Cited by 107Cardiovascular and exercise physiologyMetabolism, Diabetes, and CancerExercise and Physiological Responses

The DOI matches its Crossref record; 56 of the 59 references it cites were found in a registry or an index.

Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining

Open access

Prior, Steven J., Goldberg, Andrew P., Ortmeyer, Heidi K., Chin, Eva R., Chen, Dapeng, Blumenthal, Jacob B., Ryan, Alice S.·2015·Diabetes

DOI 10.2337/db14-1771PMC PMC4587640

Open this paper in CoChat — free account Open PDF

Abstract

Intramuscular signaling and glucose transport mechanisms contribute to improvements in insulin sensitivity after aerobic exercise training. This study tested the hypothesis that increases in skeletal muscle capillary density (CD) also contribute to exercise-induced improvements in whole-body insulin sensitivity (insulin-stimulated glucose uptake per unit plasma insulin [M/I]) independent of other mechanisms. The study design included a 6-month aerobic exercise training period followed by a 2-week detraining period to eliminate short-term effects of exercise on intramuscular signaling and glucose transport. Before and after exercise training and detraining, 12 previously sedentary older (65 ± 3 years) men and women underwent research tests, including hyperinsulinemic-euglycemic clamps and vastus lateralis biopsies. Exercise training increased Vo2max (2.2 ± 0.2 vs. 2.5 ± 0.2 L/min), CD (313 ± 13 vs. 349 ± 18 capillaries/mm2), and M/I (0.041 ± 0.005 vs. 0.051 ± 0.007 μmol/kg fat-free mass/min) (P < 0.05 for all). Exercise training also increased the insulin activation of glycogen synthase by 60%, GLUT4 expression by 16%, and 5′ AMPK-α1 expression by 21%, but these reverted to baseline levels after detraining. Conversely, CD and M/I remained 15% and 18% higher after detraining, respectively (P < 0.05), and the changes in M/I (detraining minus baseline) correlated directly with changes in CD in regression analysis (partial r = 0.70; P = 0.02). These results suggest that an increase in CD is one mechanism contributing to sustained improvements in glucose metabolism after aerobic exercise training.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2337/db14-1771

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Delayed Transcapillary Delivery of Insulin to Muscle Interstitial Fluid After Oral Glucose Load in Obese Subjects
Sjöstrand, M., Guðbjörnsdóttir, S., Strindberg, L., & Lönnroth, P. (2005) · Diabetes · doi:10.2337/diabetes.54.1.152 · Cited by 34
Retracted
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · cited 1×
“Interventions including aerobic exercise (AEX) training and weight loss reduce insulin and glucose responses to glucose tolerance tests (9,10), increase insulin-stimulated glucose uptake (11–13), and reduce progression to type 2 diabetes among people with insulin resistance (14,15).”
Background
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Untitled work
(1957) · PubMed · Cited by 1,778
Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man
Lillioja, S., Young, A. A., Culter, C. L., Ivy, J. L., Abbott, W. G., Zawadzki, J. K., Yki-Järvinen, H., Christin, L., Secomb, T. W., & Bogardus, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113088 · Cited by 782
Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women
Coggan, A. R., Spina, R. J., King, D. S., Rogers, M. A., Brown, M., Nemeth, P. M., & Holloszy, J. O. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.5.1780 · Cited by 457
Histochemical and enzymatic comparison of the gastrocnemius muscle of young and elderly men and women
Coggan, A. R., Spina, R. J., King, D. S., Rogers, M. A., Rogers, M. A., Brown, M., Nemeth, P. M., & Holloszy, J. O. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.3.b71 · Cited by 456
Four grams of glucose
Wasserman, D. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90563.2008 · Cited by 384
Time course of loss of adaptations after stopping prolonged intense endurance training
Coyle, E. F., Martin, W. H., Sinacore, D. R., Joyner, M. J., Hagberg, J. M., & Holloszy, J. O. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.57.6.1857 · Cited by 364

Flagged first, then by citations

Show all 59 references

3 of the 59 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Andres, 1966, Manual feedback technique for the control of blood glucose concentration, 489

