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Cited by 112Diabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and DiseaseLipid metabolism and disorders

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Gender Factors Affect Fatty Acids-Induced Insulin Resistance in Nonobese Humans: Effects of Oral Steroidal Contraception1

Perseghin, Gianluca, Scifo, Paola, Pagliato, Emanuela, Battezzati, Alberto, Benedini, Stefano, Soldini, Laura, Testolin, Giulio, Del Maschio, Alessandro, Luzi, Livio·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.7.7666
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Abstract

Plasma free fatty acids and intramyocellular triglycerides (IMCL) content modulate whole body insulin sensitivity in humans. To test whether the interactions between fatty acid metabolism and insulin action in nonobese humans are related to gender factors, we studied 15 young, normal weight, healthy men and 15 women matched for life habits and whole body insulin sensitivity, determined with the euglycemic-hyperinsulinemic clamp, by means of indirect calorimetry to assess substrate oxidation, localized (1)H nuclear magnetic resonance spectroscopy of calf muscles to assess IMCL content, and dual energy x-ray absorption to assess body composition. In addition, to test whether perturbation of the feminine hormonal milieu modifies these interactions, we studied 15 matched females using oral steroidal contraception (OSC). Insulin sensitivity in women, notwithstanding increased body fatness, plasma free fatty acids, IMCL content, and circulating beta-hydroxybutyrate levels and reduced lipid oxidation, was similar to that in men. Women using OSC showed a 40% reduction of insulin sensitivity associated with increased plasma free fatty acids, beta-hydroxybutyrate, cholesterol, and triglycerides levels and a slight increment in IMCL content compared with women with intact hormonal cycles. In all groups the IMCL content was inversely related to insulin sensitivity. In conclusion, nonobese, healthy, young women are as insulin sensitive as men, notwithstanding the higher levels of postabso…

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Crossref · 10.1210/jcem.86.7.7666

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9 of 9 references verified0 citation errors · 0 not checkable

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  • When circulating estrogen concentration rises to supraphysiological levels, or when powerful synthetic estrogens like oral contraceptives are used, insulin resistance develops.

    “Similarly, when circulating estrogen concentration rises to supraphysiological levels [24], or when powerful synthetic estrogens like oral contraceptives are used [37], insulin resistance develops.”

    From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [37]

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Metadata

Authors
Perseghin, G., Scifo, P., Pagliato, E., Battezzati, A., Benedini, S., Soldini, L., Testolin, G., Del Maschio, A., & Luzi, L.
Affiliations
  • Vita-Salute San Raffaele University (IT)
  • University of Milan (IT)
Corresponding author
Perseghin, Gianluca
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-07
Volume
86
Issue
7
Pages
3188-3196
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.7.7666
OpenAlex
W2143051201
Cited by
112
References
9
Citations by year
2026: 1 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 7
FWCI
2.97
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
insulin resistance, sex differences, oral contraceptives, plasma free fatty acids, intramyocellular triglyceride, beta-hydroxybutyrate, lipid oxidation, whole-body insulin sensitivity, non-obese women, fatty acid metabolism, hormonal contraception
MeSH terms
Adult, Blood Glucose, Body Composition, C-Peptide, Calorimetry, Indirect, Cholesterol, Contraceptives, Oral, Fatty Acids, Nonesterified, Female, Humans, Insulin, Insulin Resistance, Male, Magnetic Resonance Spectroscopy, Regression Analysis, Sex Characteristics, Triglycerides, Glucose Clamp Technique, Absorptiometry, Photon, Receptors, Tumor Necrosis Factor, Muscle, Skeletal, 3-Hydroxybutyric Acid, Leptin

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