Partial pancreatectomy in adult humans does not provoke β-cell regeneration

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011 · see citing works

Type 2 diabetes: principles of pathogenesis and therapy

Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662 · see citing works

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219 · see citing works

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92172 · Cited by 1,114 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215318 · Cited by 1,006 · see citing works

A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development

Bonner‐Weir, S., Baxter, L. A., Schuppin, G. T., & Smith, F. E. (1993) · Diabetes · doi:10.2337/diab.42.12.1715 · Cited by 675 · see citing works

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

Yoon, K., Ko, S., Cho, J., Lee, J. M., Ahn, Y., Song, K. H., Yoo, S. J., Kang, M. I., Cha, B. Y., Lee, K. W., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020735 · Cited by 645 · see citing works

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

Meier, J. J., Bhushan, A., Butler, A. E., Rizza, R. A., & Butler, P. C. (2005) · Diabetologia · doi:10.1007/s00125-005-1949-2 · Cited by 493 · see citing works

β cell replication is the primary mechanism for maintaining postnatal β cell mass

Georgia, S. K., & Bhushan, A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22098 · Cited by 468 · see citing works

New sources of pancreatic β-cells

Bonner‐Weir, S., & Weir, G. C. (2005) · Nature Biotechnology · doi:10.1038/nbt1115 · Cited by 390 · see citing works

Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy.

Kassem, S., Ariel, I., THORNTON, P. S., Scheimberg, I. B., & Gläser, B. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1325 · Cited by 361 · see citing works

Clinical features of 52 neonates with hyperinsulinism.

de Lonlay-Debeney, P., Poggi-Travert, F., Fournet, J., Sempoux, C., Vici, C., Brunelle, F., Touati, G., Rahier, J., Junien, C., Nihoul-Fékété, C., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904153401505 · Cited by 306 · see citing works

Glucagon-like peptide 1(GLP-1) in biology and pathology

Meier, J. J., & Nauck, M. A. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.538 · Cited by 288 · see citing works

Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4

Tourrel‐Cuzin, C., Bailbé, D., Lacorne, M., Meile, M.-J., Kergoat, M., & Portha, B. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1443 · Cited by 285 · see citing works

Glucagon-Like Peptide-1 and the Islet β-Cell: Augmentation of Cell Proliferation and Inhibition of Apoptosis

Drucker, D. J. (2003) · Endocrinology · doi:10.1210/en.2003-1147 · Cited by 274 · see citing works

A MORPHOLOGICAL STUDY OF THE ENDOCRINE PANCREAS IN HUMAN PREGNANCY

Van Assche, F. A., Aerts, L., & Prins, F. D. (1978) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1978.tb15835.x · Cited by 267 · see citing works

Hyperinsulinemic Hypoglycemia After Gastric Bypass Surgery Is Not Accompanied by Islet Hyperplasia or Increased β-Cell Turnover

Meier, J. J., Butler, A. E., Galasso, R., & Butler, P. C. (2006) · Diabetes Care · doi:10.2337/dc06-0392 · Cited by 249 · see citing works

Effects of Hemipancreatectomy on Insulin Secretion and Glucose Tolerance in Healthy Humans

Kendall, D. M., Sutherland, D. E. R., Najarian, J. S., Goetz, F. C., & Robertson, R. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003293221305 · Cited by 244 · see citing works

beta-cell turnover: its assessment and implications.

Bonner-Weir, S. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s20 · Cited by 230 · see citing works

Extra-insular beta cells associated with ductules are frequent in adult human pancreas

Bouwens, L., & PIPELEERS, D. G. (1998) · Diabetologia · doi:10.1007/s001250050960 · Cited by 229 · see citing works

Expansion and redifferentiation of adult human pancreatic islet cells

Ouziel-Yahalom, L., Zalzman, M., Anker-Kitai, L., Knoller, S., Bar, Y., Glandt, M., Herold, K. C., & Efrat, S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.187 · Cited by 200 · see citing works

Relationship Between β-Cell Mass and Fasting Blood Glucose Concentration in Humans

Ritzel, R. A., Butler, A. E., Rizza, R. A., Veldhuis, J. D., & Butler, P. C. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-1538 · Cited by 197 · see citing works

A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development

Bonner-Weir, S., Baxter, L. A., Schuppin, G. T., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.12.1715 · Cited by 195 · see citing works

Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes

Meier, J., Lin, J. C., Butler, A., Galasso, R., Martinez, D., & Butler, P. (2006) · Diabetologia · doi:10.1007/s00125-006-0308-2 · Cited by 192 · see citing works