Sorted by citations

Update on the effects of physical activity on insulin sensitivity in humans
Bird, S. R., & Hawley, J. A. (2017) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2016-000143 · Cited by 646
Exercise Promotes Healthy Aging of Skeletal Muscle
Cartee, G. D., Hepple, R. T., Bamman, M. M., & Zierath, J. R. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.007 · Cited by 483
Microvascular Dysfunction and Hyperglycemia: A Vicious Cycle With Widespread Consequences
Stehouwer, C. D. A. (2018) · Diabetes · doi:10.2337/dbi17-0044 · Cited by 317
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Saxton, S. N., Clark, B., Withers, S., Eringa, E. C., & Heagerty, A. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00034.2018 · Cited by 290
Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults
Ryan, B. J., Schleh, M. W., Ahn, C., Ludzki, A. C., Gillen, J. B., Varshney, P., Pelt, D. W. V., Pitchford, L. M., Chenevert, T. L., Gioscia‐Ryan, R. A., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa345 · Cited by 228
Vascular senescence in cardiovascular and metabolic diseases
Katsuumi, G., Shimizu, I., Yoshida, Y., & Minamino, T. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00018 · Cited by 196
Sarcopenia Is Associated With Lower Skeletal Muscle Capillarization and Exercise Capacity in Older Adults
Prior, S. J., Ryan, A. S., Blumenthal, J. B., Watson, J. M., Katzel, L. I., & Goldberg, A. P. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw017 · Cited by 146
Self-citation
The role of the microcirculation in muscle function and plasticity
Hendrickse, P. W., & Degens, H. (2019) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-019-09520-2 · Cited by 137
Where frailty meets diabetes
Perkisas, S., & Vandewoude, M. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2743 · Cited by 120
Impact of Endurance and Resistance Training on Skeletal Muscle Glucose Metabolism in Older Adults
Consitt, L. A., Dudley, C., & Saxena, G. (2019) · Nutrients · doi:10.3390/nu11112636 · Cited by 128
Interactions between insulin and exercise
Richter, E. A., Sylow, L., & Hargreaves, M. (2021) · Biochemical Journal · doi:10.1042/bcj20210185 · Cited by 99
Molecular mechanisms by which aerobic exercise induces insulin sensitivity
Yaribeygi, H., Atkin, S. L., Simental‐Mendía, L. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28066 · Cited by 108
Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021) · Journal of Diabetes Research · doi:10.1155/2021/7796727 · Cited by 91
Recent Progress in Space Physiology and Aging
Strollo, F., Gentile, S., Strollo, G., Mambro, A., & Vernikos, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01551 · Cited by 85
The Urgent Need for Recommending Physical Activity for the Management of Diabetes During and Beyond COVID-19 Outbreak
Marçal, I. R., Fernandes, B., Viana, A. A., & Ciolac, E. G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.584642 · Cited by 75
Influence of different modes of exercise training on inflammatory markers in older adults with and without chronic diseases: A systematic review and meta-analysis
Khalafi, M., Akbari, A., Symonds, M. E., Pourvaghar, M. J., Rosenkranz, S. K., & Tabari, E. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156303 · Cited by 69
The Microvasculature and Skeletal Muscle Health in Aging
Landers‐Ramos, R. Q., & Prior, S. J. (2018) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000151 · Cited by 72
Self-citation
Multifaceted Interweaving Between Extracellular Matrix, Insulin Resistance, and Skeletal Muscle
Ahmad, K., Lee, E. J., Moon, J. S., Park, S., & Choi, I. (2018) · Cells · doi:10.3390/cells7100148 · Cited by 65
Skeletal Muscle Microvascular-Linked Improvements in Glycemic Control From Resistance Training in Individuals With Type 2 Diabetes
Russell, R., Hu, D., Greenaway, T. M., Blackwood, S. J., Dwyer, R. M., Sharman, J. E., Jones, G., Squibb, K. A., Brown, A. A., Otáhal, P., et al. (2017) · Diabetes Care · doi:10.2337/dc16-2750 · Cited by 64
Female Mice Have Higher Angiogenesis in Perigonadal Adipose Tissue Than Males in Response to High-Fat Diet
Rudnicki, M., Abdifarkosh, G., Rezvan, O., Nwadozi, E., Roudier, E. A., & Haas, T. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01452 · Cited by 68
