Short leukocyte telomere length predicts risk of diabetes in American Indians: the strong heart family study
Open accessAbstract
Telomeres play a central role in cellular aging, and shorter telomere length has been associated with age-related disorders including diabetes. However, a causal link between telomere shortening and diabetes risk has not been established. In a well-characterized longitudinal cohort of American Indians participating in the Strong Heart Family Study, we examined whether leukocyte telomere length (LTL) at baseline predicts incident diabetes independent of known diabetes risk factors. Among 2,328 participants free of diabetes at baseline, 292 subjects developed diabetes during an average 5.5 years of follow-up. Compared with subjects in the highest quartile (longest) of LTL, those in the lowest quartile (shortest) had an almost twofold increased risk of incident diabetes (hazard ratio [HR] 1.83 [95% CI 1.26-2.66]), whereas the risk for those in the second (HR 0.87 [95% CI 0.59-1.29]) and the third (HR 0.95 [95% CI 0.65-1.38]) quartiles was statistically nonsignificant. These findings suggest a nonlinear association between LTL and incident diabetes and indicate that LTL could serve as a predictive marker for diabetes development in American Indians, who suffer from disproportionately high rates of diabetes.
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In several studies, baseline LTL predicted the subsequent development of cancers, cardiovascular disease, diabetes or mortality.
“In several studies, not only did baseline LTL correlate with medical illnesses cross-sectionally but predicted the subsequent development of cancers, CVD, diabetes or mortality (Cawthon et al., 2003; Willeit et al 2010; Zhao et al., 2014).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Zhao et al., 2014
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- Authors
- Zhao, J., Zhu, Y., Lin, J., Matsuguchi, T., Blackburn, E., Zhang, Y., Cole, S. A., Best, L. G., Lee, E. T., & Howard, B. V.
- Affiliations
- Tulane University (US)
- University of California, San Francisco (US)
- University of Oklahoma Health Sciences Center (US)
- Texas Biomedical Research Institute (US)
- Missouri Breaks Industries Research (United States) (US)
- MedStar Health Research Institute (US)
- Corresponding author
- Zhao, Jinying
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2013-12-13
- Volume
- 63
- Issue
- 1
- Pages
- 354-362
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC3868043
- OpenAlex
- W2146855172
- Cited by
- 161
- References
- 48
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 13 · 2021: 14 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 21 · 2016: 19 · 2015: 13 · 2014: 15 · 2013: 1
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (K01AG034259)
- National Heart, Lung, and Blood Institute (U01HL041652, U01HL041654, U01 HL-41642, U01HL065520, R21HL092363, U01HL 41652, U01HL065521, U01 HL-65521, R01HL109301, U01 HL-65520, U01HL41654, U01HL041642)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK091369)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- leukocyte telomere length, telomere shortening, diabetes risk, new-onset diabetes, Native Americans, Strong Heart Family Study, cellular aging, predictive biomarkers, nonlinear relationship, diabetes epidemiology
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Female, Humans, Indians, North American, Leukocytes, Male, Middle Aged, Risk, Incidence, Cellular Senescence, Telomere Shortening
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