The DOI matches its Crossref record.
Depot- and Sex-Specific Differences in Human Leptin mRNA Expression: Implications for the Control of Regional Fat Distribution
Abstract
Obese subjects with excess intra-abdominal fat deposition suffer greater adverse metabolic consequences than do similarly overweight subjects with a predominantly subcutaneous distribution of adiposity. Little is known about the factors regulating the regional distribution of body fat. Leptin is a recently characterized protein secreted by adipocytes that appears to provide a long-term hormonal feedback signal regulating fat mass. No systematic evaluation of site-related differences in human adipocyte leptin expression has been reported to date. Levels of leptin mRNA were examined by quantitative reverse transcription-polymerase chain reaction in adipocytes isolated from omental and subcutaneous adipose depots of nonobese and mildly obese individuals undergoing elective surgery. In all individuals studied (n = 24), leptin mRNA levels were higher in subcutaneous than in omental adipocytes (P < 0.0001). In contrast, there were no consistent site-specific differences in the expression of glycerol-3-phosphate dehydrogenase mRNA. The subcutaneous-toomental ratio of leptin mRNA expression was markedly higher in women (5.5 ± 1.1-fold) than in men (1.9 ± 0.2-fold) (P < 0.02). A significant relationship between BMI and leptin mRNA expression was demonstrable in the subcutaneous adipocytes of women (P < 0.006). Thus, leptin mRNA appears to be expressed predominantly by subcutaneous adipocytes, particularly in women. These findings suggest a possible role for leptin in the control of adipose tissue distribution and mass.
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Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593
Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal-Puig, A., Considine, R. V., & O’Rahilly, S. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2199 · Cited by 572
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Cnop, M., Landchild, M. J., Vidal, J., Havel, P. J., Knowles, N. G., Carr, D. R., Wang, F., Hull, R. L., Boyko, E. J., Retzlaff, B. M., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1005 · Cited by 432
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Rayner, D. V., & Trayhurn, P. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100198 · Cited by 250
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Shi, H., Seeley, R. J., & Clegg, D. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.004 · Cited by 242
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BackgroundEffect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function
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You, T., Yang, R., Lyles, M. F., Gong, D., & Nicklas, B. J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00419.2004 · Cited by 173
Kraunsøe, R., Boushel, R., Hansen, C. N., Schjerling, P., Qvortrup, K., Støckel, M., Mikines, K. J., & Dela, F. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.184754 · Cited by 149
Mirza, M. S. (2011) · ISRN Gastroenterology · doi:10.5402/2011/592404 · Cited by 148
Rodriguez, A., Catalan, V., Gomez-Ambrosi, J., & Fruhbeck, G. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207781039599 · Cited by 133
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Walker, G. E., Marzullo, P., Ricotti, R., Bona, G., & Prodam, F. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0023 · Cited by 90
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Gill, M. S., Hall, C. M., Tillmann, V., & Clayton, P. E. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00736.x · Cited by 51
Micke, G. C., Sullivan, T. M., McMillen, I. C., Gentili, S., & Perry, V. E. A. (2011) · Reproduction · doi:10.1530/rep-10-0332 · Cited by 34
Metadata
- Authors
- Montague, C. T., Prins, J. B., Sanders, L., Digby, J. E., & O'Rahilly, S.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1997-03-01
- Volume
- 46
- Issue
- 3
- Pages
- 342-347
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2140967957
- Cited by
- 562
- References
- 0
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- closed
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