Cited by 122Diabetes and associated disordersDiabetes Management and ResearchAdrenal Hormones and Disorders

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Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes

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Jones, Angus G., McDonald, Timothy J., Shields, Beverley M., Hagopian, William, Hattersley, Andrew T.·2021·Diabetes Care

DOI 10.2337/dc20-2834PMC PMC8247509

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Abstract

Latent autoimmune diabetes of adults (LADA) is typically defined as a new diabetes diagnosis after 35 years of age, presenting with clinical features of type 2 diabetes, in whom a type 1 diabetes–associated islet autoantibody is detected. Identifying autoimmune diabetes is important since the prognosis and optimal therapy differ. However, the existing LADA definition identifies a group with clinical and genetic features intermediate between typical type 1 and type 2 diabetes. It is unclear whether this is due to 1) true autoimmune diabetes with a milder phenotype at older onset ages that initially appears similar to type 2 diabetes but later requires insulin, 2) a disease syndrome where the pathophysiologies of type 1 and type 2 diabetes are both present in each patient, or 3) a heterogeneous group resulting from difficulties in classification. Herein, we suggest that difficulties in classification are a major component resulting from defining LADA using a diagnostic test—islet autoantibody measurement—with imperfect specificity applied in low-prevalence populations. This yields a heterogeneous group of true positives (autoimmune type 1 diabetes) and false positives (nonautoimmune type 2 diabetes). For clinicians, this means that islet autoantibody testing should not be undertaken in patients who do not have clinical features suggestive of autoimmune diabetes: in an adult without clinical features of type 1 diabetes, it is likely that a single positive antibody will represent a false-positive result. This is in contrast to patients with features suggestive of type 1 diabetes, where false-positive results will be rare. For researchers, this means that current definitions of LADA are not appropriate for the study of autoimmune diabetes in later life. Approaches that increase test specificity, or prior likelihood of autoimmune diabetes, are needed to avoid inclusion of participants who have nonautoimmune (type 2) diabetes. Improved classification will allow improved assignment of prognosis and therapy as well as an improved cohort in which to analyze and better understand the detailed pathophysiological components acting at onset and during disease progression in late-onset autoimmune diabetes.

