Cited by 164Pancreatic function and diabetesIon channel regulation and functionIon Transport and Channel Regulation

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A TP-Sensitive K+ Channel–Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR1−/− Mouse α-Cells

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Gromada, Jesper, Ma, Xiaosong, Høy, Marianne, Bokvist, Krister, Salehi, Albert, Berggren, Per-Olof, Rorsman, Patrik·2004·Diabetes

DOI 10.2337/diabetes.53.suppl_3.s181

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Abstract

Patch-clamp recordings and glucagon release measurements were combined to determine the role of plasma membrane ATP-sensitive K+ channels (KATP channels) in the control of glucagon secretion from mouse pancreatic α-cells. In wild-type mouse islets, glucose produced a concentration-dependent (half-maximal inhibitory concentration [IC50] = 2.5 mmol/l) reduction of glucagon release. Maximum inhibition (∼50%) was attained at glucose concentrations >5 mmol/l. The sulfonylureas tolbutamide (100 μmol/l) and glibenclamide (100 nmol/l) inhibited glucagon secretion to the same extent as a maximally inhibitory concentration of glucose. In mice lacking functional KATP channels (SUR1−/−), glucagon secretion in the absence of glucose was lower than that observed in wild-type islets and both glucose (0–20 mmol/l) and the sulfonylureas failed to inhibit glucagon secretion. Membrane potential recordings revealed that α-cells generate action potentials in the absence of glucose. Addition of glucose depolarized the α-cell by ∼7 mV and reduced spike height by 30% Application of tolbutamide likewise depolarized the α-cell (∼17 mV) and reduced action potential amplitude (43%). Whereas insulin secretion increased monotonically with increasing external K+ concentrations (threshold 25 mmol/l), glucagon secretion was paradoxically suppressed at intermediate concentrations (5.6–15 mmol/l), and stimulation was first detectable at >25 mmol/l K+. In α-cells isolated from SUR1−/− mice, both tolbutamide and glucose failed to produce membrane depolarization. These effects correlated with the presence of a small (0.13 nS) sulfonylurea-sensitive conductance in wild-type but not in SUR1−/− α-cells. Recordings of the free cytoplasmic Ca2+ concentration ([Ca2+]i) revealed that, whereas glucose lowered [Ca2+]i to the same extent as application of tolbutamide, the Na+ channel blocker tetrodotoxin, or the Ca2+ channel blocker Co2+ in wild-type α-cells, the sugar was far less effective on [Ca2+]i in SUR1−/− α-cells. We conclude that the KATP channel is involved in the control of glucagon secretion by regulating the membrane potential in the α-cell in a way reminiscent of that previously documented in insulin-releasing β-cells. However, because α-cells possess a different complement of voltage-gated ion channels involved in action potential generation than the β-cell, moderate membrane depolarization in α-cells is associated with reduced rather than increased electrical activity and secretion.

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Ng, X. W., Chung, Y. H., & Piston, D. W. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200026 · Cited by 39
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Authors: Gromada, J., Ma, X., Høy, M., Bokvist, K., Salehi, A., Berggren, P.-O., & Rorsman, P.
Affiliations: From the Lilly Research Laboratories, Hamburg, Germany
Lund University (SE)
University of Copenhagen (DK)
Karolinska Institutet (SE)
Churchill Hospital (GB)
ORCID: Gromada, Jesper
Ma, Xiaosong
Bokvist, Krister
Salehi, Albert
Berggren, Per-Olof
Rorsman, Patrik
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2004-12-01
Volume: 53
Issue: suppl_3
Pages: S181-S189
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.53.suppl_3.s181
OpenAlex: W2050636523
Cited by: 164
References: 45
Citations by year: 2026: 4 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 10 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 12
FWCI: 10.11
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: ATP-sensitive potassium channels, SUR1, glucagon secretion, alpha cells, glucose regulation, sulfonylureas, tolbutamide, glibenclamide, membrane potential, action potential, intracellular calcium, insulin secretion, islets, tetrodotoxin
MeSH terms: Adenosine Triphosphate, Animals, Glucagon, Glucose, Membrane Potentials, Mice, Inbred C57BL, Reference Values, Potassium Channels, Mice, Knockout, Mice

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A TP-Sensitive K+ Channel–Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR1−/− Mouse α-Cells

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