Prolonged exercise training improves the acute type II muscle fibre satellite cell response in healthy older men
Snijders, T., Nederveen, J. P., Bell, K. E., Lau, S. W., Mazara, N., Kumbhare, D. A., Phillips, S. M., & Parise, G. (2018) · The Journal of Physiology · doi:10.1113/jp276260 · Cited by 66
Aerobic Exercise Improves Microvascular Function in Older Adults
HURLEY, D. M., Williams, E. R., CROSS, J. M., RIEDINGER, B. R., Meyer, R. A., Abela, G. S., & Slade, J. M. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001854 · Cited by 53
Metabolic Regulation of Angiogenesis in Diabetes and Aging
Sawada, N., & Arany, Z. P. (2017) · Physiology · doi:10.1152/physiol.00039.2016 · Cited by 55
Leptin is a physiological regulator of skeletal muscle angiogenesis and is locally produced by PDGFRα and PDGFRβ expressing perivascular cells
Nwadozi, E., Ng, A. S., Strömberg, A., Liu, H.-Y., Olsson, K., Gustafsson, T. P., & Haas, T. L. (2018) · Angiogenesis · doi:10.1007/s10456-018-9641-6 · Cited by 52
Effects of Exercise Training in Hypoxia Versus Normoxia on Vascular Health
Montero, D., & Lundby, C. (2016) · Sports Medicine · doi:10.1007/s40279-016-0570-5 · Cited by 47
Effects of Exercise Training Intensity and Duration on Skeletal Muscle Capillarization in Healthy Subjects: A Meta-analysis
Liu, Y., Christensen, P. M., Hellsten, Y., & Gliemann, L. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002955 · Cited by 45
The Effect of Exercise on Glucoregulatory Hormones: A Countermeasure to Human Aging: Insights from a Comprehensive Review of the Literature
Sellami, M., Bragazzi, N. L., Slimani, M., Hayes, L. D., Jabbour, G., Giorgio, A. D., & Dugué, B. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16101709 · Cited by 50
The Impact of Training on the Loss of Cardiorespiratory Fitness in Aging Masters Endurance Athletes
Burtscher, J., Strasser, B., Burtscher, M., & Millet, G. P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191711050 · Cited by 54
Exercising for Insulin Sensitivity – Is There a Mechanistic Relationship With Quantitative Changes in Skeletal Muscle Mass?
Paquin, J., Lagacé, J., Brochu, M., & Dionne, I. J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.656909 · Cited by 49
The acute vs. chronic effect of exercise on insulin sensitivity: nothing lasts forever
DiMenna, F. J., & Arad, A. D. (2020) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000239 · Cited by 46
An accumulation of muscle macrophages is accompanied by altered insulin sensitivity after reduced activity and recovery
Reidy, P. T., Yonemura, N. M., Madsen, J. H., McKenzie, A. I., Mahmassani, Z. S., Rondina, M. T., Lin, Y. K., Kaput, K. L., & Drummond, M. J. (2019) · Acta Physiologica · doi:10.1111/apha.13251 · Cited by 35
Resistance training preserves high-intensity interval training induced improvements in skeletal muscle capillarization of healthy old men: a randomized controlled trial
Leuchtmann, A. B., Mueller, S. M., Aguayo, D., Petersen, J. A., Ligon‐Auer, M., Flück, M., Jung, H. H., & Toigo, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-63490-x · Cited by 37
Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high‐fat diet
Nwadozi, E., Roudier, E. A., Rullman, E., Tharmalingam, S., Liu, H., Gustafsson, T. P., & Haas, T. L. (2016) · The FASEB Journal · doi:10.1096/fj.201600245r · Cited by 32
Capillary rarefaction: a missing link in renal and cardiovascular disease?
Steegh, F., Keijbeck, A. A., de Hoogt, P. A., Rademakers, T., Houben, A. J. H. M., Reesink, K. D., Stehouwer, C. D. A., Daemen, M. J. A. P., & Peutz‐Kootstra, C. J. (2023) · Angiogenesis · doi:10.1007/s10456-023-09883-8 · Cited by 28
Angiogenic potential is reduced in skeletal muscle of aged women
Nørregaard, L. B., Høier, B., Hansen, C. C., Leinum, M., Carter, H. H., Jørgensen, T. S., Bangsbo, J., & Hellsten, Y. (2020) · The Journal of Physiology · doi:10.1113/jp280189 · Cited by 28
Years of endurance exercise training remodel abdominal subcutaneous adipose tissue in adults with overweight or obesity
Ahn, C., Zhang, T., Yang, G., Rode, T., Varshney, P., Ghayur, S., Chugh, O. K., Jiang, H., & Horowitz, J. F. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01103-x · Cited by 30
