Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and women
Open accessAbstract
Poor sleep quality and short sleep duration are associated with increased incidence and progression of a number of chronic health conditions observed at greater frequency among the obese and those experiencing high levels of stress. Accelerated cellular aging, as indexed by telomere attrition in immune cells, is a plausible pathway linking sleep and disease risk. Prior studies linking sleep and telomere length are mixed. One factor may be reliance on leukocytes, which are composed of varied immune cell types, as the sole measure of telomere length. To better clarify these associations, we investigated the relationships of global sleep quality, measured by the Pittsburgh Sleep Quality Index (PSQI), and diary-reported sleep duration with telomere length in different immune cell subsets, including granulocytes, peripheral blood mononuclear cells (PBMCs), CD8+ and CD4+ T lymphocytes, and B lymphocytes in a sample of 87 obese men and women (BMI mean=35.4, SD=3.6; 81.6% women; 62.8% Caucasian). Multiple linear regression analyses were performed adjusting for age, gender, race, education, BMI, sleep apnea risk, and perceived stress. Poorer PSQI global sleep quality was associated with statistically significantly shorter telomere length in lymphocytes but not granulocytes and in particular CD8+ T cells (b=-56.8 base pairs per one point increase in PSQI, SE=20.4, p=0.007) and CD4+ T cells (b=-37.2, SE=15.9, p=0.022). Among separate aspects of global sleep quality, low perceived sleep quality and decrements in daytime function were most related to shorter telomeres. In addition, perceived stress moderated the sleep-CD8+ telomere association. Poorer global sleep quality predicted shorter telomere length in CD8+ T cells among those with high perceived stress but not in low stress participants. These findings provide preliminary evidence that poorer global sleep quality is related to telomere length in several immune cell types, which may serve as a pathway linking sleep and disease risk in obese individuals.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Shorter leukocyte telomere length has been linked with markers of sleep disturbances (PSQI) in a sample of 245 healthy midlife women and of 87 obese adults, with the latter study reporting a link with telomere length of CD8 and CD4 T cells in particular.
“shorter leukocyte telomere length, a proposed marker of cellular senescence, has been linked with markers of sleep disturbances (assessed by the PSQI) in a sample of 245 healthy midlife women (451) and of 87 obese adults (446), with the latter study reporting a link with telomere length of CD8 and CD4 T cells in particular”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [446]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234 · see citing works
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807 · see citing works
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596 · see citing works
Self-citationTelomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,492 · see citing works
Ohayon, M. M., Carskadon, M. A., Guilleminault, C., & Vitiello, M. V. (2004) · Sleep · doi:10.1093/sleep/27.7.1255 · Cited by 3,349 · see citing works
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002 · see citing works
Self-citationUsing the Berlin Questionnaire To Identify Patients at Risk for the Sleep Apnea Syndrome
Netzer, N. C., Stoohs, R. A., Netzer, C. M., Clark, K., & Strohl, K. P. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-7-199910050-00002 · Cited by 2,973 · see citing works
Sleep Health: Can We Define It? Does It Matter?
Buysse, D. J. (2014) · SLEEP · doi:10.5665/sleep.3298 · Cited by 2,607 · see citing works
Hayes, A. F., & Matthes, J. (2009) · Behavior Research Methods · doi:10.3758/brm.41.3.924 · Cited by 2,452 · see citing works
Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies
Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010) · Sleep · doi:10.1093/sleep/33.5.585 · Cited by 2,224 · see citing works
Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults
Cappuccio, F. P., Taggart, F. M., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., & Miller, M. A. (2008) · Sleep · doi:10.1093/sleep/31.5.619 · Cited by 2,076 · see citing works
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,012 · see citing works
Quantity and Quality of Sleep and Incidence of Type 2 Diabetes
Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010) · Diabetes Care · doi:10.2337/dc09-1124 · Cited by 1,670 · see citing works
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · see citing works
The human emotional brain without sleep—a prefrontal amygdala disconnect
Yoo, S.-S., Gujar, N., Hu, P., Jolesz, F. A., & Walker, M. P. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.007 · Cited by 1,303 · cited 2× · see citing works
“, 2012) and leads to enhanced amygdala activation, a brain region critical to processing emotion and regulating stress physiology, in response to threatening stimuli (Yoo et al., 2007).”