Mechanisms of Compensatory β-Cell Growth in Insulin-Resistant Rats

Jetton, T. L., Lausier, J., LaRock, K., Trotman, W., Larmie, B. L., Habibovic, A., Peshavaria, M., & Leahy, J. L. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2294 · Cited by 171 · see citing works

Combination Therapy With Epidermal Growth Factor and Gastrin Increases β-Cell Mass and Reverses Hyperglycemia in Diabetic NOD Mice

Suarez‐Pinzon, W. L., Yan, Y., Power, R. F., Brand, S. J., & Rabinovitch, A. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2596 · Cited by 153 · see citing works

Effects of Autoimmunity and Immune Therapy on β-Cell Turnover in Type 1 Diabetes

Sherry, N., Kushner, J. A., Glandt, M., Kitamura, T., Brillantes, A.-M. B., & Herold, K. C. (2006) · Diabetes · doi:10.2337/db05-1034 · Cited by 153 · see citing works

Postprandial Suppression of Glucagon Secretion Depends on Intact Pulsatile Insulin Secretion

Meier, J. J., Kjems, L. L., Veldhuis, J. D., Lefèbvre, P., & Butler, P. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1449 · Cited by 144 · see citing works

Beta cell proliferation and growth factors

Nielsen, J. H., Svensson, C., Galsgaard, E. D., Møldrup, A., & Billestrup, N. (1999) · Journal of Molecular Medicine · doi:10.1007/s001090050302 · Cited by 135 · see citing works

Regulation of Pancreatic β-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse

Peshavaria, M., Larmie, B. L., Lausier, J., Satish, B., Habibovic, A., Roskens, V. A., LaRock, K., Everill, B., Leahy, J. L., & Jetton, T. L. (2006) · Diabetes · doi:10.2337/db06-0017 · Cited by 125 · see citing works

Decrease in β-Cell Mass Leads to Impaired Pulsatile Insulin Secretion, Reduced Postprandial Hepatic Insulin Clearance, and Relative Hyperglucagonemia in the Minipig

Kjems, L., Kirby, B. M., Welsh, E. M., Veldhuis, J. D., Straume, M., McIntyre, S. S., Yang, D., Lefèbvre, P., & Butler, P. C. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2001 · Cited by 110 · see citing works

IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication

Rhodes, C. J. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0240303 · Cited by 93 · see citing works

Cellular sources of new pancreatic β cells and therapeutic implications for regenerative medicine

Halban, P. A. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1021 · Cited by 88 · see citing works

Effects of Partial Surgical Pancreatectomy in Rats

Pearson, K., Scott, D. J., & Torrance, B. (1977) · Gastroenterology · doi:10.1016/s0016-5085(77)80258-8 · Cited by 84 · see citing works

Mechanisms of Impaired Fasting Glucose and Glucose Intolerance Induced by a ∼50% Pancreatectomy

Matveyenko, A. V., Veldhuis, J. D., & Butler, P. C. (2006) · Diabetes · doi:10.2337/db06-0345 · Cited by 76 · see citing works

Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes

Kl�ppel, G., Drenck, C. R., Oberholzer, M., & Heitz, P. U. (1984) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00737292 · Cited by 72 · see citing works

Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans

Meier, J. J., Butler, A. E., Galasso, R., RIZZA, R. A., & Butler, P. C. (2006) · Diabetologia · doi:10.1007/s00125-006-0410-5 · Cited by 71 · see citing works

Impaired β-cell regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of type II diabetes

Plachot, C., Movassat, J., & Portha, B. (2001) · Histochemistry and Cell Biology · doi:10.1007/s004180100302 · Cited by 53 · see citing works

Compensatory Adaption to Partial Pancreatectomy in the Rat*

Lee, H. C., Bonner‐Weir, S., Weir, G. C., & Leahy, J. L. (1989) · Endocrinology · doi:10.1210/endo-124-3-1571 · Cited by 53 · see citing works

Comment on: Meier JJ, Lin JC, Butler AE, Galasso R, Martinez DS, Butler PC (2006) Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 49:1838–1844

Zhao, H. (2006) · Diabetologia · doi:10.1007/s00125-006-0411-4 · Cited by 46 · see citing works

Guanylin in the human pancreas: a novel luminocrine regulatory pathway of electrolyte secretion via cGMP and CFTR in the ductal system

Kulaksiz, H., Schmid, A., Hönscheid, M., Eissele, R., Klempnauer, J. L., & Cetin, Y. (2001) · Histochemistry and Cell Biology · doi:10.1007/s004180000244 · Cited by 44 · see citing works

Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats

Jetton, T. L., Liu, Y. Q., Trotman, W., Sun, X., Leahy, J. L., & Nevin, P. W. (2001) · Diabetologia · doi:10.1007/s001250100011 · Cited by 42 · see citing works

The outcome in Australian children with hyperinsulinism of infancy: early extensive surgery in severe cases lowers risk of diabetes

Jack, M., Greer, R. M., Thomsett, M. J., Walker, R. M., BELL, J. R., Choong, C. S., Cowley, D. M., Herington, A. C., & Cotterill, A. M. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01725.x · Cited by 39 · see citing works

β-Cell function and islet morphology in normal, obese, and obese β-cell mass-reduced Göttingen minipigs

Larsen, M. O., Juhl, C. B., Pørksen, N. K., Gotfredsen, C. F., Carr, R. D., Ribel, U., Wilken, M., & Rolin, B. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00352.2004 · Cited by 39 · see citing works

Increase in B-cells in the pancreatic remnant after partial pancreatectomy in pigs

Löhr, M. J., Liibbersmeyer, J., Otremba, B. J., Klapdor, R., Grossner, D., & Klöppel, G. (1988) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02890027 · Cited by 30 · see citing works

Accommodation to a reduced islet cell mass in dogs

Marincola, F. M., Cobb, L. F., Horaguchi, A., Maeda, M., & Merrell, R. C. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.247.4.e456 · Cited by 11 · see citing works

The Discovery and Development of Liraglutide and Semaglutide

Knudsen, L. B., & Lau, J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00155 · Cited by 970 · see citing works

Diabetes Mellitus and the β Cell: The Last Ten Years

Ashcroft, F. M., & Rorsman, P. (2012) · Cell · doi:10.1016/j.cell.2012.02.010 · Cited by 902 · see citing works

Pancreatic β‐cell mass in European subjects with type 2 diabetes

Rahier, J., Guiot, Y., Goebbels, R. M., Sempoux, C., & Henquin, J. C. (2008) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00969.x · Cited by 756 · see citing works

Pancreas regeneration

Zhou, Q., & Melton, D. A. (2018) · Nature · doi:10.1038/s41586-018-0088-0 · Cited by 384 · see citing works

Structural similarities and differences between the human and the mouse pancreas

Dolenšek, J., Rupnik, M. S., & Stožer, A. (2015) · Islets · doi:10.1080/19382014.2015.1024405 · Cited by 342 · see citing works

Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice

Tschen, S.-I., Dhawan, S., Gurlo, T., & Bhushan, A. (2009) · Diabetes · doi:10.2337/db08-1651 · Cited by 331 · see citing works

Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age

Rankin, M. M., & Kushner, J. A. (2009) · Diabetes · doi:10.2337/db08-1198 · Cited by 327 · see citing works

The Cells of the Islets of Langerhans

Xavier, G. D. S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7030054 · Cited by 300 · see citing works

Islet β cell mass in diabetes and how it relates to function, birth, and death

Weir, G. C., & Bonner‐Weir, S. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12031 · Cited by 296 · see citing works

β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes

Saisho, Y. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i1.109 · Cited by 263 · see citing works

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

Kahn, S. E., Zraika, S., Utzschneider, K. M., & Hull, R. L. (2009) · Diabetologia · doi:10.1007/s00125-009-1321-z · Cited by 255 · see citing works

Role of Reduced β-Cell Mass Versus Impaired β-Cell Function in the Pathogenesis of Type 2 Diabetes

Meier, J. J., & Bonadonna, R. C. (2013) · Diabetes Care · doi:10.2337/dcs13-2008 · Cited by 242 · see citing works

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

Cnop, M., Hughes, S. J., Igoillo‐Esteve, M., Hoppa, M. B., Sayyed, F., van de Laar, L., Gunter, J. H., de Koning, E. J. P., Walls, G. V., Gray, D. W. G., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1562-x · Cited by 240 · see citing works

β-Cell Growth and Regeneration: Replication Is Only Part of the Story

Bonner‐Weir, S., Li, W., Ouziel-Yahalom, L., Guo, L., Weir, G. C., & Sharma, A. (2010) · Diabetes · doi:10.2337/db10-0084 · Cited by 233 · see citing works

The Pathophysiology of Hyperglycemia in Older Adults: Clinical Considerations

Lee, P., & Halter, J. B. (2017) · Diabetes Care · doi:10.2337/dc16-1732 · Cited by 211 · see citing works

