Pregnancy complications in infertile patients with polycystic ovary syndrome: updated evidence
Abstract
Polycystic ovary syndrome (PCOS) is a common female disorder with a pathogenesis still today not completely known. To the present, PCOS is considered more than just a reproductive disorder since several metabolic consequences that could affect women's health during different stages of reproductive and post-reproductive life were reported. The aim of the current review was to evaluate present evidence-based data regarding the pregnancy complications in infertile patients with PCOS. An extensive literature search until February 2018 was performed in PubMed, Medline, the Cochrane Library and Web of Science. Outcomes were classified in: early pregnancy complications, late pregnancy complications, perinatal complications, offspring health and long-term offspring and maternal health. Even if the exact mechanisms involved are still unclear, women with PCOS have an increased risk of pregnancy-related complications, such as gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia (PE), premature delivery and caesarean section. Moreover, the offspring of women with PCOS are also at increased risk of congenital anomalies and hospitalization in childhood. Further studies are needed to study the mechanism underlying pregnancy complications in PCOS and to identify any interventions to reduce the risk of obstetric and neonatal risks in women affected by PCOS and in their offspring.
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PCOS is associated with a higher incidence of fertility assistance and complications of pregnancy, including gestational hypertension and diabetes.
“PCOS is associated with a higher incidence of fertility assistance and complications of pregnancy, including gestational hypertension and diabetes.12,17,18,21, 22, 23, 24”
From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [23]
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- Authors
- Palomba, S., Falbo, A., Daolio, J., Battaglia, F. A., & La Sala, G. B.
- Affiliations
- Azienda ospedaliera "Bianchi-Melacrino-Morelli" (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Venue
- Minerva Ginecologica
- Publisher
- Edizioni Minerva Medica
- Published
- 2018-11
- Volume
- 70
- Issue
- 6
- Pages
- 754-760
- ISSN
- 0026-4784 (ISSN-L)
- 1827-1650
- OpenAlex
- W2800569548
- Cited by
- 22
- References
- 46
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 6 · 2020: 3 · 2019: 4 · 2018: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Minerva Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- polycystic ovary syndrome, pregnancy complications, infertility, gestational diabetes mellitus, gestational hypertension, preeclampsia, preterm birth, cesarean section, perinatal complications, offspring health, congenital malformations, maternal health
- MeSH terms
- Cesarean Section, Female, Humans, Infertility, Female, Polycystic Ovary Syndrome, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk Factors, Diabetes, Gestational, Hypertension, Pregnancy-Induced, Premature Birth
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