A practical guide for the management of steroid induced hyperglycaemia in the hospital
Open accessAbstract
Glucocorticoids represent frequently recommended and often indispensable immunosuppressant and anti-inflammatory agents prescribed in various medical conditions. Despite their proven efficacy, glucocorticoids bear a wide variety of side effects among which steroid induced hyperglycaemia (SIHG) is among the most important ones. SIHG, potentially causes new-onset hyperglycaemia or exacerbation of glucose control in patients with previously known diabetes. Retrospective data showed that similar to general hyperglycaemia in diabetes, SIHG in the hospital and in outpatient settings detrimentally impacts patient outcomes, including mortality. However, recommendations for treatment targets and guidelines for in-hospital as well as outpatient therapeutic management are lacking, partially due to missing evidence from clinical studies. Still, SIHG caused by various types of glucocorticoids is a common challenge in daily routine and clinical guidance is needed. In this review, we aimed to summarize clinical evidence of SIHG in inpatient care impacting clinical outcome, establishment of diagnosis, diagnostic procedures and therapeutic recommendations.
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The prevalence of consistent use of glucocorticoid therapy in hospitalized individuals can approach 10-15%, and these medications can induce hyperglycemia in 56-86% of these individuals with and without preexisting diabetes.
“The prevalence of consistent use of glucocorticoid therapy in hospitalized individuals can approach 10-15%, and these medications can induce hyperglycemia in 56-86% of these individuals with and without preexisting diabetes (124-126).”
From 16. Diabetes Care in the Hospital: Standards of Care in Diabetes—2026 (2026) · cites this paper as [124]
Section 2 (page not available) reports that 70% of hospitalized patients without a history of diabetes developed hyperglycaemia when given relevant glucocorticoid doses. It does not report that 10–15% of hospitalized people consistently use glucocorticoids, or establish a 56–86% hyperglycaemia range for patients both with and without preexisting diabetes. (LLM, conf=0.87)
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- Authors
- Aberer, F., Hochfellner, D. A., Sourij, H., & Mader, J. K.
- Affiliations
- Medical University of Graz (AT)
- Corresponding author
- Sourij, Harald
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2021-05-16
- Volume
- 10
- Issue
- 10
- Pages
- 2154
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC8157052
- OpenAlex
- W3163132739
- Cited by
- 110
- References
- 72
- Citations by year
- 2026: 24 · 2025: 25 · 2024: 24 · 2023: 15 · 2022: 21 · 2021: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- glucocorticoids, hyperglycemia management, diabetes mellitus, inpatient care, glycemic control, mortality, treatment goals
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