Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study
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OBJECTIVE—The aim of this secondary analysis of the Finnish Diabetes Prevention Study was to assess the effects of lifestyle intervention on metabolic syndrome and its components. RESEARCH DESIGN AND METHODS—A total of 522 middle-aged overweight men and women with impaired glucose tolerance were randomized into an individualized lifestyle intervention group or a standard care control group. National Cholesterol Education Program criteria were used for the definition of metabolic syndrome. RESULTS—At the end of the study, with a mean follow-up of 3.9 years, we found a significant reduction in the prevalence of metabolic syndrome in the intervention group compared with the control group (odds ratio [OR] 0.62 [95% CI 0.40–0.95]) and in the prevalence of abdominal obesity (0.48 [0.28–0.81]). CONCLUSIONS—The results suggest that lifestyle intervention may also reduce risk of cardiovascular disease in the long run.
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If LDL-C goals are not achieved on maximally tolerated statins, drug combinations may offer additional LDL-C lowering, but outcome evidence is limited.
“If LDL-C goals are not achieved on maximally tolerated doses of statins, drug combinations may offer additional lowering of LDL-C, but the evidence from outcome studies is limited. 354”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [354]
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- Authors
- Ilanne-Parikka, P., Eriksson, J. G., Lindström, J., Peltonen, M., Aunola, S., Hämäläinen, H., Keinänen-Kiukaanniemi, S., Laakso, M., Valle, T. T., Lahtela, J., Uusitupa, M., Tuomilehto, J., & on behalf of the Finnish Diabetes Prevention Study Group
- Affiliations
- Diabetes Center, Finnish Diabetes Association, Tampere, Finland
- University of Helsinki (FI)
- Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
- Finnish Institute for Health and Welfare (FI)
- Department of Health and Functional Capacity, Laboratory for Population Research, National Public Health Institute, Turku, Finland
- Research Department, Social Insurance Institution, Turku, Finland
- Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
- Oulu University Hospital (FI)
- Tampere University Hospital (FI)
- University of Eastern Finland (FI)
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2008-04-01
- Volume
- 31
- Issue
- 4
- Pages
- 805-807
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2115945685
- Cited by
- 218
- References
- 14
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 9 · 2016: 20 · 2015: 15 · 2014: 11 · 2013: 21 · 2012: 21
- FWCI
- 17.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Helsingin Yliopisto
- Juho Vainion Säätiö
- Kuopion Yliopistollinen Sairaala
- Novo Nordisk
- Oulun Yliopisto
- Novo Nordisk Fonden
- Pirkanmaan Sairaanhoitopiiri
- Tays
- Diabetestutkimussäätiö
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- lifestyle intervention, metabolic syndrome, impaired glucose tolerance, abdominal obesity, cardiovascular risk, Finnish Diabetes Prevention Study, type 2 diabetes prevention
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Female, Finland, Follow-Up Studies, Glucose Tolerance Test, Humans, Life Style, Male, Middle Aged, Time Factors, Prevalence, Metabolic Syndrome
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