Cited by 184Mental Health Treatment and AccessSchizophrenia research and treatmentSuicide and Self-Harm Studies

Excess mortality in severe mental illness: 10-year population-based cohort study in rural Ethiopia

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Fekadu, Abebaw, Medhin, Girmay, Kebede, Derege, Alem, Atalay, Cleare, Anthony J., Prince, Martin, Hanlon, Charlotte, Shibre, Teshome·2015·British Journal of Psychiatry

Abstract

Background: Evidence on mortality in severe mental illness (SMI) comes primarily from clinical samples in high-income countries. Aims: To describe mortality in people with SMI among a population cohort from a low-income country. Method: We followed-up 919 adults (from 68 378 screened) with SMI over 10 years. Standardised mortality ratios (SMR) and years of life lost (YLL) as a result of premature mortality were calculated. Results: In total 121 patients (13.2%) died. The overall SMR was twice that of the general population; higher for men and people with schizophrenia. Patients died about three decades prematurely, mainly from infectious causes (49.6%). Suicide, accidents and homicide were also common causes of death. Conclusions: Mortality is an important adverse outcome of SMI irrespective of setting. Addressing common natural and unnatural causes of mortality are urgent priorities. Premature death and mortality related to self-harm should be considered in the estimation of the global burden of disease for SMI.

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Authors
Fekadu, A., Medhin, G., Kebede, D., Alem, A., Cleare, A. J., Prince, M., Hanlon, C., & Shibre, T.
Affiliations
King's College London (GB)
Corresponding author
Fekadu, Abebaw
Venue
British Journal of Psychiatry
Published
2015-04
Volume
206
Issue
4
Pages
289-296
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
OpenAlex
W2091355806
Cited by
184
References
49
Citations by year
2026: 7 · 2025: 18 · 2024: 14 · 2023: 23 · 2022: 14 · 2021: 27 · 2020: 19 · 2019: 12 · 2018: 15 · 2017: 14 · 2016: 15 · 2015: 5 · 2014: 1
FWCI
26.73
Type
journal article
Language
en
Open access
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
World Health Organization
Topics
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Keywords
severe mental illness, mortality, premature mortality, schizophrenia, suicide, infectious disease mortality, years of life lost, global burden of disease, rural Ethiopia, low-income countries
MeSH terms
Accidents, Adolescent, Adult, Bipolar Disorder, Cause of Death, Depression, Ethiopia, Female, Homicide, Humans, Male, Middle Aged, Poverty, Rural Population, Schizophrenia, Suicide, Cohort Studies, Sex Distribution, Young Adult

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