Leptin: The Tale of an Obesity Gene

Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome

Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C., & Matsuzawa, Y. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1126 · Cited by 1,072

Lipotoxic diseases

Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875

BDNF regulates eating behavior and locomotor activity in mice

Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D., & Ashford, M. L. J. (1997) · Nature · doi:10.1038/37379 · Cited by 628

Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin

Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575

Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea

Phillips, B. G., Kato, M., Narkiewicz, K., Choe, I., & Somers, V. K. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.1.h234 · Cited by 430

The expression of adipogenic genes is decreased in obesity and diabetes mellitus

Nadler, S. T., Stoehr, J. P., Schueler, K. L., Tanimoto, G., Yandell, B. S., & Attie, A. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11371 · Cited by 386

Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice

Saxena, N. K., Ikeda, K., Rockey, D. C., Friedman, S. L., & Anania, F. A. (2002) · Hepatology · doi:10.1053/jhep.2002.32029 · Cited by 382

Overfeeding Rapidly Induces Leptin and Insulin Resistance

Wang, J., Obici, S., Morgan, K., Barzilai, N., Feng, Z., & Rossetti, L. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2786 · Cited by 355

Evidence for a Novel Peripheral Action of Leptin as a Metabolic Signal to the Adrenal Gland: Leptin Inhibits Cortisol Release Directly

Bornstein, S. R., Uhlmann, K., Haidan, A., Ehrhart-Bornstein, M., & Scherbaum, W. A. (1997) · Diabetes · doi:10.2337/diab.46.7.1235 · Cited by 344

Leptin and hyperleptinemia - from friend to foe for cardiovascular function

Ren, J. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1810001 · Cited by 305

Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects

Miyazawa-Hoshimoto, S., Takahashi, K., Bujo, H., Hashimoto, N., & Saito, Y. (2003) · Diabetologia · doi:10.1007/s00125-003-1221-6 · Cited by 254

Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin

Havel, P. J., Uriu-Hare, J. Y., Liu, T., Stanhope, K. L., Stern, J. S., Keen, C. L., & Ahrén, B. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.5.r1482 · Cited by 198

Leptin Rapidly Lowers Food Intake and Elevates Metabolic Rates in Lean and ob/ob Mice ,

Mistry, A. M., Swick, A. G., & Romsos, D. R. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.10.2065 · Cited by 188

Recent weight gain in patients with newly diagnosed obstructive sleep apnea

Phillips, B. G., Hisel, T. M., Kato, M., Pesek, C. A., Dyken, M. E., Narkiewicz, K., & Somers, V. K. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917090-00009 · Cited by 183

Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance

Pocai, A., Morgan, K., Buettner, C., Gutierrez-Juarez, R., Obici, S., & Rossetti, L. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3182 · Cited by 153

Visceral and Subcutaneous Adiposity: Are Both Potential Therapeutic Targets for Tackling the Metabolic Syndrome?

Rodriguez, A., Catalan, V., Gomez-Ambrosi, J., & Fruhbeck, G. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207781039599 · Cited by 133

Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus*

Légrádi, G., Emerson, C. H., Ahima, R. S., Flier, J. S., & Lechan, R. M. (1997) · Endocrinology · doi:10.1210/en.138.6.2569 · Cited by 505

Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus

Legradi, G., Emerson, C. H., Ahima, R. S., Rand, W. M., Flier, J. S., & Lechan, R. M. (1998) · Neuroendocrinology · doi:10.1159/000054354 · Cited by 131

Gender Factors Affect Fatty Acids-Induced Insulin Resistance in Nonobese Humans: Effects of Oral Steroidal Contraception1

Perseghin, G., Scifo, P., Pagliato, E., Battezzati, A., Benedini, S., Soldini, L., Testolin, G., Del Maschio, A., & Luzi, L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7666 · Cited by 112

Renal effects of leptin in normotensive, hypertensive, and obese rats

Villarreal, D., Reams, G., Freeman, R. H., & Taraben, A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.6.r2056 · Cited by 88

Lipolysis sensation by white fat afferent nerves triggers brown fat thermogenesis

Garretson, J. T., Szymanski, L. A., Schwartz, G. J., Xue, B., Ryu, V., & Bartness, T. J. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.013 · Cited by 80

Improvement of Metabolism among Obese Breast Cancer Survivors in Differing Weight Loss Regimens

Jen, K. ‐. C., Djuric, Z., DiLaura, N. M., Buison, A., Redd, J. N., Maranci, V., & Hryniuk, W. M. (2004) · Obesity Research · doi:10.1038/oby.2004.38 · Cited by 59

Short‐term effects of prednisolone and dexamethasone on circulating concentrations of leptin and sex hormone‐binding globulin in children being treated for acute lymphoblastic leukaemia

Wallace, A. M., Tucker, P., Williams, D. M., Hughes, I. A., & Ahmed, S. F. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01790.x · Cited by 57

Leptin is suppressed during infusion of recombinant human insulin-like growth factor I (rhIGF I) in normal rats

Böni-Schnetzler, M., Hauri, C., & Zapf, J. (1999) · Diabetologia · doi:10.1007/s001250051134 · Cited by 45

Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma

Mittenbühler, M. J., Sprenger, H.-G., Gruber, S., Wunderlich, C. M., Kern, L., Brüning, J. C., & Wunderlich, F. T. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.010 · Cited by 18