The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Brain Magnetic Resonance Imaging Correlates of Impaired Cognition in Patients With Type 2 Diabetes
Abstract
The structural correlates of impaired cognition in type 2 diabetes are unclear. The present study compared cognition and brain magnetic resonance imaging (MRI) between type 2 diabetic patients and nondiabetic control subjects and assessed the relationship between cognition and MRI findings and blood pressure and metabolic control. The study included 113 patients and 51 control subjects. Brain MRI scans were rated for white matter lesions (WMLs), cortical and subcortical atrophy, and infarcts. Neuropsychological test scores were divided into five cognitive domains and expressed as standardized Z values. Type 2 diabetes was associated with deep WMLs (P = 0.02), cortical (P < 0.001) and subcortical (P < 0.05) atrophy, (silent) infarcts (P = 0.06), and impaired cognitive performance (attention and executive function, information-processing speed, and memory, all P < 0.05). Adjustment for hypertension did not affect the results. Within the type 2 diabetic group, cognitive function was inversely related with WMLs, atrophy, and the presence of infarcts (adjusted for age, sex, and estimated IQ), and there was a modest association with HbA1c and diabetes duration. This association was strongest for age, even more so than in control subjects. We conclude that cognitive impairments in patients with type 2 diabetes are not only associated with subcortical ischemic changes in the brain, but also with increased brain atrophy.
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Cites
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The Prevalence of Comorbid Depression in Adults With Diabetes
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Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study
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Incidence and Risk Factors of Silent Brain Infarcts in the Population-Based Rotterdam Scan Study
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Type 2 diabetes mellitus, cognitive impairment and dementia
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The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function
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NIDDM and Blood Pressure as Risk Factors for Poor Cognitive Performance: The Framingham Study
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“One populationbased study found that hypertensive patients with type 2 diabetes were at the greatest risk for poor cognitive performance (31), but other longitudinal studies did not observe an evident relation between hypertension and cognitive performance (9,32,33), in line with the present observations.”
ResultKanaya, A. M., Barrett-Connor, E., Gildengorin, G., & Yaffe, K. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.12.1327 · Cited by 255
Cited by
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597
Silent brain infarcts: a systematic review
Vermeer, S. E., Longstreth, W. T., & Koudstaal, P. J. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70170-9 · Cited by 1,221
Cognitive Dysfunction and Diabetes Mellitus
Kodl, C. T., & Seaquist, E. R. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0034 · Cited by 802
Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy
Tesfaye, S., & Selvarajah, D. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2239 · Cited by 615
Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes
Gold, S. M., Dziobek, I., Sweat, V., Tirsi, A., Rogers, K., Bruehl, H., Tsui, W., Richardson, S., Javier, E., & Convit, A. (2007) · Diabetologia · doi:10.1007/s00125-007-0602-7 · Cited by 489
Metadata
- Authors
- Manschot, S. M., Brands, A. M. A., van der Grond, J., Kessels, R. P. C., Algra, A., Kappelle, L. J., Biessels, G. J., & on behalf of the Utrecht Diabetic Encephalopathy Study Group
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-04-01
- Volume
- 55
- Issue
- 4
- Pages
- 1106-1113
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2136800398
- Cited by
- 482
- References
- 11
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Manschot, S. M., Brands, A. M. A., van der Grond, J., Kessels, R. P. C., Algra, A., Kappelle, L. J., Biessels, G. J., & on behalf of the Utrecht Diabetic Encephalopathy Study Group. (2006). Brain Magnetic Resonance Imaging Correlates of Impaired Cognition in Patients With Type 2 Diabetes. Diabetes. https://doi.org/10.2337/diabetes.55.04.06.db05-1323
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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