Diabetes mellitus—advances and challenges in human β-cell proliferation

Wang, P., Fiaschi‐Taesch, N., Vasavada, R. C., Scott, D. K., Garcı́a-Ocaña, A., & Stewart, A. F. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.9 · Cited by 204 · see citing works

MafA and MafB activity in pancreatic β cells

Hang, Y., & Stein, R. W. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.05.003 · Cited by 204 · see citing works

Regeneration and Repair of the Exocrine Pancreas

Murtaugh, L. C., & Keefe, M. D. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071727 · Cited by 197 · see citing works

Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes

Weir, G. C., Gaglia, J. L., & Bonner‐Weir, S. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30022-x · Cited by 192 · see citing works

MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic β-Cells

Wang, Y., Liu, J., Liu, C., Naji, A., & Stoffers, D. A. (2012) · Diabetes · doi:10.2337/db12-0451 · Cited by 191 · see citing works

Current Advances and Travails in Islet Transplantation

Harlan, D. M., Kenyon, N. S., Korsgren, O., Roep, B. O., & for the Immunology of Diabetes Society (2009) · Diabetes · doi:10.2337/db09-0476 · Cited by 190 · see citing works

Stem cells versus plasticity in liver and pancreas regeneration

Kopp, J. L., Grompe, M., & Sander, M. (2016) · Nature Cell Biology · doi:10.1038/ncb3309 · Cited by 176 · see citing works

Functional Assessment of Pancreatic β-Cell Area in Humans

Meier, J. J., Menge, B. A., Breuer, T. G. K., Müller, C., Tannapfel, A., Uhl, W. H., Schmidt, W. E., & Schrader, H. (2009) · Diabetes · doi:10.2337/db08-1611 · Cited by 164 · see citing works

Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans

Meier, J. J., Breuer, T. G. K., Bonadonna, R. C., Tannapfel, A., Uhl, W. H., Schmidt, W. E., Schrader, H., & Menge, B. (2012) · Diabetologia · doi:10.1007/s00125-012-2466-8 · Cited by 144 · see citing works

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

Fiaschi‐Taesch, N., Salim, F. G., Kleinberger, J. W., Troxell, R., Cózar‐Castellano, I., Selk, K. L., Cherok, E., Takane, K. K., Scott, D. K., & Stewart, A. F. (2010) · Diabetes · doi:10.2337/db09-1776 · Cited by 135 · see citing works

You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes

Lai, M.-C., Chandrasekera, P. C., & Barnard, N. D. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.30 · Cited by 129 · see citing works

Pancreatogenic Diabetes after Pancreatic Resection

Maeda, H., & Hanazaki, K. (2011) · Pancreatology · doi:10.1159/000328785 · Cited by 127 · see citing works

Minireview: Update on Incretin Biology: Focus on Glucagon-Like Peptide-1

Brubaker, P. L. (2010) · Endocrinology · doi:10.1210/en.2010-0115 · Cited by 122 · see citing works

Predominance of β-Cell Neogenesis Rather Than Replication in Humans With an Impaired Glucose Tolerance and Newly Diagnosed Diabetes

Yoneda, S., Uno, S., Iwahashi, H., Fujita, Y., Yoshikawa, A., Kozawa, J., Okita, K., Takiuchi, D., Eguchi, H., Nagano, H., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3832 · Cited by 122 · see citing works

Endogenous Pancreatic β Cell Regeneration: A Potential Strategy for the Recovery of β Cell Deficiency in Diabetes

Zhong, F., & Jiang, Y. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00101 · Cited by 110 · see citing works

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD–severe combined immunodeficiency (SCID) mice

Levitt, H., Cyphert, T. J., Pascoe, J. L., Hollern, D. A., Abraham, N., Lundell, R. J., Rosa, T., Romano, L., Zou, B., O'Donnell, C. P., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1919-1 · Cited by 108 · see citing works

Reduced Pancreatic Volume and β-Cell Area in Patients With Chronic Pancreatitis

Schrader, H., Menge, B. A., Schneider, S., Belyaev, O., Tannapfel, A., Uhl, W. H., Schmidt, W. E., & Meier, J. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.083 · Cited by 108 · see citing works

Regenerative medicine and cell-based approaches to restore pancreatic function

Ellis, C. E., Ramzy, A., & Kieffer, T. J. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.93 · Cited by 90 · see citing works

β-cell development and turnover during prenatal life in humans

Meier, J. J., Köhler, C. U., Alkhatib, B., Sergi, C. M., Junker, T., Klein, H. H., Schmidt, W. E., & Fritsch, H. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-1053 · Cited by 90 · see citing works

