The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation
Abstract
Although there is significant interest in elucidating the role of placenta-derived exosomes (PdEs) during pregnancy, the exosomal profile in pregnancies complicated by gestational diabetes mellitus (GDM) remains to be established. The aim of this study was to compare the gestational-age profile of PdEs in maternal plasma of GDM with normal pregnancies and to determine the effect of exosomes on cytokine release from human umbilical vein endothelial cells. A prospective cohort of patients was sampled at three time points during pregnancy for each patient (i.e., 11–14, 22–24, and 32–36 weeks' gestation). A retrospective stratified study design was used to quantify exosomes present in maternal plasma of normal (n = 13) and GDM (n = 7) pregnancies. Gestational age and pregnancy status were identified as significant factors contributing to variation in plasma exosome concentration (ANOVA, P < 0.05). Post hoc analyses established that PdE concentration increased during gestation in both normal and GDM pregnancies; however, the increase was significantly greater in GDM (∼2.2-fold, ∼1.5-fold, and ∼1.8-fold greater at each gestational age compared with normal pregnancies). Exosomes isolated from GDM pregnancies significantly increased the release of proinflammatory cytokines from endothelial cells. Although the role of exosomes during GDM remains to be fully elucidated, exosome profiles may be of diagnostic utility for screening asymptomatic populations.
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Cites
1 retracted
Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling
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RetractedStandards of Medical Care in Diabetes
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Hyperglycemia and adverse pregnancy outcomes
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Standards of medical care in diabetes—2014
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s014 · Cited by 4,572
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Cited by
Application of exosomes as liquid biopsy in clinical diagnosis
Zhou, B., Xu, K., Zheng, X., Chen, T., Wang, J., Song, Y., Shao, Y., & Zheng, S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00258-9 · Cited by 685
Pathophysiology of Gestational Diabetes Mellitus
Berberoglu, Z. (2019) · EMJ Diabetes · doi:10.33590/emjdiabet/10313616 · Cited by 129
Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress
Sheller, S., Papaconstantinou, J., Urrabaz-Garza, R., Richardson, L., Saade, G., Salomon, C., & Menon, R. (2016) · PLOS ONE · doi:10.1371/journal.pone.0157614 · Cited by 121
Extracellular vesicles as personalized medicine
Beetler, D. J., Di Florio, D. N., Bruno, K. A., Ikezu, T., March, K. L., Cooper, L. T., Wolfram, J., & Fairweather, D. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101155 · Cited by 101
Diagnosis of gestational diabetes: Evidence and pitfalls
Wong, T., Immanuel, J., Wong, V. W., Barnes, R., & Simmons, D. (2025) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2025.102069 · Cited by 4
Metadata
- Authors
- Salomon, C., Scholz-Romero, K., Sarker, S., Sweeney, E., Kobayashi, M., Correa, P., Longo, S., Duncombe, G., Mitchell, M. D., Rice, G. E., & Illanes, S. E.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2015-12-30
- Volume
- 65
- Issue
- 3
- Pages
- 598-609
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2228844665
- Cited by
- 299
- References
- 42
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation. https://app.cochat.ai/papers/10.2337/db15-0966
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- Salomon, C., Scholz-Romero, K., Sarker, S., Sweeney, E., Kobayashi, M., Correa, P., Longo, S., Duncombe, G., Mitchell, M. D., Rice, G. E., & Illanes, S. E. (2016). Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation. Diabetes. https://doi.org/10.2337/db15-0966
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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