Capillary Endothelial Insulin Transport: The Rate-limiting Step for Insulin-stimulated Glucose Uptake
Williams, I. M., & Wasserman, D. H. (2021) · Endocrinology · doi:10.1210/endocr/bqab252 · Cited by 27
Physical Activity Is Associated With Glucose Tolerance Independent of Microvascular Function: The Maastricht Study
Montero, D., Houben, A. J. H. M., Koster, A., Muris, D. M. J., Schram, M. T., Gronenschild, E. H. B. M., Sep, S. J. S., Henry, R. M. A., Kallen, C., Schaper, N. C., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1526 · Cited by 26
Aging-like metabolic and adrenal changes in microgravity: State of the art in preparation for Mars
Strollo, F., & Vernikos-Danellis, J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.028 · Cited by 24
Exercise and Vascular Insulin Sensitivity in the Skeletal Muscle and Brain
Olver, T. D., Laughlin, M. H., & Padilla, J. (2019) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000182 · Cited by 23
Mechanistic Causes of Reduced Cardiorespiratory Fitness in Type 2 Diabetes
Abushamat, L. A., McClatchey, P. M., Scalzo, R. L., Schauer, I. E., Huebschmann, A. G., Nadeau, K. J., Liu, Z., Regensteiner, J. G., & Reusch, J. E. B. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa063 · Cited by 23
Age Reduces Microvascular Function in the Leg Independent of Physical Activity
Tonson, A., NOBLE, K. E., Meyer, R. A., Rozman, M., Foley, K. T., & Slade, J. M. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001281 · Cited by 20
Changes in microvascular density differentiate metabolic health outcomes in monkeys with prior radiation exposure and subsequent skeletal muscle ECM remodeling
Fanning, K. M., Pfisterer, B. R., Davis, A., Presley, T. D., Williams, I. M., Wasserman, D. H., Cline, J. M., & Kavanagh, K. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00108.2017 · Cited by 19
Long-term Effects of Moderate versus High Durations of Aerobic Exercise on Biomarkers of Breast Cancer Risk: Follow-up to a Randomized Controlled Trial
Friedenreich, C. M., Wang, Q., Yasui, Y., Stanczyk, F. Z., Duha, A., Brenner, D. R., & Courneya, K. S. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0523 · Cited by 17
Increased capillary density in skeletal muscle is not associated with impaired insulin sensitivity induced by bed rest in healthy young men
Montero, D., Oberholzer, L., Haider, T., Andersen, A. B., Dandanell, S., Meinild‐Lundby, A., Maconochie, H., & Lundby, C. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0195 · Cited by 19
High-Intensity Interval Training as Redox Medicine: Targeting Oxidative Stress and Antioxidant Adaptations in Cardiometabolic Disease Cohorts
Reljic, D. (2025) · Antioxidants · doi:10.3390/antiox14080937 · Cited by 23
Muscle-Specific Sensitivity to Voluntary Physical Activity and Detraining
Hyatt, J. K., Brown, E., Deacon, H. M., & McCall, G. E. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01328 · Cited by 17
Physical activity and sedentary behavior show distinct associations with tissue‐specific insulin sensitivity in adults with overweight
Wanders, L., Gijbels, A., Bakker, E. A., Trouwborst, I., Jardon, K. M. C., Manusama, K., Hul, G. B. J., Feskens, E. J. M., Afman, L. A., Blaak, E. E., et al. (2023) · Acta Physiologica · doi:10.1111/apha.13945 · Cited by 16
3D analysis of capillary network in skeletal muscle of obese insulin-resistant mice
Umek, N., Horvat, S., Cvetko, E., Kreft, M., Janáček, J., Kubínová, L., Pintarič, T. S., & Eržen, I. (2019) · Histochemistry and Cell Biology · doi:10.1007/s00418-019-01810-7 · Cited by 15
Exercise and Cardiovascular Progenitor Cells
Landers‐Ramos, R. Q., Sapp, R. M., Shill, D. D., Hagberg, J. M., & Prior, S. J. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180030 · Cited by 16
Self-citation
Exercise protects vascular function by countering senescent cells in older adults
Meng, J., Geng, Q., Jin, S., Teng, X., Xiao, L., Wu, Y., & Tian, D. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1138162 · Cited by 17
Twenty-Four week Taichi training improves pulmonary diffusion capacity and glycemic control in patients with Type 2 diabetes mellitus
Liu, X., Zhu, H., Peng, Y., Liu, Y., & Shi, X. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299495 · Cited by 16