Identification of seven loci affecting mean telomere length and their association with disease
CARDIoGRAM consortium, Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2528 · Cited by 933 · see citing works
A prospective study of self-reported sleep duration and incident diabetes in women
Ayas, N. T., White, D. P., Al-Delaimy, W. K., Manson, J. E., Stampfer, M. J., Speizer, F. E., Patel, S., & Hu, F. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.380 · Cited by 883 · see citing works
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
Haycock, P. C., Heydon, E. E., Kaptoge, S., Butterworth, A. S., Thompson, A., & Willeit, P. (2014) · BMJ · doi:10.1136/bmj.g4227 · Cited by 856 · see citing works
Telomeres and telomerase: Their mechanisms of action and the effects of altering their functions
Blackburn, E. H. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.11.036 · Cited by 838 · see citing works
Self-citationImpact of insufficient sleep on total daily energy expenditure, food intake, and weight gain
Markwald, R. R., Melanson, E. L., Smith, M. R., Higgins, J., Perreault, L., Eckel, R. H., & Wright, K. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216951110 · Cited by 810 · see citing works
Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773 · see citing works
Sleep Duration as a Risk Factor for Diabetes Incidence in a Large US Sample
Gangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., & Malaspina, D. (2007) · Sleep · doi:10.1093/sleep/30.12.1667 · Cited by 573 · see citing works
Sick and tired: does sleep have a vital role in the immune system?
Bryant, P. A., Trinder, J., & Curtis, N. (2004) · Nature Reviews Immunology · doi:10.1038/nri1369 · Cited by 551 · see citing works
Beccuti, G., & Pannain, S. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3283479109 · Cited by 507 · see citing works
Cell aging in relation to stress arousal and cardiovascular disease risk factors
Epel, E. S., Lin, J., Wilhelm, F. H., Wolkowitz, O. M., Cawthon, R., Adler, N. E., Dolbier, C., Mendes, W. B., & Blackburn, E. H. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.08.011 · Cited by 450 · see citing works
Self-citationSelf-Reported Sleep Duration is Associated with the Metabolic Syndrome in Midlife Adults
Hall, M. H., Muldoon, M. F., Jennings, J. R., Buysse, D. J., Flory, J. D., & Manuck, S. B. (2008) · Sleep · doi:10.1093/sleep/31.5.635 · Cited by 447 · see citing works
Lin, J., Epel, E., Cheon, J., Kroenke, C., Sinclair, E., Bigos, M., Wolkowitz, O., Mellon, S., & Blackburn, E. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.09.012 · Cited by 426 · see citing works
Self-citationWikby, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00212-1 · Cited by 414 · see citing works
Stress and telomere biology: a lifespan perspective
Shalev, I., Entringer, S., Wadhwa, P. D., Wolkowitz, O. M., Puterman, E., Lin, J., & Epel, E. S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.010 · Cited by 400 · see citing works
Self-citationMinkel, J. D., Banks, S., Htaik, O., Moreta, M. C., Jones, C. W., McGlinchey, E. L., Simpson, N. S., & Dinges, D. F. (2012) · Emotion · doi:10.1037/a0026871 · Cited by 379 · see citing works
Validation of a 3-Factor Scoring Model for the Pittsburgh Sleep Quality Index in Older Adults
Cole, J. C., Motivala, S. J., Buysse, D. J., Oxman, M. N., Levin, M. J., & Irwin, M. R. (2006) · SLEEP · doi:10.1093/sleep/29.1.112 · Cited by 377 · see citing works
Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · cited 2× · see citing works
“An increased proportion of CD8+CD28 T cells predicts poorer antibody response (Effros et al., 1994), increased susceptibility to the common cold (Cohen et al., 2013), and early mortality in elderly adults (Wikby et al., 2002).”
Obesity, Inflammation, and Insulin Resistance – A Mini-Review
Zeyda, M., & Stulnig, T. M. (2009) · Gerontology · doi:10.1159/000212758 · Cited by 364 · see citing works
Reduced telomerase activity in human T lymphocytes exposed to cortisol
Choi, J., Fauce, S. R., & Effros, R. B. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.004 · Cited by 352 · see citing works
Self-reported sleep quality is associated with the metabolic syndrome
Jennings, J. R., Muldoon, M. F., Hall, M., Buysse, D. J., & Manuck, S. B. (2007) · Sleep · doi:10.1093/sleep/30.2.219 · Cited by 344 · see citing works
Immunosenescence: what does it mean to health outcomes in older adults?
