Plasma advanced glycation end products are decreased in obese children compared with lean controls
Abstract
OBJECTIVE: In obesity, the combined effects of enhanced food consumption, enhanced oxidative stress and microinflammation could augment the advanced glycation end products (AGEs) accumulation in plasma. We compared the plasma concentrations of AGEs and the soluble receptor for AGEs (sRAGE) in relation to markers of oxidative stress, microinflammation and renal function in obese and lean children/adolescents. METHODS: In 18 apparently healthy obese children/adolescents (7 females/11 males; age: 5-18 years; body mass index, BMI: 27.3+/-3.3 kg/m2) and 18 healthy lean controls (10 females/8 males; age: 4-17 years, BMI: 22.4+/-2.1 kg/m2) the plasma concentration of N(epsilon)-carboxymethyllysine (CML), fructoselysine (FL), AGE-associated fluorescence, sRAGE, high sensitive-C-reactive protein (hsCRP), interleukin-6 (IL-6) and urinary 8-hydroxy-2-deoxyguanosine (U-8-OHdG) excretion, plasma advanced oxidation protein products (AOPPs), renal function, and the HOMA index of insulin resistance were determined. RESULTS: Obese children/adolescents had significantly lower concentrations of plasma FL (6.8+/-0.3 mmol/mol lysine vs. 7.7+/-0.3, p<0.02), CML (0.14+/-0.03 mmol/mol lysine vs. 0.22+/-0.04, p<0.001), and fluorescent AGEs (223+/-37 arbitrary units (AU) vs. 318+/-64, p<0.01) than their lean counterparts. Plasma sRAGE concentration did not differ (2.3+/-0.6 ng/ml vs. 2.6+/-0.6). Obese children/adolescents were more insulin-resistant (HOMA index: p<0.01), exhibited higher levels of markers of inflammation (hs-CRP: p<0.03; IL-6: p<0.02), of oxidative stress (AOPPs: p<0.05; 8-OHdG: p<0.04) and had a higher creatinine clearance (p<0.01) and proteinuria (p<0.01). CONCLUSIONS: We present the first evidence that childhood/adolescent obesity is characterized by lower plasma AGE levels, despite lower insulin sensitivity, enhanced oxidative stress and microinflammation. An enhanced removal of AGE peptides via hyperfiltration may partially contribute to the lower plasma AGE levels.
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In metabolic syndrome studies, CRP concentration was consistently reduced in intervention groups receiving a Mediterranean diet.
“In other related studies involving individuals with the metabolic syndrome, a consistent reduction in CRP concentration in the intervention group receiving the Mediterranean diet has been shown (291,292) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [292]
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Self-citation
- Authors
- Šebeková, K., Somoza, V., Jarčušková, M., Heidland, A., & Podracká, L.
- Affiliations
- University of Pavol Jozef Šafárik (SK)
- University of Würzburg (DE)
- ORCID
- Somoza, Veronika
- Venue
- International Journal of Pediatric Obesity
- Publisher
- Informa UK Limited
- Published
- 2009-01
- Volume
- 4
- Issue
- 2
- Pages
- 112-118
- ISSN
- 1747-7166 (ISSN-L)
- 1747-7174
- OpenAlex
- W2064974773
- Cited by
- 82
- References
- 44
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 9 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 3
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pediatric Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- childhood obesity, advanced glycation end products, carboxymethyllysine, fructoselysine, soluble receptor for advanced glycation end products, oxidative stress, microinflammation, insulin resistance, renal function, creatinine clearance, urinary 8-hydroxy-2'-deoxyguanosine, advanced oxidation protein products, C-reactive protein, interleukin-6, HOMA index, children and adolescents
- MeSH terms
- Receptor for Advanced Glycation End Products, 8-Hydroxy-2'-Deoxyguanosine, Adolescent, Blood Glucose, C-Reactive Protein, Child, Child, Preschool, Deoxyguanosine, Female, Fluorescence, Humans, Inflammation, Insulin, Kidney, Lysine, Male, Receptors, Immunologic, Biomarkers, Case-Control Studies, Glycation End Products, Advanced, Oxidative Stress, Overweight
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