Effect of exercise training on insulin-stimulated glucose disposal: A systematic review and meta-analysis of randomized controlled trials
Rebello, C. J., Zhang, D., Kirwan, J. P., Lowe, A. C., Emerson, C. J., Kracht, C. L., Steib, L. C., Greenway, F. L., Johnson, W. D., & Brown, J. C. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01283-8 · Cited by 16
Endothelial function following glucose ingestion in adults with prediabetes: Role of exercise intensity
Malin, S. K., Rynders, C. A., Weltman, J. Y., Roberts, L. J., Barrett, E. J., & WELTMAN, A. L. (2016) · Obesity · doi:10.1002/oby.21522 · Cited by 15
Pathways in Skeletal Muscle: Protein Signaling and Insulin Sensitivity after Exercise Training and Weight Loss Interventions in Middle-Aged and Older Adults
Ryan, A. S., Li, G., McMillin, S. L., Prior, S. J., Blumenthal, J. B., & Mastella, L. (2021) · Cells · doi:10.3390/cells10123490 · Cited by 13
Self-citation
Bone Mineral Density and Body Composition are Associated with Circulating Angiogenic Factors in Post-menopausal Women
Spangenberg, A., Maghsoodi, N., Dulnoan, D., Moore, A. E. B., Edwards, S. F., Frost, M. L., & Hampson, G. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0186-7 · Cited by 13
Lifestyle modification in the management of insulin resistance states in overweight/obesity: the role of exercise training
Thaane, T., Motala, A. A., & McKune, A. J. (2019) · Journal of Endocrinology Metabolism and Diabetes of South Africa · doi:10.1080/16089677.2019.1608054 · Cited by 15
Mitochondria, glycogen, and lipid droplets in skeletal muscle during testosterone treatment and strength training: a randomized, double‐blinded, placebo‐controlled trial
Jensen, R. C., Christensen, L. L., Nielsen, J., Schrøder, H. D., Kvorning, T., Gejl, K. D., Højlund, K., Glintborg, D., & Andersen, M. (2018) · Andrology · doi:10.1111/andr.12492 · Cited by 13
EXERCÍCIO FÍSICO COMO TRATAMENTO NÃO FARMACOLÓGICO PARA A MELHORA DA SAÚDE PÓS-MENOPAUSA
Diniz, T. A., Rossi, F. E., Buonani, C., Mota, J. A. P. S., & Júnior, I. F. F. (2017) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-869220172304156418 · Cited by 16
Research trends and hotspots of exercise for people with sarcopenic: A bibliometric analysis
Zang, W., Chen, H., Yan, J. H., Li, D., Xiao, N., Zheng, X., & Zhang, Z. (2023) · Medicine · doi:10.1097/md.0000000000035148 · Cited by 12
Prazosin Can Prevent Glucocorticoid Mediated Capillary Rarefaction
Mandel, E. R., Dunford, E. C., Trifonova, A., Abdifarkosh, G., Teich, T., Riddell, M. C., & Haas, T. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166899 · Cited by 11
Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice
Jiang, D., Liu, C., Chen, Y., Xing, X., Zheng, D., Guo, Z., & Lin, S. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1268-8458 · Cited by 11
The role of exosomes for sustained specific cardiorespiratory and metabolic improvements in males with type 2 diabetes after detraining
Mastrototaro, L., Apostolopoulou, M., Hartwig, S., Straßburger, K., Lipaeva, P., Trinks, N., Karusheva, Y., Gancheva, S., Trenkamp, S., Lehr, S., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105471 · Cited by 11
Prognostic Impact of Peak Oxygen Consumption in Heart Failure: A Systematic Review and Meta-Analysis
Prokopidis, K., Irlik, K., Piaśnik, J., Michalska, Z., Hendel, M., Nabrdalik, K., & Lip, G. Y. H. (2025) · ESC Heart Failure · doi:10.1002/ehf2.15391 · Cited by 10
The role of perfusion in the oxygen extraction capability of skin and skeletal muscle
Thorn, C. E., & Shore, A. C. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00047.2016 · Cited by 10
A computational model of the effect of capillary density variability on oxygen transport, glucose uptake, and insulin sensitivity in prediabetes
Sové, R. J., Goldman, D., & Fraser, G. M. (2016) · Microcirculation · doi:10.1111/micc.12342 · Cited by 10
Cardiovascular Aging and Physical Activity: Insights From Metabolomics
Lim, R. M. H., & Koh, A. S.-M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.728228 · Cited by 10
The Association Between Physical Activity and Peripheral Neuropathy in Diabetic Patients: A Cross-Sectional Multicenter Study From Saudi Arabia
Alkhotani, R. Y., Al‐Dubai, S. A. R., Almeshaly, M. S., Alautabi, A. S., Maqulah, S. F., Alghamdi, Z., & Alahmadi, Z. S. (2023) · Cureus · doi:10.7759/cureus.34504 · Cited by 10