β-Cell regeneration: the pancreatic intrinsic faculty

Desgraz, R., Bonal, C., & Herrera, P. L. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.09.004 · Cited by 89 · see citing works

Metabolic consequences of a 50% partial pancreatectomy in humans

Menge, B., Schrader, H., Breuer, T. G. K., Dabrowski, Y., Uhl, W. H., Schmidt, W. E., & Meier, J. J. (2008) · Diabetologia · doi:10.1007/s00125-008-1219-1 · Cited by 86 · see citing works

A Central Pancreatectomy for Benign or Low-Grade Malignant Neoplasms

Hirono, S., Tani, M., Kawai, M., Ina, S., 西岡, 亮., Miyazawa, M., Shimizu, A., Uchiyama, K., & Yamaue, H. (2009) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-009-0934-3 · Cited by 85 · see citing works

Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets

Stokes, R., Cheng, K., Deters, N. A., Lau, S. M., Hawthorne, W. J., O’Connell, P. J., Stolp, J., Grey, S. T., Loudovaris, T., Kay, T. W. H., et al. (2012) · Cell Transplantation · doi:10.3727/096368912x647180 · Cited by 72 · see citing works

Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas

Fiaschi‐Taesch, N., Kleinberger, J. W., Salim, F. G., Troxell, R., Wills, R. C., Tanwir, M., Casinelli, G. P., Cox, A. E., Takane, K. K., Scott, D. K., et al. (2013) · Diabetes · doi:10.2337/db12-0777 · Cited by 69 · see citing works

Assessment of Pancreatic Hardness—Surgeon versus Durometer

Belyaev, O., Herden, H., Meier, J. J., Müller, C., Seelig, M. H., Herzog, T., Tannapfel, A., Schmidt, W. E., & Uhl, W. H. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.08.022 · Cited by 66 · see citing works

An examination of β‐cell function measures and their potential use for estimating β‐cell mass

Kahn, S. E., Carr, D. B., Faulenbach, M. V., & Utzschneider, K. M. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00945.x · Cited by 59 · see citing works

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells

Chen, H., Kleinberger, J. W., Takane, K. K., Salim, F. G., Fiaschi‐Taesch, N., Pappas, K., Parsons, R. E., Jiang, J., Zhang, Y., Liu, H., et al. (2015) · Diabetes · doi:10.2337/db15-0083 · Cited by 58 · see citing works

Inventing Liraglutide, a Glucagon-Like Peptide-1 Analogue, for the Treatment of Diabetes and Obesity

Knudsen, L. B. (2019) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00048 · Cited by 56 · see citing works

Histopathology of Type 1 Diabetes: Old Paradigms and New Insights

Coppieters, K. T., & von Herrath, M. G. (2009) · The Review of Diabetic Studies · doi:10.1900/rds.2009.6.85 · Cited by 55 · see citing works

Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and β-cell mass to age-related insulin resistance in rats

Matveyenko, A. V., Veldhuis, J. D., & Butler, P. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90451.2008 · Cited by 54 · see citing works

Regulation of beta cell replication

Lee, Y. C., & Nielsen, J. H. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.08.033 · Cited by 53 · see citing works

cMyc Is a Principal Upstream Driver of β-Cell Proliferation in Rat Insulinoma Cell Lines and Is an Effective Mediator of Human β-Cell Replication

French, E. K., Kleinberger, J. W., Salim, F. G., Cox, A. E., Takane, K. K., Scott, D. K., & Stewart, A. F. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1074 · Cited by 53 · see citing works

FTY720 Normalizes Hyperglycemia by Stimulating β-Cell in Vivo Regeneration in db/db Mice through Regulation of Cyclin D3 and p57KIP2

Zhao, Z., Choi, J.-W., Zhao, C., & Ma, Z. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.305359 · Cited by 51 · see citing works

Dynamic pathology of islet endocrine cells in type 2 diabetes: β‐Cell growth, death, regeneration and their clinical implications

Yagihashi, S., Inaba, W., & Mizukami, H. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12424 · Cited by 50 · see citing works

Distinctions Between the Islets of Mice and Men: Implications for New Therapies for Type 1 and 2 Diabetes

Levetan, C. S., & Pierce, S. M. (2012) · Endocrine Practice · doi:10.4158/ep12138.ra · Cited by 50 · see citing works

Stress‐induced adaptive islet cell identity changes

Cigliola, V., Thorel, F., Chera, S., & Herrera, P. L. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12726 · Cited by 49 · see citing works

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells

Sullivan, B. A., Hollister‐Lock, J., Bonner‐Weir, S., & Weir, G. C. (2014) · Diabetes · doi:10.2337/db14-1675 · Cited by 47 · see citing works

Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass

Spears, E., Serafimidis, I., Powers, A. C., & Gavalas, A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.722250 · Cited by 46 · see citing works

Organoids from the Human Fetal and Adult Pancreas

Balak, J. R. A., Juksar, J., Carlotti, F., Nigro, A. L., & de Koning, E. J. P. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1261-z · Cited by 46 · see citing works

Overview of the Gliptin Class (Dipeptidyl Peptidase-4 Inhibitors) in Clinical Practice

Bohannon, N. J. V. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.01.1953 · Cited by 45 · see citing works

Determinants of glucose control in patients with chronic pancreatitis

Schrader, H., Menge, B., Zeidler, C., Ritter, P. R., Tannapfel, A., Uhl, W. H., Schmidt, W. E., & Meier, J. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1705-0 · Cited by 45 · see citing works

Adult Pancreatic Alpha-Cells: A New Source of Cells for Beta-Cell Regeneration

Chung, C.-H., & Levine, F. (2010) · The Review of Diabetic Studies · doi:10.1900/rds.2010.7.124 · Cited by 45 · see citing works

Diabetes associated with pancreatic diseases

Meier, J. J., & Giese, A. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000199 · Cited by 44 · see citing works

The regulation of pre- and post-maturational plasticity of mammalian islet cell mass

Mezza, T., & Kulkarni, R. (2014) · Diabetologia · doi:10.1007/s00125-014-3251-7 · Cited by 44 · see citing works

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

Saisho, Y., Manesso, E., Butler, A. E., Galasso, R., Kavanagh, K., Flynn, M., Zhang, L., Clark, P. B., Gurlo, T., TOFFOLO, G. M., et al. (2011) · Diabetes · doi:10.2337/db09-1368 · Cited by 41 · see citing works

Aging induces a distinct gene expression program in mouse islets

Rankin, M. M., & Kushner, J. A. (2010) · Islets · doi:10.4161/isl.2.6.13376 · Cited by 39 · see citing works

Pancreatic β-Cell Development and RegenerationPreprint

Kerper, N. R., Ashe, S., & Hebrok, M. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040741 · Cited by 38 · see citing works

Agenesis of the dorsal pancreas: systematic review of a clinical challenge

Cienfuegos, J. A., Rotellar, F., Salguero, J., Benito, A., Solórzano, J. L., & Sangro, B. (2016) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2016.4474/2016 · Cited by 36 · see citing works

Diminished glucagon suppression after β-cell reduction is due to impaired α-cell function rather than an expansion of α-cell mass

Meier, J. J., Ueberberg, S., Korbas, S., & Schneider, S. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2010 · Cited by 35 · see citing works

Sry-box (Sox) transcription factors in gastrointestinal physiology and disease

Gracz, A. D., & Magness, S. T. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00489.2010 · Cited by 34 · see citing works

Regeneration of pancreatic beta-cell mass for the treatment of diabetes

Domínguez‐Bendala, J., Inverardi, L., & Ricordi, C. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.679654 · Cited by 33 · see citing works

Patients get more long-term benefit from central pancreatectomy than distal resection: A meta-analysis

Xu, S. B., Zhu, Y., Zhou, W., Xie, K., & Mou, Y. P. (2013) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2013.02.003 · Cited by 33 · see citing works

Short- and long-term outcomes of laparoscopic organ-sparing resection in pancreatic neuroendocrine tumors: a single-center experience

Cienfuegos, J. A., Salguero, J., Núñez-Córdoba, J. M., Ruiz‐Canela, M., Benito, A., Ocaña, S., Zozaya, G., Martí‐Cruchaga, P., Pardo, F., Hernández-Lizoáin, J. L., et al. (2017) · Surgical Endoscopy · doi:10.1007/s00464-016-5411-y · Cited by 33 · see citing works

Exendin-4 Improves Blood Glucose Control in Both Young and Aging Normal Non-Diabetic Mice, Possible Contribution of Beta Cell Independent Effects

Fan, R., Kang, Z., He, L., Chan, J. C. N., & Xu, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020443 · Cited by 31 · see citing works

Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage

Cox, A. R., Lam, C. J., Rankin, M. M., King, K. B., Chen, P., Martinez, R., Li, C., & Kushner, J. A. (2016) · Diabetologia · doi:10.1007/s00125-016-3922-7 · Cited by 31 · see citing works

β-Cell Proliferation After a Partial Pancreatectomy Is Independent of IRS-2 in Mice

Togashi, Y., Shirakawa, J., Orime, K., Kaji, M., Sakamoto, E., Tajima, K., Inoue, H., Nakamura, A., Tochino, Y., Goshima, Y., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1796 · Cited by 27 · see citing works

Birth and Death of Human β-Cells in Pancreases from Cadaver Donors, Autopsies, Surgical Specimens, and Islets Transplanted into Mice

Caballero, F., Siniakowicz, K., Hollister‐Lock, J., Duran, L., Katsuta, H., Yamada, T., Lei, J., Deng, S., Westermark, G. T., Markmann, J. F., et al. (2013) · Cell Transplantation · doi:10.3727/096368912x659916 · Cited by 27 · see citing works

Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion

Tiwari, S., Roel, C., Wills, R. C., Casinelli, G. P., Tanwir, M., Takane, K. K., & Fiaschi‐Taesch, N. (2015) · Diabetes · doi:10.2337/db14-1885 · Cited by 27 · see citing works

Mouse Pancreas Stem/Progenitor Cells Get Augmented by Streptozotocin and Regenerate Diabetic Pancreas After Partial Pancreatectomy

Mohammad, S. A., Metkari, S., & Bhartiya, D. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09919-x · Cited by 27 · see citing works

Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition

Streckel, E., Braun-Reichhart, C., Herbach, N., Dahlhoff, M., Keßler, B., Blutke, A., Bähr, A., Übel, N., Eddicks, M., Ritzmann, M., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0431-2 · Cited by 25 · see citing works

Adult human β‐cell neogenesis?

Demeterco, C., Hao, E., Lee, S., Itkin-Ansari, P., & Levine, F. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01105.x · Cited by 25 · see citing works

Regulated and Reversible Induction of Adult Human β-Cell Replication

Takane, K. K., Kleinberger, J. W., Salim, F. G., Fiaschi‐Taesch, N., & Stewart, A. F. (2011) · Diabetes · doi:10.2337/db11-0580 · Cited by 25 · see citing works

Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells

Lee, S., Hao, E., Levine, F., & Itkin‐Ansari, P. (2011) · Islets · doi:10.4161/isl.3.6.17923 · Cited by 24 · see citing works

Local In Vivo GSK3β Knockdown Promotes Pancreatic β Cell and Acinar Cell Regeneration in 90% Pancreatectomized Rat

Figeac, F., Ilias, A., Bailbé, D., Portha, B., & Movassat, J. (2012) · Molecular Therapy · doi:10.1038/mt.2012.112 · Cited by 23 · see citing works

Long-term recovery of β-cell function after partial pancreatectomy in humans

Menge, B. A., Breuer, T. G. K., Ritter, P. R., Uhl, W. H., Schmidt, W. E., & Meier, J. J. (2011) · Metabolism · doi:10.1016/j.metabol.2011.09.019 · Cited by 23 · see citing works

Pancreatic β cell regeneration: to β or not to β

Guney, M. A., Lorberbaum, D. S., & Sussel, L. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.10.019 · Cited by 23 · see citing works

Role of the Mammalian Target of Rapamycin (mTOR) Complexes in Pancreatic β-Cell Mass Regulation

Bartolomé, A., & Guillén, C. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800174-5.00017-x · Cited by 22 · see citing works

Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system

Rigal, S., Casas, B., Kanebratt, K. P., Huldt, C. W., Magnusson, L. U., Müllers, E., Karlsson, F. H., Clausen, M., Hansson, S., Leonard, L., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06514-w · Cited by 21 · see citing works

β-cell replication and islet neogenesis following partial pancreatectomy

Lee, S. H., Hao, E., & Levine, F. (2011) · Islets · doi:10.4161/isl.3.4.16338 · Cited by 21 · see citing works

Potencial role of stem cell therapy in type 1 diabetes mellitus

Couri, C. E. B., & Voltarelli, J. C. (2008) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302008000200029 · Cited by 21 · see citing works

Validation of different replication markers for the detection of beta-cell proliferation in human pancreatic tissue

Köhler, C. U., Kreuter, A., Rozynkowski, M., Rahmel, T., Uhl, W. H., Tannapfel, A., Schmidt, W. E., & Meier, J. J. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2009.12.021 · Cited by 21 · see citing works

Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area

Campbell‐Thompson, M., Dixon, L. R., Wasserfall, C. H., Monroe, M., McGuigan, J., Schatz, D., Crawford, J. M., & Atkinson, M. A. (2008) · Diabetologia · doi:10.1007/s00125-008-1200-z · Cited by 21 · see citing works