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Baekkeskov, S., Aanstoot, H.-J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P.-D. (1990) · Nature · doi:10.1038/347151a0 · Cited by 1,964
ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIES
Bottazzo, G., Florin-Christensen, A., & Doniach, D. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90140-8 · Cited by 1,469
Insulin antibodies in insulin-dependent diabetics before insulin treatment
Palmer, J. P., Asplin, C. M., Clemons, P., Lyen, K., Tatpati, O., Raghu, P. K., & Paquette, T. L. (1983) · Science · doi:10.1126/science.6362005 · Cited by 1,078
UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes
Turner, R., Stratton, I., Horton, V., Manley, S., Zimmet, P., Mackay, I. R., Shattock, M., Bottazzo, G. F., & Holman, R. (1997) · The Lancet · doi:10.1016/s0140-6736(97)03062-6 · Cited by 779
Interpretation by Physicians of Clinical Laboratory Results
Casscells, W., Schoenberger, A., & Graboys, T. B. (1978) · New England Journal of Medicine · doi:10.1056/nejm197811022991808 · Cited by 765
The clinical utility of C‐peptide measurement in the care of patients with diabetes
Jones, A. G., & Hattersley, A. T. (2013) · Diabetic Medicine · doi:10.1111/dme.12159 · Cited by 666
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Tuomi, T., Groop, L., Zimmet, P., Rowley, M. J., Knowles, W. J., & Mackay, I. R. (1993) · Diabetes · doi:10.2337/diab.42.2.359 · Cited by 578
Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies.
Tuomi, T., Carlsson, A., Li, H., Isomaa, B., Miettinen, A., Nilsson, A.-L., Nissén, M., Ehrnström, B. O., Forsén, B., Snickars, B., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.1.150 · Cited by 504
Mechanisms of Autoantibody-Induced Pathology
Ludwig, R. J., Vanhoorelbeke, K., Leypoldt, F., Kaya, Z., Bieber, K., McLachlan, S. M., Komorowski, L., Luo, J., Cabral-Marques, O., Hammers, C. M., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00603 · Cited by 491
Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank
Thomas, N. J., Jones, S. E., Weedon, M. N., Shields, B. M., Oram, R. A., & Hattersley, A. T. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30362-5 · Cited by 417
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2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2024
American Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Gaglia, J. L., Hilliard, M. E., Johnson, E. L., et al. (2024) · Diabetes Care · doi:10.2337/dc24-s002 · Cited by 2,086
2. Diagnosis and classification of diabetes: standards of care in diabetes-2025
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Ebekozien, O., Echouffo-Tcheugui, J. B., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s002 · Cited by 1,393
2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026
American Diabetes Association Professional Practice Committee for Diabetes*, Bajaj, M., McCoy, R. G., Balapattabi, K., Bannuru, R. R., Bellini, N. J., Bennett, A. K., Beverly, E. A., Briggs Early, K., ChallaSivaKanaka, S., et al. (2026) · Diabetes Care · doi:10.2337/dc26-s002 · Cited by 473
Adult-Onset Type 1 Diabetes: Current Understanding and Challenges
Leslie, R. D., Evans‐Molina, C., Freund-Brown, J., Buzzetti, R., Dabelea, D., Gillespie, K. M., Goland, R., Jones, A. G., Kacher, M. L., Phillips, L. S., et al. (2021) · Diabetes Care · doi:10.2337/dc21-0770 · Cited by 288
Self-citation
Heterogeneity and endotypes in type 1 diabetes mellitus
REDONDO, M. J., & Morgan, N. G. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00853-0 · Cited by 182
The Incidence of Adult-Onset Type 1 Diabetes: A Systematic Review From 32 Countries and Regions
Harding, J. L., Wander, P. L., Zhang, X., Li, X., Karuranga, S., Chen, H., Sun, H., Xie, Y., Oram, R. A., Magliano, D. J., et al. (2022) · Diabetes Care · doi:10.2337/dc21-1752 · Cited by 149
C‐peptide determination in the diagnosis of type of diabetes and its management: A clinical perspective
Maddaloni, E., Bolli, G. B., Frier, B. M., Little, R. R., Leslie, R. D., Pozzilli, P., & Buzzetti, R. (2022) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14785 · Cited by 135
Phenotypic and genetic classification of diabetes
Deutsch, A. J., Ahlqvist, E., & Udler, M. S. (2022) · Diabetologia · doi:10.1007/s00125-022-05769-4 · Cited by 108
Understanding diabetes heterogeneity: key steps towards precision medicine in diabetes
Leslie, R. D., Ronald, C. W., Franks, P. W., Nadeau, K. J., Pearson, E. R., & REDONDO, M. J. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00159-6 · Cited by 112
Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes
Phillip, M., Achenbach, P., Addala, A., Albanese-O’Neill, A., Battelino, T., Bell, K. J., Besser, R. E. J., Bonifacio, E., Colhoun, H. M., Couper, J. J., et al. (2024) · Diabetes Care · doi:10.2337/dci24-0042 · Cited by 79
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Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes
Phillip, M., Achenbach, P., Addala, A., Albanese-O’Neill, A., Battelino, T., Bell, K. J., Besser, R. E. J., Bonifacio, E. E., Colhoun, H. M., Couper, J., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06205-5 · Cited by 83
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The epidemiology of type 1 diabetes mellitus in older adults
Tomic, D., Harding, J. L., Jenkins, A. J., Shaw, J. E., & Magliano, D. J. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01046-z · Cited by 58
“It is considered a variant of T1DM that is somewhat enriched for T2DM features and typically progresses more slowly than does classic autoimmune T1DM in children and young adults 74 .”
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Type 1 diabetes presenting in adults: Trends, diagnostic challenges and unique features
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Identifying Type 1 and 2 Diabetes in Population Level Data: Assessing the Accuracy of Published Approaches
Thomas, N. J., McGovern, A. P., Young, K., Sharp, S. A., Weedon, M. N., Hattersley, A. T., Dennis, J., & Jones, A. G. (2022) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2022.10.022 · Cited by 31
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Trends in the incidence of young-adult-onset diabetes by diabetes type: a multi-national population-based study from an international diabetes consortium