Intermittent compression induces transitory hypoxic stimuli, upstream vasodilation and enhanced perfusion of skin capillaries, independent of age and diabetes
Thorn, C. E., Adio, A. O., Fox, R. H., Gardner, A. M. N., WINLOVE, C. P., & Shore, A. C. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00657.2020 · Cited by 9
Radiological frontiers in understanding paraspinal muscle pathophysiology in chronic low back pain
Li, X., Dong, F., Chen, X., Luo, X., & Wang, W. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1653876 · Cited by 8
Effects of Short-Term Exercise in Overweight/Obese Adults with Insulin Resistance or Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials
Thaane, T., Motala, A. A., & McKune, A. J. (2018) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000816 · Cited by 7
Physical Activity, Cardiorespiratory Fitness, and the Diabetes Spectrum
Nylén, E., & Kokkinos, P. F. (2019) · Springer eBooks · doi:10.1007/978-3-030-04816-7_11 · Cited by 8
Microvascular Damage in a Young Female Archer Assessed by Nailfold Videocapillaroscopy: A Case Report
Sirufo, M. M., Bassino, E. M., Pietro, F. D., Ginaldi, L., & Martinis, M. D. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17124218 · Cited by 10
Anti-diabetic Effects of Macronutrients via Modulation of Angiogenesis: A Comprehensive Review on Carbohydrates and Proteins
Khosravifar, M., Sajadimajd, S., & Bahrami, G. (2022) · Current Molecular Medicine · doi:10.2174/1566524022666220321125548 · Cited by 9
Mechanisms Involved in Glycemic Control Promoted by Exercise in Diabetics
Andrade, E. F., Silva, V. D. O., Orlando, D. R., & Pereira, L. J. (2018) · Current Diabetes Reviews · doi:10.2174/1573399814666180214144717 · Cited by 7
The role of exercise induced capillarization adaptations in skeletal muscle aging: a systematic review
Ding, Y., Wan, Q., Kim, J.-C., Liu, W., & Ji, W. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1681184 · Cited by 6
Skeletal muscle myosin heavy chain expression and 3D capillary network changes in streptozotocin-induced diabetic female mice
Umek, N., Pušnik, L., Ugwoke, C. K., Šink, Ž., Horvat, S., Janáček, J., & Cvetko, E. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2023.9843 · Cited by 7
Unilateral hindlimb ischaemia‐induced systemic inflammation is associated with non‐ischaemic skeletal muscle inflammation
Evans, W. S., Pena, G. S., Gelman, B., Kuzmiak‐Glancy, S., & Prior, S. J. (2024) · Experimental Physiology · doi:10.1113/ep091901 · Cited by 6
Self-citation
Aerobic Exercise Preconditioning Does Not Augment Muscle Hypertrophy During Subsequent Resistance Exercise Training in Healthy Older Adults
Betz, M. W., Monsegue, A. P., Houben, L. H. P., Hendriks, F. K., van Kranenburg, J. M. X., Aussieker, T., Adriaans, B. P., Houben, A. J. H. M., Verdijk, L. B., van Loon, L. J. C., et al. (2025) · Sports Medicine · doi:10.1007/s40279-025-02229-y · Cited by 8
Functional magnetic resonance imaging reveals dysfunction of the paraspinal muscles in patients with chronic low back pain: a cross-sectional study
Chen, J., Huang, Y., Zeng, X., Ma, J., Huang, X., Liang, H., & He, B. (2023) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-22-1106 · Cited by 6
Compared to moderate-intensity continuous training, short-term high-intensity interval training demonstrates enhanced effects on metabolic flexibility in adult males with obesity
Zhang, J.-Z., Liu, X., Lu, S., Cao, Z., & Zhu, Z. (2025) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2025.07.005 · Cited by 5
Metabolic effects of prazosin on skeletal muscle insulin resistance in glucocorticoid-treated male rats
Dunford, E. C., Mandel, E. R., Mohajeri, S., Haas, T. L., & Riddell, M. C. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00146.2016 · Cited by 5
The effect of eight weeks combined training with omega-3 supplementation on the levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in older women
Arabzadeh, E., Nazar, N. K., Gholami, M., Koosha, M. S. R., & Zargani, M. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.03.018 · Cited by 4
Effects of exercise training with weight loss on skeletal muscle expression of angiogenic factors in overweight and obese older men