McElhaney, J. E., & Effros, R. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.023 · Cited by 340 · see citing works
Sleep disturbance is associated with cardiovascular and metabolic disorders
Grandner, M. A., JACKSON, N. J., Pak, V. M., & Gehrman, P. (2011) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2011.00990.x · Cited by 338 · see citing works
O’Donovan, A., Pantell, M. S., Puterman, E. M., Dhabhar, F. S., Blackburn, E. H., Yaffe, K. S., Cawthon, R., Opresko, P. L., Hsueh, W.-C., Satterfield, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019687 · Cited by 338 · see citing works
Self-citationThe role of CD8<sup>+</sup> T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336 · see citing works
T Cell Replicative Senescence in Human Aging
P. Chou, J., & B. Effros, R. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219711 · Cited by 323 · see citing works
Epel, E. S., Merkin, S. S., Cawthon, R., Blackburn, E. H., Adler, N. E., Pletcher, M. J., & Seeman, T. E. (2008) · Aging · doi:10.18632/aging.100007 · Cited by 315 · see citing works
Self-citationGrandner, M. A., Chakravorty, S., Perlis, M. L., Oliver, L., & Gurubhagavatula, I. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2013.09.012 · Cited by 300 · cited 1× · see citing works
“…conditions observed at greater prevalence among overweight and obese individuals, including type 2 diabetes, coronary heart disease, and metabolic syndrome (Ayas et al., 2003; Cappuccio et al., 2010a; Gangwisch et al., 2007; Grandner et al., 2012, 2014; Hall et al., 2008; Jennings et al., 2007).”
Sleep disturbances are correlated with decreased morning awakening salivary cortisol
Backhaus, J., Junghanns, K., & Hohagen, F. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.01.010 · Cited by 287 · see citing works
Verhoeven, J. E., Révész, D., Epel, E. S., Lin, J., Wolkowitz, O. M., & Penninx, B. W. J. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.151 · Cited by 270 · see citing works
Self-citationNocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects
Irwin, M., Clark, C., Kennedy, B., Christian Gillin, J., & Ziegler, M. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00031-x · Cited by 268 · see citing works
Jennings, J. R., Kamarck, T. W., Everson-Rose, S. A., Kaplan, G. A., Manuck, S. B., & Salonen, J. T. (2004) · Circulation · doi:10.1161/01.cir.0000143840.77061.e9 · Cited by 229 · see citing works
Sleep deprivation alters pupillary reactivity to emotional stimuli in healthy young adults
Franzen, P. L., Buysse, D. J., Dahl, R. E., Thompson, W. K., & Siegle, G. J. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.10.010 · Cited by 226 · see citing works
Starkweather, A. R., Alhaeeri, A. A., Montpetit, A. J., Brumelle, J., Filler, K., Montpetit, M., Mohanraj, L., Lyon, D., & Jackson‐Cook, C. K. (2013) · Nursing Research · doi:10.1097/nnr.0000000000000009 · Cited by 217 · see citing works
Does cellular aging relate to patterns of allostasis?
