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Chronically Increased Transforming Growth Factor-β1 Strongly Inhibits Hippocampal Neurogenesis in Aged Mice
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TGFβ signaling can negatively regulate NSC proliferation and neurogenesis via TGFβ binding to its receptors (TGFBR1, TGFBR2, and TGFBR3), leading to TGFβ signal transduction from the cell surface to the cytoplasm.
“TGFβ signaling could negatively regulate NSC proliferation and neurogenesis via TGFβ binding to its receptors (TGFBR1, TGFBR2, and TGFBR3), a process that could lead to TGFβ signal transduction from the cell surface to the cytoplasm [32, 33].”
From M2 microglia-derived small extracellular vesicles modulate NSC fate after ischemic stroke via miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3 axis (2025) · cites this paper as [32]
TGFβ signaling is a canonical signaling pathway that modulates CNS development, and its inhibition can promote adult neural stem/progenitor cell proliferation and neurogenesis.
“TGFβ signaling is a canonical signaling pathway that modulates the CNS development, and its inhibition can promote adult neural stem/progenitor cells proliferation and neurogenesis [32, 62].”
From M2 microglia-derived small extracellular vesicles modulate NSC fate after ischemic stroke via miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3 axis (2025) · cites this paper as [32]
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Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
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Self-citationInflammation is detrimental for neurogenesis in adult brain
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Irradiation induces neural precursor-cell dysfunction
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Self-citationInflammation in Neurodegenerative Disease—A Double-Edged Sword
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“Nestin-immunoreactive processes that radially span the dentate gyrus granule cell layer are characteristic of individual neural stem/progenitor cells.(49) Such profiles were reduced by 75% in TGF- 1 mice (Figure 1E).”
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Metadata
- Authors
- Buckwalter, M. S., Yamane, M., Coleman, B. S., Ormerod, B. K., Chin, J. T., Palmer, T., & Wyss-Coray, T.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 169
- Issue
- 1
- Pages
- 154-164
- ISSN
- 0002-9440
- Cited by
- 127
- References
- 8
- Language
- en
- Funders
- National Institutes of Health (AG20603, NS40994)
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