Magliano, D. J., Chen, L., Morton, J. I., Salim, A., Carstensen, B., Gregg, E. W., Pavkov, M. E., Arffman, M., Colhoun, H. M., Ha, K. H., et al. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00243-2 · Cited by 27
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Burahmah, J., Zheng, D., & Leslie, R. D. (2022) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2022.06.003 · Cited by 18
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Thaler, M., Roos, M., Petersmann, A., Seißler, J., Peter, A., Landgraf, R., Müller, U., Müller‐Wieland, D., Nauck, M. A., Heinemann, L., et al. (2022) · Diabetologie und Stoffwechsel · doi:10.1055/a-1744-2856 · Cited by 14
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Fu, X., Xu, Z., Tan, Q., Wei, W., & Wang, Z. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01465-5 · Cited by 13
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Diabetes autoimune latente do adulto (LADA): fisiopatologia, critérios diagnósticos e associação com doenças autoimunes
de Figueiredo, B. Q., Durante, G., Amorim, G. S., Presot, I. Q., Souza, J. R., Soares, L. D. S., Oliveira, N. S. S., Assunção, P. E. P., Porto, S. S., & Medeiros, V. L. O. (2021) · Research Society and Development · doi:10.33448/rsd-v10i11.19532 · Cited by 2
Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults
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Jamjoom, H., Verma, A. K., & Chakera, A. J. (2024) · Practical Diabetes · doi:10.1002/pdi.2517 · Cited by 1
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Patil, M. S., Mane, P. M., Datkhile, K. D., Garud, A., Kale, S. R., Patil, S. S., & Patil, S. R. (2024) · African Journal of Biomedical Research · doi:10.53555/ajbr.v27i4s.4785 · Cited by 2
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Fu, X., Tan, Q., Wei, W., Ding, S., & Wang, Z. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01435-x · Cited by 1
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Susanto, H., Aulanni’am, A., Wuragil, D. K., Taufiq, A., Sunaryono, S., Purnomo, J. D. T., Krisnawati, D. I., & Sholeh, M. (2025) · INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY · doi:10.33086/ijmlst.v7i1.6028 · Cited by 1
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Jones, A. G., & Eichmann, M. (2022) · Diabetes · doi:10.2337/dbi22-0007 · Cited by 1
Self-citation
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Thomas, N. J. M., McGovern, A. P., Young, K., Sharp, S. A., Weedon, M. N., Hattersley, A. T., Dennis, J., & Jones, A. G. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4125231
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Adult-onset autoimmune diabetes
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Alcívar, A. B. A., & de Corcho, O. J. P. (2022) · Anatomía Digital · doi:10.33262/anatomiadigital.v5i4.2361
Exploring the Landscape of Latent Autoimmune Diabetes and Maturity Onset Diabetes of the Young in Africa: A Scoping Review
Ombui, D., & Khalid, A. M. (2023) · F1000Research · doi:10.12688/f1000research.133995.1
Clinical prediction models combining routine clinical measures identify participants with youth-onset diabetes who maintain insulin secretion in the range associated with type 2 diabetes: The SEARCH for Diabetes in Youth StudyPreprint
Jones, A. G., Shields, B. M., Oram, R. A., Dabelea, D., Hagopian, W., Lustigova, E., SHAH, A. S., Knupp, J., Mottl, A. K., D’Agostino, R. B., et al. (2023) · medRxiv · doi:10.1101/2023.09.27.23296128
Self-citation
Comments on the notion of false positivity in measurements of autoantibodies. Reply to Grill V, Sørgjerd E, Hals I, Carlsson S [letter]
Thomas, N. J. M., & Jones, A. G. (2024) · Diabetologia · doi:10.1007/s00125-023-06062-8
Self-citation
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Herrera, G. J. M., & Mendoza-Fuentes, M. (2024) · Revista Colombiana de Endocrinología Diabetes & Metabolismo · doi:10.53853/encr.11.3.870
Diabetes Management with Current Guidelines.
Karadeniz, Y. (2023) · doi:10.69860/nobel.9786053359111.12
Frequency of detection and factors of elevated levels of diabetes-associated autoantibodies in the blood of patients with clinical type 2 diabetes mellitus
Saienko, Y. A., & Mankovsky, B. (2025) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.21.2.2025.1512
Translating Genes into Insight: Causal Genomics for Diabetes Risk Prediction
Zahoor, S., Lió, P., Dias, G. H., & Hasanuzzaman, M. (2025) · Lecture notes in computer science · doi:10.1007/978-3-032-00652-3_18
Islet autoimmunity in young First Nations women with prediabetes and type 2 diabetes
Wicks, M. M., Wood, A. J., Titmuss, A., Shaw, J. E., Wentworth, J. M., Colman, P. G., Brown, A. D. H., Maple-Brown, L. J., & Barr, E. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112977
Renal hypouricemia type 2 in a patient with latent autoimmune diabetes in adults: a case report and literature review
Cui, Y., Liu, H., & Dong, R. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04626-x
Approach to the patient with type 2 diabetes treated with SGLT-2 inhibitor: art of effective and safe prescription
Gosmanov, A. R. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf690
Against the Grain: Insulinoma-Associated Protein 2 Positive Latent Autoimmune Diabetes in Adults Defying Ethnic Prevalence Trends
Narasimhan, A., Deshpande, I., Kalluru, P. K. R., & Chan, K. (2025) · AACE Endocrinology and Diabetes · doi:10.1016/j.aed.2025.12.017
Latent autoimmune diabetes in adults phenotype with recurrent hypoglycemia as diagnostic challenge (case report)
Goga, T. M., & Zeqiraj, A. (2025) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.21.8.2025.1663
Unveiling a Novel MT-TS1 m.7479G>A in Mitochondrial Diabetes: The Critical Role of mtDNA Sequencing in Atypical Cases
Danek, E., Pyrlis, F., Ali, A. S., & Ekinci, E. I. (2025) · JCEM Case Reports · doi:10.1210/jcemcr/luaf341
Definition, diagnosis and classification of diabetes mellitus
Ékoé, J.-M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00342-3
Prevalence, Diagnostic Role, and Clinical Features of Zinc Transporter 8 Autoantibody in Korean Children and Adolescents With Diabetes Mellitus
Shin, S., Woo, H. A., Lee, H., Lee, Y. J., Kim, H. Y., Lee, Y. A., Shin, C. S., Lee, H., & Kim, J. (2026) · Journal of Korean Medical Science · doi:10.3346/jkms.2026.41.e118
A Case-Based Analysis of Social Drivers in Diabetes Outcomes
Matics, K. (2026) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2026.105761

