Association of Metabolically Healthy and Unhealthy Obesity Phenotypes with Oxidative Stress Parameters and Telomere Length in Healthy Young Adult Men. Analysis of the MAGNETIC Study
Open accessAbstract
Obesity is a significant factor related to metabolic disturbances that can lead to metabolic syndrome (MetS). Metabolic dysregulation causes oxidative stress, which affects telomere structure. The current study aimed to evaluate the relationships between telomere length, oxidative stress and the metabolically healthy and unhealthy phenotypes in healthy young men. Ninety-eight participants were included in the study (49 healthy slim and 49 obese patients). Study participants were divided into three subgroups according to body mass index and metabolic health. Selected oxidative stress markers were measured in serum. Relative telomere length (rTL) was measured using quantitative polymerase chain reaction. The analysis showed associations between laboratory markers, oxidative stress markers and rTL in metabolically healthy and unhealthy participants. Total oxidation status (TOS), total antioxidant capacity (TAC) and rTL were significantly connected with metabolically unhealthy obesity. TAC was associated with metabolically healthy obesity. Telomeres shorten in patients with metabolic dysregulation related to oxidative stress and obesity linked to MetS. Further studies among young metabolically healthy and unhealthy individuals are needed to determine the pathways related to metabolic disturbances that cause oxidative stress that leads to MetS.
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Telomeres are shorter especially in obesity accompanied by metabolic abnormalities leading to metabolic syndrome.
“Increased visceral adipose tissue is further associated with oxidative stress and it has been shown that telomeres are shorter especially in obesity that is accompanied by metabolic abnormalities leading to metabolic syndrome [21].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [21]
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Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
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- Authors
- Lejawa, M., Osadnik, K., Osadnik, T., & Pawlas, N.
- Affiliations
- Medical University of Silesia (PL)
- Corresponding author
- Lejawa, Mateusz
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2021-01-11
- Volume
- 10
- Issue
- 1
- Pages
- 93
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC7826733
- OpenAlex
- W3118332550
- Cited by
- 30
- References
- 71
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 4
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Narodowe Centrum Nauki (UMO-2014113IBINZ5/03166)
- Śląski Uniwersytet Medyczny (KNW-1-039/N/8/K)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- metabolically healthy obesity, metabolically unhealthy obesity, oxidative stress, telomere length, metabolic syndrome, total antioxidant capacity, young men, obesity phenotypes, body mass index
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