The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
Open accessAbstract
Accumulation of misfolded proteins in the endoplasmic reticulum triggers a cellular stress response called the unfolded protein response (UPR) that protects the cell against the toxic buildup of misfolded proteins. Previously, we reported that UPR activation is increased in Alzheimer's disease (AD) patients. How the UPR relates to the pathological hallmarks of AD is still elusive. In the present study, the involvement of UPR activation in neurofibrillary degeneration in AD was investigated. Immunoreactivity for the phosphorylated UPR activation markers pancreatic ER kinase (pPERK), eukaryotic initiation factor 2alpha, and inositol-requiring enzyme 1alpha was observed in hippocampal neurons associated with granulovacuolar degeneration. The percentage of pPERK-immunoreactive neurons was increased in AD cases compared with nondemented control cases and with the Braak stage for neurofibrillary changes. Although absent from neurofibrillary tangles, pPERK immunoreactivity was most abundant in neurons with diffuse localization of phosphorylated tau protein. Additional analyses showed that pPERK immunoreactivity was associated with ubiquitin and the ubiquitin binding protein p62. A strong co-occurrence of immunoreactivity for both pPERK and glycogen synthase kinase 3beta in neurons was also observed. Together, these data indicate that UPR activation in AD neurons occurs at an early stage of neurofibrillary degeneration and suggest that the prolonged activation of the UPR is involved in both tau phosphorylation and neurodegeneration in AD pathogenesis.
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Increased eIF2α correlates with increased p-eIF2α in Alzheimer's disease.
“Increased eIF2α correlates with increased p‐eIF2α in AD as previously reported 17, 34, 49, 50.”
From Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome (2016) · cites this paper as [49]
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- Authors
- Hoozemans, J. J. M., van Haastert, E. S., Nijholt, D. A. T., Rozemuller, A. J. M., Eikelenboom, P., & Scheper, W.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Hoozemans, Jeroen J.M.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 174
- Issue
- 4
- Pages
- 1241-1251
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC2671357
- OpenAlex
- W2167500696
- Cited by
- 600
- References
- 59
- Citations by year
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- FWCI
- 19.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Internationale Stichting Alzheimer Onderzoek (07506)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- unfolded protein response, Alzheimer's disease, hippocampal neurons, neurofibrillary degeneration, tau phosphorylation, eIF2α, IRE1α, granulovacuolar degeneration, ubiquitin, p62, glycogen synthase kinase-3β, endoplasmic reticulum stress, neurodegeneration
- MeSH terms
- Sequestosome-1 Protein, Glycogen Synthase Kinase 3 beta, Aged, Aged, 80 and over, Alzheimer Disease, Inclusion Bodies, Endoribonucleases, Female, Hippocampus, Humans, Immunohistochemistry, Male, Middle Aged, Neurons, Phosphorylation, Eukaryotic Initiation Factor-2, tau Proteins, Protein Serine-Threonine Kinases, Protein Folding, eIF-2 Kinase, Ubiquitin, Glycogen Synthase Kinase 3, Adaptor Proteins, Signal Transducing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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