Evans, W. S., Blumenthal, J. B., Heilman, J. M., Ryan, A. S., & Prior, S. J. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00084.2021 · Cited by 4
Self-citation
Fiziksel Aktivitenin Kısıtlanması: Yetişkin ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar
Değer, E. B., & Vardar, S. A. (2021) · Uludağ Üniversitesi Tıp Fakültesi Dergisi · doi:10.32708/uutfd.833931 · Cited by 3
Comment on Prior et al. Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining. Diabetes 2015;64:3386–3395
Montero, D. (2016) · Diabetes · doi:10.2337/db15-1461 · Cited by 3
Synergistic Effects of Microencapsulated Polyphenols and Concurrent Training on Metabolic Health and Fitness in Overweight/Obese Adults with Prediabetes
Sukatta, U., Rugthaworn, P., Klinsukhon, K., Tumnark, P., Songcharern, N., Teethaisong, Y., Kanpetta, Y., & Phoemsapthawee, J. (2025) · Nutrients · doi:10.3390/nu17213358 · Cited by 2
Fibre morphology, intramyocellular lipid content and 3D capillary architecture in human postural, respiratory and locomotor muscles in type 2 diabetes mellitus
Pollak, N., Janáček, J., Saudek, F., Cvetko, E., Radochová, B., Alibegović, A., Ugwoke, C. K., Basello, D. A., Šink, Ž., Pušnik, L., et al. (2026) · Histochemistry and Cell Biology · doi:10.1007/s00418-026-02477-7 · Cited by 2
Exercise and Cardiovascular Progenitor Cells
Landers‐Ramos, R. Q., Sapp, R. M., Shill, D. D., Hagberg, J. M., & Prior, S. J. (2019) · Comprehensive physiology · doi:10.1002/j.2040-4603.2019.tb00078.x · Cited by 2
Self-citation
Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women
Honda, M., Tsuboi, A., Minato-Inokawa, S., Kitaoka, K., Takeuchi, M., Yano, M., Kurata, M., Wu, B., Kazumi, T., & Fukuo, K. (2021) · Diabetology International · doi:10.1007/s13340-021-00525-2 · Cited by 2
Effects of detraining on cardiovascular risk factors in older adults: A systematic review and meta-analysis
Zheng, Y., Li, L., Jeong, H. G., Moon, Y. J., Yun, H., Chae, J., Lee, J.-H., Jo, W., Lee, S., Jang, S., et al. (2025) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2025.100714 · Cited by 1
Advances in electrical stimulation-based therapeutic technologies for sarcopenia prevention and treatment
Rahaman, K. A., Kim, M.-J., Jung, Y., Kang, S., & Han, H. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.01.035 · Cited by 2
Rehabilitace a preskripce pohybové aktivity u kardiovaskulárních a vybraných interních onemocnění
Vysoký, R., & Konečný, P. (2022) · doi:10.5507/fzv.22.24461250 · Cited by 1
Shedding light on the assessment of skeletal muscle capillarization using near‐infrared spectroscopy: future directions and applications
McCarthy, D. G., Coates, A. M., Binet, E. R., Bone, J., & Powley, F. J. (2022) · The Journal of Physiology · doi:10.1113/jp284032 · Cited by 1
Response to Comment on Prior et al. Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining. Diabetes 2015;64:3386–3395
Prior, S. J., Goldberg, A. P., Ortmeyer, H. K., Chin, E. R., Chen, D., Blumenthal, J. B., & Ryan, A. S. (2016) · Diabetes · doi:10.2337/dbi15-0038 · Cited by 1
Self-citation
The Relationship Between Elevations in Glucocorticoids and Diabetes Development in Rats on Skeletal Muscle Insulin Resistance and the Microvasculature
Dunford, E. C. (2016) · YorkSpace (York University) · Cited by 1
Enforced inactivity in the elderly and diabetes risk: initial estimates of the burden of an unintended consequence of COVID-19 lockdownPreprint
Kipps, C., Hamer, M., Hill, N. E., & Lorgelly, P. K. (2020) · medRxiv · doi:10.1101/2020.06.06.20124065 · Cited by 1
Author’s Reply to Sani et al.: “Effects of Exercise Training in Hypoxia Versus Normoxia on Vascular Health: Comments on Clinical Importance”—Facing Common Misconceptions Concerning Meta-Analysis in Biomedical Research
Montero, D. (2016) · Sports Medicine · doi:10.1007/s40279-016-0614-x
Adipose tissue metabolism and cardiometabolic health in obesity
Stinkens (2017) · Research Publications (Maastricht University) · doi:10.26481/dis.20171005rs
Effects of Modified Arm Swing Exercise Program on Capillary Plasma Glucose and Body Composition in People with Uncontrolled Type 2 Diabetes
Terathongkum, S., Phonyiam, R., & Lininger, J. (2019) · THE BANGKOK MEDICAL JOURNAL · doi:10.31524/bkkmedj.2019.09.012