Authors: Jones, A. G., McDonald, T. J., Shields, B. M., Hagopian, W., & Hattersley, A. T.
Affiliations: University of Exeter (GB)
Pacific Northwest Research Institute, Seattle, WA
Corresponding author: Jones, Angus G.
Hattersley, Andrew T.
ORCID: Jones, Angus G.
McDonald, Timothy J.
Shields, Beverley M.
Hagopian, William
Hattersley, Andrew T.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2021-06-01
Volume: 44
Issue: 6
Pages: 1243-1251
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/dc20-2834
PMC: PMC8247509
OpenAlex: W3161458931
Cited by: 122
References: 55
Citations by year: 2026: 28 · 2025: 21 · 2024: 24 · 2023: 20 · 2022: 20 · 2021: 9
FWCI: 2.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.diabetesjournals.org/content/license (vor)
Locations: Diabetes Care (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Open Research Exeter (University of Exeter) (acceptedVersion)
Figshare (submittedVersion)
Royal Devon and Exeter Research Repository (Royal Devon and Exeter) (submittedVersion, public-domain)
Funders: Wellcome Trust (098395/Z/12/Z)
National Institute for Health and Care Research (ICA-SCL-2016-02-003, CS-2015-15-018)
National Institute of Diabetes and Digestive and Kidney Diseases (U01DK063829)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: latent autoimmune diabetes in adults, type 1 diabetes, type 2 diabetes, islet autoantibodies, diagnostic specificity, false positives, disease classification, disease heterogeneity, diagnostic criteria
MeSH terms: Latent Autoimmune Diabetes in Adults, Adult, Autoantibodies, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Insulin

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Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes

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