Tomiyama, A. J., O’Donovan, A., Lin, J., Puterman, E. M., Lazaro, A., Chan, J. L., Dhabhar, F. S., Wolkowitz, O. M., Kirschbaum, C., Blackburn, E. H., et al. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.11.016 · Cited by 206 · see citing works
Self-citationPosnett, D. N., Edinger, J. W., Manavalan, J. S., Irwin, C., & Marodon, G. (1999) · International Immunology · doi:10.1093/intimm/11.2.229 · Cited by 202 · see citing works
Body mass index and leukocyte telomere length in adults: a systematic review and meta‐analysis
Müezzinler, A., Zaineddin, A. K., & Brenner, H. (2013) · Obesity Reviews · doi:10.1111/obr.12126 · Cited by 179 · see citing works
Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study
Zee, R. Y. L., Castonguay, A. J., Barton, N. S., Germer, S., & Martin, M. (2009) · Translational research · doi:10.1016/j.trsl.2009.09.012 · Cited by 169 · see citing works
Stress, immune reactivity and susceptibility to infectious disease
Marsland, A. L., Bachen, E. A., Cohen, S., Rabin, B. S., & Manuck, S. B. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00923-x · Cited by 166 · see citing works
Zhao, J., Zhu, Y., Lin, J., Matsuguchi, T., Blackburn, E., Zhang, Y., Cole, S. A., Best, L. G., Lee, E. T., & Howard, B. V. (2014) · Diabetes · doi:10.2337/db13-0744 · Cited by 161 · see citing works
Self-citationPuterman, E., Lin, J., Krauss, J., Blackburn, E. H., & Epel, E. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.70 · Cited by 150 · see citing works
Self-citationCohen, S., Janicki‐Deverts, D., Turner, R. B., Casselbrant, M. L., Li‐Korotky, H., Epel, E. S., & Doyle, W. J. (2013) · JAMA · doi:10.1001/jama.2013.613 · Cited by 148 · see citing works
Self-citationJackowska, M., Hamer, M., Carvalho, L. A., Erusalimsky, J. D., Butcher, L., & Steptoe, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047292 · Cited by 127 · see citing works
T Cell Replicative Senescence in Human Aging
Chou, J. P., & Effros, R. B. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319090016 · Cited by 118 · see citing works
Dysregulated physiological stress systems and accelerated cellular aging
Révész, D., Verhoeven, J. E., Milaneschi, Y., de Geus, E. J. C., Wolkowitz, O. M., & Penninx, B. W. J. H. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.027 · Cited by 112 · see citing works
Puterman, E., & Epel, E. (2012) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2012.00465.x · Cited by 106 · see citing works
Self-citationShort Telomeres Compromise β-Cell Signaling and Survival
Guo, N., Parry, E. M., Li, L.-S., Kembou, F., Lauder, N., Hussain, M. A., Berggren, P.-O., & Armanios, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017858 · Cited by 100 · see citing works
Shorter Leukocyte Telomere Length in Midlife Women with Poor Sleep Quality
Prather, A. A., Puterman, E., Lin, J., O'Donovan, A., Krauss, J., Tomiyama, A. J., Epel, E. S., & Blackburn, E. H. (2011) · Journal of Aging Research · doi:10.4061/2011/721390 · Cited by 100 · see citing works
Self-citationAssociations between Rotating Night Shifts, Sleep Duration, and Telomere Length in Women
Liang, G., Schernhammer, E. S., Qi, L., Gao, X., Vivo, I. D., & Han, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023462 · Cited by 99 · see citing works
Cribbet, M. R., Carlisle, M., Cawthon, R. M., Uchino, B. N., Williams, P. G., Smith, T. W., Gunn, H. E., & Light, K. C. (2014) · Sleep · doi:10.5665/sleep.3308 · Cited by 93 · see citing works
Kleemeier Award Lecture 2008 – the canary in the coal mine: telomeres and human healthspan
Effros, R. B. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp001 · Cited by 58 · see citing works
Prather, A. A., Puterman, E. M., Epel, E. S., & Dhabhar, F. S. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.09.010 · Cited by 54 · see citing works
Self-citationSleep inflammation and cardiovascular disease
Meier-Ewert, H. K. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e560 · Cited by 43 · see citing works
Lee, K. A., Gay, C., Humphreys, J. C., Portillo, C. J., Pullinger, C. R., & Aouizerat, B. E. (2014) · SLEEP · doi:10.5665/sleep.3328 · Cited by 39 · see citing works
Savolainen, K., Eriksson, J. G., Kajantie, E., Lahti‐Pulkkinen, M., & Räikkönen, K. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.11.779 · Cited by 36 · see citing works