Authors: Prior, S. J., Goldberg, A. P., Ortmeyer, H. K., Chin, E. R., Chen, D., Blumenthal, J. B., & Ryan, A. S.
Affiliations: University of Maryland, Baltimore (US)
University of Maryland, College Park (US)
Corresponding author: Prior, Steven J.
ORCID: Prior, Steven J.
Ortmeyer, Heidi K.
Chin, Eva R.
Chen, Dapeng
Blumenthal, Jacob B.
Ryan, Alice S.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2015-06-11
Volume: 64
Issue: 10
Pages: 3386-3395
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/db14-1771
PMC: PMC4587640
OpenAlex: W2147920255
Semantic Scholar: 8f1e5c01b44dc4526bbf5b18b3fc6fa198133465
Cited by: 107
References: 59
Citations by year: 2026: 6 · 2025: 9 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 15 · 2018: 13 · 2017: 7 · 2016: 15 · 2015: 2
FWCI: 24.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.diabetesjournals.org/site/license (vor, 295 d)
Locations: Diabetes (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (K23-AG040775, P30-AG028747)
American Federation for Aging Research
U.S. Department of Veterans Affairs
National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK072488)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: insulin sensitivity, aerobic exercise training, detraining, older adults, glucose uptake, glycogen synthase, GLUT4, AMPK, glucose transport, hyperinsulinemic-euglycemic clamp, vastus lateralis
MeSH terms: Aged, Aged, 80 and over, Aging, Capillaries, Female, Glucose, Humans, Insulin Resistance, Male, Middle Aged, Exercise, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks