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A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction

Reinhardt, Martin, Thearle, Marie S., Ibrahim, Mostafa, Hohenadel, Maximilian G., Bogardus, Clifton, Krakoff, Jonathan, Votruba, Susanne B.·2015·Diabetes
DOI 10.2337/db14-1881PMC PMC4512223
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Abstract

Successful weight loss is variable for reasons not fully elucidated. Whether effective weight loss results from smaller reductions in energy expenditure during caloric restriction is not known. We analyzed whether obese individuals with a “thrifty” phenotype, that is, greater reductions in 24-h energy expenditure during fasting and smaller increases with overfeeding, lose less weight during caloric restriction than those with a “spendthrift” phenotype. During a weight-maintaining period, 24-h energy expenditure responses to fasting and 200% overfeeding were measured in a whole-room indirect calorimeter. Volunteers then underwent 6 weeks of 50% caloric restriction. We calculated the daily energy deficit (kilocalories per day) during caloric restriction, incorporating energy intake and waste, energy expenditure, and daily activity. We found that a smaller reduction in 24-h energy expenditure during fasting and a larger response to overfeeding predicted more weight loss over 6 weeks, even after accounting for age, sex, race, and baseline weight, as well as a greater rate of energy deficit accumulation. The success of dietary weight loss efforts is influenced by the energy expenditure response to caloric restriction. Greater decreases in energy expenditure during caloric restriction predict less weight loss, indicating the presence of thrifty and spendthrift phenotypes in obese humans.

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Metadata

Authors
Reinhardt, M., Thearle, M. S., Ibrahim, M., Hohenadel, M. G., Bogardus, C., Krakoff, J., & Votruba, S. B.
Affiliations
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ
Venue
Diabetes
Publisher
American Diabetes Association
Published
2015-05-11
Volume
64
Issue
8
Pages
2859-2867
ISSN
  • 0012-1797
  • 1939-327X
DOI
10.2337/db14-1881
PMC
PMC4512223
Cited by
91
References
9
Language
en
Licence
www.diabetesjournals.org/site/license (vor, 266 d)
Funders
Intramural Research Program of the NIH, NIDDK

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