Obesity and Immunosenescence: Psychological, Behavioral and Biochemical Pathways
Prather, A. A., Aschbacher, K., Lustig, R. H., & Epel, E. S. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4776-4_11 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
Stress and telomere shortening: Insights from cellular mechanisms
Lin, J., & Epel, E. S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101507 · Cited by 398 · see citing works
Self-citationLindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.007 · Cited by 285 · see citing works
Self-citationMathur, M. B., Epel, E., Kind, S., Desai, M., Parks, C. G., Sandler, D. P., & Khazeni, N. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.02.002 · Cited by 252 · see citing works
Self-citationThe fetal programming of telomere biology hypothesis: an update
Entringer, S., de Punder, K., Buß, C., & Wadhwa, P. D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0151 · Cited by 189 · see citing works
Carroll, J. E., Irwin, M. R., Levine, M., Seeman, T. E., Absher, D., Assimes, T., & Horvath, S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.07.008 · Cited by 173 · see citing works
Stress, telomeres, and psychopathology: toward a deeper understanding of a triad of early aging
Epel, E. S., & Prather, A. A. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045054 · Cited by 153 · see citing works
Self-citationPsychosocial stressors and telomere length: A current review of the science
Rentscher, K. E., Carroll, J. E., & Mitchell, C. (2020) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040119-094239 · Cited by 138 · see citing works
Carroll, J. E., Cole, S. W., Seeman, T. E., Breen, E. C., Witarama, T., Arevalo, J. M. G., Ma, J., & Irwin, M. R. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.08.024 · Cited by 129 · see citing works
Bachmann, M. C., Bellalta, S., Basoalto, R., Gómez‐Valenzuela, F., Jalil, Y., Lépez, M., Matamoros, A., & Rommy von Bernhardi, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.570083 · Cited by 96 · see citing works
Psychoneuroimmunology—developments in stress research
Straub, R. H., & Cutolo, M. (2017) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-017-0574-2 · Cited by 94 · see citing works
Sleep and biological aging: A short review
Carroll, J., & Prather, A. A. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.021 · Cited by 93 · see citing works
Self-citationInsomnia and Telomere Length in Older Adults
Carroll, J. E., Esquivel, S., Goldberg, A., Seeman, T. E., Effros, R. B., Dock, J., Olmstead, R., Breen, E. C., & Irwin, M. R. (2016) · Sleep · doi:10.5665/sleep.5526 · Cited by 85 · see citing works
Carroll, J., Bower, J. E., & Ganz, P. A. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00580-3 · Cited by 79 · see citing works
Sleep characteristics of U.S. adults before and during the COVID-19 pandemic
Hisler, G. C., & Twenge, J. M. (2021) · Social Science & Medicine · doi:10.1016/j.socscimed.2021.113849 · Cited by 68 · see citing works
Barragán, R., Ortega‐Azorín, C., Sorlí, J. V., Asensio, E. M., Coltell, Ó., St‐Onge, M., Portolés, O., & Corella, D. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010076 · Cited by 63 · see citing works
Baseline biopsychosocial determinants of telomere length and 6-year attrition rate
Révész, D., Milaneschi, Y., Terpstra, E. M., & Penninx, B. W. J. H. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.007 · Cited by 63 · see citing works
Sleep, Sleep Disorders, and Immune Function
Tan, H., Gozal, D., & Gozal, D. (2019) · Springer eBooks · doi:10.1007/978-3-030-14738-9_1 · Cited by 61 · see citing works
Sleep Duration and Telomere Length in Children
James, S., McLanahan, S., Jeanne Brooks-gunn, B., Mitchell, C. M., Schneper, L. M., Wagner, B., & Notterman, D. A. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.05.014 · Cited by 51 · see citing works
Carroll, J., Irwin, M. R., Seeman, T. E., Roux, A. V. D., Prather, A. A., Olmstead, R., Epel, E. S., Lin, J., & Redline, S. S. (2019) · SLEEP · doi:10.1093/sleep/zsz089 · Cited by 49 · see citing works
Self-citationPostpartum sleep loss and accelerated epigenetic aging
Carroll, J., Ross, K. M., Horvath, S., Okun, M. L., Hobel, C. J., Rentscher, K. E., Coussons‐Read, M. E., & Schetter, C. D. (2021) · Sleep Health · doi:10.1016/j.sleh.2021.02.002 · Cited by 49 · see citing works
Stress and Alzheimer’s disease: A senescence link?
Lyons, C. E., & Bartolomucci, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.010 · Cited by 47 · see citing works
Delayed sleep-onset and biological age: late sleep-onset is associated with shorter telomere length
Wynchank, D., Bijlenga, D., Penninx, B. W. J. H., Lamers, F., Beekman, A. T. F., Kooij, J. J. S., & Verhoeven, J. E. (2019) · SLEEP · doi:10.1093/sleep/zsz139 · Cited by 41 · see citing works
Mason, A. E., Hecht, F. M., Daubenmier, J. J., Sbarra, D. A., Lin, J., Moran, P. J., Schleicher, S., Acree, M. C., Prather, A. A., & Epel, E. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000616 · Cited by 38 · see citing works
Self-citationStress and immunological aging
Reed, R. G. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.012 · Cited by 36 · see citing works
The complex associations between obstructive sleep apnea and auto-immune disorders: A review
Vakil, M., Park, S., & Broder, A. R. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.12.004 · Cited by 34 · see citing works
Alan, S., Vurgeç, B. A., Çevik, A., Gözüyeşil, E., & Sürücü, Ş. G. (2020) · Yonago acta medica · doi:10.33160/yam.2020.11.016 · Cited by 33 · see citing works
Yip, T., Feng, Y., Fowle, J., & Fisher, C. B. (2021) · Sleep Health · doi:10.1016/j.sleh.2021.05.008 · Cited by 34 · see citing works
Stress and sleep remain significant predictors of health after controlling for negative affect
Benham, G., & Charak, R. (2019) · Stress and Health · doi:10.1002/smi.2840 · Cited by 31 · see citing works
A Cross-Sectional Analysis of Telomere Length and Sleep in the Women’s Health Initiative
Grieshober, L., Wactawski‐Wende, J., Blair, R. H., Mu, L., Liu, J., Nie, J., Carty, C. L., Hale, L. E., Kroenke, C. H., LaCroix, A. Z., et al. (2019) · American Journal of Epidemiology · doi:10.1093/aje/kwz134 · Cited by 27 · see citing works
Lin, C.-C., Wang, H., Liaw, S., Chiu, C., & Lin, M.-W. (2018) · Clinical Oral Investigations · doi:10.1007/s00784-018-2560-5 · Cited by 28 · see citing works
Prather, A. A. (2019) · Sleep and Health · doi:10.1016/b978-0-12-815373-4.00024-1 · Cited by 27 · see citing works
Self-citationTowards Understanding the Design of Positive Pre-sleep Through a Neurofeedback Artistic Experience
Semertzidis, N. A., Sargeant, B., Dwyer, J. L., Mueller, F., & Zambetta, F. (2019) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3290605.3300804 · Cited by 28 · see citing works
Awuah, W. A., Huang, H. Y. R., Kalmanovich, J. B., Mehta, A., Mikhailova, T., Ng, J. C., Abdul‐Rahman, T., Adebusoye, F. T., Tan, J. K., Kamanousa, K., et al. (2023) · Medicine · doi:10.1097/md.0000000000034614 · Cited by 27 · see citing works
Leukocyte telomere length and hippocampus volume: a meta-analysis
Nilsonne, G., Tamm, S., Månsson, K. N. T., Åkerstedt, T., & Lekander, M. (2015) · F1000Research · doi:10.12688/f1000research.7198.1 · Cited by 23 · see citing works
Manoliu, A., Bosch, O. G., Brakowski, J., Brühl, A. B., & Seifritz, E. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.022 · Cited by 25 · see citing works
Aroke, E. N., Wiggins, A. M., Hobson, J. M., Srinivasasainagendra, V., Quinn, T. L., Kottae, P., Tiwari, H. K., Sorge, R. E., & Goodin, B. R. (2023) · Molecular Pain · doi:10.1177/17448069231210648 · Cited by 22 · see citing works
Association between sleep parameters and longitudinal shortening of telomere length
Jin, J.-H., Kwon, H. S., Choi, S. H., Koh, S., Lee, E.-H., Jeong, J. H., Jang, J., Park, K. W., Kim, E., Kim, H. J., et al. (2022) · Aging · doi:10.18632/aging.203993 · Cited by 21 · see citing works
Xie, H., Yin, J., Bai, Y., Peng, H., Zhou, X., & Bai, J. (2018) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-018-5219-6 · Cited by 20 · see citing works
Sleep, Disturbances of Sleep, Stress and Obesity: A Narrative Review
Marks, R., & Landaira, M. (2016) · Journal of Obesity & Eating Disorders · doi:10.21767/2471-8203.100006 · Cited by 21 · see citing works
The association between sleep quality and telomere length: A systematic literature review
