characterization of novel CoFe2O4–BaTiO3 multiferroic core–shell-type nanostructures. Acta Mater. 2010;58:764–769. [Google Scholar]
  18. [20]Kitagawa Y, Hiraoka Y, Honda T, Ishikura T, Nakamura H, Kimura T. Low-field magnetoelectric effect at room temperature. Nat. Mater. 2010;9:797–802. doi: 10.1038/nmat2826. [DOI] [PubMed] [Google Scholar] · DOI
  19. [21]Luo W, et al. Room-temperature simultaneously enhanced magnetization and electric polarization in BiFeO3 ceramic synthesized by magnetic annealing. Appl. Phys. Lett. 2009;94:202507. [Google Scholar]
  20. [22]Nair M, Guduru R, Liang P, Hong J, Sagar V, Khizroev S. Externally controlled on-demand release of anti-HIV drug using magneto-electric nanoparticles as carriers. Nat. Commun. 2013;4:1707. doi: 10.1038/ncomms2717. [DOI] [PubMed] [Google Scholar] · DOI
  21. [23]Guduru R, Khizroev S. Magnetic field‐controlled release of paclitaxel drug from functionalized magnetoelectric nanoparticles. Part. Part. Syst. Char. 2013;31(5):605–611. [Google Scholar]
  22. [24]Calvo P, Gouritin B, Chacun H, et al. Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery. Pharm. Res. 2001;18(8):1157–1166. doi: 10.1023/a:1010931127745. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  23. [25]Guduru R, Liang P, Runowicz C, Nair M, Alturi V, Khizroev S. Magnetetolectric nanoparticles to enable field-controlled high-specificity drug delivery to eradicate ovarian cancer cells. Sci. Rep. 2013;3:2953. doi: 10.1038/srep02953. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  24. [26]Eskandar E, Rabinov J, Barker FG. Tracking neural stem cells in patients with brain trauma. N. Engl. J. Med. 2006;355(22):2376–2378. doi: 10.1056/NEJMc055304. [DOI] [PubMed] [Google Scholar] · DOI
  25. [27]Kim DK, Zhang Y, Kehr J, Klason T, Bjelke B, Muhammed M. Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administrated into the rat brain. J. Mag. Mag. Mat. 2001;225:256–261. [Google Scholar]
  26. [28]Goodwill PW, Scott GC, Stang PP, Conolly SM. Narrowband magnetic particle imaging. IEEE Trans. Med. Imaging. 2009;28:1231–1237. doi: 10.1109/TMI.2009.2013849. [DOI] [PubMed] [Google Scholar] · DOI
  27. [29]Weizenecker J, Gleich B, Rahmer J, Dahnke H, Borgert J. Three-dimensional real-time in vivo magnetic particle imaging. Phys. Med. Biol. 2009;54:L1. doi: 10.1088/0031-9155/54/5/L01. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  28. [30]Yassa MA, Muftuler LT, Stark CE. Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo . Proc. Natl Acad. Sci. USA. 2010;107:12687–12691. doi: 10.1073/pnas.1002113107. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  29. [31]Khizroev SK, Bain JA, Kryder MH. Considerations in the design of probe heads for 100 Gbit/in 2 recording density. IEEE. Trans. Magn. 1997;33:2893–2895. [Google Scholar]
  30. [32]Koch C, Tononi G. Can machines be conscious? IEEE Spectrum. 2008;45(6):55. [Google Scholar]; • Presents a concept of reverse-brain engineering.

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Authors
Guduru, R., Liang, P., Hong, J., Rodzinski, A., Hadjikhani, A., Horstmyer, J., Levister, E., & Khizroev, S.
Affiliations
  • Florida International University (US)
  • University of California, Riverside (US)
  • University of California, Berkeley (US)
  • Neuroscience Centers of Florida Foundation, Miami, FL33124, USA
  • University of California, Irvine (US)
ORCID
Venue
Nanomedicine
Publisher
Informa UK Limited
Published
2015-05-08
Volume
10
Issue
13
Pages
2051-2061
ISSN
  • 1743-5889 (ISSN-L)
  • 1748-6963
DOI
10.2217/nnm.15.52
PMC
PMC4910966
OpenAlex
W1960233454
Cited by
171
References
2
Citations by year
2026: 14 · 2025: 22 · 2024: 19 · 2023: 21 · 2022: 21 · 2021: 13 · 2020: 15 · 2019: 11 · 2018: 8 · 2017: 14 · 2016: 12 · 2015: 1
FWCI
5.80
Type
journal article
Language
en
Open access
Locations
  • Nanomedicine (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (#ECCS-1408063 and IIP-1237818)
  • NIH DA (#R01DA034547-01)
  • Department of Defense (DoD) Defense Microelectronics Activity (#H94003–09–2–0904)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Multiferroics and related materials
Keywords
magnetoelectric nanoparticles, neurostimulation, blood-brain barrier penetration, EEG, multifunctional nanoparticles
MeSH terms
Animals, Blood-Brain Barrier, Brain, Cobalt, Electroencephalography, Electromagnetic Fields, Female, Ferric Compounds, Titanium, Barium Compounds, Mice, Nanoparticles, Magnets

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