Novel therapeutics and targets for the treatment of diabetes

Aicher, T. D., Boyd, S. A., McVean, M., & Celeste, A. J. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.1 · Cited by 21 · see citing works

Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area

Xue, S., Wasserfall, C. H., Parker, M., McGrail, S., MCGRAIL, K. M., Campbell‐Thompson, M., Schatz, D., Atkinson, M. A., & Haller, M. J. (2009) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2008.12.004 · Cited by 20 · see citing works

β-Cell dedifferentiation, reduced duct cell plasticity, and impaired β-cell mass regeneration in middle-aged rats

Téllez, N., Vilaseca, M., Martí, Y., Pla, A., & Montanya, E. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00502.2015 · Cited by 20 · see citing works

An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes

Soldovieri, L., Giuseppe, G. D., Ciccarelli, G., Quero, G., Cinti, F., Brunetti, M., Nista, E. C., Gasbarrini, A., Alfieri, S., Pontecorvi, A., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101754 · Cited by 19 · see citing works

Blood Glucose Homeostasis in the Course of Partial Pancreatectomy – Evidence for Surgically Reversible Diabetes Induced by Cholestasis

Ehehalt, F., Sturm, D., Rösler, M., Distler, M., Weitz, J., Kersting, S., Ludwig, B., Schwanebeck, U., Saeger, H., Solimena, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134140 · Cited by 19 · see citing works

Delayed improvement of insulin secretion after autologous islet transplantation in partially pancreatectomized patients

Jung, H. S., Choi, S., Kim, S. J., Choi, D.-W., Heo, J., Lee, K. T., Lee, J. K., Jang, K., Lee, B., Jee, J.-H., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.05.015 · Cited by 19 · see citing works

Betatrophin—Promises Fading and Lessons Learned

Kaestner, K. H. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.016 · Cited by 18 · see citing works

Betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans

Espes, D., Martinell, M., Liljebäck, H., & Carlsson, P. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0676-4 · Cited by 18 · see citing works

Enhancement of β-Cell Regeneration by Islet Transplantation After Partial Pancreatectomy in Mice

Jung, H. S., Ahn, Y., Oh, S.-H., Kim, Y. S., No, H., Lee, M., & Kim, K.-W. (2009) · Transplantation · doi:10.1097/tp.0b013e3181b07a02 · Cited by 17 · see citing works

Sitagliptin plus pantoprazole can restore but not maintain insulin independence after clinical islet transplantation: results of a pilot study

Senior, P. A., Koh, A., Yau, J., Imes, S., Dinyari, P., Malcolm, A. J., Light, P. E., & Shapiro, A. M. J. (2016) · Diabetic Medicine · doi:10.1111/dme.13131 · Cited by 16 · see citing works

Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation

Shcheglova, E. G., Błaszczyk, K., & Borowiak, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.734597 · Cited by 16 · see citing works

Human Fucci Pancreatic Beta Cell Lines: New Tools to Study Beta Cell Cycle and Terminal Differentiation

Carlier, G., Maugein, A., Cordier, C., Pechberty, S., Garfa‐Traoré, M., Martin, P., Scharfmann, R., & Albagli, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108202 · Cited by 15 · see citing works

β-Cell Generation: Can Rodent Studies Be Translated to Humans?

Carlotti, F., Zaldumbide, A., Ellenbroek, J. H., Spijker, H. S., Hoeben, R. C., & de Koning, E. J. P. (2011) · Journal of Transplantation · doi:10.1155/2011/892453 · Cited by 15 · see citing works

1448-P: Partial Pancreatectomy Increased α-Cell Volume Density, but Not Compensated ß-Cell Volume in Japanese Subjects

Takeuchi, Y., Mizukami, H., Osonoi, S., Kudoh, K., SASAKI, T., & Yagihashi, S. (2022) · Diabetes · doi:10.2337/db22-1448-p

Impaired β-cell regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of type II diabetes

Plachot, C., Movassat, J., & Portha, B. (2001) · Histochemistry and Cell Biology · doi:10.1007/s004180100302 · Cited by 53 · see citing works

Pancreatic Regeneration After Partial Pancreatectomy in Rodents

Li, W., Chen, C., Chien, H.-Y., & Bonner‐Weir, S. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-45307-1_5 · Cited by 3 · see citing works

The impact of ligation of the pancreatic duct or partial pancreatectomy on islets regeneration

Cha, L. (2009) · International Journal of Internal Medicine

β-cell replication and islet neogenesis following partial pancreatectomy

Lee, S. H., Hao, E., & Levine, F. (2011) · Islets · doi:10.4161/isl.3.4.16338 · Cited by 21 · see citing works