Sabot, D., Lovegrove, R. A., & Stapleton, P. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100577 · Cited by 21 · see citing works
Riestra, P., Gebreab, S. Y., Xu, R., Khan, R., Quarels, R., Gibbons, G. H., & Davis, S. (2017) · Sleep And Breathing · doi:10.1007/s11325-016-1451-8 · Cited by 19 · see citing works
Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity
Ford, B. N., & Savitz, J. B. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00288-7 · Cited by 17 · see citing works
Christian, L. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.010 · Cited by 18 · see citing works
Sexual intimacy in couples is associated with longer telomere length
de Baca, T. C., Epel, E. S., Robles, T. F., Coccia, M., Gilbert, A., Puterman, E. M., & Prather, A. A. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.03.022 · Cited by 18 · see citing works
Self-citationCarrot-based fermentation juice rich in sleep-promoting components improved sleep in mice
Liu, D., Zhang, J., Chen, J., Zhang, C., Yi, H., & Liu, D. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1043055 · Cited by 16 · see citing works
Ding, Y., Lin, H., Zhou, S., Wang, K., Li, L., Zhang, Y., Yao, Y., Gao, M., Liu, X., & He, N. (2018) · Aging and Disease · doi:10.14336/ad.2018.0204 · Cited by 16 · see citing works
Carroll, J., Olmstead, R. E., Cole, S. W., Breen, E. C., Arevalo, J. M. G., & Irwin, M. R. (2023) · GeroScience · doi:10.1007/s11357-023-00741-5 · Cited by 13 · see citing works
Bhatt, S. P., Guleria, R., & Vikram, N. K. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.682739 · Cited by 11 · see citing works
Effect of Psychosocial Factors on Eating Behaviors and BMI Among African American Women
Pickett, S., & McCoy, T. P. (2017) · Clinical Nursing Research · doi:10.1177/1054773817713420 · Cited by 11 · see citing works
Khan, R., Gebreab, S. Y., Crespo, P. R., Xu, R., Gaye, A., & Davis, S. (2017) · Quality of Life Research · doi:10.1007/s11136-017-1610-9 · Cited by 11 · see citing works
Fostitsch, A. J., Schwarzer, G., Buchgeister, M., Surbeck, W., Lahmann, C., Spiegelhalder, K., Frase, L., & Spieler, D. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102073 · Cited by 10 · see citing works
Sleep deprivation and aging are metabolically linked across tissues
Sengupta, A., Tudor, J. C., Cusmano, D. M., Baur, J. A., Abel, T. G., & Weljie, A. M. (2023) · SLEEP · doi:10.1093/sleep/zsad246 · Cited by 9 · see citing works
Petermann-Rocha, F. E., Valera‐Gran, D., Fernández-Pires, P., Martens, D. S., Júlvez, J., Rodríguez-Dehli, C., Andiarena, A., Lozano, M., Fernández‐Somoano, A., Lertxundi, A., et al. (2022) · Pediatric Research · doi:10.1038/s41390-022-02255-w · Cited by 9 · see citing works
Nguyen, M. T., Lycett, K., Olds, T., Matricciani, L., Vryer, R., Ranganathan, S., Burgner, D. P., Saffery, R., & Wake, M. A. (2019) · SLEEP · doi:10.1093/sleep/zsz200 · Cited by 9 · see citing works
Qiu, H., Shi, M., Zhong, Z., Hu, H., Sang, H., Zhou, M., & Feng, Z. (2024) · Biomedicines · doi:10.3390/biomedicines12081874 · Cited by 6 · see citing works
Liu, Q., Song, L., Fan, G., Wu, M., Bi, J., Xu, L., Xiong, C., Xia, W., Cao, Z., Xu, S., et al. (2023) · Sleep Health · doi:10.1016/j.sleh.2023.03.001 · Cited by 6 · see citing works
Chang, T. H. C., Hicks, J. B., Izadi, Z., Marwaha, A. S., Allen, A. J. M. H., Hajipour, M., Conklin, A., & Ayas, N. (2026) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2026.102255 · Cited by 5 · see citing works
Kim, A. Y., & Kim, N. (2022) · Journal of Korean Biological Nursing Science · doi:10.7586/jkbns.2022.24.4.235 · Cited by 4 · see citing works
Güzeldere, H. K. B., Aksoy, M., Demircan, T., Yavuz, M., & BELER, M. (2023) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14620 · Cited by 5 · see citing works
Coppola, A. M., Mehl, M. R., Tackman, A. M., Dawson, S. C., O’Hara, K. L., & Sbarra, D. A. (2022) · Journal of Social and Personal Relationships · doi:10.1177/02654075221135855 · Cited by 4 · see citing works
Alharbi, A. S., Altwaim, S. A., Alharbi, A. S., & Alsulami, S. (2023) · Cureus · doi:10.7759/cureus.33211 · Cited by 4 · see citing works
Factors related to telomere length
Prather, A. A., Hecht, F. M., & Epel, E. S. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.12.001 · Cited by 4 · see citing works
Self-citationPrather, A. A., Gao, Y., Betancourt, L., Kordahl, R. C., Sriram, A., Huang, C., Hays, S. R., Kukreja, J., Calabrese, D. R., Venado, A. E., et al. (2024) · JHLT Open · doi:10.1016/j.jhlto.2024.100170 · Cited by 3 · see citing works
Self-citationTelomere length in sleep disorders
Eşel, G., Eker, Ö. O., Amraliyev, A., Asdemir, A., Biçer, E. Ö., Mermer, D. B., Dündar, M., Eşel, E., & İsmailoğulları, S. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112851 · Cited by 2 · see citing works
Is Depression Associated With Accelerated Aging? Mechanisms and Implications
Lindqvist, D., Simon, N. M., & Wolkowitz, O. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00019-6 · Cited by 2 · see citing works
Modern understanding of the consequences of lack of sleep
Gavrilov, Y. V. (2022) · Medical academic journal · doi:10.17816/maj81192 · Cited by 2 · see citing works
Taşdemir, S., & Öz, O. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.12.002 · Cited by 2 · see citing works
Buntinx, Y., Hendrix, J., Wyns, A., Campenhout, J. V., Xiong, H.-Y., Laeremans, T., Cuesta‐Sancho, S., Aerts, J. L., Nijs, J., & Polli, A. (2025) · Biomolecules · doi:10.3390/biom15111601 · Cited by 1 · see citing works
Khanal, M. K., Karimi, L., Saunders, P., Cavaggion, J., Nguyen, K., & de Courten, B. V. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113255 · Cited by 2 · see citing works
Marvisi, M. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.08.1472 · Cited by 1 · see citing works
Restoring Homeostasis as a Promising Therapeutic Strategy for Obesity and Sleep DisordersPreprint
Kumar, V., Ghosh, S., Mishra, P. K., Aziz, A., Mehta, R., & Sinha, J. K. (2023) · Preprints.org · doi:10.20944/preprints202305.1615.v1 · Cited by 1 · see citing works
Telomeres And Early Life Stress: A Review
Singh, T. B., Niranjan Hebbar, Y. R., Majumder, U., & Dash, A. K. (2017) · IOSR Journal of Dental and Medical Sciences · doi:10.9790/0853-1601120912
The effect of neuroeducational methods on telomere length dynamics
Serapinas, D., Serapinienė, A., Šimaitytė, P., Daugirdaitė, I., Valantinas, A., & Leliugiene, M. M. (2020) · Medical Studies · doi:10.5114/ms.2020.96784
Obesity-Mediated Alterations in Immune Function, Host Defense, and Lung Disease
Reichenbach, A., Guerrero, S. C., & Rastogi, D. (2024) · Respiratory medicine · doi:10.1007/978-3-031-52696-1_2
Prather, A. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13954-3.00042-5
Self-citationLi, J., Ding, S., Zhang, X., Tang, L., & Jiang, W. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02170-1
Lancaster, A. J., Blackburn, B. E., Loughmiller, S. K., Archibeck, M. J., Gililland, J. M., & Anderson, L. A. (2026) · SICOT-J · doi:10.1051/sicotj/2026029
- Authors
- Prather, A. A., Gurfein, B., Moran, P., Daubenmier, J., Acree, M., Bacchetti, P., Sinclair, E., Lin, J., Blackburn, E., Hecht, F. M., & Epel, E. S.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Prather, Aric A.
- Epel, Elissa S.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 47
- Pages
- 155-162
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC4468027
- OpenAlex
- W2027992900
- Cited by
- 79
- References
- 72
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 7 · 2015: 4
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH/NHLBI (K08HL112961)
- NIH/NCCAM (P01AT005013, K24 AT007827)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep quality, telomere length, obesity, perceived stress, CD8+ T cells, CD4+ T cells, B cells, granulocytes, peripheral blood mononuclear cells, cellular aging, Pittsburgh Sleep Quality Index, sleep duration
- MeSH terms
- Adult, Female, Humans, Leukocytes, Male, Middle Aged, Obesity, Sleep, Stress, Psychological, Telomere, Telomere Shortening
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
